CN100413546C - Anti-infection hard film external catheter and producing method - Google Patents
Anti-infection hard film external catheter and producing method Download PDFInfo
- Publication number
- CN100413546C CN100413546C CNB2006100521733A CN200610052173A CN100413546C CN 100413546 C CN100413546 C CN 100413546C CN B2006100521733 A CNB2006100521733 A CN B2006100521733A CN 200610052173 A CN200610052173 A CN 200610052173A CN 100413546 C CN100413546 C CN 100413546C
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- CN
- China
- Prior art keywords
- catheter
- infection
- chitosan
- hard film
- infectious
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000002924 anti-infective effect Effects 0.000 title claims abstract description 17
- 238000000034 method Methods 0.000 title claims description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 35
- 229920001661 Chitosan Polymers 0.000 claims abstract description 24
- 239000000463 material Substances 0.000 claims abstract description 15
- 208000015181 infectious disease Diseases 0.000 claims abstract description 11
- 238000001291 vacuum drying Methods 0.000 claims abstract description 6
- 239000011248 coating agent Substances 0.000 claims abstract description 5
- 238000000576 coating method Methods 0.000 claims abstract description 5
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 230000003115 biocidal effect Effects 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 abstract description 3
- 229910052709 silver Inorganic materials 0.000 abstract description 3
- 239000004332 silver Substances 0.000 abstract description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 206010002091 Anaesthesia Diseases 0.000 description 5
- 230000037005 anaesthesia Effects 0.000 description 5
- 239000010408 film Substances 0.000 description 4
- 239000003792 electrolyte Substances 0.000 description 3
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 229910001961 silver nitrate Inorganic materials 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The present invention is external anti-infectious hard film catheter, which is one catheter with one 15 cm long section possessing coated or compounded anti-infectious material in the front end. The anti-infectious material has broad antibacterial activity, high tissue tolerance and good compatibility with the material in most medical equipment, and consists of chitosan 15-30 wt%, chitosan derivative 20-60 wt%, sodium hyaluuronate 5-40 wt% and glycerine 3-12 wt%. The external anti-infectious hard film catheter is produced through forming gel of the anti-infectious material, coating the gel in the 15 cm long section in the front end of the catheter, and vacuum drying at 30deg.c, or preparing one layer of nanometer silver film on the catheter. The external anti-infectious hard film catheter is used as the anaesthetic passage peridural anaesthesis without infection.
Description
Technical field:
The present invention relates to the refreshing footpath of a kind of anti-infective epidural space and block conduit and manufacture method, belong to and have anti-infective medical apparatus and instruments joint product and manufacture method.
Background technology:
Existing more than the 70 year history of the refreshing footpath block anesthesia of epidural space, it is one of anesthesia of present domestic relatively extensive use, use this method anesthesia, must there be a conduit to insert epidural space, along with the reach of science, conduit is inserted from the anesthesia use and has been born to postoperative analgesia use, but along with the time of catheter retaining human body is more and more longer, it is also increasing to the harm of human body, its main cause is that hard numb conduit is kept somewhere body for a long time and can be produced biomembrane around the conduit, and this film also is the arch-criminal that the treatment patient suffers from fatal infection.Thereby medical treatment such as use that at present the refreshing footpath block anesthesia of epidural space conduit is anaesthetized exist to human body work the mischief possible.
Summary of the invention:
The object of the present invention is to provide a kind of antimicrobial treatment of carrying out to suppress biomembranous formation, suffer from harmful anti-infection hard film external catheter and manufacture method thereby bring behind the control use epidural catheter.
The present invention finishes by following technical solution: it includes a catheter body, the coating of described catheter body front end 15cm area segments or be compounded with have broad spectrum antibiotic activity, tissue tolerance is good and good with most of armarium material compatibility, can be by compound and do not have the infection material of repellency basically; Described infection material is formulated as following weight percent by chitosan, chitosan derivatives, hyaluronate sodium, glycerol: chitosan 15-30%, chitosan derivatives 20-60%, hyaluronate sodium 5-40%, glycerol 3-12%.
Described infection material is formulated as following weight percent by chitosan, chitosan derivatives, hyaluronate sodium, glycerol: chitosan 20%, chitosan derivatives 50%, hyaluronate sodium 20%, glycerol 10%.
A kind of manufacture method of anti-infection hard film external catheter as mentioned above, it is that the component of described infection material is become certain density gel by proportioning reaction back, and coating forms at 30 ℃ of following vacuum dryings then in catheter proximal end 15cm area segments.
The present invention blocks the length that conduit inserts 15cm in the body according to the refreshing footpath of epidural, in conduit or exocoel through a kind of novel anti-infection material through technical finesse or chemical treatment and making, play the probability of using this product to protect from infection thereby make conduit can play the effect of slow release dissipation in vivo.It has simple in structure, and is easy to use, and processing technology is simple, and result of use is good, can play characteristics such as anti-infective effect well.
The specific embodiment:
Embodiment one: select following component and weight proportion for use: chitosan 20%, chitosan derivatives 50%, hyaluronate sodium 20%, glycerol 10%, the reaction back becomes the finite concentration gel coat in catheter proximal end 15cm zone, forms at 30 ℃ of following vacuum dryings then.
Embodiment two: select following component and weight proportion for use: chitosan 15%, chitosan derivatives 60%, hyaluronate sodium 20%, glycerol 5%, the reaction back becomes the finite concentration gel to be coated in catheter proximal end 15cm zone, forms at 30 ℃ of following vacuum dryings then.
Embodiment three: select following component and weight proportion for use: chitosan 30%, chitosan derivatives 30%, hyaluronate sodium 38%, glycerol 12%, the reaction back becomes the finite concentration gel to be coated in catheter proximal end 15cm zone, forms at 30 ℃ of following vacuum dryings then.
Embodiment four: prepare silver nitrate aqueous solution with redistilled water, regulate pH value, stearic hydrogen is spun drips of solution be added in the electrolyte surface, make anode with the filamentary silver of different-diameter then, negative electrode, insertion is in by electrolyte and Surfactants at Interface, and conduit prepares one deck nanometer silver thin film on stearic acid electrolyte interface.
Claims (3)
1. anti-infection hard film external catheter, it includes a catheter body, it is characterized in that catheter body front end 15cm area segments coating or be compounded with have broad spectrum antibiotic activity, tissue tolerance is good and good with most of armarium material compatibility, can be by compound and do not have the infection material of repellency basically; Described infection material is formulated as following weight percent by chitosan, chitosan derivatives, hyaluronate sodium, glycerol: chitosan 15-30%, chitosan derivatives 20-60%, hyaluronate sodium 5-40%, glycerol 3-12%.
2. anti-infection hard film external catheter according to claim 1 is characterized in that described infection material is formulated as following weight percent by chitosan, chitosan derivatives, hyaluronate sodium, glycerol: chitosan 20%, chitosan derivatives 50%, hyaluronate sodium 20%, glycerol 10%.
3. manufacture method of anti-infection hard film external catheter as claimed in claim 1 or 2, it is characterized in that the component of described infection material is become certain density gel by proportioning reaction back, and coating forms at 30 ℃ of following vacuum dryings then in catheter proximal end 15cm area segments.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100521733A CN100413546C (en) | 2006-06-27 | 2006-06-27 | Anti-infection hard film external catheter and producing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100521733A CN100413546C (en) | 2006-06-27 | 2006-06-27 | Anti-infection hard film external catheter and producing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1899629A CN1899629A (en) | 2007-01-24 |
| CN100413546C true CN100413546C (en) | 2008-08-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100521733A Active CN100413546C (en) | 2006-06-27 | 2006-06-27 | Anti-infection hard film external catheter and producing method |
Country Status (1)
| Country | Link |
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| CN (1) | CN100413546C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008326154B2 (en) | 2007-10-30 | 2013-12-12 | Uti Limited Partnership | Method and system for sustained-release of sclerosing agent |
| CN116350857A (en) * | 2023-03-31 | 2023-06-30 | 上海市第四人民医院 | Anti-infection epidural catheter and manufacturing method |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2289571Y (en) * | 1997-05-27 | 1998-09-02 | 北京金铱兰真空镀层技术开发有限公司 | Medical anti-infectious catheter |
| CN1539514A (en) * | 2003-11-03 | 2004-10-27 | 刘永庆 | Method for preparing multifunctional biological repair material |
| CN1597009A (en) * | 2003-09-17 | 2005-03-23 | 邵贤斌 | Nanometer antibacterial urinary catheter |
| US20050266038A1 (en) * | 2004-05-27 | 2005-12-01 | Thierry Glauser | Antifouling heparin coatings |
| CN2778285Y (en) * | 2005-03-28 | 2006-05-10 | 山东百多安医疗器械有限公司 | Antibacterial super slippery urethral catheter |
-
2006
- 2006-06-27 CN CNB2006100521733A patent/CN100413546C/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2289571Y (en) * | 1997-05-27 | 1998-09-02 | 北京金铱兰真空镀层技术开发有限公司 | Medical anti-infectious catheter |
| CN1597009A (en) * | 2003-09-17 | 2005-03-23 | 邵贤斌 | Nanometer antibacterial urinary catheter |
| CN1539514A (en) * | 2003-11-03 | 2004-10-27 | 刘永庆 | Method for preparing multifunctional biological repair material |
| US20050266038A1 (en) * | 2004-05-27 | 2005-12-01 | Thierry Glauser | Antifouling heparin coatings |
| CN2778285Y (en) * | 2005-03-28 | 2006-05-10 | 山东百多安医疗器械有限公司 | Antibacterial super slippery urethral catheter |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1899629A (en) | 2007-01-24 |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: JIAXING COS BIOLOGY PRODUCTS CO., LTD. Free format text: FORMER OWNER: YANG YUMIN Effective date: 20100609 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 314000 1D, BUILDING 1, DASHU GARDEN, NO.1, PENGLAI ROAD, JIAXING CITY, ZHEJIANG PROVINCE TO: 314000 BUILDING 1, (JIAXING) SCI-TECH PARK, SHANGHAI JIAOTONG UNIVERSITY, NO.228, HONGYE ROAD, XIUZHOU INDUSTRY ZONE, JIAXING CITY |
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| TR01 | Transfer of patent right |
Effective date of registration: 20100609 Address after: Hong Yip Road 314000 Jiaxing city Xiuzhou Industrial Zone No. 228 Shanghai Jiaotong University (Jiaxing) science and Technology Park Building No. 1 Patentee after: Jiaxing Western European Biological Products Co., Ltd. Address before: 1, 314000 1D, big tree garden, No. 1, Penglai Road, Jiaxing, Zhejiang Patentee before: Yang Yumin |