CN100418558C - Application of areca and extract thereof in preparation of health product for expelling lead - Google Patents
Application of areca and extract thereof in preparation of health product for expelling lead Download PDFInfo
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- CN100418558C CN100418558C CNB2006100357387A CN200610035738A CN100418558C CN 100418558 C CN100418558 C CN 100418558C CN B2006100357387 A CNB2006100357387 A CN B2006100357387A CN 200610035738 A CN200610035738 A CN 200610035738A CN 100418558 C CN100418558 C CN 100418558C
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Abstract
The present invention discloses a new application of areca and the extract for preparing health food having functions of promoting lead discharge. Since areca belongs to traditional Chinese medicine, and has less toxic and side effects, the areca can be prepared into medicine or health food for high-lead people.
Description
Technical field
The raw material that the present invention relates to is the Chinese medicine Semen Arecae, is the purposes in preparing the health product that promote lead-eliminating effect in the body specifically.
Technical background
Lead is chemical substance important in the commercial production, and is widely distributed on earth, and content is abundant, also is one of nondegradable environment heavy metal contaminants.From the biochemistry angle, lead is a kind of poisonous mineral with affinity, and it is very long to enter the interior back half-life of body, is about 1460 days.It is distributed in whole body with the form of phosphoric acid hydrogen lead earlier, wherein has 90-95% to be converted into orthophosphate and is deposited in skeleton, tooth, internal organs, skin, the hair, transfers in the blood lentamente then.So it is plumbous all have harm to each tissue system of human body, wherein responsive to lead with nervous system and hemopoietic system.Be embodied in: influence the growth and the skeleton development of intelligence, cause dyspepsia and endocrine disturbance, cause anemia, hypertension and arrhythmia, destroy renal function and immunologic function etc.In addition, lead also has carcinogenic effect.
Along with the acceleration of Chinese Urbanization and process of industrialization, the environment lead contamination is on the rise.Infer according to the expert, nearly 20 years, China's urbanite's Pb-B is ascendant trend year by year, according to international children ' s lead poisoning diagnostic criteria (blood lead value＞100ug/L), China's urban children lead poisoning prevalence rate is between 30%-40%, part urban industry contaminated area nearly 100% even there is not the common urban district of obvious industrial pollution, also has the children blood lead of 10%-30% to exceed standard.
Plumbous potential hazard to health causes people's attention day by day.At present, preventing and treating saturnine basic principle is that environment intervention, health education and clinical treatment three combine, and the environment intervention is basic, and health education is a basic means, and to being that the lead poisoning of blood lead concentration 〉=0.9umol/L is just considered Drug therapy more than the moderate.The saturnine medicine of clinical treatment mainly contains calcium disodium chelate (CaNa2EDTA), sodium dimercaptosuccinate (DMSA) etc. at present, though driving lead, these medicines can reduce lead load in the body, Plumbum removing is effective, but micro elements needed by human is run off, also can cause damage to kidney, side effect is bigger, and drives nervous lesion that plumbous medicine causes lead and reverse and have little significance, so outside the medicine Plumbum removing a good appetite suddenly appearing in a serious disease severe lead poisoning, clinically generally do not adopt.Also there are some to propose, and obtained certain curative effect, can be used for light, the moderate lead poisoning of prevention or treatment with dietetic therapy or Chinese medicine Plumbum removing.
Chinese invention patent application publication number CN1108546A once disclosed " sour-sweet gum anthelminthic tablet ", adopted Semen Arecae, Fructus Quisqualis, Fructus Mume, Omphalia, wheat straw etc. to make tablet, and the straight effect of anthelmintic is arranged.Chinese invention patent application publication number CN11056815A once disclosed " a kind of method with preparation of areca oral liquor ", adopting Semen Arecae and Semen Cucurbitae is the oral liquid of effective ingredient preparation, significant curative effect such as have parasite killing, anthelmintic, removing food stagnancy, be good for the stomach, be a kind of appetizing, spleen invigorating, aid digestion, promote the metabolic nutrient fluid with high efficiency of human body.
Semen Arecae is the mature seed of Palmae aiphyllium plant Semen Arecae Areca catechu L..Main product in Hainan, ground such as Fujian, Yunnan, Guangxi, Taiwan.Chinese medicine thinks that it has expelling intestinal worms and removing food stagnancy, and the effect of promoting the circulation of QI to induce diuresis clinically is mainly used in multiple intestinal parasitical diseases, and stagnation of QI due to dyspepsia is heavy behind the dysentery, infantile malnutrition, and edema, beriberi swell and ache etc.; Modern pharmacological research proves that it has stronger effect to taeniasis suis, can make its general paralysis; Pinworm, ancylostome, flagellate, fasciloopsis etc. are also killed effect; Treatment has certain preventive effect to bilharziasis.Infusion has inhibitory action to dermatophytes, influenza virus.Arecoline has like the choline effect.In addition, Semen Arecae can influence the growth course of sperm, causes the trimester of pregnancy hysterospasm.Do not see bibliographical information but whether Semen Arecae has the human body of promotion lead-eliminating effect.
Summary of the invention
The purpose of this invention is to provide the application in the oral formulations health product of preparation promotion lead-eliminating effect of Semen Arecae or its water extract.
Adopt Semen Arecae or its water extract as raw material, single with or make up routinely with Folium Ginkgo that formulation method can be prepared into the health product that are fit to oral any dosage form.
The present invention is that screening obtains having the Semen Arecae that clearly promotes lead-eliminating effect from Chinese medicine, can reach and promote the plumbous purpose of human body being damaged, improves symptom of Plumbum removing, alleviation or prevention, and have no side effect, be suitable for the higher crowd of blood lead and take for a long time, also be suitable for the higher child of blood lead.
The specific embodiment
The invention will be further elaborated below in conjunction with embodiment.
Embodiment 1
60 healthy Kunming mouses, cleaning level, male female half and half, body weight 18-22 gram, be divided into 5 groups, promptly the blank group is dyed plumbous model group, 3 dosage groups of high, medium and low Semen Arecae decocting liquid, every group 12, lead acetate is dissolved in the distilled water by the 40mg/kg lumbar injection, set up mice and dye plumbous animal model.
Semen Arecae decocting liquid adopts conventional decocting method preparation, and simmer down to respective concentration, decocting liquid various dose group comprises high dose group (9g/kg), middle dosage group (6g/kg), low dose group (3g/kg), gastric infusion is respectively organized in medication, and all the other each groups gavage the normal saline of equivalent, and the experiment successive administration is totally 6 weeks.Administration is got mice right femoral vein blood 40ul after finishing, and puts into the plastic centrifuge tube with cover that fills 0.36ml 1% nitric acid and shakes up; Get a side 50% femur, digest after weighing, add rare nitric acid and be settled to 5ml, with corresponding liver and the cerebral tissue got of method, with atomic spectrophotometer carry out blood and bone, liver, the brain lead content is measured; Above-mentioned data statistics is checked with T.
Table 1 Semen Arecae decocting liquid to mice blood lead, bone lead, liver and brain lead (mg/kg) content influence (x ± s, n=12)
aCompare P＜0.05 with model group
bCompare P＜0.01 with the blank group
Semen Arecae decocting liquid is obvious to the blood lead content influence, and middle high dose group and model group relatively have significant difference P＜0.05; Semen Arecae decocting liquid is obvious to the influence of bone lead content, and low middle high dose group and model group relatively have significant difference P＜0.05; Semen Arecae decocting liquid is obvious to the influence of liver lead content, and low middle high dose group and model group relatively have significant difference P＜0.05-0.01; Semen Arecae decocting liquid is obvious to the influence of brain lead content, and high dose group and model group relatively have significant difference P＜0.05.
Embodiment 2
60 healthy Kunming mouses, cleaning level, male female half and half, body weight 18-22 gram; Animal is divided into 5 groups, and promptly the blank group is dyed plumbous model group, 3 dosage groups of high, medium and low Semen Arecae decocting liquid, and 12 every group, lead acetate is dissolved in the distilled water by the 40mg/kg lumbar injection, set up mice and dye plumbous animal model.
Take by weighing Semen Arecae and Folium Ginkgo by same weight proportion, adopt conventional decocting method to prepare Semen Arecae Folium Ginkgo decocting liquid, and simmer down to respective concentration, each medication group gastric infusion, the various dose group comprises high dose group (9g/kg), middle dosage group (6g/kg), and low dose group (3g/kg) is gastric infusion respectively, all the other each groups gavage the equivalent normal saline, and the experiment successive administration is totally 6 weeks.Administration is got mice right femoral vein blood 40ul after finishing, and puts into the plastic centrifuge tube with cover that fills 0.36ml 1% nitric acid and shakes up; Get a side 50% femur, digest after weighing, add rare nitric acid and be settled to 5ml, with corresponding liver and the cerebral tissue got of method, with atomic spectrophotometer carry out blood and bone, liver, the brain lead content is measured; Above-mentioned data statistics is checked with T.
Table 2 Semen Arecae Fructus Lycii decocting liquid to mice blood lead, bone lead, liver and brain lead (mg/kg) content influence (x ± s, n=12)
aCompare P＜0.05 with model group
bCompare P＜0.01 with the blank group
Semen Arecae Folium Ginkgo decocting liquid is obvious to the blood lead content influence, and middle high dose group and model group relatively have significant difference P＜0.05; Semen Arecae Folium Ginkgo decocting liquid is obvious to the influence of bone lead content, and low middle high dose group and model group relatively have significant difference P＜0.05; Semen Arecae Folium Ginkgo decocting liquid is obvious to the influence of liver lead content, and low middle high dose group and model group relatively have significant difference P＜0.05-0.01; Semen Arecae Folium Ginkgo decocting liquid is obvious to the influence of brain lead content, and middle high dose group and model group relatively have significant difference P＜0.05.
Claims (2)
1. Semen Arecae or its water extract application in the oral formulations health product of preparation promotion lead-eliminating effect.
2. application according to claim 1 is characterized in that: Semen Arecae or its water extract and Folium Ginkgo are made the oral formulations health product that promote lead-eliminating effect jointly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100357387A CN100418558C (en) | 2006-05-31 | 2006-05-31 | Application of areca and extract thereof in preparation of health product for expelling lead |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100357387A CN100418558C (en) | 2006-05-31 | 2006-05-31 | Application of areca and extract thereof in preparation of health product for expelling lead |
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| CN1883633A CN1883633A (en) | 2006-12-27 |
| CN100418558C true CN100418558C (en) | 2008-09-17 |
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| CNB2006100357387A Expired - Fee Related CN100418558C (en) | 2006-05-31 | 2006-05-31 | Application of areca and extract thereof in preparation of health product for expelling lead |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1768838A (en) * | 2005-10-19 | 2006-05-10 | 暨南大学 | Chinese medicine preparation for promoting lead-removal and its preparation process |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1768838A (en) * | 2005-10-19 | 2006-05-10 | 暨南大学 | Chinese medicine preparation for promoting lead-removal and its preparation process |
Non-Patent Citations (4)
| Title |
|---|
| 我国保健品的现状及研发. 周俊.中国实验方剂学杂志，第S1期. 2002 |
| 我国保健品的现状及研发. 周俊.中国实验方剂学杂志，第S1期. 2002 * |
| 铅中毒防治的研究进展. 王芳，刘毅，管竞环.微量元素与健康研究，第17卷第3期. 2000 |
| 铅中毒防治的研究进展. 王芳，刘毅，管竞环.微量元素与健康研究，第17卷第3期. 2000 * |
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Granted publication date: 20080917 Termination date: 20110531 |