CN209347737U - A kind of antibacterial and the extraventricular drainage pipe to prevent adhesion - Google Patents

Abstract

A kind of antibacterial and the extraventricular drainage pipe to prevent adhesion, including drainage tube main body, further include the external coating being applied on the drainage tube body outer wall, and the external coating is poly-dopamine chitosan coat.The utility model is a kind of with antibacterial and the anti-extraventricular drainage pipe being adhered, drainage tube main body use traditional medical silica-gel ingredient, has good physical characteristic, is not easy bending, is squeezed and deformed and has excellent support power.Meanwhile classical tapered head end and side opening design, strengthen drainage efficiency.The coating of this extraventricular drainage pipe interior and exterior is poly-dopamine chitosan coat, and coating preparation is simple, has preferable adsorptivity, can stablize and be covered on silica gel drainage tube body surfaces, and be less prone to decomposition.There is the poly-dopamine of the utility model good biocompatibility and good anti-stick continuous cropping to use, it is possible to reduce the tissue of extraventricular drainage pipe and encephalic is adhered, while can reduce the antianaphylaxis of drainage tube and body.

Description

A kind of antibacterial and the extraventricular drainage pipe to prevent adhesion

Technical field

The utility model relates to the field of medical instrument technology, and in particular to a kind of antibacterial and the extraventricular drainage to prevent adhesion Pipe.

Background technique

Intraventricular drainage is will to have the drainage of several side openings after cranial drill hole rows ventricular puncture or in operation of opening cranium Pipe front end is placed in the ventricles of the brain, and liquid drain in the ventricles of the brain is gone out to an external technology.Such as because hydrocephalus causes serious intracranial pressure to increase High patient when the state of an illness is critical or even hernia cerebri or stupor occurs, using ventricular puncture or drainage, arranges as urgent decompression rescue It applies, further to check that treatment creates conditions.For Patients with Cerebral Hemorrhage, puncture drainage cerebrospinal fluid can reduce ventricles of the brain reflection and prevention and treatment Ventricular system obstruction.It is to reduce intracranial pressure for Encephalocele, is conducive to improve appearing for field of operation, often punctures telocoele, draw Epidemic meningitis spinal fluid.It is postoperative especially postoperative to release reactive intracranial pressure in fossa cranii posterior, also commonly use lateral ventricular external drainage pipe.

In addition to the conditions already mentioned, neurosurgery is after the operations such as processing cerebral hemorrhage, brain trauma, intracranial mass lesion, conventional meeting indwelling Extraventricular drainage pipe, main purpose be to monitor it is postoperative whether there is or not bleeding, exudation, to the periodic detection of the property of postoperative cerebrospinal And the situation of change of the postoperative intracranial pressure of monitoring, thus extraventricular drainage pipe is widely used in neurosurgical unit and ICU.

However, conventional use of extraventricular drainage pipe has no antibacterial functions at present, antidromicity cranium can be clinically encountered often The case of interior infection, causes patient to be obstructed when serious, and treatment cycle extends, and medical expense increases, and sequelae aggravates, even Death etc..If along with indwelling extraventricular drainage pipe overlong time, pull out drainage tube process often can because of drainage tube inner segment with The tissue of encephalic is adhered, and is caused the difficulty of tube drawing and the discomfort of patient, is even resulted in and fail normal tube drawing.Thus, face It needs a kind of to take into account anti-infective, the anti-extraventricular drainage pipe being adhered on bed.By searching for the document of existing patent, antibacterial brain at present The patent of room drainage tube is few, and has no and mention anti-the problem of being adhered.Meanwhile the use of antimicrobial coating is also less, thus the reality There are good market prospects with novel research and development.

Utility model content

The purpose of this utility model is to provide a kind of antibacterial and the extraventricular drainage pipes to prevent adhesion, for solving existing skill Art midventricle drainage tube is easily adhered, without anti-infective effect the problem of.

To solve the above-mentioned problems, the extraventricular drainage pipe that the utility model provides a kind of antibacterial and prevents adhesion, including draw Flow tube main body, further includes the external coating being applied on the drainage tube body outer wall, and the external coating is the painting of poly-dopamine chitosan Layer.

Poly-dopamine is considered as that one kind can be expected to the new material being used widely in polymer coating field.It is poly- Dopamine derives from marine organisms mussel, and raw material sources are abundant, and cheap.In alkaline environment, poly-dopamine can for it Stronger active force is generated to form various chemical bonds between object, is adhered to body surface, this makes poly-dopamine chitosan Material can be covered in medical silica-gel surface.

There are two the reactive groups of poly-dopamine, is amino group and catechu powder group respectively, and catechol group can be with Hydroxyl reacts to form hydrogen bond, can form coordinate bond with complexing of metal ion, can also be coordinated with nonmetallic such as boron ion formation Key.Moreover, with groups such as phenyl ring key may also occur for the quinone that catechol group is formed in dopamine oxidation process Interaction.Just because of catechol group can and different kinds of molecules form hydrogen bond reaction, so showing as poly-dopamine can be with It is adhered to surfaces of various materials extensively, forms the new material of stable structure.

Chitosan can be polymerize by specific reaction condition with poly-dopamine, formed poly-dopamine chitosan coat, covered Gai Ben extraventricular drainage pipe surface.Chitosan is the deacetylated product of N- of chitin, has good biocompatibility, can drop The advantages that Xie Xing, hypotoxicity, the extensive concern by researcher.It is existing the study found that chitosan with broad-spectrum antiseptic make With, there is certain inhibiting effect to algae, bacterium, fungi etc., guarantee can be provided for the antibacterial efficacy of this extraventricular drainage pipe, Reduce the incidence of intracranial infection.And poly-dopamine has good biocompatibility, the past research has shown that it with good Anti-stick continuous cropping is used, it is possible to reduce being adhered for drainage tube and intracranial tissue can also reduce the blocking of drainage tube to a certain extent, reduce Difficulty is not accommodated brought by tube drawing.

Therefore chitosan is polymerize by specific reaction condition with poly-dopamine, forms poly-dopamine chitosan coat, Be covered on this extraventricular drainage pipe surface together, realize it is anti-be adhered, anti-infectious effect.

Further, the drainage tube further includes the inner coating being applied in the drainage tube main body inner wall, the inner coating For poly-dopamine chitosan coat, while being also avoided that body for allergic reaction caused by silica gel.

It sticks to further realize antibacterial, antiallergy and avoid gluing, is equally covered on the inner wall of the drainage tube main body Poly-dopamine chitosan coat reduces drainage-fluid and glues glutinous, quickening drainage speed in pipe, while reducing bacterium in drainage tube and growing It is raw, preferably protection is realized to patient.

Further, the drainage tube main body is silica gel material.

It is silica gel material that drainage tube main body, which is arranged, in the utility model, the high temperature resistant that can resist cold, resistance to weak due to medical silicone tube It is soda acid, harmless non-toxic and tasteless；And transparency is high, high-tension, strong UV resistant, indeformable, soft, the resistance to electric arc of resistance to kink, resistance to electricity Dizzy, chemical stability, physiological inertia, it is nontoxic to the human body it is non-stimulated, hydrophobic, breathe freely, have splendid resilience, indeformable etc. excellent Point, and epoxy available ethane sterilizes under the high temperature conditions.Simultaneously in the present invention also have be not easy bending, be squeezed and deformed and With excellent support power, convenient for fixing.

Further, the drainage tube cross section is circle.

Rounded by being arranged, surface is in circular arc degree, facilitates insertion into and extracts, periphery corner angle is avoided to make the wound of patient At damage.

Further, the internal diameter of the drainage tube is 45 ~ 55mm, and outer diameter is 60 ~ 70mm.

Preferably, the internal diameter of the drainage tube is 50mm, outer diameter 65mm.

The setting of internal diameter and outer diameter can ensure the smooth drainage of encephalic hydrops, hematocele or other pollutants.

Further, the front end of the drainage tube is that closing is tapered, and multiple side openings are distributed in side wall.

It combines the design of side opening to can ensure that extraventricular drainage is smooth by the design of closing taper, reduces blocking.

Further, the drainage tube main body is equipped with the scale for mark.

Reference mark realizes preferably nursing convenient for the flow and the rate of outflow of observation drainage-fluid.

The utility model has the beneficial effects that

(1) the utility model is a kind of with antibacterial and the anti-extraventricular drainage pipe being adhered, drainage tube main body use tradition Medical silica-gel ingredient, there is good physical characteristic, be not easy bending, be squeezed and deformed and have excellent support power, meanwhile, it is classical Tapered head end and side opening design, strengthen drainage efficiency.

(2) coating of this extraventricular drainage pipe interior and exterior is poly-dopamine chitosan coat, and coating preparation is simple, is had Preferable adsorptivity can be stablized and be covered on silica gel drainage tube body surfaces, and be less prone to decomposition.

(3) there is the poly-dopamine of the utility model good biocompatibility and good anti-stick continuous cropping to use, and can subtract Being adhered for the tissue of few extraventricular drainage pipe and encephalic, can also reduce the blocking of drainage tube to a certain extent, reduce tube drawing institute band That comes does not accommodate difficulty, it is also possible to reduce the antianaphylaxis of drainage tube and body.

(4) it is constituent of chitosan that the utility model, which plays the coating composition of antibacterial efficacy, and main play prevents being adhered efficiency Coating composition is poly-dopamine, and chitosan and dopamine all have good biocompatibility, is classical organic anti-bacterial material Material, it is convenient to obtain, asepsis environment-protecting.

Detailed description of the invention

Fig. 1 is the utility model extraventricular drainage pipe longitudinal sectional view.

Fig. 2 is the utility model extraventricular drainage pipe transverse sectional view.

Specific embodiment

To keep the purposes, technical schemes and advantages of the utility model implementation clearer, below in conjunction with the utility model Attached drawing in embodiment, is further described in more detail the technical scheme in the embodiment of the utility model.In the accompanying drawings, from beginning Same or similar element or element with the same or similar functions are indicated to same or similar label eventually.Described reality Applying example is the utility model a part of the embodiment, instead of all the embodiments.Below with reference to the embodiment of attached drawing description It is exemplary, it is intended to for explaining the utility model, and should not be understood as limiting the present invention.It is practical new based on this Embodiment in type, every other implementation obtained by those of ordinary skill in the art without making creative efforts Example, fall within the protection scope of the utility model.The embodiments of the present invention are described in detail with reference to the accompanying drawing.

Embodiment 1

A kind of antibacterial and the extraventricular drainage pipe to prevent adhesion, including drainage tube main body 1, further include being applied to the drainage tube master External coating 2 on 1 outer wall of body, the external coating 2 are poly-dopamine chitosan coat.

The drainage tube main body 1 further includes the inner coating 3 being applied on 1 inner wall of drainage tube main body, and the inner coating 3 is Poly-dopamine chitosan coat.

The drainage tube main body 1 is silica gel material.

The drainage tube cross section is circle.

The internal diameter D of the drainage tube is 50mm, and outer diameter Φ is 65mm.

The front end of the drainage tube is that closing is tapered, and multiple side openings 10 are distributed in side wall.

The drainage tube main body 1 is equipped with the scale for mark.

Embodiment 2

The present embodiment difference from example 1 is that, the internal diameter D of the drainage tube is 50mm, and outer diameter Φ is 65mm.

Embodiment 3

The present embodiment difference from example 1 is that, the internal diameter D of the drainage tube is 45mm, and outer diameter Φ is 60mm.

Embodiment 4

The present embodiment difference from example 1 is that, the internal diameter D of the drainage tube is 55mm, and outer diameter Φ is 70mm.

Embodiment 5

The present embodiment provides a kind of antibacterial and the extraventricular drainage pipes to prevent adhesion, specifically includes the following steps:

S1: with silica gel preparation such as the described in any item drainage tube main bodys of 1 ~ embodiment of embodiment 4；

S2: during which preparation dopamine solution, the dopamine solution of configuration concentration 2.0mg/ml are added Tris- hydrochloric acid and accelerate Dopamine dissolution, adjusts PH to 8.5.

S3: middle layer silica gel main body is immersed directly in dopamine solution, carried out at room temperature by preparation poly-dopamine/silica gel Magnetic stirs for 24 hours, and after reaction, distilled water flushing is clean and room temperature dries.

S4: preparing low-molecular weight chitoglycan solution, and under room temperature state, the acetic acid that low molecular chitosan is dissolved in 0.2% is worked as In, adjusting PH is 5, and the concentration of low molecular chitosan is adjusted to 2mg/ml, is stirred for 24 hours.

S5: poly-dopamine/silica gel under normal temperature state, is immersed in the shell of 2mg/ml by preparation poly-dopamine chitosan/silica gel In glycan solution, average rate magnetic stirs 12h or more, and after reaction, the clean simultaneously room temperature of distilled water flushing dries obtained.

This method production is simple, and raw material inexpensively easily obtains, extraventricular drainage pipe obtained can combine it is anti-infective and Anti-stick continuous cropping is used, with good application prospect.

Embodiment of above is merely intended for describing the technical solutions of the present application, but not for limiting the present application, although referring to above preferably real Mode is applied the utility model is described in detail, those skilled in the art should understand that, it can be practical new to this The technical solution of type is modified or equivalent replacement should not all be detached from the spirit and scope of the technical scheme of the present invention.This field Technical staff can also do the design that other variations etc. are used in the utility model within the spirit of the present invention, without departing from this The technical effect of utility model.These changes made in accordance with the spirit of the present invention should all be included in the utility model Within the scope of claimed.

Claims (8)

1. a kind of antibacterial and the extraventricular drainage pipe to prevent adhesion, including drainage tube main body (1), which is characterized in that further include being applied to External coating (2) on drainage tube main body (1) outer wall, the external coating (2) are poly-dopamine chitosan coat.

2. extraventricular drainage pipe according to claim 1, which is characterized in that further include being applied to the drainage tube main body (1) Inner coating (3) on inner wall, the inner coating (3) are poly-dopamine chitosan coat.

3. extraventricular drainage pipe according to claim 1, which is characterized in that the drainage tube main body (1) is silica gel material.

4. extraventricular drainage pipe according to claim 1, which is characterized in that the drainage tube cross section is circle.

5. extraventricular drainage pipe according to claim 1, which is characterized in that the internal diameter of the drainage tube is 45 ~ 55mm, outside Diameter is 60 ~ 70mm.

6. extraventricular drainage pipe according to claim 1, which is characterized in that the internal diameter of the drainage tube is 50mm, outer diameter For 65mm.

7. extraventricular drainage pipe according to claim 1, which is characterized in that the front end of the drainage tube is that closing is tapered, Multiple side openings (10) are distributed in side wall.

8. extraventricular drainage pipe according to claim 1, which is characterized in that the drainage tube main body (1) is equipped with and is used for The scale of mark.