CN100438880C - Selenium-complement agent, and prepn. method and use thereof - Google Patents
Selenium-complement agent, and prepn. method and use thereof Download PDFInfo
- Publication number
- CN100438880C CN100438880C CNB2006100531720A CN200610053172A CN100438880C CN 100438880 C CN100438880 C CN 100438880C CN B2006100531720 A CNB2006100531720 A CN B2006100531720A CN 200610053172 A CN200610053172 A CN 200610053172A CN 100438880 C CN100438880 C CN 100438880C
- Authority
- CN
- China
- Prior art keywords
- selenium
- exchange resin
- resin
- seo
- anion exchange
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title claims description 6
- 239000003957 anion exchange resin Substances 0.000 claims abstract description 36
- 229940091258 selenium supplement Drugs 0.000 claims description 42
- 239000011347 resin Substances 0.000 claims description 23
- 229920005989 resin Polymers 0.000 claims description 23
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 21
- 239000011669 selenium Substances 0.000 claims description 21
- 229910052711 selenium Inorganic materials 0.000 claims description 21
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- 239000003795 chemical substances by application Substances 0.000 claims description 18
- 239000000243 solution Substances 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
- 239000002253 acid Substances 0.000 claims description 12
- 230000007935 neutral effect Effects 0.000 claims description 12
- 239000011734 sodium Substances 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 7
- 239000003513 alkali Substances 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 150000003342 selenium Chemical class 0.000 claims description 6
- 239000003814 drug Substances 0.000 abstract description 16
- 201000010099 disease Diseases 0.000 abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 5
- 150000002500 ions Chemical class 0.000 abstract description 4
- 239000013589 supplement Substances 0.000 abstract description 2
- QYHFIVBSNOWOCQ-UHFFFAOYSA-N selenic acid Chemical compound O[Se](O)(=O)=O QYHFIVBSNOWOCQ-UHFFFAOYSA-N 0.000 abstract 2
- FLKWPETUFDRUCE-UHFFFAOYSA-N seleninic acid Chemical compound O[SeH]=O FLKWPETUFDRUCE-UHFFFAOYSA-N 0.000 abstract 2
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 239000004459 forage Substances 0.000 abstract 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 26
- 239000003456 ion exchange resin Substances 0.000 description 23
- 229920003303 ion-exchange polymer Polymers 0.000 description 23
- 239000002585 base Substances 0.000 description 9
- 239000000047 product Substances 0.000 description 9
- 229940079593 drug Drugs 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 239000003729 cation exchange resin Substances 0.000 description 4
- 125000000524 functional group Chemical group 0.000 description 4
- 238000005342 ion exchange Methods 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical class OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
- 239000003674 animal food additive Substances 0.000 description 3
- 150000001450 anions Chemical class 0.000 description 3
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 244000144977 poultry Species 0.000 description 3
- 150000003440 styrenes Chemical class 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 238000013270 controlled release Methods 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 244000144972 livestock Species 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 230000033116 oxidation-reduction process Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 125000001453 quaternary ammonium group Chemical group 0.000 description 2
- 230000033458 reproduction Effects 0.000 description 2
- 229940082569 selenite Drugs 0.000 description 2
- 229960001471 sodium selenite Drugs 0.000 description 2
- 239000011781 sodium selenite Substances 0.000 description 2
- 235000015921 sodium selenite Nutrition 0.000 description 2
- 125000001302 tertiary amino group Chemical group 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- OKIZCWYLBDKLSU-UHFFFAOYSA-M N,N,N-Trimethylmethanaminium chloride Chemical compound [Cl-].C[N+](C)(C)C OKIZCWYLBDKLSU-UHFFFAOYSA-M 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229910001423 beryllium ion Inorganic materials 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000005341 cation exchange Methods 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000009432 framing Methods 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- -1 phenolic aldehyde Chemical class 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 150000003839 salts Chemical group 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000009919 sequestration Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 208000024877 white muscle disease Diseases 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2006100531720A CN100438880C (en) | 2006-08-28 | 2006-08-28 | Selenium-complement agent, and prepn. method and use thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2006100531720A CN100438880C (en) | 2006-08-28 | 2006-08-28 | Selenium-complement agent, and prepn. method and use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1911239A CN1911239A (en) | 2007-02-14 |
CN100438880C true CN100438880C (en) | 2008-12-03 |
Family
ID=37720402
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2006100531720A Expired - Fee Related CN100438880C (en) | 2006-08-28 | 2006-08-28 | Selenium-complement agent, and prepn. method and use thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN100438880C (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1144195A (en) * | 1996-01-12 | 1997-03-05 | 山西省卫生防疫站 | Drinking water iodine-adding method and its device |
CN1401329A (en) * | 2002-09-05 | 2003-03-12 | 浙江大学 | Oral Selenium supplement agent using bimetallic oxide as carrier, and preparing process and use method thereof |
-
2006
- 2006-08-28 CN CNB2006100531720A patent/CN100438880C/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1144195A (en) * | 1996-01-12 | 1997-03-05 | 山西省卫生防疫站 | Drinking water iodine-adding method and its device |
CN1401329A (en) * | 2002-09-05 | 2003-03-12 | 浙江大学 | Oral Selenium supplement agent using bimetallic oxide as carrier, and preparing process and use method thereof |
Non-Patent Citations (2)
Title |
---|
离子交换树脂控制药物释放研究进展. 李振华,平其能,刘国杰.离子交换与吸附,第13卷第6期. 1997 |
离子交换树脂控制药物释放研究进展. 李振华,平其能,刘国杰.离子交换与吸附,第13卷第6期. 1997 * |
Also Published As
Publication number | Publication date |
---|---|
CN1911239A (en) | 2007-02-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Hangzhou Beizi Biotechnology Co., Ltd. Assignor: Zhejiang University Contract fulfillment period: 2009.3.17 to 2014.3.17 contract change Contract record no.: 2009330001244 Denomination of invention: Selenium-complement agent, and prepn. method and use thereof Granted publication date: 20081203 License type: Exclusive license Record date: 2009.6.1 |
|
LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.3.17 TO 2014.3.17; CHANGE OF CONTRACT Name of requester: HANGZHOU BEIZI BIOISYSTECH CO., LTD. Effective date: 20090601 |
|
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20081203 Termination date: 20110828 |