CN100409849C - Medication in silkworm use for treating bacteriosis and preparation method - Google Patents
Medication in silkworm use for treating bacteriosis and preparation method Download PDFInfo
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- CN100409849C CN100409849C CNB031583695A CN03158369A CN100409849C CN 100409849 C CN100409849 C CN 100409849C CN B031583695 A CNB031583695 A CN B031583695A CN 03158369 A CN03158369 A CN 03158369A CN 100409849 C CN100409849 C CN 100409849C
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- ciprofloxacin
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Abstract
The present invention relates to a drug for silkworm for preventing and treating bacteriosis and a preparation method thereof. The drug of the present invention solves the problem that an antibacterial spectrum of the existing drug for silkworm for preventing and treating bacteriosis is not wide or medication cost is high, and the drug is prepared by mixing a ciprofloxacin derivative and an excipient and is finally prepared into capsules. The drug of the present invention has the advantages of no toxic or side effect on a human body and livestock, high safety, good prevention and treatment effect on some main bacteriosis harmful to the silkworm, low action concentration, reduced cultivation cost, simple and convenient use and operation, and lightened labor strength. The drug for silkworm for preventing and treating bacteriosis and the preparation method thereof of the present invention can be suitable for silkworm and mulberry cultivation industry.
Description
Technical field
The present invention relates to the application of ciprofloxacin derivatives capsule in preparation control bacterial disease of domestic silkworm medicine.
Technical background
Silkworm and mulberry production is peasant's a traditional sideline production, and it is one of important channel of increasing peasant income, and the quality of breed is related to peasant's income.Because silkworm self is limited to the defensive ability/resistance ability of antibacterial, very easily bacterial infection is fallen ill and is caused death, influences culture benefit, and this just needs in time and effectively select for use suitable medicine to prevent and treat.The antibacterial of harm silkworm has some kinds at present, mainly is septicaemia bacterium, a blue or green deteriorated blood pathogenic bacteria, clever bacterium deteriorated blood pathogenic bacteria.The medicine of preventing and treating on the existing market mainly contains two classes, and a class is mainly contain diseases prevention No. one, myristylpicolinum bromide, bleaching powder etc. of external disinfectant powder, and its active ingredient is nothing more than formaldehyde or calcium hypochlorite, and active ingredient is aided with carriers such as potter's clay, Calx and is patent medicine.These powder all have certain prevention effect to the source of disease of virosis, mycosis and the bacterial disease of silkworm body surface, but not obvious to invasive pathogenic bacteria effect in the body.When using external disinfectant powder that silkworm is prevented and treated be with yarn packed on medicated powder manually spread on the silkworm body, the dust of kicking up in the operating process has stimulation to people's respiratory tract, it is healthy to have damaged the operator.Adopt this method can not guarantee that a medicated powder evenly is spread on the silkworm body, has influenced curative effect; Another kind of is to kill the intravital antibacterial of intrusion silkworm by adding the food antimicrobial drug, the active ingredient of this class medicine mainly is chloromycetin, erythromycin, norfloxacin etc., wherein catilan is disabled on aquaculture, erythromycin is only effective to the septicaemia bacterium, and is invalid to the control of a blue or green deteriorated blood pathogenic bacteria, clever bacterium deteriorated blood pathogenic bacteria.Though norfloxacin is good to the prevention effect of bacteremic septicemia, its dosage is big, and unit price is higher, has increased aquaculture cost, has influenced culture benefit.
Disclose a kind of silkworm in the Chinese patent application (CN1383826A) with preventing disease medicine, it is to be combined by ciprofloxacin and distilled water.
Summary of the invention
The purpose of this invention is to provide the application of ciprofloxacin derivatives capsule in preparation control silkworm septicaemia, a blue or green septicemia medicine, this application can have better curative effect to these two kinds of bacteremic septicemias of silkworm, efficacy stability is convenient to long term store, and can reduce aquaculture cost.
For solving the problems of the technologies described above, technical scheme of the present invention: the application of ciprofloxacin derivatives capsule in preparation control silkworm septicaemia, a blue or green septicemia medicine, described capsule is made by ciprofloxacin derivatives and mixed with excipients, the mass ratio of ciprofloxacin derivatives and excipient is (45～70): (30～55), described ciprofloxacin derivatives are ciprofloxacin or ciprofloxacin lactate.
Among the present invention, described excipient is glucose or starch.
The ciprofloxacin derivatives of capsule formulation is used for silkworm septicaemia, a blue or green septicemic cemia control are had better curative effect, and help saving aquaculture cost.
Below with septicaemia bacterium, a blue or green deteriorated blood pathogenic bacteria, clever bacterium deteriorated blood pathogenic bacteria as source of disease, make ciprofloxacin derivatives and chloromycetin, erythromycin, norfloxacin compare test and specify (in following tabulation, the ciprofloxacin derivatives capsule abbreviates capsule as):
One, to the extracorporeal bacteria inhibitor test of silkworm bacteremic septicemia:
With being chilled to about 30 degrees centigrade after the culture medium thawing, add bacterium liquid, cast flat board, the reagent agent with circular hole filter paper (d=3mm) immerses variable concentrations is placed on the flat board, cultivated 24 hours for 28 degrees centigrade, mensuration antibacterial circle diameter (cm of unit), the result is as follows:
As can be seen from the above table, ciprofloxacin derivatives all has inhibitory action to three kinds of deteriorated blood pathogenic bacterias when being used to prevent and treat bacterial disease of domestic silkworm, activity is low, 50～100ppm just has comparatively ideal bacteriostasis, can remedy conventional medicine narrow antimicrobial spectrum, activity height, the defective that dosage is big.
Two, to the prophylactic tria of silkworm bacteremic septicemia
Convert the medicinal liquid that water is mixed with variable concentrations with chloromycetin, erythromycin, ciprofloxacin derivatives capsule, norfloxacin, do the test of prevention silkworm bacteremic septicemia, add the drug withdrawal of food said medicine after 2 hours, the inoculation pathogenic bacteria, sickness rate such as following table:
| Medicine name | Liquor strength | Septicaemia | A blue or green septicemia | Spirit bacterium septicemia |
| Capsule | 50ppm | 16％ | 0 | 28％ |
| Capsule | 100ppm | 12％ | 0 | 8％ |
| Chloromycetin | 500ppm | 12％ | 4％ | 100％ |
| Erythromycin | 100ppm | 0 | 100％ | 100％ |
| Norfloxacin | 500ppm | 12％ | 0 | 12％ |
As can be seen from the above table, ciprofloxacin derivatives 100ppm has preventive effect preferably to three kinds of main bacteria septicemia of silkworm, chloromycetin 500ppm is effective to septicaemia, a blue or green septicemia, invalid to clever bacterium septicemia, erythromycin is only effective to septicaemia, and is suitable with the preventive effect of ciprofloxacin derivatives when 100ppm during norfloxacin 500ppm.
Three, to the therapeutic test of silkworm bacteremic septicemia
Convert the medicinal liquid that water is mixed with variable concentrations with chloromycetin, erythromycin, ciprofloxacin derivatives capsule, norfloxacin, do the test of treatment silkworm bacteremic septicemia, freshened food said medicine, sickness rate such as following table behind the inoculation pathogenic bacteria in 4 hours:
| Medicine name | Liquor strength | Septicaemia | A blue or green septicemia | Spirit bacterium septicemia |
| Capsule | 100ppm | 0 | 0 | 84％ |
| Capsule | 150ppm | 0 | 0 | 28％ |
| Capsule | 300ppm | 0 | 0 | 8％ |
| Chloromycetin | 1000ppm | 0 | 0 | 100％ |
| Erythromycin | 1000ppm | 0 | 100％ | 100％ |
| Norfloxacin | 1000ppm | 0 | 0 | 4％ |
As can be seen from the above table, ciprofloxacin derivatives 150ppm is satisfied to silkworm septicaemia, a blue or green septicemia therapeutic effect, and 300ppm is better to clever bacterium septicemia effect.Chloromycetin 1000ppm is splendid to septicaemia, blue or green septicemia treatment, and is invalid to clever bacterium septicemia.Erythromycin is only effective to septicaemia.Norfloxacin 1000ppm is all desirable to three kinds of septicemia therapeutic effect.
Four, the cost with ciprofloxacin derivatives capsule and existing silkworm medicine compares, and chloromycetin bans use of, is not listed as wherein, and erythromycin is only effective to septicaemia, does not also have use value.Be expected to be 0.38 yuan through retail price of measuring and calculating ciprofloxacin derivatives capsule, norfloxacin is pressed 0.15 yuan every of current market price, is made into to reach the every liter of valency of diluent such as the following table of preventing and treating purpose:
As can be seen from the above table, with ciprofloxacin derivatives capsule in prevention and treatment flacherie, its cost is 1/3rd of a norfloxacin solution only, helps the silkworm raiser and reduces aquaculture cost, and is easy to utilize.
In addition, because the drug effect half-life of ciprofloxacin derivatives aqueous solution has only tens of hours, without water dissolution, its efficacy stability performance is guaranteed at preparation process Central Plains medicine in the present invention, but and long term store.In addition, because ciprofloxacin derivatives is to exist with capsule form, this has just made things convenient for numerous silkworm raisers, and the silkworm raiser does not need to carry out accurate weighing more in use, as long as take quantitative capsule apart, the water of directly converting appropriate amount stirs evenly, and has been sprayed onto on the Folium Mori just.
The specific embodiment
Raw material ciprofloxacin derivatives of the present invention, excipient are all commercially available.
Embodiment 1
Is 45: 55 mixings with the starch of ciprofloxacin and 100 order fineness with mass ratio, makes the capsule of every 300mg medicated powder.Before preventing and treating capsule is taken apart, content is dissolved in the clear water of 850ml, then medicinal liquid evenly is spread across on the Folium Mori, the degree of being with moistening is freshened food to silkworm.
Embodiment 2
Is 50: 50 mixings with the glucose of ciprofloxacin lactate and 100 order fineness with mass ratio, makes the capsule of every 300mg medicated powder.Before preventing and treating capsule is taken apart, content is dissolved in the clear water of 1000ml, then medicinal liquid evenly is spread across on the Folium Mori, the degree of being with moistening is freshened food to silkworm.
Embodiment 3
Is 63: 37 mixings with the glucose of ciprofloxacin and 100 order fineness with mass ratio, makes the capsule of every 300mg medicated powder, before preventing and treating capsule is taken apart, content is dissolved in the clear water of 1100ml, then medicinal liquid evenly is spread across on the Folium Mori, the degree of being with moistening is freshened food to silkworm.
Embodiment 4
Is 63: 37 mixings with the starch of ciprofloxacin and 100 order fineness with mass ratio, makes the capsule of every 300mg medicated powder.Before preventing and treating capsule is taken apart, content is deeper than in the clear water of 1100ml, then medicinal liquid evenly is spread across on the Folium Mori, the degree of being with moistening is freshened food to silkworm.
Embodiment 5
Is 68: 32 mixings with the starch of ciprofloxacin lactate and 100 order fineness with mass ratio, makes the capsule of every 300mg medicated powder.Before preventing and treating capsule is taken apart, content is dissolved in the clear water of 1400ml, then medicinal liquid evenly is spread across on the Folium Mori, the degree of being with moistening is freshened food to silkworm.
Embodiment 6
Is 70: 30 mixings with the glucose of ciprofloxacin and 100 order fineness with mass ratio, makes the capsule of every 300mg medicated powder.Before preventing and treating capsule is taken apart, content is dissolved in the clear water of 1500ml, then medicinal liquid evenly is spread across on the Folium Mori, the degree of being with moistening is freshened food to silkworm.
Adding food to silkworm during above medicine, according to circumstances, add the food number of times and be four age silkworm 2～3 times, five age silkworm 4～5 times.
Embodiment 7
The preparation ciprofloxacin capsular method of deriving is: after earlier starch or glucose being pulverized 100 order fineness, add hydrochloric acid ring third sand or ciprofloxacin lactate, the mass ratio of ciprofloxacin derivatives and excipient is (45～70): (30～55), make the capsule of every 300mg after stirring, then polish making sheet, be packaged to be finished product at last.
Claims (3)
1. the application of ciprofloxacin derivatives capsule in preparation control silkworm septicaemia, a blue or green septicemia medicine, described capsule is made by ciprofloxacin derivatives and mixed with excipients, the mass ratio of ciprofloxacin derivatives and excipient is (45～70): (30～55), described ciprofloxacin derivatives are ciprofloxacin or ciprofloxacin lactate.
2. according to the described application of claim 1, it is characterized in that the mass ratio of described ciprofloxacin derivatives and excipient is 63: 37.
3. application according to claim 2 is characterized in that, described excipient is a glucose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031583695A CN100409849C (en) | 2003-09-26 | 2003-09-26 | Medication in silkworm use for treating bacteriosis and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031583695A CN100409849C (en) | 2003-09-26 | 2003-09-26 | Medication in silkworm use for treating bacteriosis and preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1600311A CN1600311A (en) | 2005-03-30 |
| CN100409849C true CN100409849C (en) | 2008-08-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB031583695A Expired - Fee Related CN100409849C (en) | 2003-09-26 | 2003-09-26 | Medication in silkworm use for treating bacteriosis and preparation method |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106580994A (en) * | 2016-12-16 | 2017-04-26 | 湖北省农业科学院经济作物研究所 | Enrofloxacin hydrochloride composition and liquid medicine, and preparation methods thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1095269A (en) * | 1993-05-19 | 1994-11-23 | 山东省农业科学院实验兽药厂 | Broad-spectrum antibiotic for animal |
| CN1114189A (en) * | 1994-06-13 | 1996-01-03 | 周元铎 | Erythromycin capsule for silkworm |
| CN1383826A (en) * | 2002-06-03 | 2002-12-11 | 莒县华盛丝绸有限公司 | Silkworm disease preventing and treating medicine and its prepn |
-
2003
- 2003-09-26 CN CNB031583695A patent/CN100409849C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1095269A (en) * | 1993-05-19 | 1994-11-23 | 山东省农业科学院实验兽药厂 | Broad-spectrum antibiotic for animal |
| CN1114189A (en) * | 1994-06-13 | 1996-01-03 | 周元铎 | Erythromycin capsule for silkworm |
| CN1383826A (en) * | 2002-06-03 | 2002-12-11 | 莒县华盛丝绸有限公司 | Silkworm disease preventing and treating medicine and its prepn |
Non-Patent Citations (2)
| Title |
|---|
| 几种喹诺酮类药特对家蚕细菌性败血病的防治效果. 李云芝.山东农业科学，第2卷. 2001 |
| 几种喹诺酮类药特对家蚕细菌性败血病的防治效果. 李云芝.山东农业科学，第2卷. 2001 * |
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| CN1600311A (en) | 2005-03-30 |
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Inventor after: Zhou Yuanduo Inventor after: Pan Zhonghua Inventor after: Chen Junji Inventor after: Hang Zhongbao Inventor before: Zhou Yuanduo |
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Inventor after: Zhou Yuanduo Inventor after: Pan Zhonghua Inventor after: Chen Junji Inventor after: Hang Zhongbao Inventor after: Ben Kunjie Inventor after: Mei Yajun Inventor after: Xue Song Inventor after: Yang Yinshu Inventor before: Zhou Yuanduo Inventor before: Pan Zhonghua Inventor before: Chen Junji Inventor before: Hang Zhongbao |
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