CN100420371C - SPF level intermittently anoxic rat feeding compartment - Google Patents
SPF level intermittently anoxic rat feeding compartment Download PDFInfo
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- CN100420371C CN100420371C CNB2006100526845A CN200610052684A CN100420371C CN 100420371 C CN100420371 C CN 100420371C CN B2006100526845 A CNB2006100526845 A CN B2006100526845A CN 200610052684 A CN200610052684 A CN 200610052684A CN 100420371 C CN100420371 C CN 100420371C
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Abstract
The SPF level intermittently anoxic rat feeding compartment includes one sealed compartment body with observing window, air inputting holes and air exhausting holes distributed regularly on different side walls, one non-return valve connected to the air exhausting holes, and conic bodies on the compartment body and corresponding to the air inputting holes for homogeneous diffusion of air. The SPF level intermittently anoxic rat feeding compartment has great volume, fast homogeneous air regulation inside the compartment, precisely controlled breathe environment and required environment parameters. The present invention makes it possible to feed sufficient amount of rats for reaching correct, reliable and repeatable experiment result.
Description
Technical field:
The present invention relates to a kind of experimental animal feeding cabin, particularly simulate the rat model feeding cabin that various breathings are levied.
Background technology:
Owing at present various breathings are levied, particularly the cause of disease of sleep apnea syndrome (SAS), pathogenesis are still unclear, study certain limitation on human body, so relevant zooscopy seems particularly important.Because rat has the spontaneous respiration break-off phenomenon under sleep state, the electrical activity of brain and the mankind are similar, and the length of one's sleep is long, better tolerance, raises easily, so rat is the good animal model as the research sleep apnea syndrome.Holding time of gas concentration that generally can be by control sealed compartment body makes and raises the long-term interrupted respiration low-oxygen gas of rat in the cabin, sets up the rat model of simulation SAS by this method.General feeding cabin one side is established air inlet now, opposite side is established exhaust outlet, because air feed environment transformation period is the simulated respiration frequency, change very fast, the gas that feeds can't evenly spread in the cabin rapidly, makes that the volume of cabin body can not be excessive, and the breathing environment of simulation can not accurately be controlled, the rat quantity of raising is few, can not guarantee correctness, the repeatability and credible of experimental result.And general feeding cabin all is provisional closed box, adopts lucite bonding, more coarse, and reliability is relatively poor.
Summary of the invention:
At the deficiencies in the prior art, the invention provides a kind of can making and feed gas evenly diffusion rapidly, the SPF inter-stage breakthrough oxygen rat feeding compartment that the cabin body space is big.
The present invention includes the closed cabin body that has observation window, body one sidewall in cabin is provided with the gas input hole, another sidewall is provided with gas discharge hole, gas discharge hole connects check valve, gas input hole and gas discharge hole all have a plurality of, and regular-scattered is arranged on the respective side walls, and are provided with several and gas input hole cone one to one in the body of cabin, its awl point constitutes the even diffusion structure of gas towards the gas input hole.
The present invention is provided with a plurality of gas input holes and tap, and is provided with gas diffusion structure, has both made the volume of cabin body bigger, also can make gas concentration adjusting variation uniformly rapidly in the cabin, breathing environment is accurately controlled, the environmental parameter that simulation needs.And gas diffusion structure makes input gas can directly not blow on one's body the rat, does not influence the normal life of rat, and bigger cabin body can be raised the rat of sufficient amount, has guaranteed correctness, reliability and the repeatability of experimental result.
The distance of cone and cabin, gas input hole place body sidewall is typically provided to adjustable, and adjustments of gas diffusion velocity and position are simulated different breathing environment more easily so on demand.
Each gas input hole of the present invention can connect several magnetic valves respectively, magnetic valve is connected with the automatic detection and control device lead, detect the hole other also can being provided with of gas discharge hole, senser element places the detection hole to be connected with automatic detection and control device, constitutes full-automatic air feed control system.Whole like this air feed process can Automatic Control, and more accurate, reference record is more detailed, improves the experiment quality.
Further specify the present invention below in conjunction with drawings and Examples.
Description of drawings:
Fig. 1 is the main schematic diagram of embodiment;
Fig. 2 is the A-A profile of Fig. 1;
Fig. 3 is the rearview of Fig. 1;
Fig. 4 is the schematic block diagram of automatic air feed control.
Embodiment: as shown in the figure, cabin body 1 adopts stainless steel, on be covered with the observation window 2 of safety glass, generally require the space of cabin body 1 can raise four cage rats, promptly more than 20.Body 1 one sidewalls in cabin are provided with gas input hole 3, and another sidewall is provided with gas discharge hole 4, and gas discharge hole 4 connects check valve 6.Gas input hole 3 and gas discharge hole 4 all have a plurality of, and regular-scattered is arranged on the respective side walls, and are provided with several and gas input hole 3 cone 7 one to one in the cabin body 1, and its awl point constitutes the even diffusion structure of gas towards gas input hole 3.General gas input hole 3 is eight, gas discharge hole 4 is four, when raising SPF level (specific-pathogen free) rat model of simulation sleep apnea syndrome, two gas input hole 3 input oxygen, all the other six hole input nitrogen, the gas of input is stopped diffusion by cone 7, changes rapidly evenly.And the distance of cone 7 and cabin, gas input hole 3 place body 1 sidewall is adjustable, can adjust gas diffusion velocity and position according to different requirements like this.
Each gas input hole of present embodiment connects several magnetic valves 9 respectively, magnetic valve 9 is connected with automatic detection and control device 8 leads, detect hole 5 gas discharge hole 4 other also being provided with, senser element places detection hole 5 to be connected with automatic detection and control device 8, constitutes full-automatic air feed control system.The gas supply of whole like this intermittent hypoxia is control fully automatically, can set gas concentration and period of change in the cabin body 1 arbitrarily, but and detail record parameter.Can also connect printer 10 by interface in the reality, the printable like this parameter that goes out whole process changes, and improves correctness, reliability and the repeatability of experimental result.
Claims (3)
1. SPF inter-stage breakthrough oxygen rat feeding compartment, comprise the closed cabin body that has observation window, body one sidewall in cabin is provided with the gas input hole, another sidewall is provided with gas discharge hole, gas discharge hole connects check valve, it is characterized by: gas input hole (3) and gas discharge hole (4) all have a plurality of, regular-scattered is arranged on the respective side walls, and be provided with several and gas input hole (3) cone (7) one to one in the cabin body (1), its awl point constitutes the even diffusion structure of gas towards gas input hole (3).
2. SPF inter-stage breakthrough oxygen rat feeding compartment according to claim 1 is characterized by: the distance of cone (7) and gas input hole (3) cabin, place body (1) sidewall is adjustable.
3. SPF inter-stage breakthrough oxygen rat feeding compartment according to claim 1 and 2, it is characterized by: each gas input hole connects several magnetic valves (9) respectively, magnetic valve (9) is connected with automatic detection and control device (8) lead, detect hole (5) other also being provided with of gas discharge hole (4), senser element places detection hole (5) to be connected with automatic detection and control device (8), constitutes full-automatic air feed control system.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100526845A CN100420371C (en) | 2006-07-26 | 2006-07-26 | SPF level intermittently anoxic rat feeding compartment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100526845A CN100420371C (en) | 2006-07-26 | 2006-07-26 | SPF level intermittently anoxic rat feeding compartment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1887068A CN1887068A (en) | 2007-01-03 |
| CN100420371C true CN100420371C (en) | 2008-09-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100526845A Expired - Fee Related CN100420371C (en) | 2006-07-26 | 2006-07-26 | SPF level intermittently anoxic rat feeding compartment |
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| CN (1) | CN100420371C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101491477A (en) * | 2009-03-10 | 2009-07-29 | 中国医学科学院阜外心血管病医院 | Animal experiment device capable of providing intermittence low-oxygen environment |
| CN101584611B (en) * | 2009-06-12 | 2010-12-08 | 温州医学院 | Intermittent hypoxia big and small mice feeding cabin of linear track type |
| CN102484982A (en) * | 2010-12-06 | 2012-06-06 | 西安市第一医院 | Oxygen concentration controllable mouse rearing box |
| CN102217552B (en) * | 2011-04-26 | 2012-10-24 | 广州医学院第一附属医院 | Full-automatic hypoxic animal model breeding box |
| CN102577988A (en) * | 2012-03-08 | 2012-07-18 | 温州医学院 | Fault emergency protector for low-oxygen animal rearing cabin |
| CN109463293B (en) * | 2019-01-10 | 2024-01-30 | 成都合拓创展生物科技有限公司 | Cage for preparing rat model of ischemic and anoxic encephalopathy and feeding device |
-
2006
- 2006-07-26 CN CNB2006100526845A patent/CN100420371C/en not_active Expired - Fee Related
Non-Patent Citations (8)
| Title |
|---|
| 低氧高二氧化碳动物饲养仓的研制. 胡良冈，武宗寅，龚永生，郑绿珍，王卫.医疗卫生装备，第1期. 1997 |
| 低氧高二氧化碳动物饲养仓的研制. 胡良冈，武宗寅，龚永生，郑绿珍，王卫.医疗卫生装备，第1期. 1997 * |
| 全自动低氧高二氧化碳饲养舱的研制与临床应用. 种银保，齐悦国，钱桂生，张献全，姚伟，赵自强，史长宁.中国医疗器械杂志，第25卷第1期. 2001 |
| 全自动低氧高二氧化碳饲养舱的研制与临床应用. 种银保，齐悦国，钱桂生，张献全，姚伟，赵自强，史长宁.中国医疗器械杂志，第25卷第1期. 2001 * |
| 全自动简易型低氧饲养舱的研制. 顾斌，陈平.医疗卫生装备，第26卷第7期. 2005 |
| 全自动简易型低氧饲养舱的研制. 顾斌，陈平.医疗卫生装备，第26卷第7期. 2005 * |
| 常压低氧高二氧化碳清洁级动物饲养舱的研制. 胡良冈，龚永生，范小芳，李继武，郑绿珍.医疗卫生装备，第4期. 2003 |
| 常压低氧高二氧化碳清洁级动物饲养舱的研制. 胡良冈，龚永生，范小芳，李继武，郑绿珍.医疗卫生装备，第4期. 2003 * |
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| CN1887068A (en) | 2007-01-03 |
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