CN100393208C - Active substance combination having insecticidal and acaricide properties - Google Patents

Active substance combination having insecticidal and acaricide properties Download PDF

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CN100393208C
CN100393208C CNB2004800361767A CN200480036176A CN100393208C CN 100393208 C CN100393208 C CN 100393208C CN B2004800361767 A CNB2004800361767 A CN B2004800361767A CN 200480036176 A CN200480036176 A CN 200480036176A CN 100393208 C CN100393208 C CN 100393208C
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CN1889835A (en
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克里斯蒂安·冯克
赖讷·菲舍尔
吕迪格尔·菲舍尔
H·亨格伯格
W·安德施
沃尔夫甘·蒂莱尔特
A·克劳斯
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Bayer Intellectual Property GmbH
Bayer CropScience AG
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
    • A01N43/38—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
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Abstract

The invention relates to novel active substance combinations comprising cyclic keto-enols or other insecticides and additional insecticides from the group of anthranilic acid amines. Said active substance combinations are very suitable for controlling animal pests such as insects and undesired mites.

Description

Have the insect and the active agent combinations of acarid performance extremely extremely
The present invention relates to new active agent combinations, described bond comprises: the first, and known cyclic ketones enol (cyclic ketoenol), and, the second, known insect active compound extremely, described bond is particularly suitable for preventing and treating animal pest, for example insect and undesired acarid.
Known some cyclic ketones enol has weeding, kills insect and kills the acarid performance.The activity of these compounds is good, but not always satisfactory under low rate of application.
Knownly have weeding, kill insect or kill the unsubstituted two ring 3-aryl-pyrrolidine alkane-2 of acarid effect, 4-derovatives (EP-A 0 355 599 and EP-A 0 415 211) and the monocycle 3-aryl-pyrrolidine alkane-2 that replaces, 4-derovatives (EP-A 0 377 893 and EP-A 0 442 077).
Also known many ring 3-aryl-pyrrolidine alkane-2, (EP-A 0 456 063 for 4-derovatives (EP-A 0 442 073) and 1H-aryl-pyrrolidine alkane derovatives, EP-A 0 521 334, EP-A 0,596 298, EP-A 0 613 884, EP-A 0 613 885, WO 94,/01 997, WO 95/26954, WO 95,/20 572, EP-A 0 668 267, WO 96/25395, WO 96/35664, WO 97/01535, WO 97/02243, WO 97/36868, WO 97/43275, WO 98/05638, WO 98/06721, WO 98/25928, WO 99/16748, WO 99/24437, WO 99/43649, WO 99/48869 and WO 99/55673, WO 01/23354, WO 01/74770).The activity of these compounds is good, but also not always satisfactory under low rate of application.
The mixture of the compound of also known phthalamide and other biologically actives has insect and/or acarid effect (WO 02/087334) extremely extremely.Yet the activity of this mixture is always best.
In addition, also known multiple heterocyclic compound, organo-tin compound, benzoyl urea and pyrethroid have extremely insect, kill the characteristic of acarid (referring to WO 93/22297, WO 93/10083, DE-A 26 41 343, EP-A 0 347 488, EP-A 0 210 487, US 3,364,177 and EP-A 234 045).Yet the activity of these compounds is not always satisfactory equally.
Have now found that the 1st group of compound of formula (I) or have the 2nd group of reactive compound of insect active extremely, has synergistic effect with the mixture of the reactive compound of at least a anthranilamide (anthranilamide) that is selected from formula (II), and have good especially insect extremely and kill the acarid activity
The 1st group of compound of described formula (I) is
Figure C20048003617600041
Wherein
X represents halogen, alkyl, alkoxyl, haloalkyl, halogenated alkoxy or cyano group,
W 1, Y and Z represent hydrogen, halogen, alkyl, alkoxyl, haloalkyl, halogenated alkoxy or cyano group independently of one another,
A 3Represent hydrogen, optional separately alkyl, the alkoxyalkyl that is replaced by halogen, optional substituted saturated cyclic alkyls, optional at least one ring members of described cycloalkyl is replaced by hetero atom,
A 4Represent hydrogen or alkyl,
A 3And A 4The representative of the carbon atom that also is connected with it together is saturated or undersaturated, replacement or unsubstituted ring, optional at least one hetero atom that comprises of described ring,
D represents hydrogen, or chooses substituted alkyl, alkenyl, alkoxyalkyl, saturated cyclic alkyls wantonly, and the optional one or more ring memberses of described cycloalkyl are replaced by hetero atom,
A 3Represent saturated or undersaturated ring together with the coupled atom of D, described ring is at A 3, D part be not to be substituted or substituted, and optional at least one hetero atom that contains,
G 1Represent one of hydrogen (a) or the following group of representative
Figure C20048003617600042
E representation metal ion or ammonium ion,
L 1Represent oxygen or sulphur,
M 1Represent oxygen or sulphur,
R 20Optional separately alkyl, alkenyl, alkoxyalkyl, alkylthio alkyl, the multi-alkoxy alkyl that is replaced by halogen of representative; Or the optional cycloalkyl that is replaced by halogen, alkyl or alkoxyl, described cycloalkyl can be by at least one hetero atom at interval; Optional separately substituted phenyl, phenylalkyl, heteroaryl, phenoxyalkyl or heteroaryloxy alkyl,
R 21Optional separately alkyl, alkenyl, alkoxyalkyl, the multi-alkoxy alkyl that is replaced by halogen of representative, or representative optional separately substituted cycloalkyl, phenyl or benzyl,
R 22The optional alkyl that is replaced by halogen of representative, or optional substituted phenyl,
R 23And R 24The optional separately substituted phenyl of optional separately alkyl, alkoxyl, alkyl amino, dialkyl amido, alkylthio group, alkenylthio group, the cycloalkylthio that is replaced by halogen of representative, or representative independently of one another, benzyl, phenoxy group or thiophenyl, and
R 25And R 26Represent hydrogen independently of one another, optional separately alkyl, cycloalkyl, alkenyl, alkoxyl, the alkoxyalkyl that is replaced by halogen, the optional substituted phenyl of representative, the optional substituted benzyl of representative, or coupled nitrogen-atoms is represented optional substituted ring together, described ring is optional by oxygen or sulphur interval
Described have extremely that the 2nd group of reactive compound of insect active is preferably
(2-1) amitraz (amitraz) (being known in DE-A 20 611 32)
And/or
(2-2) Buprofezin (buprofezin) (being known in DE-A 28 24 126)
Figure C20048003617600052
And/or
(2-3) triaguron (triazamate) (being known in EP-A 0 213 718)
Figure C20048003617600053
And/or
(2-4) pymetrozine (pymetrozine) (being known in EP-A 0 314 615)
Figure C20048003617600054
And/or
(2-5) pyriproxyfen (pyriproxifen) (being known in EP-A 0 128 648)
Figure C20048003617600061
And/or
(2-6) flonicamid (flonicamid) (being known in EP-A 0 580 374)
Figure C20048003617600062
And/or
(2-7) anti-aphid becomes (pirimicarb) (being known in GB 1 181 657)
Surprisingly, active agent combinations of the present invention kills insect and/or kills the active summation that the acarid activity is higher than independent reactive compound.Therefore, have unpredictalbe real synergistic effect, rather than active simply add and.
Except that the reactive compound or a kind of the 2nd group of reactive compound (compound (2-1) is to (2-7)) of at least a formula (I), active agent combinations of the present invention also contains the reactive compound of at least a formula (II).
Preferably contain compound with following formula (I), and the active agent combinations of the reactive compound of at least a formula (II), in the compound of described formula (I),
W 1Represent hydrogen, C 1-C 4Alkyl, C 1-C 4Alkoxyl, chlorine, bromine or fluorine,
X represents C 1-C 4Alkyl, C 1-C 4Alkoxyl, C 1-C 4Haloalkyl, fluorine, chlorine or bromine,
Y and Z represent hydrogen, C independently of one another 1-C 4Alkyl, halogen, C 1-C 4Alkoxyl or C 1-C 4Haloalkyl,
A 3Represent hydrogen, or the optional separately C that is replaced by halogen 1-C 6Alkyl or C 3-C 8Cycloalkyl,
A 4Represent hydrogen, methyl or ethyl,
A 3And A 4Also coupled carbon atom is represented saturated C together 3-C 6Cycloalkyl, wherein optional annular atoms is by oxygen or sulfur, and described cycloalkyl is optional by C 1-C 4Alkyl, trifluoromethyl or C 1-C 4Alkoxyl one replaces or two replacements,
D represents hydrogen, the optional separately C that is replaced by fluorine or chlorine 1-C 6Alkyl, C 3-C 4Alkenyl or C 3-C 6Cycloalkyl,
A 3Represent optional together with D by methyl substituted C 3-C 4Alkane two bases are wherein chosen a methylene wantonly by sulfur,
G 1Represent one of hydrogen (a) or the following group of representative
E (f) or
Figure C20048003617600072
(g), especially (a) and (b), (c) or (g)
E representation metal ion or ammonium ion,
L 1Represent oxygen or sulphur,
M 1Represent oxygen or sulphur,
R 20The optional separately C that is replaced by halogen of representative 1-C 10Alkyl, C 2-C 10Alkenyl, C 1-C 4Alkoxy C 1-C 4Alkyl, C 1-C 4Alkylthio group C 1-C 4Alkyl, or optional by fluorine, chlorine, C 1-C 4Alkyl or C 1-C 2The C that alkoxyl replaces 3-C 6Cycloalkyl,
Representative is optional by fluorine, chlorine, bromine, cyano group, nitro, C 1-C 4Alkyl, C 1-C 4The phenyl that alkoxyl, trifluoromethyl or trifluoromethoxy replace,
Representative is optional separately by chlorine or methyl substituted pyridine radicals or thienyl,
R 21The optional separately C that is replaced by fluorine or chlorine of representative 1-C 10Alkyl, C 2-C 10Alkenyl, C 1-C 4Alkoxy C 2-C 4Alkyl,
The optional C that is replaced by methyl or methoxy of representative 5-C 6Cycloalkyl, perhaps
Representative is optional separately by fluorine, chlorine, bromine, cyano group, nitro, C 1-C 4Alkyl, C 1-C 4Phenyl or benzyl that alkoxyl, trifluoromethyl or trifluoromethoxy replace,
R 22The optional C that is replaced by fluorine of representative 1-C 4Alkyl, or representative is optional by fluorine, chlorine, bromine, C 1-C 4Alkyl, C 1-C 4The phenyl that alkoxyl, trifluoromethyl, trifluoromethoxy, cyano group or nitro replace,
R 23The optional separately C that is replaced by fluorine or chlorine of representative 1-C 4Alkyl, C 1-C 4Alkoxyl, C 1-C 4Alkyl amino, C 1-C 4Alkylthio group, or representative is optional separately by fluorine, chlorine, bromine, nitro, cyano group, C 1-C 4Alkoxyl, trifluoromethoxy, C 1-C 4Alkylthio group, C 1-C 4Halogenated alkylthio, C 1-C 4Phenyl, phenoxy group or thiophenyl that alkyl or trifluoromethyl replace,
R 24Represent C 1-C 4Alkoxyl or C 1-C 4Alkylthio group,
R 25Represent C 1-C 6Alkyl, C 3-C 6Cycloalkyl, C 1-C 6Alkoxyl, C 3-C 6Alkenyl, C 1-C 4Alkoxy C 1-C 4Alkyl,
R 26Represent C 1-C 6Alkyl, C 3-C 6Alkenyl or C 1-C 4Alkoxy C 1-C 4Alkyl,
R 25And R 26Also representative is optional by the C of methyl or ethyl replacement together 3-C 6Alkenyl, wherein optional carbon atom is by oxygen or sulfur.
In the preferable range of halogen group, halogen is preferably represented chlorine and fluorine.
The active ingredient bond that especially preferably contains the reactive compound of the compound of formula (I) and at least a formula (II) is in the compound of described formula (I)
W 1Represent hydrogen, methyl, ethyl, chlorine, bromine or methoxyl group,
X represents chlorine, bromine, methyl, ethyl, propyl group, isopropyl, methoxyl group, ethyoxyl or trifluoromethyl,
Y and Z represent hydrogen, fluorine, chlorine, bromine, methyl, ethyl, propyl group, isopropyl, trifluoromethyl or methoxyl group independently of one another,
A 3Represent methylidene, ethyl, propyl group, isopropyl, butyl, isobutyl group, sec-butyl, the tert-butyl group, cyclopropyl, cyclopenta or cyclohexyl,
A 4Represent hydrogen, methyl or ethyl,
A 3And A 4Also connected carbon atom is represented saturated C together 6Cycloalkyl, the optional ring members of described cycloalkyl is replaced by oxo, and optional by methyl, ethyl, methoxyl group, ethyoxyl, propoxyl group or butoxy one replacement,
D represents hydrogen, represent methylidene, ethyl, propyl group, isopropyl, butyl, isobutyl group, pi-allyl, cyclopropyl, cyclopenta or cyclohexyl,
A 3Represent optional together with D by methyl substituted C 3-C 4Alkane two bases,
G 1Represent one of hydrogen (a) or the following group of representative,
Figure C20048003617600081
Or
Figure C20048003617600082
L 1Represent oxygen or sulphur,
M 1Represent oxygen or sulphur,
R 20Represent C 1-C 8Alkyl, C 2-C 4Alkenyl, methoxy, ethoxyl methyl, ethylmercapto group methyl, cyclopropyl, cyclopenta or cyclohexyl,
Representative is optional to be replaced to dibasic phenyl by fluorine, chlorine, bromine, cyano group, nitro, methyl, ethyl, methoxyl group, trifluoromethyl or trifluoromethoxy one,
Representative is optional separately to be replaced to Disubstituted pyridine base or thienyl by chlorine or methyl one,
R 21Represent C 1-C 8Alkyl, C 2-C 4Alkenyl, methoxy ethyl, ethoxyethyl group, or represent phenyl or benzyl,
R 25And R 26Represent methylidene, ethyl independently of one another, or coupled nitrogen-atoms is represented morpholino together.
Especially preferably the active agent combinations that contains the reactive compound of the compound of formula (I) and at least a formula (II) is in the compound of described formula (I)
W 1Represent hydrogen or methyl,
X represents chlorine, bromine or methyl,
Y and Z represent hydrogen, chlorine, bromine or methyl independently of one another,
A 3And A 4Also represent saturated C with the carbon atom that links to each other with it 6Cycloalkyl, the optional ring members of described cycloalkyl is replaced by oxo, and optional by methyl, methoxyl group, ethyoxyl, propoxyl group or the replacement of butoxy list,
D represents hydrogen,
G 1Represent one of hydrogen (a) or the following group of representative
Figure C20048003617600091
Or
Figure C20048003617600092
L 1Represent oxygen or sulphur,
M 1Represent oxygen or sulphur,
R 20Represent C 1-C 8Alkyl, C 2-C 4Alkenyl, methoxy, ethoxyl methyl, ethyl methyl mercapto, cyclopropyl, cyclopenta, cyclohexyl,
Representative is optional by the monobasic phenyl of fluorine, chlorine, bromine, methyl, methoxyl group, trifluoromethyl, trifluoromethoxy, cyano group or nitro,
Representative is optional separately by chlorine or monobasic pyridine radicals of methyl or thienyl,
R 21Represent C 1-C 8Alkyl, C 2-C 4Alkenyl, methoxy ethyl, ethoxyethyl group, phenyl or benzyl,
R 25And R 26Represent methylidene, ethyl independently of one another, or coupled nitrogen-atoms is represented morpholino together.
Extremely preferably contain at least a with following formula (I-a) compound and the active agent combinations of the reactive compound of at least a formula (II).
Figure C20048003617600101
The active agent combinations that extremely preferably contains the reactive compound of the compound of formula (I-a-4) and at least a formula (II)
Figure C20048003617600103
In various character, main according to substituent character, formula (I) compound can how much and/or the form of optical isomer exist, perhaps the isomer mixture form of forming with difference exists, and can separate by conventional methods if described mixture is suitable.The invention provides pure isomer and isomer mixture, Preparation Method And The Use, and the composition that contains them.Yet, for for simplicity, hereinafter only be referred to as formula (I) compound, but this appellation implication had both referred to pure compound, if the suitable mixture that also refers to the isomeric compound of different proportion.
The active agent combinations that extremely preferably contains the reactive compound of the compound of (2-1) to (2-7) in the compound that is selected from the 2nd group and at least a formula (II).
The anthranilamide of formula (II) is similarly known compound, states in the following publication or comprises content corresponding:
WO?01/70671、WO?03/015518、WO?03/015519、WO?03/016284、WO03/016282、WO?03/016283、WO?03/024222、WO?03/062226。
General formula described in the above-mentioned publication and definition and wherein said independent compound are clearly included in this specification in this mode by reference.
Anthranilamide can be represented by following formula (II):
Wherein,
A 1And A 2Represent oxygen or sulphur independently of one another,
X 1Represent N or CR 10,
R 1Represent hydrogen, or representative optional separately one or polysubstituted C 1-C 6Alkyl, C 2-C 6Alkenyl, C 2-C 6Alkynyl or C 3-C 6Cycloalkyl, wherein said substituting group can be selected from R independently of one another 6, halogen, cyano group, nitro, hydroxyl, C 1-C 4Alkoxyl, C 1-C 4Alkylthio group, C 1-C 4Alkyl sulphinyl, C 1-C 4Alkyl sulphonyl, C 2-C 4Alkoxy carbonyl, C 1-C 4Alkyl amino, C 2-C 8Dialkyl amido, C 3-C 6Cycloalkyl amino, (C 1-C 4Alkyl) C 3-C 6Cycloalkyl amino and R 11,
R 2Represent hydrogen, C 1-C 6Alkyl, C 2-C 6Alkenyl, C 2-C 6Alkynyl, C 3-C 6Cycloalkyl, C 1-C 4Alkoxyl, C 1-C 4Alkyl amino, C 2-C 8Dialkyl amido, C 3-C 6Cycloalkyl amino, C 2-C 6Alkoxy carbonyl or C 2-C 6Alkyl-carbonyl,
R 3Represent hydrogen, R 11, or representative optional separately one or polysubstituted C 1-C 6Alkyl, C 2-C 6Alkenyl, C 2-C 6Alkynyl, C 3-C 6Cycloalkyl, wherein said substituting group can be selected from R independently of one another 6, halogen, cyano group, nitro, hydroxyl, C 1-C 4Alkoxyl, C 1-C 4Halogenated alkoxy, C 1-C 4Alkylthio group, C 1-C 4Alkyl sulphinyl, C 1-C 4Alkyl sulphonyl, C 2-C 6Alkoxy carbonyl, C 2-C 6Alkyl-carbonyl, C 3-C 6Trialkylsilkl, R 11, phenyl, phenoxy group and 5 or 6 yuan of hetero-aromatic rings, wherein phenyl, phenoxy group and 5 or 6 yuan of hetero-aromatic rings can be chosen wantonly separately and be substituted, its substituting group can be selected from one to three W group or one or more R independently of one another 12Group, perhaps,
R 2And R 3Can be connected to each other forms ring M,
R 4Represent hydrogen, C 1-C 6Alkyl, C 2-C 6Alkenyl, C 2-C 6Alkynyl, C 3-C 6Cycloalkyl, C 1-C 6Haloalkyl, C 2-C 6Halogenated alkenyl, C 2-C 6Halo alkynyl, C 3-C 6Halogenated cycloalkyl, halogen, cyano group, nitro, hydroxyl, C 1-C 4Alkoxyl, C 1-C 4Halogenated alkoxy, C 1-C 4Alkylthio group, C 1-C 4Alkyl sulphinyl, C 1-C 4Alkyl sulphonyl, C 1-C 4Halogenated alkylthio, C 1-C 4Haloalkyl sulfinyl, C 1-C 4Halogenated alkyl sulfonyl, C 1-C 4Alkyl amino, C 2-C 8Dialkyl amido, C 3-C 6Cycloalkyl amino, C 3-C 6Trialkylsilkl, or representative optional separately one or polysubstituted phenyl, benzyl or phenoxy group, wherein said substituting group can be selected from C independently of one another 1-C 4Alkyl, C 2-C 4Alkenyl, C 2-C 4Alkynyl, C 3-C 6Cycloalkyl, C 1-C 4Haloalkyl, C 2-C 4Halogenated alkenyl, C 2-C 4Halo alkynyl, C 3-C 6Halogenated cycloalkyl, halogen, cyano group, nitro, C 1-C 4Alkoxyl, C 1-C 4Halogenated alkoxy, C 1-C 4Alkylthio group, C 1-C 4Alkyl sulphinyl, C 1-C 4Alkyl sulphonyl, C 1-C 4Alkyl amino, C 2-C 8Dialkyl amido, C 3-C 6Cycloalkyl amino, C 3-C 6(alkyl) cycloalkyl amino, C 2-C 4Alkyl-carbonyl, C 2-C 4Alkoxy carbonyl, C 2-C 6Alkyl amino-carbonyl, C 3-C 8Dialkyl amino carbonyl and C 3-C 6Trialkylsilkl,
R 5And R 8Represent hydrogen, halogen separately independently of one another, or the optional separately C that replaces of representative 1-C 4Alkyl, C 1-C 4Haloalkyl, R 12, G, J ,-OJ ,-OG ,-S (O) p-J ,-S (O) p-G ,-S (O) p-phenyl, wherein said substituting group can be selected from one to three W group independently of one another or be selected from R 12, C 1-C 10Alkyl, C 2-C 6Alkenyl, C 2-C 6Alkynyl, C 1-C 4Alkoxyl and C 1-C 4Alkylthio group, wherein each substituting group can be independently from each other G, J, R by one or more 6, halogen, cyano group, nitro, amino, hydroxyl, C 1-C 4Alkoxyl, C 1-C 4Halogenated alkoxy, C 1-C 4Alkylthio group, C 1-C 4Alkyl sulphinyl, C 1-C 4Alkyl sulphonyl, C 1-C 4Halogenated alkylthio, C 1-C 4Haloalkyl sulfinyl, C 1-C 4Halogenated alkyl sulfonyl, C 1-C 4Alkyl amino, C 2-C 8Dialkyl amido, C 3-C 6The substituting group of trialkylsilkl, phenyl and phenoxy group replaces, and wherein each benzyl ring or phenoxy group ring can be chosen wantonly and be substituted, and its substituting group can be selected from one to three W group or one or more R independently of one another 12Group,
G represents 5 or 6 yuan of non-aromaticity carbocyclic rings or heterocycle separately independently of one another, described ring is optional contain one or two be selected from C (=O), SO and S (=O) 2Ring members, and described ring can be chosen wantonly by one to four and is independently from each other C 1-C 2Alkyl, halogen, cyano group, nitro and C 1-C 2The substituting group of alkoxyl replaces; Or represent C independently of one another 2-C 6Alkenyl, C 2-C 6Alkynyl, C 3-C 7Cycloalkyl, (cyano group) C 3-C 7Cycloalkyl, (C 1-C 4Alkyl) C 3-C 6Cycloalkyl, (C 3-C 6Cycloalkyl) C 1-C 4Alkyl, wherein each cycloalkyl, (alkyl) cycloalkyl and (cycloalkyl) alkyl can be chosen wantonly by one or more halogen atom and replace,
J represents optional 5 or 6 yuan of hetero-aromatic rings that replace separately independently of one another, and wherein said substituting group can be selected from one to three W group or one or more R independently of one another 12Group,
R 6Representative-C (=E independently of one another 1) R 19,-LC (=E 1) R 19,-C (=E 1) LR 19,-LC (=E 1) LR 19,-OP (=Q) (OR 19) 2,-SO 2LR 18Or-LSO 2LR 19, each E wherein 1Represent O, S, N-R independently of one another 15, N-OR 15, N-N (R 15) 2, N-S=O, N-CN or N-NO 2,
R 7Represent hydrogen, C 1-C 4Alkyl, C 1-C 4Haloalkyl, halogen, C 1-C 4Alkoxyl, C 1-C 4Halogenated alkoxy, C 1-C 4Alkylthio group, C 1-C 4Alkyl sulphinyl, C 1-C 4Alkyl sulphonyl, C 1-C 4Halogenated alkylthio, C 1-C 4Haloalkyl sulfinyl, C 1-C 4Halogenated alkyl sulfonyl,
R 9Represent C 1-C 4Haloalkyl, C 1-C 4Halogenated alkoxy, C 1-C 4Haloalkyl sulfinyl or halogen,
R 10Represent hydrogen, C 1-C 4Alkyl, C 1-C 4Haloalkyl, halogen, cyano group or C 1-C 4Halogenated alkoxy,
R 11Representative chooses one wantonly separately to trisubstituted C independently of one another separately 1-C 6Alkylthio group, C 1-C 6Alkyl sulphinyl (sulfenyl), C 1-C 6Halogenated alkylthio, C 1-C 6Haloalkyl sulfinyl (sulfenyl), thiophenyl or phenyl sulfinyl (sulfenyl), wherein said substituting group can be selected from independently of one another W ,-S (O) nN (R 16) 2,-C (=O) R 13,-L (C=O) R 14,-S (C=O) LR 14,-C (=O) LR 13,-S (O) nNR 13C (=O) R 13,-S (O) nNR 13C (=O) LR 14Or-S (O) nNR 13S (O) 2LR 14,
L represents O, NR separately independently of one another 18Or S,
R 12Representative-B (OR independently of one another separately 17) 2, amino, SH, thiocyano, C 3-C 8Trialkylsiloxy, two (C 1-C 4Alkyl) changes disulfide group (C 1-C 4-alkyldisulfide) ,-SF 5,-C (=E 1) R 19,-LC (=E 1) R 19,-C (=E 1) LR 19,-LC (=E 1) LR 19,-OP (=Q) (OR 19) 2,-SO 2LR 19Or-LSO 2LR 19,
Q represents O or S,
R 13Represent hydrogen separately independently of one another, or representative optional separately one or polysubstituted C 1-C 6Alkyl, C 2-C 6Alkenyl, C 2-C 6Alkynyl or C 3-C 6Cycloalkyl, wherein said substituting group can be selected from R independently of one another 6, halogen, cyano group, nitro, hydroxyl, C 1-C 4Alkoxyl, C 1-C 4Alkyl sulphinyl, C 1-C 4Alkyl sulphonyl, C 1-C 4Alkyl amino, C 2-C 8Dialkyl amido, C 3-C 6Cycloalkyl amino or (C 1-C 4Alkyl) C 3-C 6Cycloalkyl amino,
R 14Representative optional separately one or polysubstituted C independently of one another separately 1-C 20Alkyl, C 2-C 20Alkenyl, C 2-C 20Alkynyl or C 3-C 6Cycloalkyl, wherein said substituting group can be selected from R independently of one another 6, halogen, cyano group, nitro, hydroxyl, C 1-C 4Alkoxyl, C 1-C 4Alkyl sulphinyl, C 1-C 4Alkyl sulphonyl, C 1-C 4Alkyl amino, C 2-C 8Dialkyl amido, C 3-C 6Cycloalkyl amino and (C 1-C 4Alkyl) C 3-C 6Cycloalkyl amino, perhaps the phenyl that replaces is chosen in representative wantonly, and its substituting group can be selected from one to three W group or one or more R independently of one another 12Group,
R 15Represent hydrogen separately independently of one another, or representative optional separately one or polysubstituted C 1-C 6Haloalkyl or C 1-C 6Alkyl, wherein said substituting group can be selected from cyano group, nitro, hydroxyl, C independently of one another 1-C 4Alkoxyl, C 1-C 4Halogenated alkoxy, C 1-C 4Alkylthio group, C 1-C 4Alkyl sulphinyl, C 1-C 4Alkyl sulphonyl, C 1-C 4Halogenated alkylthio, C 1-C 4Haloalkyl sulfinyl, C 1-C 4Halogenated alkyl sulfonyl, C 1-C 4Alkyl amino, C 2-C 8Dialkyl amido, C 2-C 6Alkoxy carbonyl, C 2-C 6Alkyl-carbonyl, C 3-C 6Trialkylsilkl and the optional phenyl that replaces, its substituting group can be selected from one to three W group or one or more R independently of one another 12Group; Perhaps N ( 15) 2Representative forms the ring of ring M,
R 16Represent C 1-C 12Alkyl or C 1-C 12Haloalkyl, perhaps N (R 16) 2Representative forms the ring of ring M,
R 17Represent hydrogen or C separately independently of one another 1-C 4Alkyl, perhaps B (OR 17) 2The representative ring, two oxygen atoms connect by the chain with two to three carbon atoms in described ring, and described carbon atom is optional to be independently from each other methyl and C by one or two 2-C 6The substituting group of alkoxy carbonyl replaces,
R 18Represent hydrogen, C separately independently of one another 1-C 6Alkyl or C 1-C 6Haloalkyl, perhaps N (R 13) (R 18) representative forms the ring of ring M,
R 19Represent hydrogen separately independently of one another, or representative optional separately one or polysubstituted C 1-C 6Alkyl, wherein said substituting group can be selected from cyano group, nitro, hydroxyl, C independently of one another 1-C 4Alkoxyl, C 1-C 4Halogenated alkoxy, C 1-C 4Alkylthio group, C 1-C 4Alkyl sulphinyl, C 1-C 4Alkyl sulphonyl, C 1-C 4Halogenated alkylthio, C 1-C 4Haloalkyl sulfinyl, C 1-C 4Halogenated alkyl sulfonyl, C 1-C 4Alkyl amino, C 2-C 8Dialkyl amido, CO 2H, C 2-C 6Alkoxy carbonyl, C 2-C 6Alkyl-carbonyl, C 3-C 6Trialkylsilkl and the optional phenyl that replaces, wherein substituting group can be selected from one to three W group, C independently of one another 1-C 6Haloalkyl, C 3-C 6Cycloalkyl or optional separately by W one to trisubstd phenyl or pyridine radicals,
M represents one optional one separately to quaternary ring, described ring except contain with substituting group to R 13And R 18, (R 15) 2Or (R 16) 2Beyond the nitrogen-atoms that is connected, also contain two to six carbon atom, and optional contain nitrogen, sulphur or an oxygen atom more in addition, wherein said substituting group can be selected from C independently of one another 1-C 2Alkyl, halogen, cyano group, nitro and C 1-C 2Alkoxyl,
W represents C separately independently of one another 1-C 4Alkyl, C 2-C 4Alkenyl, C 2-C 4Alkynyl, C 3-C 6Cycloalkyl, C 1-C 4Haloalkyl, C 2-C 4Halogenated alkenyl, C 2-C 4Halo alkynyl, C 3-C 6Halogenated cycloalkyl, halogen, cyano group, nitro, C 1-C 4Alkoxyl, C 1-C 4Halogenated alkoxy, C 1-C 4Alkylthio group, C 1-C 4Alkyl sulphinyl, C 1-C 4Alkyl sulphonyl, C 1-C 4Alkyl amino, C 2-C 8Dialkyl amido, C 3-C 6Cycloalkyl amino, (C 1-C 4Alkyl) C 3-C 6Cycloalkyl amino, C 2-C 4Alkyl-carbonyl, C 2-C 6Alkoxy carbonyl, CO 2H, C 2-C 6Alkyl amino-carbonyl, C 3-C 8Dialkyl amino carbonyl or C 3-C 6Trialkylsilkl,
N represents 0 or 1 separately independently of one another,
P represents 0,1 or 2 separately independently of one another,
Wherein, at (a) R 5Represent hydrogen, C 1-C 6Alkyl, C 1-C 6Haloalkyl, C 2-C 6Halogenated alkenyl, C 2-C 6Halo alkynyl, C 1-C 4Halogenated alkoxy, C 1-C 4Halogenated alkylthio or halogen, and (b) R 8Represent hydrogen, C 1-C 6Alkyl, C 1-C 6Haloalkyl, C 2-C 6Halogenated alkenyl, C 2-C 6Halo alkynyl, C 1-C 4Halogenated alkoxy, C 1-C 4Halogenated alkylthio, halogen, C 2-C 4Alkyl-carbonyl, C 2-C 6Alkoxy carbonyl, C 2-C 6Alkyl amino-carbonyl or C 3-C 8Under the situation of dialkyl amino carbonyl, (c) exist one to be selected from R at least 6, R 11And R 12Substituting group, and (d) if there is no R 12, at least one R then 6Or R 11Be different from C 2-C 6Alkyl-carbonyl, C 2-C 6Alkoxy carbonyl, C 2-C 6Alkyl amino-carbonyl or C 3-C 8Dialkyl amino carbonyl.
The compound of general formula (II) also comprises N-oxide and salt.
In various character, main according to substituent character, formula (II) compound can how much and/or the form of optical isomer exist, perhaps the isomer mixture form of forming with difference exists, if desired, described mixture can separate by conventional methods.The invention provides pure isomer and isomer mixture, Preparation Method And The Use, and the composition that contains them.Yet, for for simplicity, hereinafter only be referred to as formula (II) compound, but this appellation implication had both referred to pure compound, if the suitable mixture that also refers to the isomeric compound of different proportion.
The active agent combinations that preferably contains formula (II-1) compound,
Figure C20048003617600161
Wherein,
R 2Represent hydrogen or C 1-C 6Alkyl,
R 3Representative is optional by a R 6The C that replaces 1-C 6Alkyl,
R 4Represent C 1-C 4Alkyl, C 1-C 2Haloalkyl, C 1-C 2Halogenated alkoxy or halogen,
R 5Represent hydrogen, C 1-C 4Alkyl, C 1-C 2Haloalkyl, C 1-C 2Halogenated alkoxy or halogen,
R 6Representative-C (=E 2) R 19,-LC (=E 2) R 19,-C (=E 2) LR 19Or-LC (=E 2) LR 19, each E wherein 2Represent O, S, N-R independently of one another 15, N-OR 15, N-N (R 15) 2, and each L represents O or NR independently of one another 18,
R 7Represent C 1-C 4Haloalkyl or halogen,
R 9Represent C 1-C 2Haloalkyl, C 1-C 2Halogenated alkoxy, S (O) pC 1-C 2Haloalkyl or halogen,
R 15Represent hydrogen separately independently of one another, or the optional separately C that replaces of representative 1-C 6Haloalkyl or C 1-C 6Alkyl, wherein said substituting group can be selected from cyano group, C independently of one another 1-C 4Alkoxyl, C 1-C 4Halogenated alkoxy, C 1-C 4Alkylthio group, C 1-C 4Alkyl sulphinyl, C 1-C 4Alkyl sulphonyl, C 1-C 4Halogenated alkylthio, C 1-C 4Haloalkyl sulfinyl or C 1-C 4Halogenated alkyl sulfonyl,
R 18Represent hydrogen or C separately 1-C 4Alkyl,
R 19Represent hydrogen or C separately independently of one another 1-C 6Alkyl,
P represents 0,1,2 independently of one another.
In the group definition mentioned as preferred group, halogen is represented fluorine, chlorine, bromine and iodine, particularly fluorine, chlorine and bromine.
The active agent combinations that especially preferably contains following formula (II-1) compound, wherein,
R 2Represent hydrogen or methyl,
R 3Represent C 1-C 4Alkyl (particularly methyl, ethyl, n-pro-pyl, isopropyl, normal-butyl, isobutyl group, sec-butyl, the tert-butyl group),
R 4Represent methylidene, trifluoromethyl, trifluoromethoxy, fluorine, chlorine, bromine or iodine,
R 5Represent hydrogen, fluorine, chlorine, bromine, iodine, trifluoromethyl or trifluoromethoxy,
R 7Represent chlorine or bromine,
R 9Represent trifluoromethyl, chlorine, bromine, difluoro-methoxy or trifluoro ethoxy.
Especially preferably contain the reactive compound of following formula (II-1) compound and the 1st group of formula (I) or be selected from the active agent combinations of the 2nd group of compound of compound (2-1) to (2-7):
Figure C20048003617600181
Figure C20048003617600182
Figure C20048003617600191
Extremely preferably contain the reactive compound of following formula: compound and the 1st group of formula (I) or be selected from the active agent combinations of the 2nd group of compound of compound (2-1) to (2-7).
Figure C20048003617600201
Figure C20048003617600211
Figure C20048003617600221
Figure C20048003617600231
Figure C20048003617600241
Emphasize the active agent combinations of the reactive compound of the reactive compound of following compound that contains formula (II-1-9) and above-mentioned the 1st group of formula (I) or the 2nd group:
A) contain (II-1-9) and active agent combinations (I-a-4).
B) contain (II-1-9) and reach (2-2) active agent combinations of Buprofezin.
C) contain (II-1-9) and reach (2-6) active agent combinations of flonicamid.
D) contain (II-1-9) and reach (2-7) active agent combinations of Aphox.
Emphasize the active agent combinations (binary is mixed) of the following compound of mentioning especially that contains a kind of formula (I) compound or the 2nd group of compound and a kind of formula (II-1):
Figure C20048003617600242
Figure C20048003617600251
Figure C20048003617600261
Figure C20048003617600281
Yet above-mentioned wide in range or preferred group definition or set forth also combination with one another as required promptly, makes up between each scope and preferable range.Described definition is applicable to end product, and correspondingly is applicable to precursor and intermediate.
The preferred active agent combinations of the present invention contains the compound of formula (I) or the 2nd group compound, and the compound of at least a formula (II), and wherein each group is the combination of above-mentioned preferred (preferably) definition.
The particularly preferred active agent combinations of the present invention contains the compound of formula (I) or the 2nd group compound, and the compound of at least a formula (II), and wherein each group is the combination of above-mentioned special preferred definition.
The especially preferred active agent combinations of the present invention contains the compound of formula (I) or the 2nd group compound, and the compound of at least a formula (II), and wherein each group is the combination of above-mentioned especially preferred definition.
Saturated or unsaturated alkyl, for example alkyl or alkenyl, or even these groups that combine with hetero atom, alkoxyl for example all can be respectively a straight chain or have side chain.
The optional group that replaces can be a replacement or polysubstituted, and wherein under polysubstituted situation, substituting group can be identical or different.
In addition, active agent combinations also can contain other antifungal, kills acarid or kill the common component (co-components) of insect active.
When the reactive compound in the active agent combinations of the present invention existed with certain weight ratio, synergy was remarkable especially.It is the preferred mixed proportion that reaches 100% activity that the required ratio that obtains synergy need not.As how discussing, the weight ratio of reactive compound can change in quite wide scope in the active agent combinations.Generally speaking, bond of the present invention contains following formula (I) reactive compound or the 2nd group of compound and second group of blending ingredients preferred and especially preferably mixing ratio:
Mixed proportion is a weight ratio.Described ratio is interpreted as formula (I) reactive compound: blending ingredients (mixing partner)
Figure C20048003617600291
Active agent combinations of the present invention is suitable for preventing and treating animal pest; be preferred for preventing and treating arthropods and nematode; particularly be present in insect and arachnid in agricultural, animal health, forestry, gardening and leisure facilities, stored article and material protection and the hygienic conditions, show good plant tolerance simultaneously, hypotoxicity of warm blooded animal and good Environmental compatibility.They are to common sensitivity and resistance species, and the whole or single developmental stage has activity.Above-mentioned insect comprises:
Isopoda (Isopoda), for example, comb beach louse (Oniscus asellus), pillworm (Armadilliudium vulgare), ball pillworm (Porcellio scaber).
Doubly sufficient order (Diplopoda), for example, Blaniulus guttulatus.
Lip foot order (Chilopoda), for example, Geophilus carpophagus, Scutigeraspp..
Comprehensive order (Symphyla), for example, Scutigerella immaculata.
Thysanoptera (Thysanura), for example, silverfish (Lepisma saccharina).
Collembola (Collembola), for example, arms Onychiurus arcticus (Onychiurus armatus).
Orthoptera (Orthoptera), for example, tame Xi (Acheta domesticus), Gryllotalpa spp kind (Gryllotalpa spp.), African migratory locust (Locusta migratoriamigratorioides), black locust belong to kind of (Melanoplus spp.), a desert locust (Schistocerca gregaria).
Blattaria (Blattaria), for example, oriental cockroach (Blatta orientalis), American cockroach (Periplaneta americana), leucophaea maderae (Leucophaeamaderae), blatta germanica (Blattella germanica).
Dermaptera (Dermaptera), for example, European earwig (Forficula auricularia).
Isoptera (Isoptera), for example, Reticulitermes kind (Reticulitermes spp.).
Anoplura (Phthiraptera), for example, body louse (Pediculus humanus corporis), Haematopinus kind (Haematopinus spp.), Linognathus kind (Linognathus spp.), Trichodectes kind (Trichodectes spp.), Damalinia kind (Damalinia spp.).
Thrips (Thysanoptera), for example, greenhouse bar hedge thrips (Hercinothripsfemoralis), onion thrips (Thrips tabaci), palm thrips (Thrips palmi), alfalfa thrips (Frankliniella accidentalis).
Heteroptera (Heteroptera), for example, Eurygasterspp belongs to kind of (Eurygaster spp.), a Dysdercus intermedius, square butt stinkbug (Piesma quadrata), bed bug (Cimex lectularius), phodnius prolixus (Rhodnius prolixus), Triatoma kind (Triatoma spp.).
Homoptera (Homoptera), for example, wild cabbage aleyrodid (Aleurodes brassicae), cassava aleyrodid (Bemisia tabaci), greenhouse whitefly (Trialeurodes vaporariorum), cotten aphid (Aphis gossypii), cabbage aphid (Brevicoryne brassicae), the tea Fischer conceals knurl aphid (Cryptomyzus ribis), aphis fabae (Aphis fabae), apple aphid (Aphispomi), wooly aphis (Eriosoma lanigerum), mealy plum aphid (Hyalopterusarundinis), grape phylloxera (Phylloxera vastatrix), the goitre woolly aphid belongs to kind of (a Pemphigus spp.), English grain aphid (Macrosiphum avenae), tumor aphid genus kind (Myzusspp.), phorodon aphid (Phorodon humuli), rhopalosiphum padi (Rhopalosiphumpadi), Empoasca flavescens kind (Empoasca spp.), Euscelis bilobatus, rice leafhopper (Nephotettix cincticeps), water wood hard a red-spotted lizard (Lecanium corni), black scale (Saissetia oleae), small brown rice planthopper (Laodelphax striatellus), brown planthopper (Nilaparvata lugens), red kidney Aspidiotus (Aonidiella aurantii), ivy Aspidiotus (Aspidiotus hederae), mealybug belongs to kind of (a Pseudococcus spp.), Psylla spp kind (Psylla spp.).
Lepidoptera (Lepidoptera), for example, Pectinophora gossypiella (Pectinophoragossypiella), loose looper (Bupalus piniarius), winter geometrid moth (Cheimatobiabrumata), the thin moth of apple (Lithocolletis blancardella), apple ermine moth (Hyponomeuta padella), diamond-back moth (Plutella xylostella), malacosoma neustria (Malacosoma neustria), pornography and drug moth (Euproctis chrysorrhoea), Euproctis kind (Lymantria spp.), cotton lyonetid (Bucculatrix thurberiella), tangerine lyonetid (Phyllocnistis citrella), Agrotis kind (Agrotis spp.), root eating insect belongs to kind of (an Euxoa spp.), the dirty Noctua kind (Feltia spp.) of cutting, earias insulana (Earias insulana), Heliothis kind (Heliothis spp.), tomato moth (Mamestra brassicae), small noctuid (Panolis flammea), Spodoptera kind (Spodoptera spp.), cabbage looper (Trichoplusia ni), codling moth (Carpocapsa pomonella), Pieris spp kind (Pieriss pp.), straw borer spp kind (Chilo spp.), corn borer (Pyrausta nubilalis), Anagasta kuehniella (Ephestia kuehniella), greater wax moth (Galleria mellonella), curtain rain moth (Tineola bisselliella), bag rain moth (Tinea pellionella), brownly knit moth (Hofmannophila pseudospretella), the yellow volume of flax moth (Cacoecia podana), Capua reticulana, spruce bunworm (Choristoneura fumiferana), grape codling moth (Clysia ambiguella) (Clysia ambiguella), tea long paper moth (Homona magnanima), the green volume of oak moth (Tortrix viridana), Cnaphaloceruss pp., Oulema oryzae (Oulemaoryzae).
Coleoptera (Coleoptera), for example, furniture death watch beetle (Anobium punctatum), lesser grain borer (Rhizopertha dominica), dislike bar bean weevil (Bruchidius obtectus), acanthoscelides obtectus (Acanthoscelides obtectus), North America house longhorn beetle (Hylotrupesbajulus), willow firefly chrysomelid (Agelastica alni), colorado potato beetle (Leptinotarsadecemlineata), horseradish daikon leaf beetle (Phaedon cochleariae), chrysomelid genus kind (Diabrotica spp.), rape golden head flea beetle (Psylliodes chrysocephala), the big Epilachna spp of Mexico (Epilachna varivestis), Atomaria spp., saw-toothed grain beetle (Oryzaephilus surinamensis), flower resembles and belongs to kind of (an Anthonomus spp.), grain weevil belongs to kind of (a Sitophiluss pp.), black grape ear image (Otiorrhynchus sulcatus), the banana collar resembles (Cosmopolites sordidus), Chinese cabbage seed tortoise resembles (Ceuthorrhynchusassimilis), alfalfa leaf resembles (Hypera postica), khapra beetle belongs to kind of (Dermestesspp.), the spot khapra beetle belongs to kind of (a Trogoderma spp.), Anthrenus kind (Anthrenus spp.), moth-eaten belong to kind of (the Attagenus spp.) of fur, moth-eaten belong to kind of (the Lyctus spp.) of powder, pollen beetle (Meligethes aeneus), Ptinus kind (Ptinus spp.), golden spider beetle (Niptus hololeucus), globose spider beetle (Gibbium psylloides), Tribolium kind (Tribolium spp.), yellow mealworm (Tenebrio molitor), click beetle belongs to kind of (an Agriotes spp.), wide chest Agriotes spp kind (Conoderus spp.), the west melolonthid in May (Melolontha melolontha), the potato melolonthid (Amphimallonsolstitialis), the brown New Zealand rib wing melolonthid (Costelytra zealandica), rice root weevil (Lissorhoptrus oryzophilus).
Hymenoptera (Hymenoptera), for example, pine sawfoy belongs to kind of (Diprion spp.), a real tenthredinidae kind (Hoplocampa spp.), the hair ant belongs to kind of (Lasius spp.), a MonomoriumMayr (Monomorium pharaonis), Vespa kind (Vespa spp.).
Diptera (Diptera), for example, Aedes kind (Aedes spp.), Anopheles kind (Anopheles spp.), Culex kind (Culex spp.), black-tailed fruit flies (Drosophilamelanogaster), Musca kind (Musca spp.), Fannia kind (Fannia spp.), calliphora erythrocephala (Calliphora erythrocephala), Lucilia kind (Lucilia spp.), Carysomyia kind (Chrysomyia spp.), Cuterebra kind (Cuterebra spp.), Gasterophilus kind (Gastrophilus spp.), Hyppobosca spp., Genus Stomoxys kind (Stomoxysspp.), Oestrus kind (Oestrus spp.), Hypoderma kind (Hypoderma spp.), Gadfly kind (Tabanus spp.), Tannia spp., Bibio hortulanus, Oscinella frit (Oscinella frit), grass Hylemyia kind (Phorbia spp.), lamb's-quarters spring fly (Pegomyiahyoscyami), Mediterranean Ceratitis spp (Ceratitis capitata), the big trypetid of olive (Dacusoleae), Europe daddy-longlegs (Tipula paludosa), Hylemyia kind (Hylemyia spp.), liriomyza bryoniae belongs to kind of (a Liriomyza spp.).
Siphonaptera (Siphonaptera), for example, Xanthopsyllacheopis (Xenopsylla cheopis), Ceratophyllus kind (Ceratophyllus spp.).
Arachnids (Arachnida), for example, Middle East gold scorpion (Scorpio maurus), latrodectus mactans (Latrodectus mactans), Acarus siro (Acarus siro), Argas kind (Argas spp.), Ornithodoros kind (Ornithodoros spp.), Dermanyssus gallinae (Dermanyssus gallinae), tea Fischer goitre mite (Eriophyes ribis), the tangerine rust mite (Phyllocoptruta oleivora) that rues, Boophilus kind (Boophilus spp.), Rh kind (Rhipicephalus spp.), Amblyomma kind (Amblyomma spp.), Hyalomma kind (Hyalomma spp.), hard tick belongs to kind of (an Ixodes spp.), Psoroptes kind (Psoroptes spp.), Chorioptes kind (Chorioptes spp.), itch mite belongs to kind of (a Sarcoptes spp.), tarsonemid belongs to kind of (a Tarsonemus spp.), Bryobia praetiosa (Bryobia praetiosa), Panonychus citri belongs to kind of (a Panonychus spp.), Tetranychus kind (Tetranychus spp.), half tarsonemid belongs to kind of (a Hemitarsonemus spp.), short whisker Acarapis kind (Brevipalpus spp.).
Plant nematode comprises, for example, Pratylenchidae belongs to kind of (a Pratylenchus spp.), similar similes thorne (Radopholus similis), fuller's teasel stem eelworm (Ditylenchusdipsaci), the nematode (Tylenchulus semipenetrans) of partly puncturing, Heterodera kind (Heterodera spp.), ball Heterodera kind (Globodera spp.), Meloidogyne kind (Meloidogyne spp.), Aphelenchoides kind (Aphelenchoides spp.), minute hand Turbatrix kind (Longidorus spp.), Xiphinema kind (Xiphinema spp.), burr Turbatrix kind (Trichodorus spp.), umbrella Aphelenchoides kind (Bursaphelenchus spp.).
The active agent combinations that contains formula (I) compound and at least a compound 1 to 15 of the present invention is particularly suitable for control " stinging feeding habits (biting) " insect.Particularly comprise following insect:
Lepidoptera (Lepidoptera), for example, Pectinophora gossypiella (Pectinophoragossypiella), loose looper (Bupalus piniarius), winter geometrid moth (Cheimatobiabrumata), the thin moth of apple (Lithocolletis blancardella), apple ermine moth (Hyponomeuta padella), diamond-back moth (Plutella xylostella), malacosoma neustria (Malacosoma neustria), pornography and drug moth (Euproctis chrysorrhoea), Euproctis kind (Lymantria spp.), cotton lyonetid (Bucculatrix thurberiella), tangerine lyonetid (Phyllocnistis citrella), Agrotis kind (Agrotis spp.), root eating insect belongs to kind of (an Euxoa spp.), the dirty Noctua kind (Feltia spp.) of cutting, earias insulana (Earias insulana), Heliothis kind (Heliothis spp.), tomato moth (Mamestra brassicae), small noctuid (Panolis flammea), Spodoptera kind (Spodoptera spp.), cabbage looper (Trichoplusia ni), codling moth (Carpocapsa pomonella), Pieris spp kind (Pieris spp.), straw borer spp kind (Chilo spp.), corn borer (Pyrausta nubilalis), Anagasta kuehniella (Ephestia kuehniella), greater wax moth (Galleria mellonella), curtain rain moth (Tineola bisselliella), bag rain moth (Tinea pellionella), brownly knit moth (Hofmannophila pseudospretella), the yellow volume of flax moth (Cacoecia podana), Capua reticulana, spruce bunworm (Choristoneura fumiferana), grape codling moth (Clysia ambiguella) (Clysia ambiguella), tea long paper moth (Homona magnanima), the green volume of oak moth (Tortrix viridana), Cnaphalocerus spp., Oulema oryzae (Oulemaoryzae).
Coleoptera (Coleoptera), for example, furniture death watch beetle (Anobium punctatum), lesser grain borer (Rhizopertha dominica), dislike bar bean weevil (Bruchidius obtectus), acanthoscelides obtectus (Acanthoscelides obtectus), North America house longhorn beetle (Hylotrupesbajulus), willow firefly chrysomelid (Agelastica alni), colorado potato beetle (Leptinotarsadecemlineata), horseradish daikon leaf beetle (Phaedon cochleariae), chrysomelid genus kind (Diabrotica spp.), rape golden head flea beetle (Psylliodes chrysocephala), the big Epilachna spp of Mexico (Epilachna varivestis), Atomaria spp., saw-toothed grain beetle (Oryzaephilus surinamensis), flower resembles and belongs to kind of (an Anthonomus spp.), grain weevil belongs to kind of (a Sitophilus spp.), black grape ear image (Otiorrhynchus sulcatus), the banana collar resembles (Cosmopolites sordidus), Chinese cabbage seed tortoise resembles (Ceuthorrhynchusassimilis), alfalfa leaf resembles (Hypera postica), khapra beetle belongs to kind of (Dermestesspp.), the spot khapra beetle belongs to kind of (a Trogoderma spp.), Anthrenus kind (Anthrenus spp.), moth-eaten belong to kind of (the Attagenus spp.) of fur, moth-eaten belong to kind of (the Lyctus spp.) of powder, pollen beetle (Meligethes aeneus), Ptinus kind (Ptinus spp.), golden spider beetle (Niptus hololeucus), globose spider beetle (Gibbium psylloides), Tribolium kind (Tribolium spp.), yellow mealworm (Tenebrio molitor), click beetle belongs to kind of (an Agriotes spp.), wide chest Agriotes spp kind (Conoderus spp.), the west melolonthid in May (Melolontha melolontha), the potato melolonthid (Amphimallonsolstitialis), the brown New Zealand rib wing melolonthid (Costelytra zealandica), rice root weevil (Lissorhoptrus oryzophilus).
The active agent combinations that contains formula (I) compound and at least a compound 5 to 8 of the present invention also is particularly suitable for control " sucking (sucking) " insect.Particularly comprise following insect:
Homoptera (Homoptera), for example, wild cabbage aleyrodid (Aleurodes brassicae), cassava aleyrodid (Bemisia tabaci), greenhouse whitefly (Trialeurodes vaporariorum), cotten aphid (Aphis gossypii), cabbage aphid (Brevicoryne brassicae), the tea Fischer conceals knurl aphid (Cryptomyzus ribis), aphis fabae (Aphis fabae), apple aphid (Aphispomi), wooly aphis (Eriosoma lanigerum), mealy plum aphid (Hyalopterusarundinis), grape phylloxera (Phylloxera vastatrix), the goitre woolly aphid belongs to kind of (a Pemphigus spp.), English grain aphid (Macrosiphum avenae), tumor aphid genus kind (Myzusspp.), phorodon aphid (Phorodon humuli), rhopalosiphum padi (Rhopalosiphumpadi), Empoasca flavescens kind (Empoasca spp.), Euscelis bilobatus, rice leafhopper (Nephotettix cincticeps), water wood hard a red-spotted lizard (Lecanium corni), black scale (Saissetia oleae), small brown rice planthopper (Laodelphax striatellus), brown planthopper (Nilaparvata lugens), red kidney Aspidiotus (Aonidiella aurantii), ivy Aspidiotus (Aspidiotus hederae), mealybug belongs to kind of (a Pseudococcus spp.), Psylla spp kind (Psylla spp.).
Particularly, active agent combinations of the present invention has the outstanding activity of control caterpillar, mealworm, spider larva, aphid and leaf miner (leaf-mining fly).
Active agent combinations can be converted into conventional formulation, for example solution, emulsion, wetting powder, suspending agent, pulvis, powder agent, paste, soluble powder, granule, outstanding newborn concentrating agents, through the natural and synthetic material of reactive compound dipping, and the microcapsule formulations in the polymer.
These preparations are made in known manner, for example reactive compound are mixed with filler, that is, mix with liquid flux and/or solid carrier, can select to use simultaneously surfactant, i.e. emulsifier and/or dispersant and/or blowing agent.
If make water as filler, also can be for example with an organic solvent as cosolvent.Following material is suitable as liquid flux basically: aromatic compound, for example dimethylbenzene, toluene or Fluhyzon; Chlorinated aromatic compound or chlorinated aliphatic hydrocarbon, for example chlorobenzene, vinyl chloride or carrene; Aliphatic hydrocarbon, for example cyclohexane or paraffin, for example mineral oil fractions, mineral oil and vegetable oil; Alcohol, for example butanols or ethylene glycol, and ether and ester; Ketone, for example acetone, MEK, methyl iso-butyl ketone (MIBK) or cyclohexanone; Intensive polar solvent, for example dimethyl formamide and dimethyl sulfoxide (DMSO); Or water.
The solid carrier that is fit to has:
For example, ammonium salt; The natural minerals of pulverizing, for example kaolin, clay, talcum powder, chalk, quartz, attapulgite, montmorillonite or diatomite; And the synthetic material of pulverizing, for example fine dispersion silica, aluminium oxide and silicate.The solid carrier that is applicable to granule is: for example pulverize the also natural rock of classification, for example calcite, marble, float stone, sepiolite and dolomite; Or synthetic inorganic and organic powder particles, and organic material particle, for example sawdust, coconut husk, corncob and tobacco stem.The emulsifier and/or the blowing agent that are fit to are: for example nonionic and anion emulsifier, for example polyoxyethylene fatty acid ester, polyoxyethylene aliphatic alcohol ether, for example alkylaryl polyglycol ether, alkylsulfonate, alkyl sulfate, arylsulphonate; Or protein hydrolysate.The dispersant that is fit to is: for example lignin sulfite waste liquor and methylcellulose.
Can use tackifier in the preparation, the natural and synthetic polymer of for example carboxymethyl cellulose, and powder, particle or latex shape, for example gum Arabic, polyvinyl alcohol and polyvinyl acetate; Or natural phospholipid, for example cephalin and lecithin, and synthetic phospholipid.Other additive can be mineral oil and vegetable oil.
Can use colouring agent, for example inorganic pigment, for example iron oxide, titanium oxide and Prussian blue; And toner, for example alizarin colouring agent, azo colouring agent and metal phthalocyanine colouring agent; And micronutrient, for example molysite, manganese salt, boron salt, mantoquita, cobalt salt, molybdenum salt and zinc salt.
Preparation generally contains the reactive compound of 0.1 to 95 weight %, preferred 0.5 to 90 weight %.
Active agent combinations of the present invention can be the commercial preparation, reach the type of service that mixes with other reactive compound by described formulation preparation, described other reactive compound is insecticide, attractant, disinfectant, bactericide, miticide, nematocide, fungicide, growth regulatory substance or weed killer herbicide for example.Insecticide comprises, for example phosphoric acid ester, carbamates, carboxylic acid esters, chlorinated hydrocarbon, phenylurea class and material of being made by microorganism etc.
Also can with other known activity compound for example weed killer herbicide mix, or mix with fertilizer and growth regulator.
During as insecticide, active agent combinations of the present invention may further be the commercial preparation, reaches the type of service that mixes with synergist by described formulation preparation.Described synergist itself not necessarily has active compound for improving reactive compound activity of the present invention.
Reactive compound content by the type of service of commercial preparation preparation can change in wide scope.The activity compound concentration of type of service can be the reactive compound of 0.0000001 to 95 weight %, preferred 0.0001 to 1 weight %.
Described compound uses with the usual manner that adapts with type of service.
When being used to prevent and treat sanitary insect pest (hygiene pest) and storing the product insect, active agent combinations is had outstanding performance aspect following two, i.e. fabulous residual activity on timber and the clay, and to the good stability of the alkali on the lime matrix.
Active agent combinations of the present invention not only has activity to plant insect, sanitary insect pest and storage product insect, also in veterinary applications to parazoon (vermin), for example hard tick, soft ticks, itch mite, harvest mite, fly (bite and suck), parasitic fly larva, lice, head louse, poultry louse and flea also have activity.Described parasite comprises:
Anoplura (Anoplurida), for example, Haematopinus kind, Linognathus kind, lice belong to kind of (Pediculusspp.), a Phtirus spp., the pipe lice belongs to kind of (a Solenopotes spp.).
Mallophaga (Mallophagida) and Amblycera (Amblycerina) and thin angle suborder (Ischnocerina), for example, hair Trichodectes kind (Trimenopon spp.), Menopon kind (Menopon spp.), huge Trichodectes kind (Trinoton spp.), Bovicola kind (Bovicola spp.), Werneckiella spp., Lepikentron spp., Damalinia kind (Damalina spp.), Trichodectes kind, Felicola kind (Felicola spp.).
Diptera and Nematocera (Nematocerina) and Brachycera (Brachycerina), for example, Aedes kind, the Anopheles kind, the Culex kind, Simulium kind (Simulium spp.), Eusimulium kind (Eusimulium spp.), owl midge kind (Phlebotomus spp.), Lutzomyia kind (Lutzomyia spp.), Bitting midge kind (Culicoides spp.), Chrysops kind (Chrysops spp.), knurl Gadfly kind (Hybomitra spp.), Atylotus kind (Atylotusspp.), the Gadfly kind, Chrysozona kind (Haematopota spp.), Philipomyia spp., honeybee Hippobosca kind (Braula spp.), the Musca kind, Hydrotaea kind (Hydrotaea spp.), the Genus Stomoxys kind, Haematobia kind (Haematobia spp.), fly does not belong to kind of (a Morellia spp.), the Fannia kind, Glossina kind (Glossina spp.), Calliphora kind (Calliphora spp.), the Lucilia kind, the Carysomyia kind, Wohlfahrtia kind (Wohlfahrtia spp.), Sarcophaga kind (Sarcophaga spp.), the Oestrus kind, the Hypoderma kind, Gasterophilus kind (Gasterophilusspp.), Hippobosca kind (Hippobosca spp.), Lipoptena kind (Lipoptena spp.), Melophagus kind (Melophagus spp.).
Siphonaptera (Siphonapterida), for example, flea belongs to kind of (Pulex spp.), a Ctenocephalus kind (Ctenocephalides spp.), objective flea belongs to kind of (Xenopsylla spp.), a Ceratophyllus kind.
Heteroptera (Heteropterida), for example, Cimex kind (Cimex spp.), Triatoma kind, Rhodnius kind (Rhodnius spp.), Triatoma kind (Panstrongylusspp.).
Blattaria (Blattarida), for example, oriental cockroach, American cockroach, blatta germanica, Supella kind (Supella spp.).
Acari (Acaria or Acarida) and back valve order (Metastigmate) and Mesostigmata (Mesostigmata), for example, Argas kind, Ornithodoros kind (Ornithodorus spp.), residual beak tick belongs to kind of (an Otobius spp.), hard tick belongs to plants, the Amblyomma kind, the Boophilus kind, Dermacentor kind (Dermacentor spp.), Haemophysalisspp., the Hyalomma kind, the Rh kind, Dermanyssus kind (Dermanyssus spp.), sting sharp mite and belong to kind of (a Raillietia spp.), Pneumonyssus kind (Pneumonyssus spp.), chest thorn mite belongs to kind of (a Sternostoma spp.), Vespacarus kind (Varroa spp.).
Axle Acarina (Actinedida) (preceding valve suborder (prostigmata)) and flour mite order (Acaridida) (Astigmata (Astigmata)), for example, honeybee shield mite belongs to kind of (an Acarapis spp.), Cheyletiella kind (Cheyletiella spp.), Ornithocheyletia kind (Ornithocheyletia spp.), Myobia kind (Myobia spp.), Psorergates kind (Psorergates spp.), Demodex kind (Demodex spp.), Trombidium kind (Trombicula spp.), Listrophorus spp., Tyroglyphus kind (Acarus spp.), Tyrophagus kind (Tyrophagus spp.), have a liking for wooden mite and belong to kind of (a Caloglyphus spp.), mite belongs to kind of (a Hypodectes spp.) under the neck, the wing mite belongs to kind of (a Pterolichus spp.), the Psoroptes kind, the Chorioptes kind, the ear itch mite belongs to kind of (an Otodectes spp.), itch mite belongs to be planted, Notoedres kind (Notoedres spp.), the lump mite belongs to kind of (a Knemidocoptes spp.), Cytodites kind (Cytodites spp.), Laminosioptes kind (Laminosioptes spp.).
Active agent combinations of the present invention also is applicable to control arthropods, described arthropods cause harm agriculture livestock, for example ox, sheep, goat, horse, pig, donkey, camel, buffalo, rabbit, chicken, turkey, duck, goose, honeybee; Other domestic animal, for example dog, cat, cage bird, pet fish and so-called experimental animal, for example hamster, cavy, rat and mouse.By described arthropods is prevented and treated, can reduce mortality and output reduction (with regard to meat, milk, hair, skin, egg, honey etc.), thereby but the active agent combinations of the application of the invention makes livestock-raising more economical, easier.
Active agent combinations of the present invention is used for veterinary applications in a known way, can be by for example tablet, capsule, oral potus, preserved material, granule, paste, pill, feed (feed-through) method, the mode of suppository is carried out administration in the stomach and intestine, can be by for example injection (intramuscular, subcutaneous, vein, in the peritonaeum etc.), the intestines external administration is carried out in implantation, but nasal administration, can be by for example soaking or embathing, spraying, sprinkle and water, drop, clean, dust, and by means of the moldings that contains reactive compound, necklace for example, ear tag, tail tag, limbs ligature (limbband), halter, concentrator marker or the like carries out percutaneous drug delivery.
When being used for livestock, poultry, domestic animal etc., preparation (for example powder, emulsion, the colloidal suspending agent) form that active agent combinations can contain the reactive compound of 1 to 80 weight % is directly used, use after also can diluting 100 to 10000 times, or described bond is used as chemical Medicatedbath lotion (chemical dip).
In addition, found that active agent combinations of the present invention shows the stronger insect active that kills to the insect of damaging industrial materials.
Mode with non-limiting instance can preferably propose following insect:
Beetle, for example North America house longhorn beetle, Chlorophorus pilosis, the furniture death watch beetle, report dead death watch beetle (Xestobium rufovillosum), Ptilinus pectinicornis (Ptilinuspecticornis), Dendrobium pertinex, pine death watch beetle (Ernobius mollis), Priobium carpini, Lyctus brunneus Stephens (Lyctus brunneus), Africa powder moth (Lyctusafricanus), south powder moth (Lyctus planicollis), quercitron moth (Lyctuslinearis), pubescence powder moth (Lyctus pubescens), Trogoxylon aequale, minthea rugicollis (Minthes rugicollis), material bark beetle kind (Xyleborus spec.), Tryptodendron spec., coffee black long moth-eaten (Apate monachus), Mongolian oak long moth-eaten (Bostrychus capucins), brown different wing long moth-eaten (Heterobostrychus brunneus), long moth-eaten plant (the Sinoxylon spec.) of sour jujube, dinoderus minutus (Dinoderus minutus).
Dermaptera insect (dermapteran), for example big wood wasp (Sirex juvencus), the big wood wasp of fir (Urocerus gigas), safe wood wasp (Urocerus gigas taignus), the Urocerus augur of strengthening.
Termite, for example European kalotermitid (Kalotermes flavicollis), a fiber crops heap sand termite (Cryptotermes brevis), ash point different termite (Heterotermes indicola), American-European reticulitermes flavipe (Reticulitermes flavipes), Sang Te reticulitermes flavipe (Reticulitermes santonensis), southern Europe reticulate pattern termite (Reticulitermeslucifugus), Darwin Australia termite (Mastotermes darwiniensis), the ancient termite (Zootermopsis nevadensis) in Nevada, coptotermes formosanus (Coptotermesformosanus).
Moth, for example silverfish.
The implication of industrial materials is interpreted as non-living body (non-living) material among the present invention, for example, is preferably polymer, adhesive, glue, paper and sheet material, leather, timber, Wood products and coating.
To be protected with especially preferred timber of the material of avoiding insect pest infestation and Wood products.
Can or contain the timber of mixture protection of described composition and the implication of Wood products is interpreted as by composition of the present invention, for example:
Construction timber, wooden frame, railroad tie, bridge module, jetty, the wooden vehicles, case, carriage, container, electric pole, wooden fagging (wood lagging), wooden doors and windows, plywood, particle board, joinery, or be usually used in the Wood products of house building or construction carpenter.
Active agent combinations can directly use, and perhaps uses with concentrate or general conventional formulation form, for example powder, granule, solution, suspending agent, emulsion or paste.
Above-mentioned preparation can prepare in a manner known way, for example reactive compound and at least a solvent or thinner, emulsifier, dispersant and/or adhesive or fixative, waterproofing agent are mixed, the words that need also can be mixed with desiccant and UV stabilizing agent, and the words that need also can be mixed with colouring agent, pigment and other processing auxiliary agent.
Be used to protect the insecticidal mixtures or the concentrate of timber and Wood products, containing concentration is 0.0001 to 95 weight %, particularly the reactive compound of the present invention of 0.001 to 60 weight %.
The usage amount of composition or concentrate depends on kind, quantity and the medium of insect.Optimum quantum of utilization can be respectively used test and is determined by a series of.But generally speaking, be benchmark with material to be protected, use 0.0001 to 20 weight %, the reactive compound of preferred 0.001 to 10 weight % is just enough.
Suitable solvent and/or thinner are organic chemistry solvent or solvent mixture, and/or low volatility oily or oil type organic chemistry solvent or solvent mixture, and/or polar organic solvent or solvent mixture, and/or water, and suitable words also have emulsifier and/or wetting agent.
The preferred organic chemistry solvent that uses as evaporation number (evaporation number) be higher than 35, flash-point is higher than 30 ℃, preferably is higher than 45 ℃ oily or oil type solvent.Described water-fast low volatility oily that uses and oil type solvent are mineral oil or its aromaticity cut that suits or the solvent mixture that contains mineral oil, preferred petroleum solvent, oil and/or alkylbenzene.
Oil that bobbin oil, the boiling range that petroleum solvent, the boiling range that mineral oil, the boiling range that the use boiling range is 170 to 220 ℃ is 170 to 220 ℃ is 250 to 350 ℃ is 160 to 280 ℃ and aromatic, turpentine wet goods are favourable.
In a preferred embodiment, the aromatic hydrocarbon that liquid fat hydrocarbon that the use boiling range is 180 to 210 ℃ or boiling range are 180 to 220 ℃ and high boiling mixture and/or the bobbin oil and/or the naphthalene monochloride of aliphatic hydrocarbon, preferred α-naphthalene monochloride.
Evaporation number is higher than 35, flash-point is higher than 30 ℃, preferably is higher than 45 ℃ organic oily of low volatility or oil type solvent, can partly replace with high volatile volatile or medium volatile organic chemistry solvent, as long as solvent mixture also has and is higher than 35 evaporation number and is higher than 30 ℃, preferably is higher than 45 ℃ flash-point, but and described mixture solvable or emulsification in this solvent mixture.
In a preferred embodiment, the part of organic chemistry solvent or solvent mixture or aliphatic polar organic solvent or solvent mixture is replaced.The preferred aliphatic organic chemistry solvent that comprises hydroxyl and/or ester group and/or ether, for example glycol ether, the ester etc. of using.
The organic chemistry adhesive that uses for purpose of the present invention is synthetic resin; And/or can in water, dilute and/or can be in the organic chemistry solvent that uses the own known bonding drying oil (binding drying oil) of dissolving or dispersion or emulsification, particularly form by following material, or comprise the adhesive of following material: acrylic resin, vinylite is polyvinyl acetate for example, mylar, polycondensation or polyaddition resin, polyurethane resin, alkyd resins or modified alkyd resin, phenol resin, hydrocarbon resins is indenes/cumarone resin for example, silicone resin, dry vegetable oil and/or drying oil and/or based on the physics dry adhesive of natural and/or synthetic resin.
As the synthetic resin of adhesive can emulsion, dispersion or solution form use.Pitch or bitumen also can be used as adhesive, and consumption is up to 10 weight %.In addition, also can use colouring agent, pigment, waterproofing agent, mask agent and inhibitor or corrosion inhibitor or the like, above material itself is known.
According to the present invention, composition or concentrate preferably contain at least a alkyd resins or modified alkyd resin, and/or dry vegetable oil is as the organic chemistry adhesive.The preferred alkyd resins that uses according to the present invention, its oil content is higher than 45 weight %, preferred 50 to 68 weight %.
Can partly or entirely be fixed agent (mixture) or plasticizer (mixture) of above-mentioned adhesive replaces.Described additive is used to prevent the reactive compound volatilization, also prevents crystallization or precipitation.Described additive preferably replaces 0.01 to 30% adhesive (is 100% in employed adhesive).
Plasticizer comes from following chemical classes: phthalic acid ester, for example dibutyl phthalate, dioctyl phthalate or phthalic acid benzyl butyl ester; Phosphate, for example tributyl phosphate; Adipate ester, for example adipic acid two (2-ethylhexyl) ester; Stearate, for example butyl stearate or amyl stearate; Oleate, for example butyl oleate; Glycerine ether or HMW glycol ether, glycerine ester and p-toluenesulfonic esters.
Fixative is chemically based on polyethylene alkyl ether, polyvinyl methyl ethermaleic anhydride for example, or based on ketone, for example benzophenone and ethylene Benzophenone.
Solvent that other is suitable or thinner, particularly water can be used as the mixture with one or more above-mentioned organic chemistry solvents or thinner, emulsifier and dispersant if appropriate.
Especially effectively wood protection is finished by plant-scale impregnation technology, for example vacuum, two vacuum or pressure process.
Active agent combinations of the present invention can be used to protect the object that contacts with salt solution or brackish water simultaneously, and for example hull, sieve, net, building, mooring equipment and signal system are in case produce dirt.
Oligochaeta (Oligochaeta) animal by anchorage, Serpulidae (Serpulidae) for example, and by the kind of shell (shell) and Ledamorpha class (goose tender tea leaves lotus (goosebarnacles)), for example different tender tea leaves lotuses belongs to (Lepas) and armour tender tea leaves lotus belongs to (Scalpellum) kind, or by the kind of barnacle (Balanomorpha) class (barnacle (acornbarnacles)), for example Balanus (Balanus) or tortoise foot belongs to the dirt that (Pollicipes) kind causes, can improve the frictional resistance of ship, thereby cause the remarkable increase of the operating cost that produces owing to frequent delay extra in high energy consumption and the dry dock.
Remove algae, for example outside the dirt that Ectocarpus kind (Ectocarpus sp.) and Ceratium kind (Ceramiumsp.) cause, by being included into also particular importance of dirt that the Entomostraka class that is generically and collectively referred to as cirrus guiding principle (Cirripedia) anchorage (cirripedcrustaceans) causes.
Beat all is to have now found that active agent combinations of the present invention has outstanding antifouling activity.
Use active agent combinations of the present invention, can avoid using the heavy metal in the following compound, described compound comprises, for example, two (trialkyltin) sulphide, three-normal-butyl tin dilaurate, three-normal-butyl chlorination tin, cuprous oxide (I), ethyl tin chloride, three-normal-butyl (2-phenyl-4-chlorophenoxy) tin, tributyltin oxide, molybdenum bisuphide, antimony oxide, n-butyl titanate polymer, phenyl (two pyridine) bismuth trichloride, three-normal-butyl tin fluoride, the two thiocarbamic acid manganese of vinyl, zine dimethyldithiocarbamate, the two thiocarbamic acid zinc of vinyl, the zinc salt and the mantoquita of 2-pyridine thiol 1-oxide, two Methyl disulfide are for the two thiocarbamates (bisdimethyldithiocarbamoylzincethylenebisthiocarbamate) of the vinyl of carbamyl zinc, zinc oxide, vinyl bisdithiocarbamic cuprous (I), cupric thiocyanate, copper naphthenate and tributyltin halide, or significantly reduce the working concentration of described compound.
If suitable, make stand-by anti-fouling paint and also can include other reactive compound in addition, preferred algicide, fungicide, weed killer herbicide, invertebrate poison, or other antifouling activity compound.
The preferred suitable component that combines with antifouling composition of the present invention is:
Algicide, 2-tert-butyl group amino-4-cyclopropyl amino-6-methyl mercapto-1 for example, 3,5-triazine, dichlorophen (dichlorophen), diuron (diuron), endothall (endothal), fentinacetate (fentin acetate), isoproturon (isoproturon), methabenz thiazuron (methabenzthiazuron), Oxyfluorfen (oxyfluorfen), quinoclamine (quinoclamine) and terbutryn (terbutryne);
Fungicide, benzo [b] thiophene carboxylic acid cyclohexyl amide S for example, S-dioxide, Euparen (dichlofluanid), fluorfolpet, 3-iodo-2-propynyl butyl carbamate, tolyfluanid (tolyfluanid), and pyroles, for example penta ring azoles (azaconazole), cyproconazole (cyproconazole), oxole bacterium (epoxyconazole), own azoles alcohol (hexaconazole), ring penta azoles bacterium (metconazole), propiconazole (propiconazole) and Tebuconazole (tebuconazole);
Invertebrate poison, for example fentinacetate, Halizan (metaldehyde), mercaptodimethur (methiocarb), niclosamide (niclosamid), UC-51762 (thiodicarb) and Landrin (trimethacarb);
Or conventional antifouling activity compound; for example 4; 5-two chloro-2-octyl groups-4-isothiazoline-3-ketone, diiodomethylparatryl sulfone, 2-(N; N-dimethyl thiocarbamoyl sulphur)-5-nitrothiazole base, sylvite, mantoquita, sodium salt and the zinc salt of 2-pyridine mercaptan 1-oxide, pyridine/triphenyl borane, the tetrabutyl two tin oxirane, 2; 3; 5; 6-tetrachloro-4-(mesyl) pyridine, 2; 4; 5; 6-daconil M, tetramethylthiuram disulfide and 2,4,6-trichlorophenyl maleimide.
The antifouling composition of the present invention that uses contains 0.001 to 50 weight %, the particularly reactive compound of the present invention of 0.01 to 20 weight % concentration.
In addition, antifouling composition of the present invention also contains conventional component, Ungerer for example, Chem.Ind.1985,37,730-732 and Williams, Antifouling MarineCoatings, Noyes, Park Ridge, the composition described in 1973.
Except that killing algae, antifungal, killing mollusk reactive compound and of the present invention killing the insect active compound, anti-fouling paint also can contain, particularly adhesive.
The examples of adhesives of generally acknowledging is the polyvinyl chloride in the dicyandiamide solution, chlorinated rubber in the dicyandiamide solution, acrylic resin in dicyandiamide solution, the particularly Aquo System, the vinyl chloride of aqueous dispersion form or organic solvent system form/vinyl acetate copolymer system, Butadiene/acrylic-nitrile rubber, drying oil is Linseed oil for example, resin ester or the modification hardening resin that combines with tar or pitch, pitch and epoxide, a spot of chlorine rubber (chlorinerubber), chlorinated polypropylene and vinyl.
If appropriate, lacquer also contains inorganic pigment, organic pigment or the colouring agent that preferably is insoluble to salt solution.Lacquer can further contain the material that makes the reactive compound controlled release, for example rosin.In addition, described lacquer also can contain plasticizer, influence modifier and other conventional ingredient of rheological properties.Compound of the present invention or said mixture also can be contained in the polishing antifouling system.
Active agent combinations of the present invention also is suitable for preventing and treating the animal pest of finding in the enclosure space, particularly insect, arachnid and acarid, described enclosure space comprises, for example residence, factory floor, office, vehicles workplace (vehicle cabin) etc.The family expenses that described bond can be used on the described insect of control kill in the insect product.They all have activity to sensitive species and resistance species and whole developmental stage.Described insect comprises:
Scorpionida (Scorpionidea), for example, the yellow scorpion (Buthus occitanus) in Mediterranean.
Acarina (Acarina), for example, adobe tick (Argas persicus), argas reflexus (Argas reflexus), tongue mite subspecies (Bryobia ssp.), Dermanyssus gallinae, sweet mite (Glyciphagus domesticus) is had a liking for by family, tampan tick (Ornithodorusmoubat), brown dog tick (Rhipicephalus sanguineus), eutrombicula alfreddugesi (Trombicula alfreddugesi), Neutrombicula autumnalis, the spy has a liking for skin mite (Dermatophagoides pteronissimus), method is had a liking for skin mite (Dermatophagoides forinae).
Araneida (Araneae), for example, catching bird spider (Aviculariidae), circle spider (Araneidae).
Opiliones (Opiliones), for example, chelifer (Pseudoscorpiones chelifer), the blind spider of the Chang Shin of Pseudoscorpiones cheiridium, (Opiliones phalangium).
Isopoda, for example, comb beach louse, ball pillworm.
Doubly sufficient order, for example, Blaniulus guttulatus, mountain cricket worm (Polydesmus spp.).
Lip foot order, for example, DIWUGONG (Geophilus spp.).
Silverfish order (Zygentoma), for example, the comb silverfish belongs to kind of (Ctenolepisma spp.), a silverfish, robber fireworm (Lepismodes inquilinus).
Blattaria, for example, oriental cockroach, blatta germanica, Asia Lian (Blattella asahinai), leucophaea maderae, angle abdomen Lian belong to kind of (a Panchlora spp.), wooden Lian belongs to kind of (Parcoblattaspp.), an Australian cockroach (Periplaneta australasiae), American cockroach, big brown big Lian (Periplaneta brunnea), smoke Perilpaneta americana (Periplaneta fuliginosa), brown belt blattaria (Supella longipalpa).
Saltatoria (Saltatoria), for example, tame Xi.
Dermaptera, for example, European earwig.
Isoptera, for example, kalotermitid belongs to kind of (Kalotermes spp.), a Reticulitermes kind.
Corrodentia (Psocoptera), for example, Lepinatus spp., powder corrodent belong to kind of (a Liposcelis spp.).
Coleoptera, for example, Anthrenus kind, fur moth-eatenly belong to kind, khapra beetle belongs to kind, a long ostomatid (Latheticus oryzae), latent instep cuckoo Eimeria kind (Necrobia spp.), Ptinus kind, lesser grain borer, grain weevil (Sitophilus granarius), rice weevil (Sitophilus oryzae), corn weevil (Sitophilus zeamais), Stegobium paniceum (Stegobium paniceum).
Diptera, for example, Aedes aegypti (Aedes aegypti), aedes albopictus (Aedesalbopictus), aedes taeniorhynchus (Aedes taeniorhynchus), the Anopheles kind, calliphora erythrocephala, great number fiber crops horsefly (Chrysozona pluvialis), five band Culex pipiens pallens (Culexquinquefasciatus), northern house (Culex pipiens), ring beak culex (Culextarsalis), Drosophila kind (Drosophila spp.), Fannia canicularis (Fanniacanicularis), housefly (Musca domestica), the owl midge kind, Sarcophagacarnaria, the Simulium kind, tatukira (Stomoxys calcitrans), the Europe daddy-longlegs.
Lepidoptera, for example, lesser wax-moth (Achroia grisella), greater wax moth, Indian meal moth (Plodia interpunctella), stopper rain moth (Tinea cloacella), bag rain moth, curtain rain moth.
Siphonaptera, for example, ctenocephalides canis (Ctenocephalides canis), ctenocephalides felis (Ctenocephalides felis), Pulex irritans (Pulex irritans), chigo (Tunga penetrans), Xanthopsyllacheopis.
Hymenoptera, for example, blazon hunchbacked ant (Camponotus herculeanus), black smelly ant (Lasius fuliginosus), black ant (Lasius niger), Lasius umbratus, MonomoriumMayr, Paravespula spp., Pavement Ant (Tetramorium caespitum).
Anoplura (Anoplura), for example, head louse (Pediculus humanus capitis), body louse, crab louse (Phthirus pubis).
Heteroptera, for example, cimex hemipterus (Cimex hemipterus), bed bug, phodnius prolixus, invasion triatomid (Triatoma infestans).
Described bond uses in the following manner: aerosol, nothing are pressed spraying (pressurelessspray) product, for example pump and atomisation agent (atomizer spray), automatically atomizing system, fogger, foam, gel, have evaporator that cellulose or polymer make with evaporator product, liquid evaporator, gel and the thin film evaporator of tablet (evaporator tablet), evaporator, unpowered (energy-free) or passive (passive) vapo(u)rization system that propellant promotes, catch moth paper, catch the moth bag and catch moth glue; Granule or pulvis; The bait that is used for shedding or be used for Poison bait station (bait station).
All plants and plant parts all can be handled according to the present invention.The implication of plant is interpreted as all plants and plant population among the present invention, for example need and unwanted wild plant or crop plants (comprising the crop plants that nature exists).Crop plants can be by conventional breeding and optimum seeking method; or by biotechnology and genetic engineering method; or the plant that obtains of the combination by preceding method, comprise genetically modified plants, also comprise the plant cultivars that is subjected to the protection of plant seedling power or is not subjected to its protection.The implication of plant parts is interpreted as all grounds of plant and underground position and plant organ, and for example bud, leaf, Hua Hegen, the example that can mention have leaf, needle, stem, do, flower, fruit body, fruit, seed, root, stem tuber and rhizome.Plant parts also comprises the plant of gathering, and asexual and sexual propagation thing, for example rice shoot, stem tuber, rhizome, cutting and seed.
The processing that utilizes reactive compound that plant and plant parts are carried out of the present invention can directly be carried out according to conventional treatment method, or act on its environment, habitat or storage area according to conventional treatment method.Described conventional method is for example flooded, sprays, vaporizes, is atomized (atomizing), broadcasts sowing, applies, and under the situation of breeding thing, particularly seed, also can apply one or more layers.
As mentioned above, can handle all plants and position thereof according to the present invention.In a preferred embodiment, handled wild plant kind and plant cultivars, or, for example merged and the plant of acquisition by hybridization or protoplast by the biological breeding method of routine, and the position.In a further preferred embodiment, also can combine-and the genetically modified plants and plant cultivars (biology of genetic modification) and the position thereof that obtain if handled with conventional method by gene engineering method-suitable.Explain as above at term " position ", " position of plant " or " plant parts ".
Particularly preferably, plant cultivars plant commercially available separately or that use is all handled according to the present invention.
According to plant species or plant cultivars, its plantation place and growth conditions (soil, weather, vegetation period, nutrition), processing of the present invention also can produce superadditivity (superadditive) (" working in coordination with ") effect.Thus, for example, for the material and the composition that can use by the present invention, can reduce its rate of application and/or widen its action spectrum and/or improve its activity, can improve plant growing, improve high temperature or cold tolerance, raising drought tolerance or water or soil salt content tolerance, improve the quality of blooming, make gather simpler and easy, hasting of maturity, raising output, improve the quality of the product of gathering and/or improve its nutritive value, improve bin stability and/or its processing characteristics of the product of gathering, these can surpass the effect of actual desired.
Preferably (promptly by the pending genetically modified plants of the present invention or plant cultivars, plant by the gene engineering acquisition) be included in all plants of having accepted genetic material in the genetic modification, described genetic material is given described plant with particularly advantageous useful properties (" feature ").The example of described characteristic has: improve plant growing, improve high temperature or cold tolerance, raising drought tolerance or water or soil salt content tolerance, improve the quality of blooming, make gather simpler and easy, hasting of maturity, raising output, improve the quality of the product of gathering and/or improve its nutritive value, improve bin stability and/or its processing characteristics of the product of gathering.Need other examples of ben described characteristic to have: to improve the resistance of plant to animal and microorganism insect, for example to the resistance of insect, acarid, phytopathogenic fungi, bacterium and/or virus, and improve the tolerance of plant to some weeding active compound.The example of the genetically modified plants that can propose is important crop plants, such as grain (wheat, rice), corn, soybean, potato, cotton, tobacco leaf, rape (oilseedrape) and fruit tree (fruit is apple, pears, citrus fruits and grape), ben is corn, soybean, potato, cotton, tobacco leaf and rape.Ben characteristic (" feature ") is for by forming toxin in plant corpus, particularly by genetic material (for example gene C ryIA (a), CryIA (b), CryIA (c), CryIIA, CryIIIA, CryIIIB2, Cry9c Cry2Ab, Cry3Bb and CryIF and the combination thereof of bacillus thuringiensis,Bt; Be designated hereinafter simply as " Bt plant ") toxin that forms in plant corpus, improve the resistance of plant to insect, arachnid, nematode, worm.Ben other characteristics (" feature ") are for improving plant to fungi, bacterium and viral resistance by systemic acquired resistance (SAR), systemin, phytoalexin, releaser and resistant gene and corresponding marking protein and toxin.Ben other characteristics (" feature ") are for improving the tolerance of plant to some weeding active compound, for example imidazolone type, sulfonylurea, glyphosate or phosphinotricin (for example " PAT " gene).The described gene of giving desirable characteristics (" feature ") also can mutually combine in the genetically modified plants body.The example of " the Bt plant " that can mention is that commercially available brand name is YIELD GARD
Figure C20048003617600481
(for example corn, cotton, soybean), KnockOut
Figure C20048003617600482
(for example corn), StarLink
Figure C20048003617600483
(for example corn), Bollgard
Figure C20048003617600484
(cotton), Nucotn
Figure C20048003617600485
(cotton) and NewLeaf
Figure C20048003617600486
The corn variety of (potato), cotton variety, soybean varieties and potato kind.The example of the plant with herbicide tolerant that can mention is that commercially available brand name is Roundup Ready
Figure C20048003617600487
(having the glyphosate tolerance, for example corn, cotton, soybean), Liberty Link (having the phosphinotricin tolerance, for example rape), IMI
Figure C20048003617600489
(having imidazolinone-tolerant) and STS
Figure C200480036176004810
Corn variety, cotton variety and the soybean varieties of (having the sulfonylureas tolerance, for example corn).The plant with Herbicid resistant that can mention (with the plant of the herbicide tolerant mode breeding of routine) comprises that name is called Clearfield
Figure C200480036176004811
Commercially available kind (for example corn).Certainly, more than narration also is applicable to the plant cultivars with genetic characteristics described or leaved for development (" feature "), and described plant will be developed and/or goes on the market in future.
Above-mentioned plant can be handled with active compound combinations of the present invention in particularly advantageous mode according to the present invention.The preferable range of said mixture also is applicable to the processing of described plant.Ben is with the mixture that the present invention mentions especially plant to be handled.
Active agent combinations of the present invention good kills insect and kills the acarid activity and can find out by following examples.Though independent reactive compound activity a little less than, the activity that bond shows surpasses the simple superposition of each separate constituent activity.
When the activity of active agent combinations is higher than the active summation of reactive compound of independent use, promptly there is the synergistic effect of insecticide and acarus-killing.
The expection activity of the bond of two kinds of given reactive compounds can utilize " Colby formula " to calculate as follows (referring to " synergistic effect of weeding bond and the calculating of antagonistic effect " S.R.Colby, Weeds 15, 20-22):
If,
X for when with mThe rate of application of g/ha (hectare) or mKilling rate when the concentration of ppm is used reactive compound A is expressed as the percentage with respect to the untreated control group,
Y for when with nThe rate of application of g/ha or nKilling rate when the concentration of ppm is used reactive compound B is expressed as the percentage with respect to the untreated control group,
E for when with mWith nThe rate of application of g/ha or mWith nKilling rate when the concentration of ppm is used reactive compound A and B is expressed as the percentage with respect to the untreated control group,
Then,
E = X + Y - X · Y 100
。
If actual insect killing rate surpasses calculated value, then the activity of bond has superadditivity, promptly has synergistic effect.In this case, actual observation to killing rate must surpass adopt following formula calculate expection killing rate value (E).
Application Example
Embodiment A
The cotten aphid test
Solvent: the dimethyl formamide of 7 weight portions
Emulsifier: the alkylaryl polyglycol ether of 2 weight portions
For preparing suitable active agent preparations,, and dope is diluted to desired concn with the water that contains emulsifier with the reactive compound of 1 weight portion and the solvent and the emulsifier of described amount.
The cotton leaf (Gossypiumhirsutum) that will seriously be infected by cotten aphid (Aphis gossypii) immerses in the active agent preparations of desired concn to be handled.
Through behind the required time, determine the percentage killing rate.All cotten aphids are killed in 100% expression; No cotten aphid is killed in 0% expression.Determined killing rate calculates (seeing 47 pages) with the Colby formula.
In this test, for example, following the application's active agent combinations shows the activity of Synergistic with respect to the reactive compound of using separately:
Table A 1: the insect of harm plant
The cotten aphid test
Figure C20048003617600511
* measured value=actual measurement is active
* calculated value=usefulness Colby formula activity calculated
Table A 2: the insect of harm plant
The cotten aphid test
Figure C20048003617600512
* measured value=actual measurement is active
* calculated value=usefulness Colby formula activity calculated
Embodiment B
The black peach aphid test
Solvent: the dimethyl formamide of 7 weight portions
Emulsifier: the alkylaryl polyglycol ether of 2 weight portions
For preparing suitable active agent preparations,, and dope is diluted to desired concn with the water that contains emulsifier with the reactive compound of 1 weight portion and the solvent and the emulsifier of described amount.
The head cabbage leaf (Brassicaoleracea) that will seriously be infected by black peach aphid (Myzus persicae) immerses in the active agent preparations of desired concn to be handled.
Through behind the required time, determine the percentage killing rate.All black peach aphids are killed in 100% expression; No black peach aphid is killed in 0% expression.Determined killing rate calculates (seeing 47 pages) with the Colby formula.
In this test, for example, following the application's active agent combinations shows the activity of Synergistic with respect to the reactive compound of using separately:
Table B1: the insect of harm plant
The black peach aphid test
Figure C20048003617600531
* measured value=actual measurement is active
* calculated value=usefulness Colby formula activity calculated
Table B2: the insect of harm plant
The black peach aphid test
* measured value=actual measurement is active
* calculated value=usefulness Colby formula activity calculated
Embodiment C
The chrysomelid larva test of horseradish ape
Solvent: the dimethyl formamide of 7 weight portions
Emulsifier: the alkylaryl polyglycol ether of 2 weight portions
For preparing suitable active agent preparations,, and dope is diluted to desired concn with the water that contains emulsifier with the reactive compound of 1 weight portion and the solvent and the emulsifier of described amount.
Handle in the active agent preparations with head cabbage (Brassica oleracea) leaf immersion desired concn, when leaf is still moistening, insert horseradish ape chrysomelid (Phaedon cochleariae) larva.
Through behind the required time, determine the percentage killing rate.The chrysomelid larva of all apes is killed in 100% expression; Chrysomelid larva is killed the 0% no ape of expression.Determined killing rate calculates (seeing 47 pages) with the Colby formula.
In this test, for example, following the application's active agent combinations shows the activity of Synergistic with respect to the reactive compound of using separately:
Table C1: the insect of harm plant
The chrysomelid larva test of horseradish ape
Figure C20048003617600551
* measured value=actual measurement is active
* calculated value=usefulness Colby formula activity calculated
Table C2: the insect of harm plant
The chrysomelid larva test of horseradish ape
Figure C20048003617600552
* measured value=actual measurement is active
* calculated value=usefulness Colby formula activity calculated
Embodiment D
Diamond-back moth test (resistant strain)
Solvent: the dimethyl formamide of 7 weight portions
Emulsifier: the alkylaryl polyglycol ether of 2 weight portions
For preparing suitable active agent preparations,, and dope is diluted to desired concn with the water that contains emulsifier with the reactive compound of 1 weight portion and the solvent and the emulsifier of described amount.
Handle in the active agent preparations with head cabbage (Brassica oleracea) leaf immersion desired concn, when leaf is still moistening, insert diamond-back moth (Plutella xylostella, resistant strain) larva.
Through behind the required time, determine the percentage killing rate.All larvas are killed in 100% expression; No larva is killed in 0% expression.Determined killing rate calculates (seeing 47 pages) with the Colby formula.
In this test, for example, following the application's active agent combinations shows the activity of Synergistic with respect to the reactive compound of using separately:
Table D: the insect of harm plant
Diamond-back moth test (resistant strain)
Figure C20048003617600571
* measured value=actual measurement is active
* calculated value=usefulness Colby formula activity calculated
Embodiment E
The greedy noctuid test in meadow
Solvent: the dimethyl formamide of 7 weight portions
Emulsifier: the alkylaryl polyglycol ether of 2 weight portions
For preparing suitable active agent preparations,, and dope is diluted to desired concn with the water that contains emulsifier with the reactive compound of 1 weight portion and the solvent and the emulsifier of described amount.
Handle in the active agent preparations with head cabbage (Brassica oleracea) leaf immersion desired concn, when leaf is still moistening, insert greedy noctuid (Spodopterafrugiperda) larva in meadow.
Through behind the required time, determine the percentage killing rate.All larvas are killed in 100% expression; No larva is killed in 0% expression.Determined killing rate calculates (seeing 47 pages) with the Colby formula.
In this test, for example, following the application's active agent combinations shows the activity of Synergistic with respect to the reactive compound of using separately:
Table E: the insect of harm plant
The greedy noctuid test in meadow
Figure C20048003617600591
* measured value=actual measurement is active
* calculated value=usefulness Colby formula activity calculated

Claims (5)

1. the composition that contains the anthranilamide of the compound of formula (I-a-4) and at least a formula (II-1),
Figure C2004800361760002C1
Wherein
R 2Represent hydrogen or methyl,
R 3Represent C 1-C 4Alkyl,
R 4Represent methylidene, trifluoromethyl, trifluoromethoxy, fluorine, chlorine, bromine or iodine,
R 5Represent hydrogen, fluorine, chlorine, bromine, iodine, trifluoromethyl or trifluoromethoxy,
R 7Represent chlorine or bromine,
R 9Represent trifluoromethyl, chlorine, bromine, difluoro-methoxy or trifluoro ethoxy.
2. the composition of claim 1 contains the compound of formula (I-a-4) and the anthranilamide of at least a (II-1) with 500: 1 to 1: 50 ratios.
3. claim 1 or the 2 described compositions purposes that is used to prevent and treat animal pest.
4. prepare the method for insecticide, it is characterized in that, claim 1 or 2 described compositions are mixed with filler and/or surfactant.
5. the method for control animal pest is characterized in that, claim 1 or 2 described compositions are applied to animal pest and/or its habitat.
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