CN100411626C - Slow-released type iodine complement agent, and prepn. method and use-thereof - Google Patents
Slow-released type iodine complement agent, and prepn. method and use-thereof Download PDFInfo
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- CN100411626C CN100411626C CNB2006100531735A CN200610053173A CN100411626C CN 100411626 C CN100411626 C CN 100411626C CN B2006100531735 A CNB2006100531735 A CN B2006100531735A CN 200610053173 A CN200610053173 A CN 200610053173A CN 100411626 C CN100411626 C CN 100411626C
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- iodine
- exchange resin
- iodide
- resin
- iodate
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- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 title claims description 64
- 239000011630 iodine Substances 0.000 title claims description 64
- 229910052740 iodine Inorganic materials 0.000 title claims description 64
- 239000003795 chemical substances by application Substances 0.000 title claims description 23
- 230000000295 complement effect Effects 0.000 title claims description 23
- 238000000034 method Methods 0.000 title claims description 7
- 239000003957 anion exchange resin Substances 0.000 claims abstract description 40
- 239000011347 resin Substances 0.000 claims description 26
- 229920005989 resin Polymers 0.000 claims description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 21
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 21
- 239000000243 solution Substances 0.000 claims description 21
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 claims description 15
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 14
- 230000007935 neutral effect Effects 0.000 claims description 14
- 239000002253 acid Substances 0.000 claims description 13
- 238000002360 preparation method Methods 0.000 claims description 8
- 239000003513 alkali Substances 0.000 claims description 7
- 239000007864 aqueous solution Substances 0.000 claims description 7
- JLKDVMWYMMLWTI-UHFFFAOYSA-M potassium iodate Chemical group [K+].[O-]I(=O)=O JLKDVMWYMMLWTI-UHFFFAOYSA-M 0.000 claims description 6
- 239000001230 potassium iodate Substances 0.000 claims description 6
- 235000006666 potassium iodate Nutrition 0.000 claims description 6
- 229940093930 potassium iodate Drugs 0.000 claims description 6
- 235000009518 sodium iodide Nutrition 0.000 claims description 5
- 239000004151 Calcium iodate Substances 0.000 claims description 4
- UHWJJLGTKIWIJO-UHFFFAOYSA-L calcium iodate Chemical compound [Ca+2].[O-]I(=O)=O.[O-]I(=O)=O UHWJJLGTKIWIJO-UHFFFAOYSA-L 0.000 claims description 4
- 235000019390 calcium iodate Nutrition 0.000 claims description 4
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims description 4
- UNMYWSMUMWPJLR-UHFFFAOYSA-L Calcium iodide Chemical compound [Ca+2].[I-].[I-] UNMYWSMUMWPJLR-UHFFFAOYSA-L 0.000 claims description 3
- 229910001640 calcium iodide Inorganic materials 0.000 claims description 3
- 229940046413 calcium iodide Drugs 0.000 claims description 3
- ICIWUVCWSCSTAQ-UHFFFAOYSA-M iodate Chemical compound [O-]I(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-M 0.000 claims description 3
- NALMPLUMOWIVJC-UHFFFAOYSA-N n,n,4-trimethylbenzeneamine oxide Chemical compound CC1=CC=C([N+](C)(C)[O-])C=C1 NALMPLUMOWIVJC-UHFFFAOYSA-N 0.000 claims description 3
- ACAYDTMSDROWHW-UHFFFAOYSA-M potassium;iodic acid;iodate Chemical compound [K+].OI(=O)=O.[O-]I(=O)=O ACAYDTMSDROWHW-UHFFFAOYSA-M 0.000 claims description 3
- 239000011697 sodium iodate Substances 0.000 claims description 3
- 235000015281 sodium iodate Nutrition 0.000 claims description 3
- 229940032753 sodium iodate Drugs 0.000 claims description 3
- XZXYQEHISUMZAT-UHFFFAOYSA-N 2-[(2-hydroxy-5-methylphenyl)methyl]-4-methylphenol Chemical compound CC1=CC=C(O)C(CC=2C(=CC=C(C)C=2)O)=C1 XZXYQEHISUMZAT-UHFFFAOYSA-N 0.000 claims description 2
- 229940107816 ammonium iodide Drugs 0.000 claims description 2
- BLQJIBCZHWBKSL-UHFFFAOYSA-L magnesium iodide Chemical compound [Mg+2].[I-].[I-] BLQJIBCZHWBKSL-UHFFFAOYSA-L 0.000 claims description 2
- 229910001641 magnesium iodide Inorganic materials 0.000 claims description 2
- 229960004839 potassium iodide Drugs 0.000 claims description 2
- 229940083599 sodium iodide Drugs 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 17
- 201000010099 disease Diseases 0.000 abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 5
- 150000002500 ions Chemical class 0.000 abstract description 5
- 239000000654 additive Substances 0.000 abstract description 2
- 230000000996 additive effect Effects 0.000 abstract description 2
- 239000013589 supplement Substances 0.000 abstract description 2
- 239000004459 forage Substances 0.000 abstract 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 26
- 239000003456 ion exchange resin Substances 0.000 description 23
- 229920003303 ion-exchange polymer Polymers 0.000 description 23
- 239000000047 product Substances 0.000 description 10
- 239000002585 base Substances 0.000 description 9
- 229940079593 drug Drugs 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 7
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical class OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 4
- 241001494479 Pecora Species 0.000 description 4
- 239000003729 cation exchange resin Substances 0.000 description 4
- 125000000524 functional group Chemical group 0.000 description 4
- 238000005342 ion exchange Methods 0.000 description 4
- 244000144977 poultry Species 0.000 description 4
- 241000238557 Decapoda Species 0.000 description 3
- 150000001450 anions Chemical class 0.000 description 3
- 238000013270 controlled release Methods 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 241000251468 Actinopterygii Species 0.000 description 2
- 206010058314 Dysplasia Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 235000019730 animal feed additive Nutrition 0.000 description 2
- 239000003674 animal food additive Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 229940005633 iodate ion Drugs 0.000 description 2
- ICIWUVCWSCSTAQ-UHFFFAOYSA-N iodic acid Chemical compound OI(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-N 0.000 description 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 description 2
- 229940006461 iodide ion Drugs 0.000 description 2
- 210000005075 mammary gland Anatomy 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 230000033116 oxidation-reduction process Effects 0.000 description 2
- 210000003800 pharynx Anatomy 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 125000001453 quaternary ammonium group Chemical group 0.000 description 2
- 206010037844 rash Diseases 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 125000001302 tertiary amino group Chemical group 0.000 description 2
- 239000011573 trace mineral Substances 0.000 description 2
- 235000013619 trace mineral Nutrition 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- DHZVWQPHNWDCFS-UHFFFAOYSA-N 2-hydroxy-3,5-diiodobenzoic acid Chemical compound OC(=O)C1=CC(I)=CC(I)=C1O DHZVWQPHNWDCFS-UHFFFAOYSA-N 0.000 description 1
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- ZQZFYGIXNQKOAV-OCEACIFDSA-N Droloxifene Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=C(O)C=CC=1)\C1=CC=C(OCCN(C)C)C=C1 ZQZFYGIXNQKOAV-OCEACIFDSA-N 0.000 description 1
- 206010053155 Epigastric discomfort Diseases 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 206010070840 Gastrointestinal tract irritation Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 201000008197 Laryngitis Diseases 0.000 description 1
- OKIZCWYLBDKLSU-UHFFFAOYSA-M N,N,N-Trimethylmethanaminium chloride Chemical compound [Cl-].C[N+](C)(C)C OKIZCWYLBDKLSU-UHFFFAOYSA-M 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 241000736919 Pelodiscus sinensis Species 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010039424 Salivary hypersecretion Diseases 0.000 description 1
- 208000028990 Skin injury Diseases 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- UOZDOLIXBYLRAC-UHFFFAOYSA-L [2-hydroxy-3-(trimethylazaniumyl)propyl]-trimethylazanium;diiodide Chemical compound [I-].[I-].C[N+](C)(C)CC(O)C[N+](C)(C)C UOZDOLIXBYLRAC-UHFFFAOYSA-L 0.000 description 1
- SHOKWSLXDAIZPP-UHFFFAOYSA-N [4-(4-iodooxy-2-methyl-5-propan-2-ylphenyl)-5-methyl-2-propan-2-ylphenyl] hypoiodite Chemical compound C1=C(OI)C(C(C)C)=CC(C=2C(=CC(OI)=C(C(C)C)C=2)C)=C1C SHOKWSLXDAIZPP-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229910001423 beryllium ion Inorganic materials 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 238000005341 cation exchange Methods 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229920001429 chelating resin Polymers 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 229910000365 copper sulfate Inorganic materials 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000006253 efflorescence Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 238000009432 framing Methods 0.000 description 1
- 210000004195 gingiva Anatomy 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- QFWPJPIVLCBXFJ-UHFFFAOYSA-N glymidine Chemical compound N1=CC(OCCOC)=CN=C1NS(=O)(=O)C1=CC=CC=C1 QFWPJPIVLCBXFJ-UHFFFAOYSA-N 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- -1 phenolic aldehyde Chemical class 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 235000007715 potassium iodide Nutrition 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 208000026451 salivation Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000009919 sequestration Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 150000003440 styrenes Chemical class 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A slow-release I-supplement used as the I-supplementing additive of forage or to prepare I-supplementing food or medicine for treating diseases is an anionic exchange resin containing the iodic acid radicals or I ions. It is prepared through the ionic exchange between iodic acid radicals or I ions and anionic exchange resin.
Description
Technical field
The present invention relates to a kind of iodine complement agent and preparation method and purposes of spacetabs type.
Background technology
Iodine is requisite composition in the thyroid.Its biochemical function mainly is to show by thyroxin, and is very extensive to the biological action of body.According to " allow use feed additive kind catalogue " of the up-to-date promulgation of China, can be used for trace compound that poultry enrich the iodine has 3 kinds of potassium iodide, potassium iodate and calcium iodate.Other chemical compound that contains iodine also has sodium iodide, ethylenediamine dihydroiodide, Hydro-Giene (Water Science)., 3,5-diiodosalicylic acid, thymiodol etc.Potassium iodide, sodium iodide poor stability are easily caused its biological activity to descend, even completely lose by other trace element oxidation in airborne oxygen and the feedstuff.In addition, when potassium iodide and other trace element (as copper sulfate) compatibility, vitamin A there is the ashamed usefulness of intensive collaborative destruction.Potassium iodate, calcium iodate are more stable, and its biological value is similar to potassium iodide, but stronger oxidant is bigger to the destruction of vitamin, and be stronger to the gastrointestinal irritation of animal.In addition, for culture fishery, aquatic feeds must drop into water body, fish and shrimp just can be ingested, in case and feedstuff entry, just be subjected to the influence of various factors (pH, temperature, osmotic pressure, wave current impact, chemical reaction etc.), produced various reactions, as dissolving, swelling, fracture, efflorescence, peel off etc.Chen Siqing etc. (1995) have studied that the prawn mixed feed is dipped in the wastage of each nutritional labeling in the water and to Effects of water environment, the molten mistake of finding mineral is very rapidly and completely, only with the percentage composition rate of descent, in the time of 5 minutes, descended 16.4～40.8%, in the time of 90 minutes, descended 69.4～76.7%, reach 84.4～93.9% in the time of 120 minutes, if calculate the weightless loss that causes, then molten mistake is totally in the time of 120 minutes for mineral.After inorganic microelement such as potassium iodide, the potassium iodate entry, be easy to molten mistake and be dissolved in the water, cause the waste of propiodal and the pollution of water environment.
Iodine comprises that organic bonded iodine, inorganic iodine and molecular iodine (are I
2), can be used for treating human diseases.Worry it is the probability of toxic reaction about the maximum of administration iodine medicine.Iodism can cause a series of symptom.Described symptom comprises that oral cavity and throat are scorching hot; Tooth and gingiva pain; Salivation increases; Rhinitis, respiratory tract; Cough; Headache; Body of gland increases; Pharynx, larynx and tonsil inflammation; Skin injury; Gastric irritation; Diarrhoea; Fever; Anorexia and depression; May take place serious, be fatal eruption (iododerma) sometimes.
The control slow-released system has selectivity and controllability to release position, speed and the mode of medicine, pesticide, fertilizer, spice, can realize the targeting transmission and the control slow release of object, improve its utilization rate and action effect, the research and the application of control slow-releasing system will bring new technological revolution to relevant industries.The key of control slow release method is the selection of controlled release carrier.Ion exchange resin (Ionexchange resin, IER) be the cancellated macromolecular compound that a class has functional group, its structure is made up of three parts: insoluble three dimensions mesh skeleton, be connected functional group on the skeleton and functional group with the exchangeable ion of opposite charges.According to the different in kind of cation exchange groups, ion exchange resin is divided into six big classes: storng-acid cation exchange resin, weak-acid cation-exchange resin, strong alkalinity anion literary composition change resin, weak-base anion-exchange resin, sequestration ion exchange resin, amphoteric ion-exchange resin, oxidation-reduction quality ion exchange resin.According to resin with tradable ionic nature, ion exchange resin is divided into cation exchange resin and anion exchange resin substantially, has acid function base (highly acid: sulfonic group (SO
3H); Faintly acid: carboxylic acid group (COOH), phosphate (PO
3H
2) etc.), the polymer that can exchange with cation is cation exchange resin; Have alkaline functional base (strong basicity: quaternary ammonium group-N (CH
3)
3Deng; Alkalescence: the primary, the second month in a season, tertiary amine groups (CH
2NH
2,--CH
2NHR ,-CH
2NR
2) etc.), the polymer that can exchange with anion is anion exchange resin.
According to the difference of resin physical arrangement, can be divided into gel-type and macroporous ion-exchange resin two big classes to ion exchange resin again.Gel type resin is the ion exchange resin of the homogeneous phase high-molecular gel structure of a class appearance transparent, the interior mutually micropore that produces of suction back resin, and counter ion can diffuse into and carry out ion exchange in the micropore that is produced by suction.The basic characteristics of macroreticular ion exchange resin be do in whole resin inside, wet or contraction, swelling all exist the duct more, bigger than general gel-type in water, thereby surface area is big, in ion exchange process, the easy diffusion mobility of ion, exchange velocity is very fast.
Full name of ion exchange resin claims to be rearranged by specific name, skeleton (or group) title, basic designation.The model name of ion exchange resin is different and fixed according to structure, form by three Arabic numerals: the classification of the first bit digital representative products, second-order digit is represented the difference of framing structure, and the 3rd bit digital is a serial number, in order to difference group, cross-linking agent etc.All macroreticular ion exchange resins add before model, and-D represents: gel-type ion-exchange resin connects Arabic numerals with " * " and represents after model.Wherein, classification designator has 0,1,2,3,4,5,6, corresponding representative strong-acid type, weak-type, strong base, weak base type, chelating type, both sexes and oxidation-reduction ion-exchange resin.The skeleton code name has 0,1, and 2,3 etc., represent polystyrene, acrylic acid series, phenolic aldehyde system, epoxy system etc. respectively.
Separation and purification pure water preparation that ion exchange resin is applied to analytical chemistry medicine for a long time reach fields such as being used for the environmental conservation blood purification in the recent period.Since proposing ion exchange resin first in 1956 and being used to delay drug release as pharmaceutical carrier, the report that utilizes ion exchange technique to delay drug release constantly increases, and has entered the practicality stage.Ion exchange resin has multiple good characteristic as pharmaceutical carrier, at present its controlled release, transdermal administration, site-specific delivery of drugs, instant, iontophoresis transdermal, nasal cavity, topical and cover side such as bitter taste of drug and application very deep research is all arranged, some product goes on the market.Ion exchange resin is control drug release in gastrointestinal tract mainly, be ion exchange resin controlled-release administrating system (Ion-Exchange ResinControlled Drag Delivery System, IERCDDS), compare with other drug-supplying systems, the main feature of IERCDDS is the volume that the release of medicine does not rely on pH value, enzymatic activity, temperature and gastrointestinal fluid in the gastrointestinal tract, because ionic species and strength maintenance thereof in the gastrointestinal fluid are constant relatively, so medicine can constant rate of speed discharge in vivo.
Summary of the invention
The iodine complement agent and preparation method and the purposes that the purpose of this invention is to provide a kind of spacetabs type.
The iodine complement agent of spacetabs type is a kind of anion exchange resin that contains commutative iodate or iodide ion, and by weight percentage, the content of iodine in anion exchange resin is 0.5～5%.
The preparation method of the iodine complement agent of spacetabs type may further comprise the steps:
1) anion exchange resin is placed 0.5～2mol/L hydrochloric acid solution of 1～2 times of resin volume soaked 2～5 hours, drain after the acid solution with water rinse to neutral, 0.5～2mol/L sodium hydroxide solution with 1～2 times of resin volume soaked 3～6 hours then, drained behind the alkali liquor with water rinse to neutral;
2) resin of step 1) is packed in the exchange column, with amount of iodine is the iodate or the iodide of anion exchange resin weight 0.5～5%, be pre-configured to the aqueous solution of 0.01～1.0mol/L, with the flow velocity of 1～10mL/min by exchange column, finish after washing 2～5 times of exchange;
3) with step 2) anion exchange resin of the load iodine of gained is being lower than 70 ℃ of oven dry down, obtains the iodine complement agent of spacetabs type.
The iodic acid that uses among the present invention (salt) is potassium iodate, potassium hydrogen diiodate, sodium iodate or calcium iodate.The said iodide of the present invention are sodium iodide, potassium iodide, ammonium iodide, calcium iodide or magnesium iodide.
The iodine complement agent of spacetabs type is as cattle, sheep, poultry, the aquatic animal feed additive that enriches the iodine.The iodine complement agent of spacetabs type is used to prepare human oral health product and the medicine that enriches the iodine and treat human diseases by the iodine of drug treatment.
Advantage of the present invention is:
(1) utilize anion exchange resin can play the characteristics of exchange interaction with anion, iodate or iodide ion are loaded in the anion exchange resin, implementation method is easy, suitability for industrialized production, and cost is lower;
(2) because ion exchange resin is a kind of control slow-released carrier of function admirable, the iodine of institute's load is had the control slow releasing function, thereby improved the absorption rate of iodine greatly;
(3) iodine complement agent of spacetabs type of the present invention has low toxicity, characteristics of high efficiency, can be used as the feed additive that enriches the iodine; Also can be used for preparing human oral health product and the medicine that enriches the iodine and treat human diseases by the iodine of drug treatment.
The specific embodiment
Anion exchange resin is strong-base anion-exchange resin or weak-base anion-exchange resin, has the alkaline functional base, comprises strong basicity (quaternary ammonium group-N (CH
3)
3) and alkalescence (primary, secondary, tertiary amine groups ,-CH
2NH
2,--CH
2NHR ,-CH
2NR
2) functional group.According to the difference of anion exchange resin physical arrangement, can be gel-type or macroporous ion-exchange resin.The anion exchange resin skeleton is polystyrene or acrylic acid series.
Embodiment 1
1) (this product is equivalent to U.S. AmberliteIRA-400 with commercially available 201 * 7 (717#) strong basicity I type anion exchange resin, West Germany LewatitM500, Japan DiaionSA-10A), place the 0.5mol/L hydrochloric acid solution of 1 times of resin volume to soak 2 hours, drain after the acid solution with water rinse to neutral, 0.5mol/L sodium hydroxide solution with 1 times of resin volume soaked 3 hours then, drained behind the alkali liquor with water rinse to neutral;
2) resin of step 1) being packed in the exchange column, is the potassium iodate of anion exchange resin weight 0.5% with amount of iodine, is pre-configured to the aqueous solution of 0.01mol/L,,, washes 2 times after reaction finishes by exchange column with the flow velocity of 1mL/min;
3) with step 2) anion exchange resin of the load iodine of gained is being lower than 70 ℃ of oven dry down, obtains the iodine complement agent of spacetabs type.By weight percentage, the content of iodine in anion exchange resin is 0.5%.
Embodiment 2
1) be that (this product is equivalent to the U.S. to weak basic anion exchange resin: AmberliteIRA-68 with commercially available D311 macroporous acrylic; Germany: AP-49 D318), place the 2mol/L hydrochloric acid solution of 2 times of resinites to soak 5 hours, drain after the acid solution with water rinse to neutral, the 2mol/L sodium hydroxide solution with 2 times of resin volumes soaked 6 hours then, drained behind the alkali liquor with water rinse to neutral;
2) resin of step 1) being packed in the exchange column, is the sodium iodate of anion exchange resin weight 1.5% with amount of iodine, is pre-configured to the aqueous solution of 0.8mol/L,,, washes 5 times after reaction finishes by exchange column with the flow velocity of 1～10mL/min;
3) with step 2) anion exchange resin of the load iodine of gained is being lower than 70 ℃ of oven dry down, obtains the iodine complement agent of spacetabs type.By weight percentage, the content of iodine in anion exchange resin is 1.5%.
Embodiment 3
1) with commercially available D201 macropore alkalescence I type anion exchange resin (the suitable U.S. of this product: AmberliteIRA-900, West Germany: Lewatit MP-500, Japan: Diaion308), place the 1mol/L hydrochloric acid solution of 1.5 times of resin volumes to soak 4 hours, drain after the acid solution with water rinse to neutral, 1mol/L sodium hydroxide solution with 1.5 times of resin volumes soaked 5 hours then, drained behind the alkali liquor with water rinse to neutral;
2) resin of step 1) being packed in the exchange column, is the potassium hydrogen diiodate of anion exchange resin weight 5% with amount of iodine, is pre-configured to the aqueous solution of 1.0mol/L,,, washes 3 times after reaction finishes by exchange column with the flow velocity of 5mL/min;
3) with step 2) anion exchange resin of the load iodine of gained is being lower than 70 ℃ of oven dry down, obtains the iodine complement agent of spacetabs type.By weight percentage, the content of iodine in anion exchange resin is 5%.
Embodiment 4
1) (this product is equivalent to the U.S.: AmberlysteIRA-94 with commercially available D301 macroreticular weakly base styrene series anion exchange resin; Amberlite IRA-93/94 DOWS MWA-1/66), place the 0.5mol/L hydrochloric acid solution of 1.5 times of resin volumes to soak 4 hours, drain after the acid solution with water rinse to neutral, the 2mol/L sodium hydroxide solution with 2 times of resin volumes soaked 4 hours then, drained behind the alkali liquor with water rinse to neutral;
2) resin of step 1) being packed in the exchange column amount of iodine is the calcium iodide of anion exchange resin weight 1.5%, is pre-configured to the aqueous solution of 0.05mol/L,,, washes 5 times after reaction finishes by exchange column with the flow velocity of 10mL/min;
3) with step 2) anion exchange resin of the load iodine of gained is being lower than 70 ℃ of oven dry down, obtains the iodine complement agent of spacetabs type.By weight percentage, the content of iodine in anion exchange resin is 1.5%.
Embodiment 5
1) be that (this product is equivalent to the U.S. to weak basic anion exchange resin: AmberliteIRA-68 with commercially available D311 macroporous acrylic; Germany: AP-49), place the 0.5mol/L hydrochloric acid solution of 2 times of resin volumes to soak 5 hours, drain after the acid solution with water rinse to neutral, the 2mol/L sodium hydroxide solution with 2 times of resin volumes soaked 6 hours then, drained behind the alkali liquor with water rinse to neutral;
2) resin of step 1) being packed in the exchange column, is the sodium iodide of anion exchange resin weight 2.5% with amount of iodine, is pre-configured to the aqueous solution of 1.0mol/L,,, washes 4 times after reaction finishes by exchange column with the flow velocity of 5mL/min;
3) with step 2) anion exchange resin of the load iodine of gained is being lower than 70 ℃ of oven dry down, obtains the iodine complement agent of spacetabs type.。By weight percentage, the content of iodine in anion exchange resin is 2.5%.
The iodine complement agent of spacetabs type is as cattle, sheep, poultry, the aquatic animal feed additive that enriches the iodine.Using method is: admix (in iodine) in cattle, sheep, poultry, the aquatic animal feed by following additive capacity: cattle 0.1～0.5mg/kg, sheep 0.1～0.4mg/kg, pig 0.1～0.5mg/kg, chicken 0.1～1mg/kg, duck 0.1～0.5mg/kg, fish 0.1～0.5mg/kg, Trionyx sinensis Wiegmann 0.2～1.5mg/kg, shrimp 0.2～1.5mg/kg.
The iodine complement agent of spacetabs type is used to prepare that the mankind enrich the iodine and treat the health product or the medicine of human diseases by the iodine of drug treatment.Using method is: dosage every day (in iodine) that is used for the treatment of the iodine complement agent of the required spacetabs type of mammary gland dysplasia: the women for body weight 60kg is 0.5～15mg/ days, and the amount ranges of preferred iodine is 2.0～7.5mg/ days.Be used to prevent dosage every day (in iodine) of the iodine complement agent of the required spacetabs type of mammary gland dysplasia: 0.125～1.5mg/ days, the amount ranges of preferred iodine was 0.225～1.25mg/ days.Dosage every day (in iodine) of iodine complement agent that is used for the spacetabs type of acute administration: 15～125mg/ days, the amount ranges of preferred iodine was 20～55mg/ days.
Claims (3)
1. the preparation method of the iodine complement agent of a spacetabs type is characterized in that the step of method is as follows:
1) anion exchange resin is placed 0.5～2mol/L hydrochloric acid solution of 1～2 times of resin volume soaked 2～5 hours, drain after the acid solution with water rinse to neutral, 0.5～2mol/L sodium hydroxide solution with 1～2 times of resin volume soaked 3～6 hours then, drained behind the alkali liquor with water rinse to neutral;
2) resin of step 1) is packed in the exchange column, with amount of iodine is the iodate or the iodide of anion exchange resin weight 0.5～5%, be pre-configured to the aqueous solution of 0.01～1.0mol/L, with the flow velocity of 1～10mL/min by exchange column, finish after washing 2～5 times of exchange;
3) with step 2) anion exchange resin of the load iodine of gained is being lower than 70 ℃ of oven dry down, obtains the iodine complement agent of spacetabs type.
2. the preparation method of the iodine complement agent of a kind of spacetabs type according to claim 1 is characterized in that said iodate is potassium iodate, potassium hydrogen diiodate, sodium iodate or calcium iodate.
3. the preparation method of the iodine complement agent of a kind of spacetabs type according to claim 1 is characterized in that said iodide are sodium iodide, potassium iodide, ammonium iodide, calcium iodide or magnesium iodide.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100531735A CN100411626C (en) | 2006-08-28 | 2006-08-28 | Slow-released type iodine complement agent, and prepn. method and use-thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100531735A CN100411626C (en) | 2006-08-28 | 2006-08-28 | Slow-released type iodine complement agent, and prepn. method and use-thereof |
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| CN100411626C true CN100411626C (en) | 2008-08-20 |
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| CN108208354B (en) * | 2018-01-18 | 2021-03-23 | 仲恺农业工程学院 | Microspheres capable of slowly releasing calcium iodate and preparation method thereof |
| CN110037050B (en) * | 2019-05-08 | 2021-02-02 | 山西大学 | High-efficiency compound iodine solution and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3947572A (en) * | 1974-07-01 | 1976-03-30 | Abbott Laboratories | Iron-resin adsorbate |
| CN1037651A (en) * | 1988-05-11 | 1989-12-06 | 格拉克索公司 | Drug adsorbates |
| CN1114526A (en) * | 1994-12-28 | 1996-01-10 | 王文有 | Process for preparation of germicide containing triiodo resin |
| CN1144195A (en) * | 1996-01-12 | 1997-03-05 | 山西省卫生防疫站 | Drinking water iodine-adding method and its device |
| CN1531399A (en) * | 2001-05-14 | 2004-09-22 | 瓦西里・彼得罗维奇・安德烈丘克 | Biologically active food additive and biologically active forage additive for preventing iodine deficiency and optimising iodine metabolism, food and forage products containing said additive |
-
2006
- 2006-08-28 CN CNB2006100531735A patent/CN100411626C/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3947572A (en) * | 1974-07-01 | 1976-03-30 | Abbott Laboratories | Iron-resin adsorbate |
| CN1037651A (en) * | 1988-05-11 | 1989-12-06 | 格拉克索公司 | Drug adsorbates |
| CN1114526A (en) * | 1994-12-28 | 1996-01-10 | 王文有 | Process for preparation of germicide containing triiodo resin |
| CN1144195A (en) * | 1996-01-12 | 1997-03-05 | 山西省卫生防疫站 | Drinking water iodine-adding method and its device |
| CN1531399A (en) * | 2001-05-14 | 2004-09-22 | 瓦西里・彼得罗维奇・安德烈丘克 | Biologically active food additive and biologically active forage additive for preventing iodine deficiency and optimising iodine metabolism, food and forage products containing said additive |
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| CN1911241A (en) | 2007-02-14 |
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