CN110251603A - Prevent and treat the Chinese medicine composition and preparation method thereof of sheep Eaton agent pneumonia - Google Patents
Prevent and treat the Chinese medicine composition and preparation method thereof of sheep Eaton agent pneumonia Download PDFInfo
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Abstract
The invention belongs to veterinary drug technical fields, more particularly to a kind of for preventing and treating the Chinese medicine composition and preparation method thereof of sheep mycoplasmal pneumonia, the Chinese medicine composition is made of the bulk pharmaceutical chemicals of following weight parts by different numbers: 15-40 parts of aster trinervius, 20-45 parts of Hypericum Chinense, 15-40 parts of macleaya cordata, 10-35 parts of evodia rutaecarpa slender acanthopanax, 25-45 parts of Chinese fanpalm seed, 10-35 parts of quassia；The present invention is pure Chinese medicinal preparation, clearing heat and detoxicating, relieving cough and asthma, antibacterial anti-inflammatory, Chinese medicine composition compatibility is reasonable, safely and effectively, and treating both manifestation and root cause of disease, no recurrence, avoid the medicament residue with antibiotic prophylaxis and treatment, ensure food safety, be suitable for being promoted in husbandry sector, has a vast market foreground and biggish economic benefit.
Description
Technical field:
The invention belongs to veterinary drug technical fields, and in particular to a kind of Chinese medicine composition for preventing and treating sheep Eaton agent pneumonia
And preparation method thereof.
Background technique:
Sheep mycoplasmal pneumonia (mycoplasmal pneumonia of sheep and goats, Mccp) is also known as sheep biography
Metachromia pleuropneumonia is a kind of highly contagious disease as caused by mycoplasma, is mainly characterized by high fever, cough, chest
Serosity and fibrinous inflammation occurs with pleura, case fatality rate is very high, and sick sheep is the main infection sources, sick lung tissue and thoracic cavity
Contain a large amount of pathogen in diffusate, mainly through respiratory secretions discharge of bacteria, the resistance to pathogen crossed in sick sheep tissue is in a timing
There is viability, this disease is often in endemicity, and contagiousness is very strong, mainly passes by air-droplet through respiratory tract in phase
Dye.
In recent years, the sheep mycoplasmal pneumonia as caused by mycoplasma, which has become, influences a kind of important thin of sheep husbandry development
Bacterium property disease, mycoplasma can persistently exist in flock of sheep, and the sheep at various ages is all susceptible, this disease main multiple in winter, summer
It can also occur, sick sheep and be major source of infection with malicious sheep, no clinical symptom has pathological change sheep, or becomes without clinical symptom without pathology
It is more typical to change the feminine gender sheep that carries disease germs；This disease there is no specific medicament therapy at present, mainly take comprehensive measures for prevention and control and heteropathy, most
Basic method is to eliminate infected animal and thorough disinfection, cuts off route of transmission, therefore should reinforce quarantine and the monitoring of this disease, to prevent
The diffusion of this disease.
For this bacterium to erythromycin, tetracycline, terramycin, Chloramphenicol-sensitive, carrying out treatment using antibiotic in time after the onset can
Mortality of animals is significantly reduced, while being properly added antibiotic in process of production to reduce the hair of the disease to a certain extent
Raw rate；But with a large amount of antimicrobials especially broad spectrum antibiotic being widely used in sheep husbandry, bacteria drug it is resistance to
Pharmacological property problem is increasingly prominent, also has research data to show that the antibiotic of sub- inhibition concentration can influence the generation of bacterium at the same time
Journey of apologizing for having done sth. wrong and the virulence that changes bacterium or bacterium to the adaptability etc. of environment, and but antibiotic be easy to remain in meat, milk,
Cause food safety hazards.
Summary of the invention:
For the defect and problem with antibiotic prophylaxis and treatment bring antibiotic residue hidden danger, the present invention is according to Chinese medicine
Medical knowledge has invented a kind of Chinese medicine composition and preparation method thereof for preventing and treating sheep mycoplasmal pneumonia, and it is former can effectively to control sheep branch
Body pneumonia.
The present invention solves scheme used by its technical problem: a kind of Chinese medicine group preventing and treating sheep Eaton agent pneumonia
Object is closed, the raw material including following parts by weight meter: 15-40 parts of aster trinervius, 20-45 parts of Hypericum Chinense, 15-40 parts of macleaya cordata, Wu Zhu
10-35 parts of cornel slender acanthopanax, 25-45 parts of Chinese fanpalm seed, 10-35 parts of quassia.
A kind of Chinese medicine composition of above-mentioned prevention and treatment sheep Eaton agent pneumonia, the raw material including following parts by weight meter:
25 parts of aster trinervius, 35 parts of Hypericum Chinense, 30 parts of macleaya cordata, 25 parts of evodia rutaecarpa slender acanthopanax, 35 parts of Chinese fanpalm seed, 25 parts of quassia.
A kind of Chinese medicine composition of above-mentioned prevention and treatment sheep Eaton agent pneumonia, the raw material including following parts by weight meter:
20 parts of aster trinervius, 30 parts of Hypericum Chinense, 30 parts of macleaya cordata, 25 parts of evodia rutaecarpa slender acanthopanax, 30 parts of Chinese fanpalm seed, 25 parts of quassia.
The present invention also provides a kind of for preventing and treating the preparation method of the Chinese medicine composition of sheep Eaton agent pneumonia, according to
Weight part ratio weighs each Chinese medicine material, and all Chinese medicine materials are put into medicine decocting tank, and raw material gross weight 8-10 is added into medicine decocting tank
The ethyl alcohol of the 65-75% of amount impregnates 2-3h again, then decocts 60min, filters, and collects filtrate；8-10 times is added into filter residue again
The ethyl alcohol of the 65-75% of amount continues to decoct 30min, and filtrate is collected by filtration, then the 5-10 times of 0.1M HCL measured is added into filter residue
Continue to decoct 30min, filtrate is collected by filtration；Merging decocts filtrate three times, is concentrated under reduced pressure into medicinal extract, drying is sprayed into powder, simultaneously
By filter residue dries pulverizing, being uniformly mixed with filtrate powder can be obtained Chinese medicine composition.
The present invention also provides another for preventing and treating the preparation method of the Chinese medicine composition of sheep Eaton agent pneumonia, presses
Each Chinese medicine material is weighed according to weight part ratio, all Chinese medicine materials are put into medicine decocting tank, raw material gross weight 10 is added into medicine decocting tank
The pure water of amount impregnates 1h again, then decocts 30min, filtrate is collected by filtration；The pure decocting of 10 times of amounts is added into filter residue again
Boil 30min；Merge decoction filtrate twice and condense into medicinal extract, extract dry is sprayed into powder；Simultaneously by filter residue dries pulverizing and filter
Powder obtained by liquid is uniformly mixed, and Chinese medicine composition can be obtained in packing pack.
It is right respectively in order to verify Chinese prescription of the invention to the minimum inhibitory concentration and minimum bactericidal concentration of sheep mycoplasma
The minimum inhibitory concentration and minimum bactericidal concentration of one plant of reference culture and 10 plants of Clinical isolations are tested, and test method is such as
Under:
(1) precision weighs every each 10g of taste Chinese medicine, uses instead after adding 10 times of amount distilled water to decoct boiling and is cooked by slow fire 20min, with 4
Layer filtered through gauze: residue filters after adding 8 times of 85% ethyl alcohol of amount to decoct 20min with method；Residue adds the hydrochloric acid of 8 times of amount 0.1M
(pH3.0) it is filtered after decocting 20min with method；Merge filtrate three times, be concentrated under reduced pressure into medicinal extract, then keeps its dense with pure water thawing
Degree is 1g/ml.
(2) sheep mycoplasma is seeded to culture medium, 37 DEG C of 48~96h of stationary culture, with sterilizing blank training by the preparation of bacterium solution
It supports base and corrects bacterial concentration, make viable count 1~2 × 108CFU/ml, it is spare.
(3) minimum inhibitory concentration (minimal inhibition concentration, MIC) measures
It is carried out using test tube doubling dilution, determines Chinese medicine minimum inhibitory concentration.25, sterile test tube is taken to be numbered,
Every pipe adds culture medium 2mL, and Chinese medicine liquid 2mL is added in the first pipe, takes out 2mL and is put into the second pipe, and so on, until the 23rd pipe
2.0ml is taken out to discard；Medical fluid is not added in 24th pipe, and as positive control, the 25th pipe is as negative control, the 25th pipe plus traditional Chinese medicine extraction
Liquid 2.0ml takes out 2.0ml and discards, bacterium is not added, as negative control, respectively manages parallel 3 parts, i.e. the concentration of drug is after mixing
(500mg/mL、250mg/mL、125mg/mL、62.5mg/mL、31.25mg/m L、15.63mg/mL、7.81mg/mL、
3.95mg/mL、1.98mg/mL、0.99mg/mL、0.49mg/mL、0.25mg/mL、0.12mg/mL、0.06mg/mL、0.03mg/
mL、15.43μg/mL、7.71μg/mL、3.86μg/mL、1.93μg/mL、0.97μg/mL、0.48μg/mL、0.24μg/mL、
0.12 μ g/mL, 0.06 μ g/mL, 0.03 μ g/mL), 10 μ L (10 of bacterium solution is added in 1~24 pipe8CFU/m L), every kind of medicine does 3
In parallel, its average value is taken, 24~36h of culture in 37 DEG C of constant incubators is placed in, observes result.
(4) minimum bactericidal concentration measures
Culture in each dilution tube for more than MIC endpoint concentration not growing bacterium is inoculated with aseptic cotton carrier streaking inoculation
It is cultivated for 24 hours on culture medium, being placed in 37 DEG C of constant incubators, observation is as a result, the region of asepsis growth is the smallest of the medicine
Bacteriocidal concentration (MIC), 3 tests are averaged.
(5) test result is shown in Table 1, as shown in Table 1, Chinese prescription of the invention to sheep mycoplasma have preferable sterilization and
Fungistatic effect.
1 Chinese prescription Niu Sizhuan mycoplasma test result of table
Beneficial effects of the present invention: the Chinese medicine composition for being used to prevent and treat sheep Eaton agent pneumonia of the invention uses
Pure traditional Chinese medicine raw material, compatibility is reasonable, safely and effectively, and treating both manifestation and root cause of disease, no recurrence, not only to sheep mycoplasma have it is good antibacterial and
Bactericidal effect, and also avoid antibiotic treatment and there is residual hidden danger, it is ensured that food safety, and preparation process is simple, energy
Enough large-scale production, easy to spread and application.
Specific embodiment:
Through moisture, climate change, feeding management is bad, the factors such as long-distance transport, leads to the outer ability decline epidemic disease of Yang Tiwei
The gas of pestilence is taken advantage of a weak point, and inside closes lung qi, lung qi heap soil or fertilizer over and around the roots is stagnant cannot to declare hair, and superinverse causes this disease for cough and asthma, after sheep infection mycoplasma
Cough, asthma are shown as, most acute body temperature increases, and up to 41~42 DEG C, extremely tired, appetite abolish is short of breath and is had
The baa of pain is expiratory dyspnea, cough, stream is with blood nose liquid；Just body temperature increases acute disease, short and wet cough occurs, with
Serosity nose liquid, appetite fall sharply, and expiratory dyspnea and pain groan, neck stretch, and back is arched upward, and eyelid swelled is shed tears, and eye has viscous
Liquid-purulent secretion；There are cough and diarrhea between chronic type sick sheep, nose liquid cuts in and out, appetite stimulator.Syntexis, physical decline, quilt
Hair is thick disorderly unglazed.
Below with reference to embodiment, the present invention is further described, to more fully understand technical solution of the present invention, needs
Bright: each Chinese medicine material 10g in selection amount is 1 part in following embodiments.
Embodiment 1: the present embodiment provides a kind of for preventing and treating the Chinese medicine composition of sheep Eaton agent pneumonia, including with
The Chinese medicine material of lower weight: aster trinervius 250g, Hypericum Chinense 350g, macleaya cordata 300g, evodia rutaecarpa slender acanthopanax 250g, Chinese fanpalm seed
350g, quassia 250g.
Preparation method: all raw materials are put into medicine decocting tank, and the 70% of 10 times of raw material gross weight amounts is added into medicine decocting tank
Ethyl alcohol impregnates 3h, then decocts 60min, filtrate is collected by filtration；70% ethyl alcohol that 10 times of amounts are added into the dregs of a decoction again decocts
Filtrate is collected by filtration in 30min；The 0.1M HCL (pH 3.0) that 10 times of amounts are added into filter residue again decocts 30min, and filter is collected by filtration
Liquid；Merging decocts filtrate three times, filtrate decompression is condensed into medicinal extract, drying is sprayed into powder, while by filter residue dries pulverizing, with filter
Liquid powder is uniformly mixed, and packing pack can be prepared by the Chinese medicine composition for preventing and treating sheep Eaton agent pneumonia.
Embodiment 2: the present embodiment provides a kind of for preventing and treating the Chinese medicine composition of sheep Eaton agent pneumonia, including with
The Chinese medicine material of lower weight: aster trinervius 200g, Hypericum Chinense 300g, macleaya cordata 300g, evodia rutaecarpa slender acanthopanax 250g, Chinese fanpalm seed
300g, quassia 250g.
Preparation method: all raw materials are put into medicine decocting tank, and 75% second of 9 times of raw material gross weight amounts is added into medicine decocting tank
Alcohol impregnates 3h, then decocts 60min, filtrate is collected by filtration；75% ethyl alcohol that 9 times of amounts are added into the dregs of a decoction again decocts 30min, mistake
Filtrate is collected in filter；The 0.1M HCL (pH 3.0) that 9 times of amounts are added into filter residue again decocts 30min, and filtrate is collected by filtration；Merge three
Filtrate decompression is condensed into medicinal extract by secondary decoction filtrate, dry to be sprayed into powder, while by filter residue dries pulverizing, being mixed with filtrate powder
It closes uniformly, packing pack can be prepared by the Chinese medicine composition for preventing and treating sheep Eaton agent pneumonia.
Embodiment 3: the present embodiment provides a kind of for preventing and treating the Chinese medicine composition of sheep Eaton agent pneumonia, including with
The Chinese medicine material of lower weight: aster trinervius 150g, Hypericum Chinense 450g, macleaya cordata 150g, evodia rutaecarpa slender acanthopanax 350g, Chinese fanpalm seed
250g, quassia 100g.
Preparation method: all raw materials are put into medicine decocting tank, and 65% second of 8 times of raw material gross weight amounts is added into medicine decocting tank
Alcohol impregnates 2h, then decocts 60min, filtrate is collected by filtration；65% ethyl alcohol that 8 times of amounts are added into the dregs of a decoction again decocts 30min, mistake
Filtrate is collected in filter；The 0.1M HCL (pH 3.0) that 8 times of amounts are added into filter residue again decocts 30min, and filtrate is collected by filtration；Merge three
Filtrate decompression is condensed into medicinal extract by secondary decoction filtrate, dry to be sprayed into powder, while by filter residue dries pulverizing, being mixed with filtrate powder
It closes uniformly, packing pack can be prepared by the Chinese medicine composition for preventing and treating sheep Eaton agent pneumonia.
Embodiment 4: the present embodiment provides a kind of for preventing and treating the Chinese medicine composition of sheep Eaton agent pneumonia, including with
The Chinese medicine material of lower weight: aster trinervius 400g, Hypericum Chinense 200g, macleaya cordata 400g, evodia rutaecarpa slender acanthopanax 100g, Chinese fanpalm seed
450g, quassia 350g.
Preparation method: weighing each Chinese medicine material according to weight part ratio, all Chinese medicine materials be put into medicine decocting tank, to boiling medicine
The pure water that 10 times of raw material gross weight amounts are added in tank impregnates 1h, then decocts 30min, filtrate is collected by filtration；Add again into filter residue
The pure water for entering 10 times of amounts decocts 30min；Merge and decoct filtrate twice and condense into medicinal extract, extract dry is sprayed into powder；Together
When powder obtained by filter residue dries pulverizing and filtrate is uniformly mixed, packing pack can be obtained for preventing and treating sheep mycoplasma
The Chinese medicine composition of pneumonia.
Embodiment 5: drug effect verifying
2 months 2018, one Yang Chang of Shangqiu county Zhang, which allocated and transported 150 mutton sheeps from other places, after raising 10 days, 124
Sheep starts to fall ill, and cardinal symptom is appetite stimulator, argol, expiratory dyspnea, suffers from 41 DEG C of sheep body temperature, eye conjunctiva flush, nasal cavity dryness, oral cavity
There is mucus, is diagnosed as sheep mycoplasmal pneumonia.
Sick sheep is randomly divided into 4 groups, every group 31, first group is treated using Chinese medicine made from the embodiment of the present invention 1,
Second group is treated using Chinese medicine composition made from the embodiment of the present invention 2；Third group is using made from the embodiment of the present invention 3
Chinese medicine composition is treated；4th group is treated using Chinese medicine composition made from the embodiment of the present invention 4；4 groups of test groups
According to 1 ton of every 2kg spice, twice a day, 3d is used in conjunction, sheep is allowed to be freely eaten, the symptom of every group of sick sheep is recorded during test, tries
It tests and the results are shown in Table 2.
Therapeutic effect of the different group drugs of table 2 to sheep Eaton agent pneumonia
| Group | It cures number (head) | Death toll (head) | Cure rate (%) |
| First group | 29 | 2 | 93.55 |
| Second group | 28 | 3 | 90.32 |
| Third group | 26 | 5 | 83.87 |
| 4th group | 26 | 5 | 83.87 |
As shown in Table 2, using the first He of the Chinese medicine composition for preventing and treating sheep Eaton agent pneumonia of the invention
The cure rate of second test group sick sheep reaches 90%, and the cure rate of third and fourth group of sick sheep is greater than 83%, illustrates of the invention
Chinese medicine composition has good curative effect for treatment sheep Eaton agent pneumonia.
Typical case
Case 1:2017 November, one Yang Chang of the Sanmenxia Gorge raise 500 goats, and part sheep only falls ill, and clinical symptom is to suffer from
Sheep body temperature is increased up to 41 DEG C, and expiratory dyspnea is in abdominal respiration, is diagnosed as sheep mycoplasmal pneumonia；It is mixed with Chinese medicine 2kg of the invention
1 ton of material, twice a day, is used in conjunction 3d, sheep is allowed to be freely eaten, and the 3rd day state of an illness of medication is controlled, and bottom out is to normal.
Case 2:2018 May, the sheep of one Yang Chang of Hebei, part 20kg or so occur cough and asthma, suffer from the main table of sheep
Now thick for breathing asthma, abdominal respiration is obvious, and appetite abolish, constipation, mouth color is crimson, eye conjunctiva flush, pulse condition flood number.According to clinic
Symptom Observation and molecular diagnosis are diagnosed as sheep mycoplasmal pneumonia；Twice a day connected with 1 ton of Chinese medicine 2kg spice of the invention
With 3d, sheep is allowed to be freely eaten；The 3rd day state of an illness of medication is controlled, and bottom out is to normal.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the present invention, all in the spirit and principles in the present invention
Any modifications, equivalent replacements, and improvements done in range, should all be included in the protection scope of the present invention.
Claims (5)
1. a kind of Chinese medicine composition for preventing and treating sheep Eaton agent pneumonia, it is characterised in that: the original including following parts by weight meter
Material: 15-40 parts of aster trinervius, 20-45 parts of Hypericum Chinense, 15-40 parts of macleaya cordata, 10-35 parts of evodia rutaecarpa slender acanthopanax, Chinese fanpalm seed 25-45
Part, 10-35 parts of quassia.
2. a kind of Chinese medicine composition for preventing and treating sheep Eaton agent pneumonia according to claim 1, it is characterised in that: packet
Include the raw material of following parts by weight meter: 25 parts of aster trinervius, 35 parts of Hypericum Chinense, 30 parts of macleaya cordata, 25 parts of evodia rutaecarpa slender acanthopanax, Chinese fanpalm seed
35 parts, 25 parts of quassia.
3. a kind of Chinese medicine composition for preventing and treating sheep Eaton agent pneumonia according to claim 1, it is characterised in that: packet
Include the raw material of following parts by weight meter: 20 parts of aster trinervius, 30 parts of Hypericum Chinense, 30 parts of macleaya cordata, 25 parts of evodia rutaecarpa slender acanthopanax, Chinese fanpalm seed
30 parts, 25 parts of quassia.
4. a kind of as described in any one of claims 1-3 for preventing and treating the system of the Chinese medicine composition of sheep Eaton agent pneumonia
Preparation Method, it is characterised in that: weigh each Chinese medicine material according to weight part ratio, all Chinese medicine materials be put into medicine decocting tank, to decoct
The ethyl alcohol that the 65-75% that 8-10 times of raw material gross weight is measured is added in medicinal cupping impregnates 2-3h, then decocts 60min, filters, and collects filtrate；
The ethyl alcohol that the 8-10 times of 65-75% measured is added into filter residue again continues to decoct 30min, filtrate is collected by filtration, then be added into filter residue
The 5-10 times of 0.1M HCL measured continues to decoct 30min, and filtrate is collected by filtration；Merging decocts filtrate three times, is concentrated under reduced pressure into medicinal extract,
Drying is sprayed into powder, while by filter residue dries pulverizing, being uniformly mixed with filtrate powder can be obtained Chinese medicine composition.
5. a kind of as described in any one of claims 1-3 for preventing and treating the system of the Chinese medicine composition of sheep Eaton agent pneumonia
Preparation Method, it is characterised in that: weigh each Chinese medicine material according to weight part ratio, all Chinese medicine materials be put into medicine decocting tank, to decoct
The pure water that 10 times of raw material gross weight amounts are added in medicinal cupping impregnates 1h, then decocts 30min, filtrate is collected by filtration；Again into filter residue
The pure water that 10 times of amounts are added decocts 30min；Merge decoction filtrate twice and condense into medicinal extract, extract dry is sprayed into powder；Together
When powder obtained by filter residue dries pulverizing and filtrate is uniformly mixed, Chinese medicine composition can be obtained in packing pack.
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Application publication date: 20190920 |