CN100425271C

CN100425271C - Detoxicating and kidney defending clyster powder

Info

Publication number: CN100425271C
Application number: CNB031125433A
Authority: CN
Inventors: 张世岭; 王铁英
Original assignee: Individual
Current assignee: Individual
Priority date: 2003-06-14
Filing date: 2003-06-14
Publication date: 2008-10-15
Anticipated expiration: 2023-06-14
Also published as: CN1565484A

Abstract

The present invention provides detoxicating and kidney defending clyster powder, which belongs to medicine for treating renal failure made from Chinese herbal medicine. The detoxicating and kidney defending clyster powder is prepared by raw materials, such as rhubarb powder, oyster powder, dandelion powder, red sage root powder and glabrous greenbrier rhizome powder in proportion. Because the clyster powder is made from traditional Chinese medicine, the manufacture cost is low, and the expense of treatment is low. The present invention is used for patients' clysis, the dosage of the medicine can be increased, and the disadvantages that large dose of oral taking leads to digestive canal untoward reactions, such as nausea, vomitus, etc., the drug effect is low when the medicine is orally taken by small dose, etc. are avoided. The repeatability is good, so the clyster powder can be taken for many times per day. The dosage and frequency of clysis can be flexibly selected according to the state of illness without precise instruments and complicated operation. Patients can be treated at home, so the treatment expense is further reduced and the treatment effect is good.

Description

Detoxicating is protected the kidney clyster powder

Technical field

The invention provides a kind of medicine for the treatment of renal failure, especially a kind of medicine made from Chinese herbal medicine.

Background technology

Renal failure is a kind of commonly encountered diseases and frequently-occurring disease of serious harm human life health.This disease is treated in many in the world at present employing dialysis therapies (hemodialysis and peritoneal dialysis) and renal transplantation.The former needs expensive armarium and complicated technology, and the medical expense height causes Most patients to be difficult to bear, and only is the excretory function that part has substituted kidney.The latter the most important thing is to be difficult to seek for the kidney source, and postoperative is for control and the monitoring of long term maintenance to patient's rejection, and expense is surprisingly also big.Like this, even developed countries such as America and Europe also feel headache to the medical expense of renal failure.People are studying always cheap, the tangible medicine of drug effect, but do not succeed, a great problem of medical circle become.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of detoxicating to protect the kidney clyster powder, to improve therapeutic effect, reduction treatment cost.

The present invention is achieved in that detoxicating protects the kidney clyster powder, and the proportioning of described clyster powder is,

Radix Et Rhizoma Rhei powder 30～50 weight portions

Concha Ostreae powder 20～30 weight portions

Herba Taraxaci powder 20～35 weight portions

Radix Salviae Miltiorrhizae powder 26～32 weight portions

Rhizoma Smilacis Glabrae powder 30～45 weight portions.

This detoxicating is protected the kidney clyster powder, adopts the Chinese medicine medicine to make, low cost of manufacture, so medical expense is cheap.The coloclysis that is used for patient, can improve amount of drug, avoided heavy dose of cause when oral feel sick, side effect of digestive tract such as vomiting and the low dose of low shortcoming of drug effect when oral, good reproducibility, can repeatedly use every day, select dosage and coloclysis number of times flexibly for use, do not need accurate instrument and equipment and complicated operations technology according to the state of an illness, patient can treat at home, with further reduction medical expense.Therapeutic effect is good.

The specific embodiment

Further specify the present invention below.

Described Radix Et Rhizoma Rhei powder, Concha Ostreae powder, Herba Taraxaci powder, Radix Salviae Miltiorrhizae powder, Rhizoma Smilacis Glabrae powder are after Radix Et Rhizoma Rhei, Concha Ostreae, Herba Taraxaci, Radix Salviae Miltiorrhizae, Rhizoma Smilacis Glabrae are pulverized, to cross 120 mesh sieves and obtain.

By proportioning, be that unit of weight is formed the potion medicine with the gram.After the mixing, add 500 milliliters of boiling water in this agent medicine, treat can slowly carry out coloclysis when temperature is reduced to 39～40 ℃, after 1 hour it is excreted, the operational approach of coloclysis is identical with general retention enema method.According to the state of an illness, can irritate every day 2～4 times.

Because intravital metabolic waste of renal function patient such as urotoxin etc. can not fully be discharged through urine, the urotoxin concentration in the blood promptly raises gradually.To each organs and tissues disperse (to the low local disperse of concentration, being referred to as Brownian movement on the physics by the high place of concentration), the tissue of being encroached on will recurring structure and the change of function when acquiring a certain degree, and gastrointestinal is no exception.Can cause hyperemia, edema, erosion thus, in addition hemorrhage.Radix Et Rhizoma Rhei in the present invention's the clyster powder has the diarrhea effect, can remove gastral urotoxin, and simultaneously, it also can make intravital non-protein nitrogen (NPN) and essential amino acids be combined into albumen, and the effect that turns waste into wealth is arranged.Owing to need the participation of potassium ion in the albumen building-up process, so can reduce high blood K again ⁺, high blood K ⁺Can cause this patient dead because of sudden cardiac arrest.The main component of Concha Ostreae is a calcium carbonate.Calcium carbonate can become water-fast material to excrete with gastral phosphorus complexation, corrected should disease hypocalcemia, and calcium and phosphorus metabolism disorder is one of six big mechanism of uremia's protracted course of disease.Herba Taraxaci has the bactericidal function, so the effect of renal function protecting is arranged.Because the uremic patient state of an illness is heavy, resistance reduces, and bacterial infection easily takes place, and antibacterial can quicken the non-protein nitrogen that proteinic decomposition produces in the digestive tract increases, kidney burden and make that sb.'s illness took a turn for the worse.The bactericidal function that Herba Taraxaci has just in time can prevent the generation of this problem.Ancients say prolonged illness must the stasis of blood, and modern science thinks that anticoagulant must appear in the renal failure patient, so anticoagulant therapy promotes the recovery of renal function to be of great benefit to suppressing the deterioration of renal function, Radix Salviae Miltiorrhizae is exactly a kind of generally acknowledged anticoagulant good medicine.Rhizoma Smilacis Glabrae has diuresis.

It below is the clinical observation material of the present invention's clyster powder.

The therapeutic effect of clyster powder for checking the present invention carries out clinical treatment observation to 103 routine patients, and selects medical history, the state of an illness, age, 67 routine patients that sex is suitable to organize in contrast.All cases all meet the definite renal failure diagnostic criteria in " internal medicine " (Ye Rengao chief editor, January calendar year 2001, the 5th edition, People's Health Publisher).It is normal 10%～20% to be that glomerular filtration rate (GFR) is low to moderate, and patient's serum creatinine significantly raises, and (be about 450～707umol/L), anemia is more obvious, and nocturia increases and water and electrolyte disturbance, and slight gastrointestinal tract, cardiovascular and nervus centralis symptom are arranged.Treatment is organized among the 103 routine patients, male 60 examples, women 48 examples, average 42.5 years old of age, the average 521 ± 8umol/l of serum creatinine, protopathy: chronic nephritis 71 examples, chronic pyelonephritis 20 examples, renal calculus 7 examples, renal tuberculosis 5 examples.Among the matched group 67 routine patients, male 40 examples, women 27 examples, 41.8 years old mean age, the average 518 ± 7umol/l of serum creatinine.Protopathy: chronic nephritis 42 examples, chronic pyelonephritis 15 examples, renal calculus 7 examples, multiple cystic kidney 1 example, renal tuberculosis 2 examples.Matched group gives low protein diet, essential amino acids, 2-ketoacid (German Fresenius card is than blocking than company limited production) and symptomatic treatment.The treatment group adds on the basis of above-mentioned treatment with detoxicating protects kidney clyster powder enema treatment, and every day, coloclysis was 2～4 times.The enema treatment method is with above-mentioned.

The standard that curative effect determinate standard is drafted with reference to national renal failure conservative treatment in 1987 special meeting, i.e. produce effects: A, sx or disappearance; B, endogenous creatinine clearance rate increases 〉=30%; C, serum creatinine reduces 〉=30%.Above A item indispensability, it is decidable that B, C possess 1.Effectively: A, sx or disappearance; B, endogenous creatinine clearance rate increases 〉=20%; C, serum creatinine reduces 〉=20%; D with the logarithm or the inverse of serum creatinine, analyzes its slope significance person with linear regression equation before and after the treatment.Above A item indispensability, it is decidable that B, C, D possess one.Invalid: as not meet produce effects and condition for validity person.

Result: treatment group produce effects 46 examples, effective 42 examples, invalid 15 examples.Total effective rate 85.4%, matched group produce effects 16 examples, effective 25 examples, invalid 26 examples, total effective rate 61.2%.Two groups of total effective rate contrasts have significant difference (P＜0.01).

Embodiment

Get Radix Et Rhizoma Rhei powder 40g, Concha Ostreae powder 25g, Herba Taraxaci powder 25g, Radix Salviae Miltiorrhizae powder 29g, Rhizoma Smilacis Glabrae powder 35g composition potion detoxicating guarantor kidney clyster powder.Radix Et Rhizoma Rhei powder, Concha Ostreae powder, Herba Taraxaci powder, Radix Salviae Miltiorrhizae powder, Rhizoma Smilacis Glabrae powder are after Radix Et Rhizoma Rhei, Concha Ostreae, Herba Taraxaci, Radix Salviae Miltiorrhizae, Rhizoma Smilacis Glabrae are pulverized, to cross 120 mesh sieves and obtain.

Claims

1, detoxicating is protected the kidney clyster powder, it is characterized in that, the proportioning of described clyster powder is,

Radix Et Rhizoma Rhei powder 30～50 weight portions

Concha Ostreae powder 20～30 weight portions

Herba Taraxaci powder 20～35 weight portions

Radix Salviae Miltiorrhizae powder 26～32 weight portions

Rhizoma Smilacis Glabrae powder 30～45 weight portions.