CN100452975C - Water dispersed tablet of pyrethroid pesticide and its prepn - Google Patents
Water dispersed tablet of pyrethroid pesticide and its prepn Download PDFInfo
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- CN100452975C CN100452975C CNB2005100120305A CN200510012030A CN100452975C CN 100452975 C CN100452975 C CN 100452975C CN B2005100120305 A CNB2005100120305 A CN B2005100120305A CN 200510012030 A CN200510012030 A CN 200510012030A CN 100452975 C CN100452975 C CN 100452975C
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Abstract
The present invention relates to new preparation form of pyrethroid pesticide for household and farm use, and is especially one kind of water dispersed tablet of pyrethroid pesticide and its preparation process. The water dispersed tablet of pyrethroid pesticide is prepared with pyrethroid pesticide, other pesticide component, disintegrant, adhesive, effervescent agent, wetting agent, disperser and stuffing, and through mixing, crushing and tabletting. It has simple preparation process, high herbicidal effect, accurate use amount, less environmental pollution and other advantages.
Description
Technical field
The present invention relates to novel form of a kind of pyrethroid insecticides and preparation method thereof, particularly a kind of water dispersed tablet of pyrethroid pesticide and preparation method thereof.
Background technology
Pyrethroid insecticides is widely used in the control of pests such as family, city, assanation etc. and agricultural.Present commercial kind has kind more than 40, and mainly processing formulation has missible oil, wetting powder, aqueous emulsion, microemulsion, aerosol, water-dispersible granules etc.But all there is the bad grasp of consumption in these formulations, store, transportation is inconvenient, easily cause defectives such as environmental pollution and existing wet method compressing tablet disintegration of tablet time is undesirable.
Below illustrate representative pyrethroid insecticides kind and uses thereof:
Adopted name: Cyhalothrin
Trade name; Time
Chemical name: 3-(2-chloro-3,3,3-trifluoro propenyl)-2,2-dimethyl cyclopropane carboxylic acid--cyano group-3-phenoxybenzyl ester
Controlling object: can prevent and treat anthonomus grandis, cotton bollworm, corn borer, cotton spider mites, Phyllotreta cruciferae, diamond-back moth, cabbage caterpillar, prodenia litura, potato aphid, colorado potato beetle etc., also effective to sanitary insect pests such as mosquito, fly, cockroaches.
Adopted name: cyfloxylate
English common name: cyfluthrin
Other title: cyfluthrin, hundred set
Controlling object: fruit tree pest control apple yellow aphid.Vegetable-crop pest-insect control cabbage caterpillar.
Adopted name: bifenthrin
English common name: bifenthrin
Other title: Uranus, Biphenthrin, the spirit of worm mite
Controlling object: be applicable to crops such as fruit tree, vegetables, tealeaves, cotton, prevent eliminating aphis,
Insects such as leaf miner, leafhopper, tetranychid and mite etc.
Adopted name: flucythrinate, the good letter of guarantor, flucythrinate
English name: Flucythrinate (ANSI) .Guardian.Cythrin.FuchingJugr
The scope of application is mainly used on the crops such as cotton, vegetables, fruit tree and prevents and treats Lepidoptera, and various pests such as Homoptera, diptera, coleoptera also have certain inhibitory action to tetranychid.
Adopted name: brofluthrinate
English common name brofluthrinate
Controlling object: can be used for preventing and treating insect and evil mites such as Lepidoptera on the crops such as vegetables, fruit tree, cotton, soybean, tealeaves, Homoptera, can be used for preventing and treating the honeybee mite.
Also have the pyrethroid insecticides of other kind in addition, do not enumerate one by one here.
In order to overcome the bad grasp of consumption that existing formulation exists, store, transport inconvenience, easily cause the defective of environmental pollution and existing undesirable grade of disintegration of tablet time, the invention provides a kind of water dispersed tablet of pyrethroid pesticide novel form.
Summary of the invention
The object of the present invention is to provide a kind of water dispersed tablet of pyrethroid pesticide;
Another object of the present invention is to provide a kind of preparation method of water dispersed tablet of pyrethroid pesticide.
The present invention relates to a kind of water dispersed tablet of pyrethroid pesticide, it comprises the component of following portions by weight proportioning:
Pyrethroid insecticides 0.1-90.0 part
Effervescent agent 1.0-20.0 part
Binding agent 2.0-10.0 part
Disintegrant 0.5-30.0 part
Wetting agent 0.5-20.0 part
Dispersant 0.5-30.0 part
Filler 0.5-60.0 part.
Water dispersed tablet of pyrethroid pesticide of the present invention, the parts by weight proportioning of its preferred each component is:
Pyrethroid insecticides 5.0-70.0 part
Effervescent agent 2.0-10.0 part
Binding agent 2.0-5.0 part
Disintegrant 10.0-20.0 part
Wetting agent 1.0-10.0 part
Dispersant 2.0-20.0 part
Filler 10.0-50.0 part.
According to water dispersed tablet of pyrethroid pesticide of the present invention, wherein said pyrethroid insecticides is Cyhalothrin, cyfloxylate, bifenthrin, cypermethrin, tetramethrin, allethrin, flucythrinate, brofluthrinate, phenothrin, permethrin, fenpropathrin, tralomethrin, tefluthrin, sumicidin or ether chrysanthemum ester.Wherein preferably Cyhalothrin, cyfloxylate, bifenthrin, tetramethrin, allethrin, flucythrinate or brofluthrinate.
According to water dispersed tablet of pyrethroid pesticide of the present invention, wherein said effervescent agent is selected from sodium carbonate, sodium bicarbonate, potash, citric acid and citric acid, is preferably selected from sodium carbonate, sodium bicarbonate and citric acid; Described binding agent is selected from industrial starch, methylcellulose, carboxymethyl cellulose and polyvinylpyrrolidone, is preferably selected from polyvinylpyrrolidone; Described disintegrant is selected from microcrystalline cellulose, Ac-Di-Sol, sodium carboxymethylcellulose, polyvinylpyrrolidone and hydroxypropyl cellulose, is preferably selected from microcrystalline cellulose; Described wetting agent is selected from bay alcohol radical sodium sulphate, neopelex and lauryl sodium sulfate, preferred neopelex; Described dispersant is selected from sodium lignin sulfonate, NNO and nekal, is preferably selected from sodium lignin sulfonate and NNO; Described filler is selected from lactose, calcium sulphate, sucrose, talcum powder, silica gel, dolomol and precipitated calcium carbonate, is preferably selected from talcum powder, silica gel, dolomol and precipitated calcium carbonate.
Wherein NNO is naphthalenesulfonate formaldehyde condensation compound sodium salt (degree of polymerization 〉=5).
Described dispersant sodium lignin sulfonate and NNO equal proportion are mixed use, and its dispersion effect is better.
Water dispersed tablet of pyrethroid pesticide of the present invention further comprises other insecticide.Other insecticide comprises Methomyl, carbosulfan, Aphox, Buprofezin, ABG-6215, flufenoxuron, UC 62644, the spirit of volt ant, bromine worm cyanogen, fluorine worm nitrile, azoles mite ester, Acetamiprid, pyrrole propyl ether etc.
In water dispersed tablet of pyrethroid pesticide, can be used alone or as a mixture as each agricultural chemicals of the pyrethroid insecticides of active component, also can mix and use with other pesticide, make various mixed type water dispersed tablets.
The invention still further relates to a kind of preparation method of water dispersed tablet of pyrethroid pesticide, its be with each component after mixing, pulverizing, adopt direct compression of full-powder method compressing tablet to make described dispersed tablet, its every weight is the 20-300 milligram.
The disintegrant of selecting for use in the water dispersed tablet of pyrethroid pesticide of the present invention can be accelerated the disintegration rate of tablet in water, wherein especially with the microcrystalline cellulose best results.Dispersant also can select sodium lignin sulfonate to mix use with NNO, and for example the equal proportion adding can obtain good dispersion effect.
According to the preparation method of water dispersed tablet of pyrethroid pesticide of the present invention, it is that each component materials mixing, pulverizing are made it to reach 325 orders, adopts full powder dry powder direct tabletting method processing technology direct tablet compressing.
Why the present invention can adopt full powder dry powder direct tabletting method compressing tablet to be because filtered out suitable binding agent, disintegrant, and dry powder can directly be suppressed in flakes.Microcrystalline cellulose and polyvinylpyrrolidone have for example been selected for use.
Processing technology of the present invention can shorten production cycle and energy savings owing to omitted granulation, baking operation, enhances productivity.This technology also is applicable to the formulation processing of other thermo-responsive medicines, can prevent that thermo-responsive medicine from decomposing institute's content extremely and descending the minimizing loss of active ingredients.Compare with the wet method tablet forming technique, this technology can further be improved the disintegration of tablet time.
Advantages such as water dispersed tablet of pyrethroid pesticide of the present invention has the accurate measurement of use, transportation safety, is beneficial to store and the container configuration, and is easy to carry, and environmental pollution is little.
Embodiment
Embodiment 1
Take by weighing each component raw material by following proportioning:
Brofluthrinate 40 grams
Microcrystalline cellulose 14 grams
Polyvinylpyrrolidone 4 grams
NaHCO
36 grams
Citric acid 6 grams
NNO 5 grams
Sodium lignin sulfonate 5 grams
Neopelex 1 gram
Dolomol 2 grams
Talcum powder 2 grams
Precipitated calcium carbonate 15 grams
Above-mentioned each component is fully mixed, after ultramicro grinding makes it to reach 325 orders, its direct tablet compressing is become 1000, promptly obtain described brofluthrinate water dispersed tablet.
Embodiment 2
Take by weighing each component raw material by following proportioning:
Brofluthrinate 35 grams
Microcrystalline cellulose 14 grams
Polyvinylpyrrolidone 4 grams
NaHCO
36 grams
Citric acid 6 grams
NNO 5 grams
Neopelex 1 gram
Dolomol 2 grams
Silica gel 2 grams
Precipitated calcium carbonate 25 grams
According to embodiment 1 described method, each component raw material of said ratio is made the brofluthrinate water dispersed tablet of 1000 described content.
Embodiment 3
Take by weighing each component raw material by following proportioning:
Brofluthrinate 25 grams
Microcrystalline cellulose 14 grams
Polyvinylpyrrolidone 4 grams
NaHCO
36 grams
Citric acid 6 grams
NNO 5 grams
Neopelex 1 gram
Dolomol 2 grams
Silica gel 2 grams
Talcum powder 2 grams
Precipitated calcium carbonate 33 grams
According to embodiment 1 described method, each component raw material of said ratio is made the brofluthrinate water dispersed tablet of 1000 described content.
Embodiment 4
Take by weighing each component raw material by following proportioning:
Cyhalothrin 25 grams
Microcrystalline cellulose 14 grams
Polyvinylpyrrolidone 4 grams
NaHCO
36 grams
Citric acid 6 grams
NNO 5 grams
Neopelex 1 gram
Dolomol 2 grams
Silica gel 2 grams
Talcum powder 2 grams
Precipitated calcium carbonate 33 grams
According to embodiment 1 described method, each component raw material of said ratio is made the Cyhalothrin water dispersed tablet of 1000 described content.
Embodiment 5
Take by weighing each component raw material by following proportioning:
Cyfloxylate 25 grams
Microcrystalline cellulose 14 grams
Polyvinylpyrrolidone 4 grams
NaHCO
36 grams
Citric acid 6 grams
NNO 5 grams
Neopelex 1 gram
Dolomol 2 grams
Silica gel 2 grams
Talcum powder 2 grams
Precipitated calcium carbonate 33 grams
According to embodiment 1 described method, each component raw material of said ratio is made the cyfloxylate water dispersed tablet of 1000 described content.
Embodiment 6
Take by weighing each component raw material by following proportioning:
Flucythrinate 25 grams
Microcrystalline cellulose 14 grams
Polyvinylpyrrolidone 4 grams
NaHCO
36 grams
Citric acid 6 grams
NNO 5 grams
Neopelex 1 gram
Dolomol 2 grams
Silica gel 2 grams
Talcum powder 2 grams
Precipitated calcium carbonate 33 grams
Each component raw material of said ratio is made the flucythrinate water dispersed tablet of 1000 described content according to embodiment 1 described method.
Embodiment 7
Take by weighing each component raw material by following proportioning:
Bifenthrin 25 grams
Microcrystalline cellulose 14 grams
Polyvinylpyrrolidone 4 grams
NaHCO
36 grams
Citric acid 6 grams
NNO 5 grams
Neopelex 1 gram
Dolomol 2 grams
Silica gel 2 grams
Talcum powder 2 grams
Precipitated calcium carbonate 33 grams
According to embodiment 1 described method, each component raw material of said ratio is made the bifenthrin water dispersed tablet of 1000 described content.
Embodiment 8
Take by weighing each component raw material by following proportioning:
Allethrin 20 grams
Microcrystalline cellulose 14 grams
Polyvinylpyrrolidone 4 grams
NaHCO
36 grams
Citric acid 6 grams
NNO 5 grams
Neopelex 1 gram
Dolomol 2 grams
Silica gel 2 grams
Talcum powder 2 grams
Precipitated calcium carbonate 38 grams
According to embodiment 1 described method, each component raw material of said ratio is made the allethrin water dispersed tablet of 1000 described content.
Embodiment 9
Take by weighing each component raw material by following proportioning:
Tetramethrin 15 grams
Allethrin 10 grams
Microcrystalline cellulose 14 grams
Polyvinylpyrrolidone 4 grams
NaHCO
36 grams
Citric acid 6 grams
NNO 5 grams
Neopelex 1 gram
Dolomol 2 grams
Silica gel 2 grams
Talcum powder 2 grams
Precipitated calcium carbonate 33 grams
According to embodiment 1 described method, each component raw material of said ratio is made the tetramethrin of 1000 described content and the mixed type water dispersed tablet of allethrin.
Embodiment 10
Take by weighing each component raw material by following proportioning:
Bifenthrin 10 grams
Fluorine worm nitrile 10 grams
Microcrystalline cellulose 14 grams
Polyvinylpyrrolidone 4 grams
NaHCO
36 grams
Citric acid 6 grams
NNO 5 grams
Neopelex 1 gram
Dolomol 2 grams
Silica gel 2 grams
Talcum powder 2 grams
Precipitated calcium carbonate 38 grams
According to embodiment 1 described method, each component raw material of said ratio is made the bifenthrin of 1000 described content and the mixed type water dispersed tablet of other insecticide (fluorine worm nitrile).
Embodiment 11
Take by weighing each component raw material by following proportioning:
Cyhalothrin 10 grams
Fluorine worm nitrile 10 grams
Microcrystalline cellulose 14 grams
Polyvinylpyrrolidone 4 grams
NaHCO
36 grams
Citric acid 6 grams
NNO 5 grams
Neopelex 1 gram
Dolomol 2 grams
Silica gel 2 grams
Talcum powder 2 grams
Precipitated calcium carbonate 38 grams
According to embodiment 1 described method, each component raw material of said ratio is made the cyhalothrin of 1000 described content and the mixed type water dispersed tablet of other insecticide (fluorine worm nitrile).
Embodiment 12
The dispersivity test of pyrethroid water dispersed tablet:
Under the room temperature, in the container that the top can seal, add about 800 ml tap waters.Add any brofluthrinate water dispersed tablet and airtight container top among the embodiment 1-3.Can observe brofluthrinate water dispersed tablet deployment conditions.This brofluthrinate water dispersed tablet drops down onto container bottom and begins and disperses.Can observe its complete jitter time and be no more than 3 minutes.
The prior art Tabules is the patent of invention CN12266134A of Britain Zenika company application on August 18th, 1999 for example, and the 10-25% gamma cyhalothrin is in 5-25 ℃ of water, and the jitter time of aqueous dispersion tablets is no more than 5 minutes.The jitter time that this shows pyrethroid water dispersed tablet of the present invention is more faster than the jitter time of the aqueous dispersion tablets of existing formulation.
Claims (8)
1. water dispersed tablet of pyrethroid pesticide, its component by the following portions by weight proportioning is formed:
Pyrethroid insecticides 0.1-90.0 part
Effervescent agent 1.0-20.0 part
Binding agent 2.0-10.0 part
Disintegrant 0.5-30.0 part
Wetting agent 0.5-20.0 part
Dispersant 0.5-30.0 part
Filler 0.5-60.0 part;
Wherein said effervescent agent is selected from sodium carbonate, sodium bicarbonate, potash, citric acid and citric acid; Described binding agent is selected from industrial starch, methylcellulose, carboxymethyl cellulose and polyvinylpyrrolidone; Described disintegrant is selected from microcrystalline cellulose, Ac-Di-Sol, sodium carboxymethylcellulose, polyvinylpyrrolidone and hydroxypropyl cellulose; Described wetting agent is selected from bay alcohol radical sodium sulphate, neopelex and lauryl sodium sulfate; Described dispersant is selected from sodium lignin sulfonate, NNO and nekal; Described filler is selected from lactose, calcium sulphate, sucrose, talcum powder, silica gel, dolomol and precipitated calcium carbonate.
2. the described water dispersed tablet of pyrethroid pesticide of root a tree name claim 1 is characterized in that described aqueous dispersion tablets is made up of the component of following portions by weight proportioning:
Pyrethroid insecticides 5.0-70.0 part
Effervescent agent 2.0-10.0 part
Binding agent 2.0-5.0 part
Disintegrant 10.0-20.0 part
Wetting agent 1.0-10.0 part
Dispersant 2.0-20.0 part
Filler 10.0-50.0 part.
3. the described water dispersed tablet of pyrethroid pesticide of root a tree name claim 2 is characterized in that described effervescent agent is selected from sodium carbonate, sodium bicarbonate and citric acid; Described binding agent is selected from polyvinylpyrrolidone; Described disintegrant is selected from microcrystalline cellulose; Described wetting agent is selected from neopelex; Described dispersant is selected from sodium lignin sulfonate and NNO; Described filler is selected from talcum powder, silica gel, dolomol and precipitated calcium carbonate.
4. the described water dispersed tablet of pyrethroid pesticide of root a tree name claim 3 is characterized in that described dispersant sodium lignin sulfonate and NNO equal proportion mixing use.
5. any described water dispersed tablet of pyrethroid pesticide of root a tree name claim 1-4 is characterized in that described pyrethroid insecticides is Cyhalothrin, cyfloxylate, bifenthrin, cypermethrin, tetramethrin, allethrin, flucythrinate, brofluthrinate, phenothrin, permethrin, fenpropathrin, tralomethrin, tefluthrin, sumicidin or ether chrysanthemum ester.
6. the described water dispersed tablet of pyrethroid pesticide of root a tree name claim 5 is characterized in that described pyrethroid insecticides is Cyhalothrin, cyfloxylate, bifenthrin, tetramethrin, allethrin, flucythrinate or brofluthrinate.
7. the preparation method of each described water dispersed tablet of pyrethroid pesticide of root a tree name claim 1-6, its be with each component after mixing, pulverizing, adopt direct compression of full-powder method compressing tablet to make described water dispersed tablet.
8. the preparation method of the described water dispersed tablet of pyrethroid pesticide of root a tree name claim 7 is characterized in that every weight of prepared water dispersed tablet is the 20-300 milligram.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100120305A CN100452975C (en) | 2005-06-28 | 2005-06-28 | Water dispersed tablet of pyrethroid pesticide and its prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100120305A CN100452975C (en) | 2005-06-28 | 2005-06-28 | Water dispersed tablet of pyrethroid pesticide and its prepn |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1887090A CN1887090A (en) | 2007-01-03 |
| CN100452975C true CN100452975C (en) | 2009-01-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100120305A Active CN100452975C (en) | 2005-06-28 | 2005-06-28 | Water dispersed tablet of pyrethroid pesticide and its prepn |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102283241B (en) * | 2011-07-31 | 2013-09-11 | 河北工程大学 | Pyrethroid pesticide water-dispersible tablets |
| CN104920442A (en) * | 2015-04-10 | 2015-09-23 | 青岛科技大学 | Deltamethrin water-dispersible floating tablet and preparation method therefor |
| BR112019011777A2 (en) | 2016-12-07 | 2020-02-04 | Adama Makhteshim Ltd | stable, low-foaming, self-dispersing and stable pesticide formulation. |
| CN107751253A (en) * | 2017-11-17 | 2018-03-06 | 安徽康宇生物科技工程有限公司 | A kind of throwing type desinsection tablet |
-
2005
- 2005-06-28 CN CNB2005100120305A patent/CN100452975C/en active Active
Non-Patent Citations (2)
| Title |
|---|
| 农药新剂型-水分散片剂. 王勇等.农药，第43卷第6期. 2004 |
| 农药新剂型-水分散片剂. 王勇等.农药，第43卷第6期. 2004 * |
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| CN1887090A (en) | 2007-01-03 |
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Owner name: BEIJING GUANGYUAN YINONG CHEMICAL CO.,LTD. Free format text: FORMER OWNER: ZHANG ZONGJIAN Effective date: 20090703 |
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Effective date of registration: 20090703 Address after: No. 20, Xueyuan Road, Beijing, Haidian District, two North Church Building Patentee after: Beijing Grand Agrochem Co., Ltd. Address before: Beijing City, Anwar 18 District No. 504 Patentee before: Zhang Zongjian |