CN100388923C - Chinese-medicinal preparation and making method for treating acute corneitis and releasing visual fatigue - Google Patents
Chinese-medicinal preparation and making method for treating acute corneitis and releasing visual fatigue Download PDFInfo
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- CN100388923C CN100388923C CNB2006100169689A CN200610016968A CN100388923C CN 100388923 C CN100388923 C CN 100388923C CN B2006100169689 A CNB2006100169689 A CN B2006100169689A CN 200610016968 A CN200610016968 A CN 200610016968A CN 100388923 C CN100388923 C CN 100388923C
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Abstract
A Chinese medicine for treating acute conjunctivitis and keratitis and relaxing visual fatigue is prepared from bear gall and borneol. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of ophthalmic diseases, a kind of Chinese medicine preparation for the treatment of acute keratitis, alleviating asthenopia is especially disclosed, be used for the treatment of acute bacterial eye conjunctivitis, epidemic keratoconjunctivitis, but alleviating asthenopia also, the preparation technology of this medicine is provided simultaneously, has belonged to traditional Chinese medical science pharmaceutical technology field.
Background technology
Acute bacterial eye conjunctivitis, epidemic keratoconjunctivitis belong to common clinical, frequently-occurring disease, and especially be high period of disease spring.As untimely treatment, usually can cause mass-sending in the many places of crowds such as unit, school; Asthenopia is the comparatively common disease of a kind of clinical ophthalmology, and it is owing to reason such as excessively watching attentively, and the momentary visual function that causes goes down and a series of malaise symptoms.The blurred vision that goes out to lose face, eye is dried, puckery, bitterly, symptom such as itch, symptoms such as nauseating dizzy and general malaise appear in weight person.Be everlasting and take place among the excess eye-using crowds such as student, Computer worker, driver.Asthenopia is not a kind of independently disease, but a kind of syndrome.
At present, for treatment acute bacterial conjunctivitis, epidemic keratoconjunctivitis, though ocular disease such as the eye due to the eyestrain does, itches, puckery, pain have many medicines, and some curative effects have been obtained, but mostly be chemical drugs, some side effect, untoward reaction are often arranged, still lack distinguished and the medicine that untoward reaction is little of effect.So people still a kind ofly can treat acute bacterial conjunctivitis, epidemic keratoconjunctivitis seeking, the Chinese medicine liquid eye drip preparation of ocular disease such as the eye due to the eyestrain does, itches, puckery, pain and few side effects, safe, determined curative effect.
Summary of the invention
The invention provides a kind of Chinese medicine preparation for the treatment of acute keratitis, alleviating asthenopia, have significant curative effect, and the little characteristics of toxic and side effects.
The invention also discloses the preparation technology of above-mentioned Chinese medicine preparation, be applicable to suitability for industrialized production.
To acute keratitis and asthenopic pathogenesis and Therapeutic Principle, selected natural drug is a raw material prescription compatibility, makes Chinese medicine preparation according to China's Chinese medicine in the present invention, and it is made active component raw material and is made up of the component of following per distribution ratio:
Fel Ursi powder 7%～21%, natural Broneolum Syntheticum 2.3%～6.9%.
Chinese medicine preparation of the present invention, its preparation component of making mainly is made up of following per distribution ratio:
Fel Ursi powder 7%～21%, natural Broneolum Syntheticum 2.3%～6.9%, Borax 4.65%～13.95%, boric acid 23.2%～69.6%, sodium chloride 7.65%～22.95%, ethyl hydroxybenzoate 0.6%～1.8%, sodium carboxymethyl cellulose 4.65%～13.95%.
The concrete production technology of medicine of the present invention may further comprise the steps: get Fel Ursi powder, add 10 times of water gaging dissolvings, adding ethanol to determining alcohol again is 50%, refluxes 1 hour, filters, and the filtrate decompression evaporate to dryness is pulverized; With Borax, boric acid, sodium chloride, ethyl hydroxybenzoate, stir soluble in waterly, filter, standby.Get Borneolum Syntheticum and be dissolved in 10 times of amount ethanol, adding waits water gaging again, after crystallite to be had is separated out, filters, and water flushing crystallite is to there not being the alcohol flavor; Sodium carboxymethyl cellulose is placed water, left standstill 24 hours, sucking filtration is collected filtrate, will dissolve in this carboxymethylcellulose sodium solution with Borneo camphor.
Merge above-mentioned two kinds of solution, add water to 1000ml, mixing, sterilization, packing, promptly.
Side's mesoboric acid, Borax are transferred pH value as buffer agent, scope 5～9; With sodium chloride, ethyl hydroxybenzoate as isoosmotic adjusting agent, scope 0.7～1.5%; With sodium carboxymethyl cellulose etc. as the viscosity regulator, scope 5～8 centipoises; And antiseptic etc. is made Chinese medicine compound eye drip preparation jointly.
Function cures mainly: resolving heat and reducing pathogenic fire, improving acuity of vision and removing nebula, spasmolytic are used for the acute bacterial conjunctivitis that flaming up of liver-fire, pyretic toxicity are hindered the network type, epidemic keratoconjunctivitis.The eye of stagnated heat of liver channel type is done, is itched, puckery, pain symptom, and alleviates the eyestrain.
Usage and dosage: eye drip, each 1-2 drips, and 6 times on the one, or follow the doctor's advice.
The Fang Xieyu pharmacology analysis: among the present invention, Fel Ursi powder, the nature and flavor bitter cold, nontoxic, the function heat-clearing and toxic substances removing, antibacterial anti-inflammatory, suppressing the hyperactive liver makes eye bright, and spasmolytic is monarch drug; Borneolum Syntheticum, nature and flavor are worked hard, are slightly cold, and function is led to all keys, the stagnated fire of loosing, and the nebula of dispelling makes eye bright, and clearing away heat to alleviate pain is ministerial drug.Two medicines are formed resolving heat and reducing pathogenic fire jointly, improving acuity of vision and removing nebula, the agent of spasmolytic.All flaming up of liver-fire, pyretic toxicity are hindered acute bacterial conjunctivitis, the epidemic keratoconjunctivitis of network type, and ocular disease such as the eye due to the eyestrain of stagnated heat of liver channel type does, itches, puckery, pain use this product eye drip very suitable.
Below experiment shows the clinical therapeutic efficacy of medicine of the present invention:
One, Drug therapy flaming up of liver-fire of the present invention, pyretic toxicity are hindered the acute bacterial conjunctivitis of network type, the clinical research of epidemic keratoconjunctivitis.
(1) diagnostic criteria
1, flaming up of liver-fire, pyretic toxicity are hindered network syndrome standard:
(1) conjunctival congestion scorching hot swell and ache or white of the eye on point-like or lamellar hemorrhage are arranged, a lot of secretion in the eye sticks that eyelid, photophobia are shed tears, blurred vision, black eyeball punctate keratitis.
(2) reach node under the jaw before fever of the body headache, xerostomia, bitter taste, yellow urine dry stool or the ear.
(3) red tongue with yellow fur, stringy pulse or number.
2, doctor trained in Western medicine medical diagnosis on disease standard
(1) acute bacterial conjunctivitis
1. morbidity is anxious, mostly is bilateral, and contact history is often arranged.
2. foreign body sensation or burn feeling are arranged, with slight photophobia shed tears, secretions is many, morning time-out up and down margo palpebrae often have secretions to adhere blurred vision.
3. conjunctival congestion is remarkable, and is the most remarkable with near conjunctival congestion palpebral conjunctiva and the fornices, seriously ill person's eyelid swelled, and chemosis, and can be with point-like, lamellar subconjunctival hemorrhage.
4. the conjunctival epithelium scraping blade can be seen polynucleosis.
5. the person that do not have ready conditions makes antibacterial culturing can obtain positive pathogenic bacterium.
(2) epidemic virus membranous conjunctivitis
When 1. falling ill upper respiratory tract infection symptoms can be arranged.
2. morbidity is anxious, mostly is bilateral, and outbreak of epidemic has seriously to keep in dark place, shed tears and foreign body sensation sometimes.
3. many with reaching the submandibular lymph nodes enlargement before the ear.
4. conjunctiva is significantly congested, bulbar conjunctiva and blepharoedema, and watery secretion, point-like or lamellar are hemorrhage under the multiple conjunctiva.
5. conjunctival epithelium comes off, and the painted back of the fluorescein ancient blue streak of slit lamp is down that the thin point-like epithelium layer down of green reaches the infiltration of essence shallow-layer down.
6. corneal sensation is gone down or is disappeared.
7. scraping blade can be seen monocytosis.
8. the person that do not have ready conditions makes virus and separates susceptible of proof.
(2) efficacy assessment standard
1, traditional Chinese medical science sign efficacy determination
Recovery from illness: symptomatology and sign integration≤2 minute.
Produce effects: symptomatology and sign integration reduce more than 2/3.
Effectively: symptomatology and sign integration reduce more than 1/3.
Invalid: symptomatology and sign integration reduce less than 1/3.
2, doctor trained in Western medicine efficacy determination
1. acute bacterial conjunctivitis
Cure: 1) subjective symptoms and local inflammation disappear, integration≤2 minute.
2) antibacterial culturing feminine gender, conjunctival epithelium scraping blade are normal.
Produce effects: subjective symptoms and local inflammation take a turn for the better, and integration reduces more than 2/3.
Effectively: subjective symptoms and local inflammation take a turn for the better, and integration reduces more than 1/3.
Invalid: subjective symptoms and local inflammation no change, integration reduces less than 1/3.
2. epizootic disease toxicity keratoconjunctivitis
Cure: 1) subjective symptoms disappears, integration≤2 minute.
2) local inflammation disappears, the corneal dyeing feminine gender.
3) the scraping blade microscopy is normal.
Produce effects: subjective symptoms and local inflammation are clearly better, and integration reduces more than 2/3.
Effectively: subjective symptoms and local inflammation take a turn for the better, and integration reduces more than 1/3.
Invalid: subjective symptoms and local inflammation no change, integration reduces less than 1/3.
(3) therapeutic effect
By Chinese Chinese medicine academy Gate of Pervasive Peace hospital as responsible department, Jilin Province Affiliated Hospital of the academy of traditional Chinese medicine, Attached Hospital, Changchun Chinese Medicinal College, 304 hospitals of PLA finish jointly.Be selected into case 300 examples (541 eyes) altogether, adopt medicine of the present invention to treat, total effective rate is 97.41%, and total obvious effective rate is 84.47%.Matched group: acute bacterial conjunctivitis adopts rifampicin eye drop, and the epidemic virus membranous conjunctivitis adopts acyclovir eyedrop, treats 150 examples (286 eyes) altogether, and total effective rate is 93.01%, total obvious effective rate 65.38%.Two groups of curative effects compare P＜0.01, and utmost point significant difference is arranged, and illustrate that the curative effect of Drug therapy acute bacterial conjunctivitis of the present invention and epizootic disease toxicity keratoconjunctivitis is better than matched group.All case is not found untoward reaction and toxic and side effects, and hepatic and renal function is had no adverse reaction.Prove that medicine of the present invention is that treatment flaming up of liver-fire, pyretic toxicity are hindered the acute bacterial conjunctivitis of network type, effective, convenient, the safe drugs of epidemic keratoconjunctivitis.
Two, the eye of Drug therapy stagnated heat of liver channel type of the present invention do, itch, puckery, pain symptom, and alleviate asthenopic clinical research.
(1) diagnostic criteria and definite foundation
1. Western medicine diagnose standard:
1. reading or watch fine work attentively can not lasting, temporary blurred vision.
2. tired, the eye of eye sourly expands, eye is dry and astringent, conjunctival congestion.
Possess 1., 2. each above person is promptly diagnosable in the bar.
2. tcm diagnosis, dialectical standard
The dialectical foundation of stagnated heat of liver channel:
Main symptom: 1. being unable to see for a long time, the time existing dim-sighted
2. the sour distending pain of eye is dry and astringent scorching hot
Inferior card: 1. born of the same parents' hyperemia of the palpebral conjunctiva
2. giddy or headache
3. vexed, or uneasy sleeping at night, or distending pain over the hypochondrium
4. bitter taste
5. superciliary ridge is ached
6. red tongue with thin and yellow fur
7. stringy pulse or stringy and rapid pulse
Possess main symptom and time 2 of cards or abovely can be diagnosed as this pattern of syndrome
(2) efficacy assessment standard
Asthenopic efficacy assessment standard
1, cure: adhere to the close eye time more than 1 hour, eye symptom and General Symptoms disappear, and total score value reduces 100% than original.
2, produce effects
1. adhere to that the close eye time lengthening is more than 1 times or at 30-60 minute.
2. blurred vision, eye symptom such as eye is tired, eye is tired, eye is dry and astringent and General Symptoms, sign are obviously improved total score value than reducing more than 50% originally.
3, effective
1. adhere to 1/2 times of close eye time lengthening or more than.
2. tired, the sour distending pain of eye of eye, eye are dry and astringent, and eye symptom such as blurred vision and General Symptoms, sign have improvement, and total score value reduces 20～50% than original.
4, invalid
Every index does not reach above-mentioned effective standard person, and eye symptom and General Symptoms, sign do not have improvement, and total score value is than reducing below 20% originally.
(3) traditional Chinese medical science disease criterion of therapeutical effect: judge the disease curative effect according to integration method.
1. produce effects: symptom disappears substantially.n≥70％
2. effective: symptom is extenuated.30％≤n＜70％
3. invalid: the basic no change of symptom.n＜30％
(4) therapeutic effect
As responsible department, Attached Hospital, Changchun Chinese Medicinal College, Shanxi Institute of Traditional Chinese Medicine finish this experiment jointly by Hospital Affiliated To Chengdu Traditional Chinese Medicine Univ.Adopt medicine of the present invention as investigational agent, the ZHENSHIMING DIYANYE of employing equivalent effect is medicine in contrast, carries out parallel check experiment asthenopia disease 202 examples at random, has obtained satisfied clinical efficacy.The clinical research result of the test shows:
It is relatively interior with the preceding group of treatment to treat back three results that make a house call, test group and matched group asthenopia value all have obvious decline, effective percentage is respectively 97.05% and 95.10%, and treatment back test group and matched group tcm syndrome efficacy analysis effective percentage are respectively 92.15% and 89.21% (seeing Table 1,2).
Table 1 asthenopia clinical curative effect analysis
Annotate: produce effects=recovery from illness+produce effects, effectively=recovery from illness+produce effects+effectively,
Obvious effective rate compares: x
2=0.178 P=0.673; Effective percentage compares: x
2=0.520 P=0.471.
Table 2 tcm syndrome efficacy analysis
Annotate: effectively=produce effects+effectively, effective percentage compares: x
2=0.522 P=0.470.
Two groups of curative effects relatively illustrate the non-contrast medicine that is inferior to of the asthenopic effective percentage of agents alleviate of the present invention.All case is not found untoward reaction and toxic and side effects, proves that medicine of the present invention is to alleviate asthenopic effective, convenient, safe drugs.
In sum, by twice clinical research proof medicine of the present invention can resolving heat and reducing pathogenic fire, improving acuity of vision and removing nebula, spasmolytic, can be used for the acute bacterial conjunctivitis that flaming up of liver-fire, pyretic toxicity are hindered the network type, epidemic keratoconjunctivitis.The eye of stagnated heat of liver channel type is done, is itched, puckery, pain symptom, and alleviates the eyestrain.
The specific embodiment:
By following examples the present invention is described for example further, and do not limit the present invention in any way, under the prerequisite that does not deviate from technical solution of the present invention, any change or change that those of ordinary skills that the present invention did are realized easily all will fall within the claim scope of the present invention.
Embodiment 1
Get Fel Ursi powder 3g, add 10 times of water gaging dissolvings, adding ethanol to determining alcohol again is 50%, refluxes 1 hour, filters, and the filtrate decompression evaporate to dryness is pulverized; With 2g Borax, 10g boric acid, 3.3g sodium chloride, 0.25g ethyl hydroxybenzoate, stirring is dissolved in the 400ml water, filters, and is standby.Get the 1g Borneolum Syntheticum and be dissolved in 10 times of amount ethanol, adding waits water gaging again, after crystallite to be had is separated out, filters, and water flushing crystallite is to there not being the alcohol flavor; The 2g sodium carboxymethyl cellulose is placed 500ml water, left standstill 24 hours, sucking filtration is collected filtrate, will dissolve in this carboxymethylcellulose sodium solution with Borneo camphor.
Merge above-mentioned two kinds of solution, add water to 1000ml, mixing, sterilization, packing, promptly.
Embodiment 2
Fel Ursi powder 4.5g is added 10 times of water gaging dissolvings, and adding ethanol to determining alcohol again is 50%, refluxes 1 hour, filters, and the filtrate decompression evaporate to dryness is pulverized; With 1g Borax, 5g boric acid, 1.6g sodium chloride, 0.1g ethyl hydroxybenzoate, stirring is dissolved in the 400ml water, filters, and is standby.Get the 0.5g Borneolum Syntheticum and be dissolved in 10 times of amount ethanol, adding waits water gaging again, after crystallite to be had is separated out, filters, and water flushing crystallite is to there not being the alcohol flavor; The 1g sodium carboxymethyl cellulose is placed 500ml water, left standstill 24 hours, sucking filtration is collected filtrate, will dissolve in this carboxymethylcellulose sodium solution with Borneo camphor.Above-mentioned two kinds of solution are merged, add water to 1000ml, mixing, sterilization, packing, promptly.
Embodiment 3
Get Fel Ursi powder 1.5g, add 10 times of water gaging dissolvings, adding ethanol to determining alcohol again is 50%, refluxes 1 hour, filters, and the filtrate decompression evaporate to dryness is pulverized; With 3g Borax, 14.5g boric acid, 4.9g sodium chloride, 0.38g ethyl hydroxybenzoate, stirring is dissolved in the 400ml water, filters, and is standby.Get the 1.4g Borneolum Syntheticum and be dissolved in 10 times of amount ethanol, adding waits water gaging again, after crystallite to be had is separated out, filters, and water flushing crystallite is to there not being the alcohol flavor; The 3g sodium carboxymethyl cellulose is placed 500ml water, left standstill 24 hours, sucking filtration is collected filtrate, will dissolve in this carboxymethylcellulose sodium solution with Borneo camphor.Merge above-mentioned two kinds of solution, add water to 1000ml, mixing, sterilization, packing, promptly.
Claims (3)
1. Chinese medicine preparation for the treatment of acute keratitis and alleviating asthenopia is characterized in that active raw materials is in the Chinese medicine preparation raw material total amount:
Fel Ursi powder 7%～21%, natural Broneolum Syntheticum 2.3%～6.9%, all the other are pharmaceutical adjunct.
2. Chinese medicine preparation according to claim 1 is characterized in that it being that the preparation component of making is made up of following per distribution ratio:
Fel Ursi powder 7%～21%, natural Broneolum Syntheticum 2.3%～6.9%, Borax 4.65%～13.95%, boric acid 23.2%～69.6%, sodium chloride 7.65%～22.95%, ethyl hydroxybenzoate 0.6%～1.8%, sodium carboxymethyl cellulose 4.65%～13.95%.
3. the production technology of claim 1 or 2 described Chinese medicine preparation may further comprise the steps: get Fel Ursi powder, add 10 times of water gagings dissolvings, adding ethanol to determining alcohol again is 50%, refluxes 1 hour, filters filtrate decompression evaporate to dryness, pulverizing; With Borax, boric acid, sodium chloride, ethyl hydroxybenzoate, stir soluble in waterly, filter, standby; Get Borneolum Syntheticum and be dissolved in 10 times of amount ethanol, adding waits water gaging again, after crystallite to be had is separated out, filters, and water flushing crystallite is to there not being the alcohol flavor; Sodium carboxymethyl cellulose is placed water, left standstill 24 hours, sucking filtration is collected filtrate, will dissolve in this carboxymethylcellulose sodium solution with Borneo camphor; Merge above-mentioned two kinds of solution, add water to amount of formulation, mixing, sterilization, packing, promptly.
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101675939B (en) * | 2008-09-16 | 2012-04-04 | 谭振花 | Traditional Chinese medicine for treating eye keratitis and preparation method |
| CN102895330B (en) * | 2012-09-07 | 2016-10-05 | 富阳宏成科技咨询有限公司 | A kind of eye drip medicine treating conjunctivitis |
| CN103977030B (en) * | 2014-05-14 | 2018-08-03 | 汪华东 | A kind of compound crocodile Choline eye drops |
| CN108904593A (en) * | 2018-07-12 | 2018-11-30 | 云南大理瑞鹤药业有限公司 | Bear gall health mesh eye drops and preparation method thereof |
| CN108938672B (en) * | 2018-09-27 | 2020-09-01 | 延边大学 | Traditional Chinese medicine composition and traditional Chinese medicine preparation for rehabilitation treatment of ischemic cerebral apoplexy |
| CN110201028A (en) * | 2019-07-17 | 2019-09-06 | 山东瞳仁健康科技有限责任公司 | A kind of ointment and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1204528A (en) * | 1998-07-06 | 1999-01-13 | 王荣征 | Medcinal composition for treatment of myopia, amblyopia and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1204528A (en) * | 1998-07-06 | 1999-01-13 | 王荣征 | Medcinal composition for treatment of myopia, amblyopia and preparation method thereof |
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