CN100490867C - Traditional Chinese medicine composition for treating gynecologic inflammation and its preparing method - Google Patents
Traditional Chinese medicine composition for treating gynecologic inflammation and its preparing method Download PDFInfo
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- CN100490867C CN100490867C CNB2007100538211A CN200710053821A CN100490867C CN 100490867 C CN100490867 C CN 100490867C CN B2007100538211 A CNB2007100538211 A CN B2007100538211A CN 200710053821 A CN200710053821 A CN 200710053821A CN 100490867 C CN100490867 C CN 100490867C
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Abstract
A Chinese medicine for treating the gynecologic inflammation is prepared from 8 Chinese-medicinal materials including patrinia herb, green chiretta, Chinese angelica root, cyprus tuber, etc by supercritical CO2 extracting, microwave drying and superfine pulverizing. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to field of medicaments, relate to a kind of Chinese medicine composition for the treatment of gynecological inflammation and preparation method thereof specifically.
Background technology
Gynecological inflammation is meant that female genital system infects caused disease, is adult female's common, frequently-occurring disease, adult female's infection in various degree in the whole world about 87% gynecological inflammation.The gynecological inflammation clinical manifestation is also varied, the cause of disease is complicated and often with multiple severe complication, common clinically have vaginitis, cervicitis, pelvic inflammatory disease, an endometritis etc., often prolongedly do not heal, have a strong impact on women's quality of life and love life, and can cause infertile, bring out female reproductive system tumor etc.According to World Health Organization (WHO) China women's a investigation is shown: the women at reproduction age has 2.58 hundred million approximately in China, and wherein about 41.7% suffers from gynecological's inflammatory diseases in various degree, and married women's sickness rate is more up to 70%; Along with the opening of people's attitude towards sex and the increase day by day of Dink family, miscarriage is the women rise year by year in recent years, and miscarriage initiation inflammation of uterus is almost 100%, and therefore gynecological inflammation has become a big disease that perplexs China women at present.Prevalence height, relapse rate height are the main features of gynaecological inflammation disease, reflect that simultaneously the gynecological inflammation medicine market demand is huge.Along with the development of social economy and culture and the enhancing of women's self health consciousness, gynecological inflammation medication growth in recent years is very fast, great changes have also taken place in the market structure of gynecological inflammation medication, Chinese patent medicine occupies leading position in gynecological inflammation medication market, because the Chinese patent medicine side effect is little, determined curative effect is suitable for long-term prescription, adapted to the gynecological inflammation characteristics of recurrence easily, clinical practice is very extensive.
Though there is the Chinese patent medicine of a lot of treatment gynecological inflammations in market, but most of curative effects are undesirable, these medicines are many to exist defective because of prescription and preparation technology, in light of this situation, according to the gynecological inflammation etiology and pathogenesis, establish rational prescription, improving preparation technology becomes the thing that people are badly in need of solving with the content that improves effective ingredient.
Summary of the invention
The object of the present invention is to provide a kind ofly at invading in the noxious dampness, disorder of QI and blood, dash multiple gynecological inflammation prescriptions such as the leukorrhagia of appointing due to impaired, waist stomachache, attach most importance to removing damp-heat, assistant with invigorate blood circulation, enrich blood, the Chinese medicine composition of the treatment gynecological inflammation of kidney tonifying.Method of treatment clear, logical, sharp, that mend that medicine of the present invention has connected can overcome present weak point with veriety well.The preparation method of Chinese medicine composition of the present invention is on the basis of existing drug preparation technique, utilize modern advanced technology of preparing, to improve the active constituent content of medicine, resource economizes in raw materials, give full play to the therapeutic effect of medicine, overcome the deficiencies in the prior art.
Purpose of the present invention can adopt following measure to realize:
Chinese medicine composition of the present invention is a raw material through extracting with Caulis Mahoniae, Herba Patriniae, Herba Andrographis, Caulis Spatholobi, Radix Angelicae Sinensis, Rhizoma Cyperi, Fructus Rosae Laevigatae, Semen Euryales, adds suitable adjuvant and makes; Raw materials of effective components composition and weight ratio thereof are in this medicine: Caulis Mahoniae 12-40%, Herba Patriniae 10-40%, Herba Andrographis 5-25%, Caulis Spatholobi 10-40%, Radix Angelicae Sinensis 5-40%, Rhizoma Cyperi 5-25%, Fructus Rosae Laevigatae 10-30%, Semen Euryales 12-40%.
Optimum ratio: Caulis Mahoniae 18%, Herba Patriniae 12%, Herba Andrographis 10%, Caulis Spatholobi 14%, Radix Angelicae Sinensis 8%, Rhizoma Cyperi 8%, Fructus Rosae Laevigatae 15%, Semen Euryales 15%.
The preparation method of Chinese medicine composition of the present invention may further comprise the steps:
A, get Herba Patriniae, Radix Angelicae Sinensis, Rhizoma Cyperi by weight and be ground into coarse powder, adopt the CO2 supercritical methanol technology to extract volatile oil, standby;
B, get 65%-85% ethanol reflux, extract, 1-1.5 hour that medicinal residues behind Caulis Mahoniae, Herba Andrographis, Caulis Spatholobi, Fructus Rosae Laevigatae, Semen Euryales and the extraction volatile oil are put into 8-12 times of weight ratio jointly by weight, filter, filtrate recycling ethanol, concentrating under reduced pressure becomes clear extractum, relative density is 1.20-1.35, and is standby;
C, will adopt the medicinal residues behind the alcohol reflux to decoct with water 40 minutes again-1 hour, and filter, filtrate decompression is concentrated into relative density 1.20-1.35, and is standby;
D, the clear extractum of b step gained and c step gained concentrated solution are merged, drying under reduced pressure or microwave drying, pulverize or superfine powder to be broken into fine powder standby;
E, a step gained volatile oil and d step gained fine powder are merged, add appropriate amount of auxiliary materials again and make different preparations.
Different preparation of the present invention is any one in granule, tablet, capsule or the soft capsule.
Chinese medicine composition of the present invention is a monarch drug with Caulis Mahoniae, Herba Patriniae, Herba Andrographis heat-clearing and toxic substances removing, dampness; Think that with Radix Angelicae Sinensis, Caulis Spatholobi, Rhizoma Cyperi be ministerial drug, dash wantonly two arteries and veins because of damp and hot heresy damage, cause the sea of blood thanks to empty, so with Radix Angelicae Sinensis, Caulis Spatholobi nourshing blood and promoting blood circulation, the unimpeded gas that dashes wantonly two warps of Rhizoma Cyperi makes to dash and appoints admittedly, dai channel approximately; Assistant is with Fructus Rosae Laevigatae, Semen Euryales kidney tonifying, astringency inducing dai channel and leukorrhagia stopping.All medicine compatibilities have removing damp-heat, blood circulation promoting and blood stasis dispelling, and the function of the astringent or styptic treatment for spontaneous sweating leukorrhagia stopping of kidney tonifying is used for the treatment of leukorrheal diseases, endometritis, chronic cervicitis, chronic pelvic inflammatory disease due to the dampness and heat stasis.Modern pharmacy studies have shown that: Caulis Mahoniae contains alkaloids compositions such as berberine, berbamine, jateorhizine, has effects such as antiinflammatory, antibacterial, analgesia; Herba Patriniae contain volatile oil,, potassium myronate, villoside, scabioside etc. have antibacterial, antiviral effect; The Herba Andrographis master contains diterpene-kind compound, as andrographolide, 14-deoxidation-11-oxygen-andrographolide etc., has pharmacological actions such as antiinflammatory action, refrigeration function, adrenal cortex reinforcing function; Radix Angelicae Sinensis is the key medicine of enriching blood by the title of " gynecological's Radix Ginseng ", contains compositions such as volatile oil (the highest with ligustilide content), ferulic acid, has excited hemopoietic function, promotes the metabolism in uterus, the pharmacological action of analgesia, calmness, antiinflammatory, enhancing human body immunity; Effective ingredient such as Caulis Spatholobi isoflavone-containing class, flavanone, chalcone, have the hemodynamics of improvement, antiplatelet aggregation. immune system is had two-ways regulation, blood fat reducing, antiatherogenic pharmacological action; Rhizoma Cyperi contains effective ingredient such as cyperene, α-cyperone, β-cyperone; Have lax uterine smooth muscle, estrogen-like effects, refrigeration function (it is tired and is about 6 times of sodium salicylate), antiinflammatory action, resisting pathogenic microbes effect etc.; Fructus Rosae Laevigatae contain citric acid, malic acid, tannin, etc. composition, have antivirus action.
Chinese medicine composition of the present invention is at invading in the noxious dampness, disorder of QI and blood, dash to appoint multiple gynecological inflammation prescriptions such as leukorrhagia due to impaired, waist stomachache, attach most importance to removing damp-heat, assistant with invigorate blood circulation, enrich blood, kidney tonifying, connected method of treatment clear, logical, sharp, that mend, the principle that meets the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs of the traditional Chinese medical science, made medicine is used for the treatment of multiple gynecological inflammation, has effects such as antiinflammatory, antibacterial, analgesia.
The specific embodiment
The present invention does with detailed description below with reference to embodiment:
Embodiment 1 preparation granule
Present embodiment adopts following proportioning and processing step to realize:
A, get Herba Patriniae 10%, Radix Angelicae Sinensis 10%, Rhizoma Cyperi 10% by weight and be ground into coarse powder, adopt the CO2 supercritical methanol technology to extract volatile oil, standby;
B, get Caulis Mahoniae 20%, Herba Andrographis 5%, Caulis Spatholobi 15%, Fructus Rosae Laevigatae 15%, Semen Euryales 15% and extract medicinal residues behind the volatile oil and put into the 80% ethanol reflux, extract, 1 hour of 10 times of weight ratios jointly by weight, filter, filtrate recycling ethanol, concentrating under reduced pressure becomes clear extractum, relative density is 1.25, and is standby;
C, will adopt the medicinal residues behind the alcohol reflux to decoct with water 1 hour again, and filter, filtrate decompression is concentrated into relative density 1.30, and is standby;
D, the clear extractum of b step gained and c step gained concentrated solution are merged, microwave drying, it is standby to be ground into fine powder;
E, in d step gained fine powder, add an amount of Icing Sugar, with 75% alcoholic solution as wetting agent, the system soft material, 14 mesh sieves are granulated, and put 60-80 ℃ of dryings, spray into the volatile oil that a step is extracted, mixing, 12 mesh sieve granulate, pack promptly gets 1000 bags (every bag heavy 6.0g).
Embodiment 2 preparation capsules
Present embodiment adopts following proportioning and processing step to realize:
A, get Herba Patriniae 12%, Radix Angelicae Sinensis 8%, Rhizoma Cyperi 8% by weight and be ground into coarse powder, adopt the CO2 supercritical methanol technology to extract volatile oil, standby;
B, get Caulis Mahoniae 18%, Herba Andrographis 10%, Caulis Spatholobi 14%, Fructus Rosae Laevigatae 15%, Semen Euryales 15% and extract medicinal residues behind the volatile oil and put into the 70% ethanol reflux, extract, 1 hour of 12 times of weight ratios jointly by weight, filter, filtrate recycling ethanol, concentrating under reduced pressure becomes clear extractum, relative density is 1.30, and is standby;
C, will adopt the medicinal residues behind the alcohol reflux to decoct with water 40 minutes again, and filter, filtrate decompression is concentrated into relative density 1.30, and is standby;
D, the clear extractum of b step gained and c step gained concentrated solution are merged, drying under reduced pressure is ground into suitable granule and fine powder, and is standby;
E, add the magnesium stearate of 1.5% (weight ratio) in d step gained granule and fine powder, mixing sprays into the volatile oil that a step is extracted, and mixing is loaded in capsule shells, makes 1000, promptly.
Embodiment 3 preparation tablets
Present embodiment adopts following proportioning and processing step to realize:
A, get Herba Patriniae 15%, Radix Angelicae Sinensis 8%, Rhizoma Cyperi 10% by weight and be ground into coarse powder, adopt the CO2 supercritical methanol technology to extract volatile oil, standby;
B, get Caulis Mahoniae 20%, Herba Andrographis 5%, Caulis Spatholobi 10%, Fructus Rosae Laevigatae 10%, Semen Euryales 12% and extract medicinal residues behind the volatile oil and put into the 75% ethanol reflux, extract, 1 hour of 11 times of weight ratios jointly by weight, filter, filtrate recycling ethanol, concentrating under reduced pressure becomes clear extractum, relative density is 1.30, and is standby;
C, will adopt the medicinal residues behind the alcohol reflux to decoct with water 40 minutes again, and filter, filtrate decompression is concentrated into relative density 1.30, and is standby;
D, the clear extractum of b step gained and c step gained concentrated solution are merged, drying under reduced pressure is ground into fine powder, and is standby;
E, add 15% (weight ratio) hydroxypropyl cellulose or starch in d step gained fine powder, granulate, drying adds an amount of magnesium stearate, and mixing sprays into the volatile oil that a step is extracted, mixing, and tabletting, every must about 0.4g, makes 1000, promptly.
Embodiment 4 preparation soft capsules
Present embodiment adopts following proportioning and processing step to realize:
A, get Herba Patriniae 15%, Radix Angelicae Sinensis 10%, Rhizoma Cyperi 10% by weight and be ground into coarse powder, adopt the CO2 supercritical methanol technology to extract volatile oil, standby;
B, get Caulis Mahoniae 15%, Herba Andrographis 15%, Caulis Spatholobi 10%, Fructus Rosae Laevigatae 10%, Semen Euryales 15% and extract medicinal residues behind the volatile oil and put into the 85% ethanol reflux, extract, 1 hour of 9 times of weight ratios jointly by weight, filter, filtrate recycling ethanol, concentrating under reduced pressure becomes clear extractum, relative density is 1.35, and is standby;
C, will adopt the medicinal residues behind the alcohol reflux to decoct with water 40 minutes again, and filter, filtrate decompression is concentrated into relative density 1.35, and is standby;
D, the clear extractum of b step gained and c step gained concentrated solution are merged, the decompressed microwave drying, superfine powder is broken into fine powder, and is standby;
E, get an amount of vegetable oil and add the volatile oil mixing that a step is extracted, add 0.1% Cera Flava again and in d step gained fine powder Place grinding machine, fully mix, make it suspendible; After gelatin dissolved, standby more than 1 hour 68 ℃ of insulations; Gelatin solution and drug suspension are placed the hopper of encapsulating machine respectively, be pressed into soft capsule, under 38 ± 2 ℃ of conditions, dry, promptly get soft capsule.Every dress 0.65g makes 1000, promptly.
The present invention is following further to set forth the beneficial effect that the present invention has by the clinical observation on the therapeutic effect test.
Preparation of the present invention has removing damp-heat, blood circulation promoting and blood stasis dispelling, and the function of the astringent or styptic treatment for spontaneous sweating leukorrhagia stopping of kidney tonifying is mainly used in treatment endometritis, cervicitis, pelvic inflammatory disease etc.With capsule for treating 65 routine acute and chronic pelvic inflammatory disease of the present invention, endometritis, cervicitis patient, each 4 one 6, every day 3 times, serveing on 20 days is a course of treatment.After 3 course of therapy, cure 38 examples, account for 58.46%; 25 examples that take a turn for the better account for 38.46%.Total effective rate 96.92%, invalid 1 example accounts for 1.5%.None routine untoward reaction in therapeutic process.
Claims (3)
1, a kind of Chinese medicine composition for the treatment of gynecological inflammation, it is characterized in that: raw materials of effective components composition and percentage by weight thereof are in this medicine: Caulis Mahoniae 12-40%, Herba Patriniae 10-40%, Herba Andrographis 5-25%, Caulis Spatholobi 10-40%, Radix Angelicae Sinensis 5-40%, Rhizoma Cyperi 5-25%, Fructus Rosae Laevigatae 10-30%, Semen Euryales 12-40%; And the percentage by weight sum of above-mentioned raw materials is 100%.
2, a kind of preparation method that is used for the treatment of the Chinese medicine composition of gynecological inflammation, it is characterized in that: it may further comprise the steps:
A, get Caulis Mahoniae 12-40% by weight percentage, Herba Patriniae 10-40%, Herba Andrographis 5-25%, Caulis Spatholobi 10-40%, Radix Angelicae Sinensis 5-40%, Rhizoma Cyperi 5-25%, Fructus Rosae Laevigatae 10-30%, Semen Euryales 12-40%; And the percentage by weight sum of above-mentioned raw materials is 100%;
B, Herba Patriniae, Radix Angelicae Sinensis, Rhizoma Cyperi are ground into coarse powder, adopt CO
2Supercritical methanol technology is extracted volatile oil, and is standby;
C, Caulis Mahoniae, Herba Andrographis, Caulis Spatholobi, Fructus Rosae Laevigatae, Semen Euryales and b step are extracted 65%-85% ethanol reflux, extract, 1-1.5 hour that medicinal residues behind the volatile oil are put into 8-12 times of weight jointly, filter, filtrate recycling ethanol, concentrating under reduced pressure becomes clear extractum, relative density is 1.20-1.35, and is standby;
D, will adopt the medicinal residues behind the alcohol reflux to decoct with water 40 minutes again-1 hour, and filter, filtrate decompression is concentrated into relative density 1.20-1.35, and is standby;
E, the clear extractum of c step gained and d step gained concentrated solution are merged, drying under reduced pressure or microwave drying, it is standby to be ground into fine powder;
F, b step gained volatile oil and e step gained fine powder are merged, add appropriate amount of auxiliary materials again and make different preparations.
3, the preparation method of the Chinese medicine composition of treatment gynecological inflammation according to claim 2 is characterized in that: described different preparations are any one in granule, tablet or the capsule.
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| CNB2007100538211A CN100490867C (en) | 2007-01-10 | 2007-01-10 | Traditional Chinese medicine composition for treating gynecologic inflammation and its preparing method |
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| CNB2007100538211A CN100490867C (en) | 2007-01-10 | 2007-01-10 | Traditional Chinese medicine composition for treating gynecologic inflammation and its preparing method |
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| CN100490867C true CN100490867C (en) | 2009-05-27 |
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| CN104026669A (en) * | 2014-06-16 | 2014-09-10 | 哈尔滨升益生物科技开发有限公司 | Dahurian patrinia herb soup with function of clearing away heat and toxic materials and production method thereof |
| CN104353048B (en) * | 2014-11-21 | 2018-01-30 | 孙美芬 | A kind of draft pad for being used for treating gynecological disease |
| CN105748886A (en) * | 2016-04-08 | 2016-07-13 | 广州暨南生物医药研究开发基地有限公司 | Folium artemisiae argyi-containing pharmaceutical composition for treating endometritis and preparation method thereof |
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Non-Patent Citations (4)
| Title |
|---|
| 奇经理论与妇科辩证论治关系的研究进展. 雷磊，尤昭玲.湖南中医药导报，第6卷第9期. 2000 |
| 奇经理论与妇科辩证论治关系的研究进展. 雷磊，尤昭玲.湖南中医药导报，第6卷第9期. 2000 * |
| 慢性盆腔炎治疗中成药的选择应用. 经燕，李仁杰.中国临床医生，第30卷第6期. 2002 |
| 慢性盆腔炎治疗中成药的选择应用. 经燕，李仁杰.中国临床医生，第30卷第6期. 2002 * |
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