CN1061262C - Chinese medicine eye drops for treating conjunctivitis and preparing method thereof - Google Patents

Chinese medicine eye drops for treating conjunctivitis and preparing method thereof Download PDF

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CN1061262C
CN1061262C CN 98116929 CN98116929A CN1061262C CN 1061262 C CN1061262 C CN 1061262C CN 98116929 CN98116929 CN 98116929 CN 98116929 A CN98116929 A CN 98116929A CN 1061262 C CN1061262 C CN 1061262C
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powder
conjunctivitis
chinese medicine
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CN1207322A (en
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刘毅刚
刘毅波
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刘毅刚
刘毅波
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Abstract

本发明滴眼液是一种用于治疗目赤翳障、肿痛等结膜炎、角结膜炎、睑缘炎、麦粒肿等眼病的中药制剂,它是由鱼腥草、金银花、熊胆粉、栀子、板蓝根、麻黄、珍珠粉、冰片等八味中药组成。 The present invention is an ophthalmic solution for the treatment of red eyes Yi Zhang, throat and other conjunctivitis, keratoconjunctivitis, blepharitis, hordeolum other eye Chinese medicine, it is made Houttuynia, honeysuckle, bear bile powder, gardenia, Radix, ephedra, pearl powder, borneol and other Bawei Chinese medicine. 具有清热解毒、消肿止痛等功效。 Clearing and detoxifying, swelling and pain and other effects. 据六年来对8000余病例临床观察总有效率达96.66%。 According to six years to more than 8,000 cases of clinical observation of the total effective rate was 96.66%.

Description

治疗结膜炎的中药滴眼液及其制备方法 Chinese medicine and its preparation method of treating ophthalmic conjunctivitis

本发明涉及一种中药制剂,特别是一种用于治疗目赤翳障、肿痛等结膜炎的中药制剂滴眼液及其制备方法。 The present invention relates to a traditional Chinese medicine preparation, particularly ophthalmic Chinese medicine and its preparation method for treating Yi Zhang red eyes, throat and other conjunctivitis.

结膜炎是眼科的常见病、多发病,其发病率占眼科各种疾病的首位,若反复发作、长期不愈,可使结膜组织遭受破坏,形成结膜干燥症,导致终生痛苦。 Conjunctivitis is an ophthalmic common disease, the incidence rate of the first ophthalmic diseases, if recurrent, long-term diseases, destruction of conjunctival tissue can form sicca, lead to lifelong pain. 目前,对结膜炎的治疗尚无特效疗法,一般以局部用抗生素和抗病毒眼药为主。 Currently, no effective therapy for the treatment of conjunctivitis, generally topical antibiotics and antiviral eyedrops based. 但由于本病多半非细菌、病毒直接所致,因而单纯应用抗生素和抗病毒药物往往疗效不佳,而且长期应用此类药物还会造成结膜的菌群失调,使细菌、病毒对抗生素、抗病毒药物产生耐药性,加之药物本身的副作用,对正常组织也有影响和破坏,由于细菌核蛋白与哺乳动物细胞内线粒体的核蛋白相似,所以抗生素和抗病毒眼药如庆大霉素、氯霉素等,在抑制细菌蛋白合成的过程中,也影响了人体细胞线体的蛋白合成。 But because the disease mostly non bacteria, viruses directly caused so simple antibiotics and antiviral drugs are often poor efficacy, and long-term use of these drugs can also cause conjunctival flora, bacteria, viruses, antibiotic, antiviral resistance to the drug, combined with its own side effects, and also affect normal tissue damage due to bacterial nucleoprotein nucleoprotein mammalian mitochondrial similar, such as antibiotics and antiviral eyedrops gentamicin, chloramphenicol factors such as, in the process of inhibition of bacterial protein synthesis, protein synthesis also affect the human body cell lines. 一些抗病毒药物在抑制病毒核酸合成的同时,也影响了人体细胞的通透性,细胞破坏从而也影响了原发病的治疗。 Some antiviral while suppressing the viral nucleic acid synthesis, also affects permeability of human cells, which also affects the cell disruption treatment of primary disease.

本发明的目的在于提供一种对细菌、病毒有杀伤和抑制作用而对宿主结膜、角膜组织无毒副作用的安全方便有效的中药制剂滴眼液及其制备方法。 Object of the present invention is to provide an anti-toxic side effects and inhibition of the host conjunctiva, corneal tissue to facilitate safe and effective method for preparing ophthalmic formulations medicine bacteria, viruses.

本发明提供的中药制剂滴眼液其配方是由中药:鱼腥草、金银花、熊胆粉、栀子、板兰根、麻黄、珍珠粉和冰片制成滴眼剂。 Chinese medicine of the present invention provides ophthalmic formulation which is medicine: Houttuynia eye drop, honeysuckle, bear bile powder, gardenia, Langen, ephedra, borneol and pearl powder. 它们各组份的重量比是:鱼腥草10-150g、金银花5-80g、熊胆粉0.3-10g、栀子5-80g、板兰根5-80g、麻黄1-50g、珍珠粉0.1-20g、冰片0.05-0.2g,以上八味中药采用水醇法提取制备的中药滴眼液1000ml,浓度2.6~47%。 The weight ratio of the components thereof are: Houttuynia 10-150g, honeysuckle 5-80g, bear bile powder 0.3-10g, gardenia 5-80g, Isatidis 5-80g, ephedra 1-50g, pearl powder 0.1-20g, borneol 0.05-0.2g, Chinese herbal extract prepared above Bawei hydroalcoholic method ophthalmic medicine 1000ml, a concentration of 2.6 to 47%. 本发明的制备工艺见附图1,以上八味中药除熊胆粉、冰片粉碎成细粉备用外,其余鱼腥草等六味按药典规程加水煎煮3次,每次各40分钟,合并煎液过滤,滤液浓缩至糖浆状,在80-90℃下相对密度为1.20~1.25的稠膏,加95%乙醇,使含醇量达60%,搅匀,静止24小时,滤过,滤液回收乙醇。 Preparation process of the invention, see Figure 1, in addition to the above medicine Bawei bile powder, crushed into fine powder borneol standby, the remaining procedures Houttuynia liuwei Pharmaceutical Press boiling water three times each for 40 minutes and combined decoction was filtered, the filtrate was concentrated to a syrup, 80-90 deg.] C at a relative density of 1.20 to 1.25 thick paste, adding 95% ethanol to 60% alcohol content, stir, stationary for 24 hours, filtered, the filtrate recovery ethanol. 按上述方法再用乙醇处理2次,使含醇量分别达到70%,80%,回收乙醇至无醇味止;将上述药液加蒸溜水至800ml,冷藏24小时过滤。 Treated with ethanol two times as described above, that the alcohol content reaches 70%, 80%, recovering ethanol until no flavor alcohols stop; the chemical solution was added to distilled water to 800ml, refrigerate for 24 hours and filtered. 将上述备用药粉加入滤液中,充分搅拌使其溶解。 The filtrate was added to the spare powder, stir to dissolve. 另取氯化纳8g、山梨酸1.5g,加少量水使其溶解,加入药液中,搅匀,再加1ml吐温-80搅均匀,用NaOH调节PH值为7-8,放置24小时,过滤,自滤器上添加蒸溜水至1000ml,摇匀密封,用100℃流通蒸汽灭菌30分钟,无菌分装即得。 Another sodium chloride 8g, sorbic acid 1.5g, plus a small amount of water to dissolve the added liquid, mix, stir well plus 1ml Tween-80 with NaOH to adjust the PH value of 7-8, for 24 hours , filter, since the filter add distilled water to 1000ml, shake sealing, sterilization with live steam 100 ℃ 30 minutes to obtain a sterile packaging.

结膜炎属于中医的“赤丝脉”及“天行赤眼”,热毒蕴结于目,灼伤目经,则见目赤、畏光、眼睑溃烂。 Conjunctivitis belonging TCM "red silk Pulse" and "day Red Eye", toxic heat Accumulation in the head, through the head burns, see the red eyes, photophobia, eyelid ulceration. 对其治疗以清热解毒、消肿止痛为主。 Its treatment to detoxify, swelling and pain based. 配方中鱼腥草、金银花以清热解毒为主药,辅以熊胆、栀子、板兰根共助主药以清热解毒,其中金银花、熊胆、栀子又可凉血以祛目赤,佐以麻黄用其温性以防主辅药苦寒太过,珍珠、冰片清热消肿止痛。 Houttuynia formulations, honeysuckle to detoxify based medicine, supplemented bear bile, gardenia, Langen primary drug co-promoter to detoxify, wherein honeysuckle, bear bile, gardenia cooling but also to remove red eye, accompanied ephedra with its main warm to prevent too bitter cold adjuvants, the pearl, borneol heat swelling and pain. 所以本发明滴眼液对结膜炎具有清热解毒、消肿止痛之功效。 Therefore, the present ophthalmic solution has detoxification of conjunctivitis, swelling and pain effect.

本发明研制成功之后,经哈尔滨市卫生局审核,哈尔滨市药品检验所检测,由黑龙江省中医药大学药厂试制,应用于临床试验。 After the successful development of the invention, the audit by the Harbin Municipal Health Bureau, the Harbin City Drug testing by the Heilongjiang Province Medical University pharmaceutical trial, in clinical trials.

中药制剂滴眼液,使用时滴入眼睑内1次1-2滴,一日4-6次,急性期每小时1次。 Eye drops formulation medicine, the use of the eyelid dropped 1-2 drops once a day 4-6 times, acute phase every hour.

本发明经过6年来对8000余例眼病患者临床观察,证实其具有如下优点和积极效果:1、见效快、治愈率高、疗效稳定、应用范围广。 The present invention is six years of clinical observation of more than 8,000 patients after eye patients, their proven advantages and positive effects as follows: 1, quick, high cure rate, efficacy and stability, a wide range of applications. 一般用药后20分钟左右即见效,充血及眼不适感减轻,经观察对比,总有效率96.66%,显效率达75.24%,除对急慢性和疼痛性结膜炎有明显的疗效外,对目赤翳障、肿痛等角结膜炎、睑缘炎、麦粒肿、沙眼等也有较好的疗效,应用本发明治愈的患者,未发现停药后有复发现象。 Usually about 20 minutes after the administration that is effective, to alleviate congestion and ocular discomfort, contrast was observed, the total efficiency of 96.66%, effective rate was 75.24%, in addition to have a significant effect on pain and acute and chronic conjunctivitis, the red eyes of Yi Zhang, swelling isometric conjunctivitis, blepharitis, hordeolum, trachoma, also has a good effect, the present invention is applied to cure patients, found no recurrence after treatment.

2、无刺激性、无耐药性和无副作用。 2, non-irritating, non-resistance and no side effects. 滴眼液滴入眼内对角膜、结膜无刺激性、无不适感觉,患者长期反复应用未发现有毒副作用和耐药性。 Drops in the eye drops on corneal, conjunctival irritation, no discomfort, patients with long-term repeated application not found toxic side effects and drug resistance.

3、对应用市场上出售的抗生素、抗病毒眼药水具有耐药性的结膜炎患者,应用治疗结膜炎的中药滴眼液后仍然有效。 3, application of antibiotics sold on the market, has anti-viral conjunctivitis eye drops in patients with drug resistance, treatment of conjunctivitis eye drops after medicine is still valid.

实施例:本发明的制备工艺:取鱼腥草80g、金银花40g、熊胆粉8g、栀子24g、板兰根24g、麻黄10g、珍珠粉8g、冰片0.1g八味中药,按如上工艺流程制成1000ml活疗结膜炎的中药滴眼液。 Example: Preparation process of the invention: Houttuyniae 80g, honeysuckle 40g, bear bile powder 8g, gardenia 24g, Isatidis 24g, ephedra 10g, pearl powder 8g, borneol 0.1g Bawei medicine, made according to the process described above Chinese medicine treatment of conjunctivitis eye drops 1000ml live.

Claims (2)

1.一种治疗结膜炎的中药滴眼液,其特征在于它是由下列用量的原料制成的:鱼腥草10~150g 金银花5~80g熊胆粉0.3~10g 栀 子5~80g板兰根5~80g 麻 黄1~50g珍珠粉0.1~20g 冰 片0.05~0.2g 1. A method of treating conjunctivitis ophthalmic medicine, characterized in that it is made from the raw material of the following amounts: 10 ~ 150g Houttuynia honeysuckle 5 ~ 80g gardenia bile powder 0.3 ~ 10g 5 5 ~ 80g Langen ephedra 1 ~ 50g ~ 80g pearl powder 0.1 ~ 20g borneol 0.05 ~ 0.2g
2.根据权利要求1所述的治疗结膜炎的中药滴眼液,其特征在于它的制备方法是:A、将鱼腥草、金银花、栀子、板兰根、麻黄、珍珠粉水煎3次各40分钟,合并煎液过滤浓缩成在80~90℃下相对密度为1.2~1.25的稠膏,加入95%浓度的乙醇,使含醇量依次达到60%、70%和80%,备静置24小时后回收乙醇至无醇味止;B、在上述药液A中加入蒸馏水至800ml,冷藏24小时过滤后加入熊胆、冰片细粉,充分溶解后加入氯化钠8g、山梨酸1.5g搅匀再加入1ml土温-80,用NaOH调节PH值为7-8,静止24小时过滤;C、将上述药液B添加蒸馏水至1000ml,摇匀密封,用100℃流通蒸汽灭菌30分钟后无菌分装。 The therapeutic medicine conjunctivitis ophthalmic solution according to claim 1, characterized in that it is prepared: A, Houttuynia will, honeysuckle, gardenia, Langen, ephedra, pearl powder 3 times each decoction 40 minutes, combined decoction concentrated to a thick paste was filtered relative density of 1.2 to 1.25 at 80 ~ 90 ℃, adding 95% strength ethanol, the amount of alcohol-containing successively 60%, 70% and 80%, allowed to stand prepared recovering ethanol until no flavor alcohol stop after 24 h; B, in the chemical solution A was added in distilled water to 800ml, was added bile, borneol powder was filtered after 24 hours refrigerated, 8g of sodium chloride was added after fully dissolved, 1.5g sorbic acid stir 1ml Tween-80 was added, adjusting the PH value of 7-8 with NaOH, filtered stationary 24 hours; C, the chemical solution B added to distilled water 1000ml, shake sealed, sterilized with live steam 100 ℃ 30 minutes aseptic packaging.
CN 98116929 1998-08-19 1998-08-19 Chinese medicine eye drops for treating conjunctivitis and preparing method thereof CN1061262C (en)

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