CN100482249C - Application of 'Kidney Benefiting Injection' in the process for preparing medicine to treat nephrotic syndrome - Google Patents
Application of 'Kidney Benefiting Injection' in the process for preparing medicine to treat nephrotic syndrome Download PDFInfo
- Publication number
- CN100482249C CN100482249C CNB2004100394211A CN200410039421A CN100482249C CN 100482249 C CN100482249 C CN 100482249C CN B2004100394211 A CNB2004100394211 A CN B2004100394211A CN 200410039421 A CN200410039421 A CN 200410039421A CN 100482249 C CN100482249 C CN 100482249C
- Authority
- CN
- China
- Prior art keywords
- nephrotic syndrome
- injection
- application
- shenkang
- preparing medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002347 injection Methods 0.000 title claims abstract description 6
- 239000007924 injection Substances 0.000 title claims abstract description 6
- 206010029164 Nephrotic syndrome Diseases 0.000 title claims description 13
- 239000003814 drug Substances 0.000 title claims description 7
- 210000003734 kidney Anatomy 0.000 title description 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000009457 shenkang Substances 0.000 claims abstract description 19
- 241000628997 Flos Species 0.000 claims description 2
- 239000009636 Huang Qi Substances 0.000 claims description 2
- 206010030113 Oedema Diseases 0.000 abstract description 4
- 208000017169 kidney disease Diseases 0.000 abstract 2
- 208000011580 syndromic disease Diseases 0.000 abstract 2
- 206010001580 Albuminuria Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 244000299790 Rheum rhabarbarum Species 0.000 abstract 1
- 235000009411 Rheum rhabarbarum Nutrition 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 238000007599 discharging Methods 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 235000005412 red sage Nutrition 0.000 abstract 1
- 210000002700 urine Anatomy 0.000 abstract 1
- 208000020832 chronic kidney disease Diseases 0.000 description 7
- 208000022831 chronic renal failure syndrome Diseases 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 230000003907 kidney function Effects 0.000 description 4
- 208000037157 Azotemia Diseases 0.000 description 3
- 230000001447 compensatory effect Effects 0.000 description 3
- 102000009027 Albumins Human genes 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 206010020880 Hypertrophy Diseases 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 208000009852 uremia Diseases 0.000 description 2
- 229930024421 Adenine Natural products 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 1
- 229960000643 adenine Drugs 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000008378 epithelial damage Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 201000008627 kidney hypertrophy Diseases 0.000 description 1
- 210000003584 mesangial cell Anatomy 0.000 description 1
- 210000000713 mesentery Anatomy 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 210000000885 nephron Anatomy 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention is application of Shenkang injection in treating kidney disease syndrome. The Shenkang injection is prepared with the extract of rhubarb, red sage and other Chinese medicinal materials, has the functions of benefiting vital energy, enhancing body's resistance, dispersing blood clots and discharging turbid urine, and can treat kidney disease syndrome effectively via improving the dropsy, hypertension and albuminuria of the patient.
Description
The present invention relates to the application of a kind of SHENKANG ZHUSHEYE in the medicine of preparation treatment nephrotic syndrome.
SHENKANG ZHUSHEYE is the new drug of the treatment chronic renal failure of Jiahui, Xi'an pharmaceutcal corporation, Ltd research and development.It is to extract the injection of making by Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, the Radix Astragali, Flos Carthami, has QI invigorating and consolidates, and the effect of dissipating stasis and purging turbidity is applicable to the chronic renal failure patient.Medicine is directly by intravenous injection, and effect is rapid, the bioavailability height, and short treating period, good effect especially has better effects to infringement more than the renal function moderate.Main result of study is as follows: (1) animal experiment study shows: the SHENKANG ZHUSHEYE of high dose (50% SHENKANG ZHUSHEYE 0.8ml/100g), middle dosage (25% SHENKANG ZHUSHEYE 0.8ml/100g) can obviously reduce chronic renal failure (CRF) rat and blood urea nitrogen (BUN), creatinine (Cr) level, alleviate the azotemia that carrying out property increases the weight of, rising hemoglobin (Hb), improve anemia, still can improve albumin (ALB) level to adenine CRF rat, the kidney hypertrophy is alleviated, and the kidney coefficient obviously reduces.Pathological observation shows: SHENKANG ZHUSHEYE can alleviate the glomerule hypertrophy, suppress mesangial cell and mesentery substrate hypertrophy, obviously reduce the hardening ratio of glomerule, alleviate renal tubules overdistension and epithelial damage, alleviate interstitial fibrosis, promote the reparation and the mitochondrial hyperplasia of renal cells.(2) clinical research shows: treatment group SHENKANG ZHUSHEYE, and matched group drips with kidney is quiet, and renal function is lost the compensatory phase to SHENKANG ZHUSHEYE and there is good result in uremia the phase, and two groups of curative effects are excellent with the treatment group all relatively, P＜0.05.In sum, SHENKANG ZHUSHEYE can alleviate the carrying out property damage of the compensatory nephron of CRF rat and the carrying out property of renal function goes down, thereby delays the process of CRF.Renal function is lost the compensatory phase in clinical observation and there is good result in uremia the phase.Do not see at present the clinical report that is used for nephrotic syndrome.
The object of the present invention is to provide the application of a kind of SHENKANG ZHUSHEYE in the medicine of preparation treatment nephrotic syndrome.
The present invention is by the application of SHENKANG ZHUSHEYE in the medicine of preparation treatment nephrotic syndrome.In the III phase clinical in, add with SHENKANG ZHUSHEYE 100ml among 10% the glucose 300ml, intravenous drip, every day 1 time, 28 days is 1 course of treatment, treats 39 routine nephrotic syndrome patients.The result shows, SHENKANG ZHUSHEYE produce effects 41.03% (16/39) is effective 46.15 (18/39), total effective rate 87.18%; Conclusion: the injection of kidney health can obviously improve nephrotic syndrome patient's edema, HP, treats the nephrotic syndrome patient effectively.
The invention has the advantages that: improve nephrotic syndrome patient's edema, HP, do not see obvious toxic-side effects.
With specific embodiment the present invention is elaborated below:
Among the glucose 300ml of SHENKANG ZHUSHEYE 100ml adding 10%, intravenous drip, every day 1 time, 28 days is 1 course of treatment.Can obviously improve nephrotic syndrome patient's edema, HP, treat the nephrotic syndrome patient effectively.
Claims (1)
1, the application of a kind of SHENKANG ZHUSHEYE in the medicine of preparation treatment nephrotic syndrome, SHENKANG ZHUSHEYE are to extract the injection of making by Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, the Radix Astragali, Flos Carthami.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100394211A CN100482249C (en) | 2004-02-11 | 2004-02-11 | Application of 'Kidney Benefiting Injection' in the process for preparing medicine to treat nephrotic syndrome |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100394211A CN100482249C (en) | 2004-02-11 | 2004-02-11 | Application of 'Kidney Benefiting Injection' in the process for preparing medicine to treat nephrotic syndrome |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1654061A CN1654061A (en) | 2005-08-17 |
| CN100482249C true CN100482249C (en) | 2009-04-29 |
Family
ID=34892339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100394211A Expired - Lifetime CN100482249C (en) | 2004-02-11 | 2004-02-11 | Application of 'Kidney Benefiting Injection' in the process for preparing medicine to treat nephrotic syndrome |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100482249C (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102475760B (en) * | 2010-11-30 | 2014-04-02 | 西安世纪盛康药业有限公司 | Kidney-health compound preparation for treating chronic renal failure and preparation method thereof |
| CN102475755B (en) * | 2010-11-30 | 2013-12-04 | 西安世纪盛康药业有限公司 | Shenkang aerosol for treating chronic renal failure and preparation method of Shenkang aerosol |
| CN102475763B (en) * | 2010-11-30 | 2013-12-04 | 西安世纪盛康药业有限公司 | Shenkang dripping pill for treating chronic renal failure and preparation method thereof |
| CN102475753B (en) * | 2010-11-30 | 2014-04-02 | 西安世纪盛康药业有限公司 | Kidney-health patch for treating chronic renal failure and preparation method thereof |
| CN102475762B (en) * | 2010-11-30 | 2013-12-18 | 西安世纪盛康药业有限公司 | Shenkang oral liquid compound preparation for treating chronic renal failure and preparation method of Shenkang oral liquid compound preparation |
| CN102475754B (en) * | 2010-11-30 | 2013-12-18 | 西安世纪盛康药业有限公司 | Shenkang soft capsule for treating chronic renal failure and preparation method of Shenkang soft capsule |
| CN102475761B (en) * | 2010-11-30 | 2013-12-18 | 西安世纪盛康药业有限公司 | Shenkang oral solid compound preparation for treating chronic renal failure and preparation method of Shenkang oral solid compound preparation |
| CN102475758B (en) * | 2010-11-30 | 2013-12-18 | 西安世纪盛康药业有限公司 | Shenkang tablet for treating chronic renal failure and preparation method of Shenkang tablet |
| CN103054961B (en) * | 2011-10-24 | 2014-08-13 | 西安世纪盛康药业有限公司 | Application of Shenkang injection in preparation of medicament for treating chronic renal failure complication or complication caused by dialysis |
| CN103099854B (en) * | 2011-11-11 | 2014-08-13 | 西安世纪盛康药业有限公司 | Application of Shenkang injection in preparing drug for preventing and treating cardiovascular and cerebrovascular diseases |
| CN103285096B (en) * | 2012-02-22 | 2015-03-04 | 西安世纪盛康药业有限公司 | Applications of Shenkang injection in preparation of medicine used for treatment of hypertensive nephropathy |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1356117A (en) * | 2001-01-11 | 2002-07-03 | 李方瑞 | Capsule 'Tangniaoshenkang' for treating diabetes |
| CN1289610C (en) * | 2001-07-31 | 2006-12-13 | 克莱里安特财务(Bvi)有限公司 | Novel formazan reactive dyes |
-
2004
- 2004-02-11 CN CNB2004100394211A patent/CN100482249C/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1356117A (en) * | 2001-01-11 | 2002-07-03 | 李方瑞 | Capsule 'Tangniaoshenkang' for treating diabetes |
| CN1289610C (en) * | 2001-07-31 | 2006-12-13 | 克莱里安特财务(Bvi)有限公司 | Novel formazan reactive dyes |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1654061A (en) | 2005-08-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100482249C (en) | Application of 'Kidney Benefiting Injection' in the process for preparing medicine to treat nephrotic syndrome | |
| CN100482248C (en) | Application of 'Kidney Benefiting Injection' in the process for preparing medicine to treat diabetic nephropathy | |
| CN102258693A (en) | Traditional Chinese medicine for treating hypertension | |
| CN102526611A (en) | Chinese medicinal composition for treating chronic heart failure | |
| CN101987125B (en) | Medicine for treating verruca plana and preparation method thereof | |
| CN1883642A (en) | Medicine for treating mammary glands hyperplasia | |
| CN103301305A (en) | Traditional Chinese medicine for treating prostatic hyperplasia | |
| CN102526614B (en) | Chinese medicinal kidney healing powder for treating chronic renal failure | |
| CN101569685A (en) | External medicine for treating verruca plana | |
| CN1294971C (en) | 'Niaoduqing' granule taken after being mixed with boiling water for cutting uraemia | |
| CN1160102C (en) | Chinese medicine for curing female chronic inflammation | |
| CN100393346C (en) | Traditional Chinese medicine for treating leuhemia | |
| CN103751293A (en) | Traditional Chinese medicinal composition for treating chronic nephritis | |
| CN109876127A (en) | A kind of blood-nourishing angelica capsules and preparation method thereof | |
| CN100515477C (en) | Chinese medicine decoction for treating prolapse of lumber intercertebtral disc | |
| CN111375036B (en) | Traditional Chinese medicine composition for treating novel coronavirus pneumonia and application thereof | |
| CN1586512A (en) | Medicine for treating liver disease | |
| CN102397511A (en) | Medicament for treating flat wart | |
| CN101890145B (en) | Medicament for treating diabetes and preparation thereof | |
| CN104689219A (en) | Traditional Chinese medicine used for treating hypertension | |
| CN101829270A (en) | Traditional Chinese medicine preparation for treating chronic renal failure and preparation method | |
| CN1419917A (en) | Oral pulse-invigorating liquid for treating chronic nephritis, and preparing method thereof | |
| CN101428095A (en) | Medicinal liquor for treating semiplegia and preparation method thereof | |
| CN105663868A (en) | Traditional Chinese medicinal composition for treating aplastic anemia | |
| CN102078387A (en) | Traditional Chinese medicine for treating fibroid and ovarian cyst |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: XI'AN CENTURY SHENGKANG PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: WU FANG Effective date: 20091002 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20091002 Address after: Shaanxi province Xi'an Fengjing Industrial Park Fengjing Road No. 6 Patentee after: XI'AN SHIJISHENGKANG PHARMACEUTICAL INDUSTRY Co.,Ltd. Address before: Shaanxi city of Xi'an province high tech Zone Tang Yan Road No. 35 room B2003 Mong modern city Patentee before: Wu Fang |
|
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20090429 |
|
| DD01 | Delivery of document by public notice |
Addressee: Lv Yanying Document name: Notice of Termination of Patent Rights |
|
| DD01 | Delivery of document by public notice |