CN100464877C - Chip washing method and device - Google Patents
Chip washing method and device Download PDFInfo
- Publication number
- CN100464877C CN100464877C CNB2006100078853A CN200610007885A CN100464877C CN 100464877 C CN100464877 C CN 100464877C CN B2006100078853 A CNB2006100078853 A CN B2006100078853A CN 200610007885 A CN200610007885 A CN 200610007885A CN 100464877 C CN100464877 C CN 100464877C
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- motor
- chip
- transmission device
- sliding bar
- wash mill
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- 238000005406 washing Methods 0.000 title claims abstract description 43
- 238000000034 method Methods 0.000 title abstract description 7
- 230000005540 biological transmission Effects 0.000 claims description 26
- 238000004140 cleaning Methods 0.000 claims description 16
- 238000000018 DNA microarray Methods 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 230000003100 immobilizing effect Effects 0.000 abstract 1
- 238000009396 hybridization Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 229920003023 plastic Polymers 0.000 description 5
- 239000004033 plastic Substances 0.000 description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 4
- 229910052802 copper Inorganic materials 0.000 description 4
- 239000010949 copper Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 3
- 230000003068 static effect Effects 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 229920005479 Lucite® Polymers 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
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Abstract
One kind of chip washing method and device are disclosed. The method includes setting a motor driven conveyer over a washing container, immobilizing the washing container and driving the chip to be washed with the conveyer to move relatively to the washing container. The chip washing device includes: one outer barrel, one bottom plate fixed to the bottom of the outer barrel, one fixing board fixed inside the outer barrel, one motor fixed onto the fixing board, one slipway board fixed inside the outer barrel, one conveyer set on the slipway with input connected to the output of the motor; and one frame for holding the chip and connected to the output of the conveyer. The present invention can wash great amount of chips in identical washing effect and may be used widely in washing various kinds of electronic chips and biochips.
Description
Technical field
The present invention relates to a kind of chip wash mill.
Background technology
Existing biochip washing methods mainly contains two classes, one class is that the wash mill that adopts hybridization instrument to carry washs, the Automated Slide Pro hybridization instrument of producing as amersham pharmacia biotech company is subsidiary wash mill, though its stability is higher, but hybridization and washing need be carried out continuously, be difficult to realize independent washing operation, also be unfavorable for carrying out continuous washing in enormous quantities, its at every turn multipotency hybridization and wash 30, and be difficult to realize simultaneously the uniformity of every wash conditions.
An other class is shaking table vibration washing, and wherein shaking table is divided into common shaking table and shaking bath again.Cleaning solution can be poured in the plastic casing or in the beaker, and chip directly is put in the washing of vibrating on the copper frame in the plastic casing or in the beaker.With respect to washing on the copper frame, the mode that chip washs in plastic casing is unfavorable for washing in enormous quantities and concentrates centrifuge dripping.Chip in beaker on the copper frame by shaking table when washing vibration because beaker is different, inboard also different with the cleaning solution flow velocity in the outside with lower floor cleaning solution flow velocity at the middle and upper levels, therefore easily cause the difference that reaches clean result between sheet in the sheet.In addition, also bigger when the Volume Changes of cleaning solution is big in the beaker during shaking table vibration washing to the influence of cleaning solution flow velocity, will the repeatability of clean result be reduced.
Japanese patent application (JP2000-269176) discloses a kind of wash mill that is used for the electron trade chip, and this wash mill comprises sink, suspension rod, driving mechanism and motor, and cleaning solution is housed in the sink, controls the motion of motor by control device.The electronic chip that will be fixed on the suspension rod lower end during washing earlier slowly immerses in the cleaning solution to avoid having left over bubble in the chip internal gap.Suspension rod is static then, and the rabbling mechanism agitator treating liquid of sink bottom washs electronic chip.Its washing principle and above-mentioned shaking table vibration washing are basic identical, and the problem of existence is that there is inhomogenous phenomenon in the cleaning solution flow velocity in the sink.
Another part Japanese patent application (JP2005-349301A) discloses a kind of chip washing methods, the transmission device of driven by motor is set below washing container, described washing container maintains static, and the described chip that is washed is the motion of the cleaning solution in the mutually described washing container under the drive of transmission device.Yet also there is the inhomogenous problem of cleaning solution flow velocity in simple rotation washing motion.
Summary of the invention
At the problems referred to above, purpose of the present invention provides a kind of and realizes washing in enormous quantities, and the chip wash mill that reaches unanimity of clean result.
For achieving the above object, the present invention takes following technical scheme: a kind of chip wash mill is characterized in that it comprises: a urceolus; One base plate, it is fixed on described outer tube bottom; One fixed head, it is fixed in the described urceolus; One motor, it is fixed on the described fixed head; One chute board, it is fixed in the described urceolus; One transmission device, it is slidingly arranged on the described chute board, and its input is connected the output of described motor; But the framework of an installing chip, it is connected the output of described transmission device; One washing container, but be provided with the cleaning solution of chip on the described framework of submergence in it.
Described transmission device can comprise: a runner, its center are connected on the output shaft of described motor; One toggle-action lever, its top are connected on the described runner prejudicially; One sliding bar, its top is connected the bottom of described toggle-action lever, and the middle part of described sliding bar is slidingly arranged on the described chute board by a pin, and the bottom of described sliding bar connects described framework.
Described transmission device also can comprise: a stock, and it is provided with an exhausting hole, and the output of described motor is connected wherein in the through hole; One toggle-action lever, its top are connected in another through hole on the described stock; One sliding bar, its top is connected the bottom of described toggle-action lever, and the middle part of described sliding bar is slidingly arranged on the described chute board by a pin, and the bottom of described sliding bar connects described framework.
Described transmission device can also comprise: a runner, and it is connected on the output shaft of described motor prejudicially; One sliding panel, it is slidingly arranged on the described chute board, and its top is bent to form a baffle plate, and described baffle plate withstands on described runner top, and the bottom of described sliding panel connects described framework.
Above-mentioned each described transmission device also comprises another motor, and it is connected on described sliding bar or the sliding panel, and the output of described motor connects described framework.
Described frame roof connects a hook, and described hook connects the output of described transmission device.
Cover on described urceolus top is provided with a loam cake, is described and have the aperture that wears lead, the described tops of going up has a handle.
The transmission device of described driven by motor is more than the cover.
The present invention is owing to take above technical scheme, it has the following advantages: 1, the present invention is owing to adopt washing container motionless, the mode that the chip driven device drives is washed, therefore the driving power of drive unit can reduce, washing container diameter range of choice also can enlarge, thereby can realize the purpose of chip washing in enormous quantities easily, detersive efficiency increases substantially.2, the present invention is owing to adopt drive unit to drive the mode of chip motion, therefore not only be not subjected to the restriction of cleaning solution liquid levels flow velocity, and can add the uniformity that contacts effect between large chip and the cleaning solution, thereby guaranteed that effectively clean result of the present invention is reliable and stable, high conformity, the purpose of good reproducibility.3, transmission device of the present invention is simple, volume is little, do not need to use shaking table, just can realize the vibration up and down reciprocatingly of chip by a motor, on sliding bar, connect and realize the rotation of chip when another motor just can descend double vibrations in realization, and motion mode, motion amplitude, motion frequency and run duration can be regulated with respect to liquid.The present invention can be widely used in a large amount of washings of various electronics, biochip.
Description of drawings
Fig. 1 is the embodiment of the invention one structural representation
Fig. 2 is Fig. 1 part-structure decomposing schematic representation
Fig. 3 is the embodiment of the invention two structural representations
Fig. 4 is the embodiment of the invention three structural representations
Fig. 5 is the embodiment of the invention four structural representations
Fig. 6 is Fig. 5 part-structure decomposing schematic representation
Fig. 7 is that the present invention and other mode of washing repeatability compare
The specific embodiment
Below in conjunction with drawings and Examples the present invention is described in detail.
Method of the present invention is provided with the transmission device of driven by motor above washing container, described washing container maintains static, and the described chip that is washed moves with respect to the cleaning solution in the described washing container under the drive of transmission device.The wash mill of realizing the inventive method is as follows:
Embodiment one
As shown in Figure 1 and Figure 2, the present invention includes a urceolus 1, a loam cake 2 is set at the top of urceolus 1, loam cake 2 tops have a handle of conveniently mentioning 3, also are provided with an aperture 4 on the loam cake 2, and power line can penetrate thus.Urceolus 1 bottom connects a base plate 5 by bonding or screw, and base plate 5 related urceolus 1 can be sitting on the chip washing container 6 (for example beaker), and a cushion 7 that encloses cushioning effect can be set in the bottom of base plate 5.Connect a motor fixing plate 8 by bonding or screw in the urceolus 1, motor 9 is connected on the fixed head 8, and the center of the fixedly connected runner 10 of the output of motor 9 is provided with several apart from the different eccentric orfice 11 of centre distance prejudicially on the runner 10.Also bonding or screw connects a chute board 12 in urceolus 1, a slotted hole is set as slideway 13 on sliding panel 12.One toggle-action lever, 14 tops are articulated in the eccentric orfice 11 of runner 10 by a pin, and the bottom of toggle-action lever 14 articulates a sliding bar 15 by a pin, and a pin 16 is fixed at sliding bar 15 middle parts, and pin 16 is slidingly arranged in the slideway 13.The bottom of sliding bar 15 is by pin or fixedly connected another motor fixing plate 17 of screw, another motor 18 is connected on the fixed head 17, output at motor 18 connects a hook 19, hook is linked with the framework 20 of an installing chip on 19, and what can vertically insert some numbers on the framework 20 waits to wash chip 21.
Embodiment two
As shown in Figure 3, present embodiment and embodiment one difference are: the direct coupling hook 19 in the bottom of sliding bar 15, and second motor 18 is not set, chip 21 is only done vibration up and down reciprocatingly under the drive of sliding bar 15 like this, and does not rotate.
Embodiment three
As shown in Figure 4, present embodiment and embodiment one difference are: what be fixedly connected on motor 9 outputs is a stock 22, on stock 22, offer an exhausting hole 23, motor 9 outputs can be fixed in any one through hole 23 according to the needs of Oscillation Amplitude, toggle-action lever 14 is articulated in any another through hole 23, this structure can provide more amplitude variations again.
Embodiment four
As Fig. 5, shown in Figure 6, present embodiment and embodiment one difference are: chute board 24 is divided into left and right sides two parts, and bonding respectively or be screwed and be connected on the urceolus 1, a sliding panel 25 is set between two chute boards 24, the baffle plate 26 of a bending is formed on the top of sliding panel 25.Motor 9 outputs and the embodiment one the same runner 10 that is connected with, be provided with several on the runner 10 prejudicially apart from the different eccentric orfice 11 of centre distance, but motor 9 outputs are not the centers that is connected runner 10, but according to the amplitude needs, be fixedly connected in arbitrary eccentric orfice 11, the baffle plate 26 at sliding panel 25 tops withstands on the top of runner 10 just, and another motor 18 is installed on the sliding panel 25 by fixed head 17.When motor 9 drove runner 10 rotations, the eccentric runner of installing 10 can drive sliding panel 25 up-down vibration in slideway 24, and the chip 21 that is connected simultaneously on the motor 18 drive frameworks 20 on the sliding panel 25 is rotated motion.
In the various embodiments described above, the structure of each concrete parts all can change or exchange, and also motor 9 can only be set such as the structure of embodiment three, four, and motor 18 is not set.For another example: if urceolus 1 is enough big, the motion structure of describing in the various embodiments described above can be provided with many covers, can wash more chip simultaneously like this, and detersive efficiency is higher.
In the foregoing description, also can be with the slideway direction that can keep supplying down double vibrations by vertically changing level into, i.e. sliding bar 15 or sliding panel 25 horizontal direction double vibrationses.An other motor 18 still can be installed on sliding bar 15 or the sliding panel 25, and its motor shaft so still can move back and forth or rotatablely move for vertically downward.
In the foregoing description, urceolus 1 can be made by plastic material, lucite, plank or metal, and is transparent or opaque, and its shape can be cylindric, prism-shaped, square, cuboid or other suitable shape.Chute board 12 in the various embodiments described above, toggle-action lever 14, sliding bar 15, stock 22, sliding panel 25, runner 10 etc. can have the material of suitable hardness to make by lucite, plastics, metal or other, each parts can be single overall structure, also can be that polylith is spliced.Base plate 5 is provided with notch, can make moving component upper and lower without barrier mobile.Can be made into different shape with hook 21 parts that are connected, such as shapes such as hook-shaped, clip, jump rings.The shape of same hook also can be different, as long as can connect the framework 20 that carrying is washed chip 21, even hook 19 and framework 20 can be made into one.Urceolus 1 outside can attach the support or the box body of appropriate shape, is convenient in the wash mill use or the placement after using.
In the foregoing description, the circuit controller that connects power supply can be arranged in the urceolus 1, also can be in urceolus 1 outside.Can import the frequency of motor 9,18 motion and time etc. on the circuit controller.Because the special equipment non-of the present invention of circuit controller, it can adopt the various devices of prior art, therefore repeats no more in the present invention.
As shown in Figure 3, when the present invention uses, base plate 5 is placed on washing container 6 tops, starter motor 9, motor 9 drives toggle-action lever 14 by runner 10 and rotates, toggle-action lever 14 drives sliding bar 15 and do vibration up and down reciprocatingly in slideway 13, vibration washing up and down reciprocatingly in the cleaning solution of chip 21 in container 6 that the hook 19 that sliding bar 15 connects by its bottom drives on the framework 20.As shown in Figure 1, when sliding bar 15 bottoms have connected another motor 18, when framework 20 drive chips 21 are done vibration up and down reciprocatingly with sliding bar 15, also be rotated motion with motor 18, its clean result is better.If be provided with two motors 9,18 in addition simultaneously, can according to circumstances only start a motor 9 during use, this situation is similar with the situation that a motor 9 is set; Also can a starter motor 18, only be rotated motion.
As shown in Figure 7, be to use common chip hybridization after, its contrast of repeatability as a result of three identical experiments of adopting wash mill washing of the present invention and common shaking bath to wash.In the experiment, chip 21 is placed on the copper framework in the beaker and washs, and adopts identical chip, identical probe, identical hybridization conditions, identical sweep parameter, and every kind of mode of washing repeats 24 dot matrix, repeats three experiments.CV (the coefficient of variation of three experiments of sample positive signal average of different mode of washing from figure, the coefficient of variation), and the CV contrast of three experiments of standard gene group positive signal average can find out that the more common shaking bath clean result of wash mill of the present invention is more reliable and stable.
Claims (13)
1, a kind of chip wash mill, it comprises: the transmission device of urceolus and driven by motor is characterized in that it also comprises:
One base plate, it is fixed on described outer tube bottom;
One fixed head, it is fixed in the described urceolus;
Described motor is fixed on the described fixed head;
One chute board, it is fixed in the described urceolus;
Described transmission device is slidingly arranged on the described chute board, and its input is connected the output of described motor;
But the framework of an installing chip, it is connected the output of described transmission device;
One washing container, but be provided with the cleaning solution of chip on the described framework of submergence in it.
2, a kind of chip wash mill as claimed in claim 1 is characterized in that described transmission device comprises:
One runner, its center are connected on the output shaft of described motor;
One toggle-action lever, its top are connected on the described runner prejudicially;
One sliding bar, its top is connected the bottom of described toggle-action lever, and the middle part of described sliding bar is slidingly arranged on the described chute board by a pin, and the bottom of described sliding bar connects described framework.
3, a kind of chip wash mill as claimed in claim 2 is characterized in that: described transmission device comprises that also another is connected the motor on the described sliding bar, and the output of this motor connects described framework.
4, a kind of chip wash mill as claimed in claim 1 is characterized in that described transmission device comprises:
One stock, it is provided with an exhausting hole, and the output of described motor is connected wherein in the through hole;
One toggle-action lever, its top are connected in another through hole on the described stock;
One sliding bar, its top is connected the bottom of described toggle-action lever, and the middle part of described sliding bar is slidingly arranged on the described chute board by a pin, and the bottom of described sliding bar connects described framework.
5, a kind of chip wash mill as claimed in claim 4 is characterized in that: described transmission device comprises that also another is connected the motor on the described sliding bar, and the output of this motor connects described framework.
6, a kind of chip wash mill as claimed in claim 1 is characterized in that described transmission device comprises:
One runner, it is connected on the output shaft of described motor prejudicially;
One sliding panel, it is slidingly arranged on the described chute board, and its top is bent to form a baffle plate, and described baffle plate withstands on described runner top, and the bottom of described sliding panel connects described framework.
7, a kind of chip wash mill as claimed in claim 6 is characterized in that: described transmission device comprises that also another is connected the motor on the described sliding panel, and the output of this motor connects described framework.
8, as claim 1 or 2 or 3 or 4 or 5 or 6 or 7 described a kind of chip wash mills, it is characterized in that: described frame roof connects a hook, and described hook connects the output of described transmission device.
9, as claim 1 or 2 or 3 or 4 or 5 or 6 or 7 described a kind of chip wash mills, it is characterized in that: cover on described urceolus top is provided with a loam cake, is described and have the aperture that wears lead, the described tops of going up has a handle.
10, a kind of chip wash mill as claimed in claim 8 is characterized in that: cover on described urceolus top is provided with a loam cake, is described and have the aperture that wears lead, the described tops of going up has a handle.
11, as claim 1 or 2 or 3 or 4 or 5 or 6 or 7 or 10 described a kind of chip wash mills, it is characterized in that: by the described transmission device that is connected the driven by motor on the fixed head is more than the cover.
12, a kind of chip wash mill as claimed in claim 8 is characterized in that: by the described transmission device that is connected the driven by motor on the fixed head is more than the cover.
13, a kind of chip wash mill as claimed in claim 9 is characterized in that: by the described transmission device that is connected the driven by motor on the fixed head is more than the cover.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100078853A CN100464877C (en) | 2006-02-23 | 2006-02-23 | Chip washing method and device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100078853A CN100464877C (en) | 2006-02-23 | 2006-02-23 | Chip washing method and device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1810387A CN1810387A (en) | 2006-08-02 |
| CN100464877C true CN100464877C (en) | 2009-03-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100078853A Expired - Fee Related CN100464877C (en) | 2006-02-23 | 2006-02-23 | Chip washing method and device |
Country Status (1)
| Country | Link |
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| CN (1) | CN100464877C (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101063078B (en) * | 2007-04-20 | 2010-06-09 | 博奥生物有限公司 | Biological chip hybrid cleaning device |
| CN102601801B (en) * | 2012-03-23 | 2014-03-19 | 冠礼控制科技（上海）有限公司 | Single-shaft rotary mechanical arm |
| CN102806212B (en) * | 2012-07-26 | 2014-10-29 | 江阴迪林生物电子技术有限公司 | Online cleaning equipment for chips |
| CN104405841A (en) * | 2014-11-25 | 2015-03-11 | 陈洪灿 | Adjustable reciprocating driving device |
| CN107282550A (en) * | 2017-07-28 | 2017-10-24 | 合肥捌零年代网络科技有限公司 | A kind of computer hardware development vibration washing device |
| CN109909210B (en) * | 2017-12-12 | 2021-08-03 | 淮阴师范学院 | Quantitative cleaning and vibration disinfection equipment for biological experiments |
| CN108311485B (en) * | 2018-05-14 | 2020-10-27 | 江西渠成氟化学有限公司 | Cleaning device for accurate screwed pipe part |
| CN111069141A (en) * | 2019-11-25 | 2020-04-28 | 湖南新达微轴承有限公司 | Bearing cleaning is with machine of swaing |
| CN114192491B (en) * | 2020-09-02 | 2022-11-08 | 宁波舜宇光电信息有限公司 | Cleaning apparatus and method of manufacturing the same |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0289875A1 (en) * | 1987-05-08 | 1988-11-09 | Bielefeld Maschinenbau GmbH | Method and device for cleaning work pieces |
| US6302123B1 (en) * | 1999-12-28 | 2001-10-16 | Cae Ransohoff Inc. | Rotary liquid diverter for industrial parts washer |
| JP2005349301A (en) * | 2004-06-10 | 2005-12-22 | Seiko Epson Corp | Washing device and washing method |
-
2006
- 2006-02-23 CN CNB2006100078853A patent/CN100464877C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0289875A1 (en) * | 1987-05-08 | 1988-11-09 | Bielefeld Maschinenbau GmbH | Method and device for cleaning work pieces |
| US6302123B1 (en) * | 1999-12-28 | 2001-10-16 | Cae Ransohoff Inc. | Rotary liquid diverter for industrial parts washer |
| JP2005349301A (en) * | 2004-06-10 | 2005-12-22 | Seiko Epson Corp | Washing device and washing method |
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| CN1810387A (en) | 2006-08-02 |
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Address after: 102206 Beijing City, Changping District Life Science Park Road No. 18 Patentee after: CAPITALBIO Corp. Patentee after: TSINGHUA University Address before: 102206 Beijing City, Changping District Life Science Park Road No. 18 Patentee before: CAPITALBIO Corp. Patentee before: Tsinghua University |
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