CN100490873C

CN100490873C - Medicinal composition for treating high fever and preparation method thereof

Info

Publication number: CN100490873C
Application number: CNB200610109450XA
Authority: CN
Inventors: 卢能辉
Original assignee: Individual
Current assignee: Individual
Priority date: 2006-08-16
Filing date: 2006-08-16
Publication date: 2009-05-27
Anticipated expiration: 2026-08-16
Also published as: CN1907428A

Abstract

The invention relates to a pharmaceutical composition for treating high fever and process for preparation, which is prepared from raw material with the following constituents (by weight portions): ophiopogon root 7-20, hogfennel root 7.5-20, wofberry bark 10-31, talcum powder 8-28, aspirin 0.5-4, wolfberry fruit 5-18, ledebouriella root 7-22, and cimicifuga rhizome 7-21.

Description

A kind of pharmaceutical composition and preparation method for the treatment of hyperpyrexia

Technical field

The present invention relates to a kind of pharmaceutical composition for the treatment of hyperpyrexia (abbreviate as bring down a fever diffusing) and preparation method, relate in particular to a kind of pharmaceutical composition and preparation method of the hyperpyrexia that causes by SARS.

Background technology

Situation about can not bring down a fever in hospital is too numerous to mention at ordinary times, and this only is usual cat fever.Institute of hospital employing method is beaten back acupuncture with heated needle for to beat penicillin.Sars period in 2003, hyperpyrexia phenomenon still are serious, infect rapidly, are difficult to treatment control, because the complication of fever can not well be treated, cause a lot of an innocent persons' people to lose life.SARS mostly is Acute onset, generates heat to being first symptom, and body temperature is more than 38 degree, and it is high more to generate heat, and PD will be heavy more; Idol has a fear of cold, with or without headache, arthralgia and systemic pain, and chest pain or diarrhoea can be arranged.Also have tangible gradually respiratory symptom: dry cough, idol has sputum with blood streaks; Rapid breathing, tachypnea, uncomfortable in chest etc. appear in severe patient; Individual patients can further worsen, and develops into respiratory distress syndrome, causes respiratory failure.Thus, people still talk " allusion quotation " complexion changed up to now.Also there is not a kind of medicine can control the state of an illness separately at present.The pre-Seedling of SARS does not also formally enter the clinical practice stage.

Summary of the invention

At existing treatment hyperpyrexia, especially to being the inapparent technical deficiency of effect of drugs with hyperpyrexia of SARS symptom; Purpose of the present invention just is to provide a kind of pharmaceutical composition and preparation method for the treatment of hyperpyrexia, simultaneously, also is significantly to the hyperpyrexia therapeutic effect with SARS symptom.

For achieving the above object, the technical solution used in the present invention is:

A kind of pharmaceutical composition for the treatment of hyperpyrexia is characterized in that it is mainly by the preparation that comprises that following weight portion raw material components is prepared from: Radix Ophiopogonis 7-20, Radix Peucedani 7.5-20, Cortex Lycii 10-31, Talcum 8-28, aspirin 0.5-4, Fructus Lycii 5-18, Radix Saposhnikoviae 7-22, Rhizoma Cimicifugae 7-21.

Described raw material is following parts by weight of component: Radix Ophiopogonis 9-16, Radix Peucedani 9.5-15, Cortex Lycii 15-26, Talcum 9-21, aspirin 0.7-3, Fructus Lycii 7-15, Radix Saposhnikoviae 8.5-18, Rhizoma Cimicifugae 9-17.

Described raw material is following parts by weight of component: Radix Ophiopogonis 10.5, Radix Peucedani 13, Cortex Lycii 18, Talcum 18, aspirin 1, Fructus Lycii 8, Radix Saposhnikoviae 10, Rhizoma Cimicifugae 11.

Described preparation is pill, tablet, capsule.

A kind of preparation of drug combination method for the treatment of hyperpyrexia, may further comprise the steps: the weighting profit requires Radix Ophiopogonis, Radix Peucedani, Cortex Lycii, Fructus Lycii, Radix Saposhnikoviae, the Rhizoma Cimicifugae of one of 1-3 to mix, clean, sterilization, oven dry, add Talcum then, aspirin is pulverized together, makes pharmaceutical preparation at last routinely.

Introduce the effect of each raw material below:

Radix Ophiopogonis: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, and is used for dryness of the lung dry cough, the chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst.

Radix Peucedani: return lung, spleen channel, the wind heat clearing away of loosing, lowering the adverse-rising QI to resolve phlegm is used for the cough due to pathogenic wind-heat, abundant expectoration asthma, septum pectorale is full vexed.

Cortex Lycii: control asthenia hectic fever night sweat, the lung-heat cough with asthma is spitted blood, and quenches one's thirst, and the lung heat clearing pathogenic fire reducing is used for deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat.

Talcum: clearing away summer-heat and eliminating dampness, the summer-heat body is tired.

Aspirin: analgesicly bring down a fever, analgesia and antiinflammatory the formal name used at school aspirin.

Fructus Lycii: YIN nourishing invigorating the liver and kidney.

Radix Saposhnikoviae: inducing diaphoresis to dispel wind, win and wet, relieving convulsion.

Rhizoma Cimicifugae: deliver rash, heat-clearing and toxic substances removing, the elevate a turnable ladder yang-energy is used for headache due to pathogenic wind-heat, laryngopharynx swelling and pain, measles without adequate eruption.

The raw material that the present invention treats the pharmaceutical composition (it is diffusing to bring down a fever) of hyperpyrexia consists of: monarch: Radix Ophiopogonis, Radix Peucedani, Cortex Lycii, Talcum; Minister: aspirin; Assistant: Fructus Lycii, Radix Saposhnikoviae, Rhizoma Cimicifugae.

The function that the present invention treats the pharmaceutical composition (it is diffusing to bring down a fever) of hyperpyrexia cures mainly: cure mainly hyperpyrexia, can also treat the disease of flu one class.

The present invention controls pharmaceutical composition (it the is diffusing to bring down a fever) instructions of taking of hyperpyrexia: takes once for every, and 2 years old to 5 years old each 2 grams, 6 years old to 15 years old each 3 grams, 16 years old to each 4 grams of growing up.

But as hyperpyrexia interrupted (be several days burning person) again, can take the shake bile-fritillary end simultaneously when taking medicine of the present invention, produce as Foshan Fengliaoxing Pharmaceutical Co., Ltd., method is: take medicine of the present invention and take shake bile-fritillary end 8 grams, capsule after 3 hours; Took medicine of the present invention again in 3 hours again, spend 3 hours again and take the shake bile-fritillary end, like this each 3 times i.e. recoveries from illness.The elder must have wind because of the hyperpyrexia time, and wind is then gone into lung.And Fel Serpentis dispels the wind, and the tendril-leaved fritillary bulb cough-relieving treatment cardiopulmonary of coughing are so there is this effect.

The present invention has the following advantages;

1, the fever that flu is caused, clothes were once perspired and are brought down a fever in 20 minutes at the latest, and therapeutic effect is good; At least the hyperpyrexia (after bringing down a fever, also should at once change the treatment of primary symptom over to) evident in efficacy that SARS, cancer, leukemia, pneumonopathy are caused, the cure rate height has no side effect.

2, preparation method is simple, has reduced cost, and raw material sources conveniently are easy to get, and is with low cost.

Be the curative effect of proof medicine of the present invention, adopted the pharmaceutical composition (it is diffusing to bring down a fever) of treatment hyperpyrexia of inventor's following embodiment 3 to carry out zoopery and clinical trial.

One, zoopery:

(1) experiment source:

2005, World Health Organization (WHO) China office, just medicine of the present invention is done experiment on one's body from white mice.40 of the white mice that has SARS symptom that observation can be added up, white mice Mus age is that half a year is to a year and a half.

(2) experimental technique:

With mice infection SARS virus, fervescence fever and other SARS symptom appear in white mice.

Instructions of taking: medicine is made the injection injection, or sample food.Every white mice is taken once or injects once, and drug dosage is each 0.3 gram.

(3), experimental effect criterion:

Cure: the white mice temperature recovery is normal, and SARS symptom disappears, and physiological situation is normal.

Effectively: white mice is hyperpyrexia no longer, and SARS symptom obviously alleviates, and physiological situation is clearly better.

Invalid: do not bring down a fever, it is normal that physiological situation does not recover.

(4), laboratory observation result:

To 40 observation of curative effect of 14 days with white mice of SARS symptom, the result cures 39 of white mice, and effective 1, invalid 0, shared percentage ratio is respectively 97.5%, 2.5%, and 0.

Sum up:

Medicine of the present invention shows that through laboratory observation with regard to white mice, the cure rate total to the hyperpyrexia that has SARS symptom reaches 97.5%, and total effective percentage is 100%; This medicine has no side effect.

Two, case history source and typical analysis of medical record:

(1) case source:

Observation can be added up case 371 examples, wherein male 173 examples, women 198 examples, the oldest person 80 years old, reckling 1.5 years old.

(2) instructions of taking: pill, take once for every, 2 years old to 5 years old each 2 grams, 6 years old to 15 years old each 3 grams, 16 years old to each 4 grams of growing up.

(3), curative effect determinate standard:

Cure: various metabolism disorders recover normally fully, clinical symptom disappearance, clinical biochemical index ideal.

Effectively: clinical symptoms is clearly better, no longer hyperpyrexia cough, and various metabolism disorders obviously improve, and the clinical biochemical index is more satisfactory.

Invalid: clinical symptoms is not improved, and various metabolism disorders do not have change, do not reach " effectively " standard, and the clinical biochemical index is undesirable.

(4), observation of curative effect result:

To 371 routine cat fever patients' 7 days observation of curative effect, the result cures patient's 368 examples, effective patient's 3 examples, and invalid patient's 0 example, shared percentage ratio is respectively 99.19%, 0.81%, and 0.

Sum up:

Show that through clinical observation it reaches 99.19% to the total cure rate of cat fever, total effective rate is 100%; This medicine has no side effect, and cost is low, taking convenience.

In sum, the main component of medicine of the present invention has Radix Ophiopogonis, Radix Peucedani, Cortex Lycii, Talcum, aspirin, Fructus Lycii, Radix Saposhnikoviae, Rhizoma Cimicifugae.Medicine of the present invention is evident in efficacy to the hyperpyrexia that cold and high fever and SARS cause.

The specific embodiment

Embodiment 1

A kind of pharmaceutical composition (it is diffusing to bring down a fever) for the treatment of hyperpyrexia, sublimed preparation or pill:

Get following raw material (kg): Radix Ophiopogonis 7, Radix Peucedani 7.5, Cortex Lycii 10, Talcum 8, aspirin 0.5, Fructus Lycii 5, Radix Saposhnikoviae 7, Rhizoma Cimicifugae 7.

Preparation method: get above-mentioned Radix Ophiopogonis, Radix Peucedani, Cortex Lycii, Fructus Lycii, Radix Saposhnikoviae, Rhizoma Cimicifugae and mix, clean, sterilization, oven dry adds Talcum, aspirin then, is crushed to 420 order powder, makes sublimed preparation or pill then according to a conventional method.

Embodiment 2

A kind of pharmaceutical composition (it is diffusing to bring down a fever) for the treatment of hyperpyrexia, capsule:

Get following raw material (kg): Radix Ophiopogonis 20, Radix Peucedani 20, Cortex Lycii 31, Talcum 28, aspirin 4, Fructus Lycii 18, Radix Saposhnikoviae 22, Rhizoma Cimicifugae 21.

Preparation method: get above-mentioned Radix Ophiopogonis, Radix Peucedani, Cortex Lycii, Fructus Lycii, Radix Saposhnikoviae, Rhizoma Cimicifugae and mix, clean, sterilization, oven dry adds Talcum, aspirin then, is crushed to 100 order powder, makes capsule then according to a conventional method.

Embodiment 3

A kind of pharmaceutical composition (it is diffusing to bring down a fever) for the treatment of hyperpyrexia, tablet:

Get following raw material (kg): Radix Ophiopogonis 10.5, Radix Peucedani 13, Cortex Lycii 18, Talcum 18, aspirin 1, Fructus Lycii 8, Radix Saposhnikoviae 10, Rhizoma Cimicifugae 11.

Preparation method: get above-mentioned Radix Ophiopogonis, Radix Peucedani, Cortex Lycii, Fructus Lycii, Radix Saposhnikoviae, Rhizoma Cimicifugae and mix, clean, sterilization, oven dry adds Talcum, aspirin then, is crushed to 200 order powder, adds magnesium stearate 0.5kg, makes tablet then according to a conventional method.

Claims

1, a kind of pharmaceutical composition for the treatment of hyperpyrexia is characterized in that the preparation that it is prepared from by following weight portion raw material components: Radix Ophiopogonis 7-20, Radix Peucedani 7.5-20, Cortex Lycii 10-31, Talcum 8-28, aspirin 0.5-4, Fructus Lycii 5-18, Radix Saposhnikoviae 7-22, Rhizoma Cimicifugae 7-21.

2, a kind of pharmaceutical composition for the treatment of hyperpyrexia according to claim 1, it is characterized by: described raw material is following parts by weight of component: Radix Ophiopogonis 9-16, Radix Peucedani 9.5-15, Cortex Lycii 15-26, Talcum 9-21, aspirin 0.7-3, Fructus Lycii 7-15, Radix Saposhnikoviae 8.5-18, Rhizoma Cimicifugae 9-17.

3, a kind of pharmaceutical composition for the treatment of hyperpyrexia according to claim 1, it is characterized by: described raw material is following parts by weight of component: Radix Ophiopogonis 10.5, Radix Peucedani 13, Cortex Lycii 18, Talcum 18, aspirin 1, Fructus Lycii 8, Radix Saposhnikoviae 10, Rhizoma Cimicifugae 11.

4, according to claim 1 or 2 or 3 described a kind of pharmaceutical compositions for the treatment of hyperpyrexia, it is characterized by: described preparation is pill, tablet, capsule.

5, a kind of preparation of drug combination method for the treatment of hyperpyrexia, may further comprise the steps: the weighting profit requires Radix Ophiopogonis, Radix Peucedani, Cortex Lycii, Fructus Lycii, Radix Saposhnikoviae, the Rhizoma Cimicifugae of one of 1-3 to mix, clean, sterilization, oven dry, add Talcum then, aspirin is pulverized together, makes pharmaceutical preparation at last routinely.