CN100384856C - 趋化因子受体活性调节剂杂环基环戊基四氢异喹啉和杂环基环戊基四氢吡啶并吡啶 - Google Patents

趋化因子受体活性调节剂杂环基环戊基四氢异喹啉和杂环基环戊基四氢吡啶并吡啶 Download PDF

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CN100384856C
CN100384856C CNB2004800165371A CN200480016537A CN100384856C CN 100384856 C CN100384856 C CN 100384856C CN B2004800165371 A CNB2004800165371 A CN B2004800165371A CN 200480016537 A CN200480016537 A CN 200480016537A CN 100384856 C CN100384856 C CN 100384856C
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alkyl
compound
hydroxyl
cor
halogen
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CN1805965A (zh
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G·布托拉
S·D·戈布尔
A·帕斯特纳克
杨立虎
周昌友
C·R·莫耶斯
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Merck and Co Inc
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CNB2004800165371A 2003-04-17 2004-04-14 趋化因子受体活性调节剂杂环基环戊基四氢异喹啉和杂环基环戊基四氢吡啶并吡啶 Expired - Fee Related CN100384856C (zh)

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US46367303P 2003-04-17 2003-04-17
US60/463,673 2003-04-17

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CN1805965A CN1805965A (zh) 2006-07-19
CN100384856C true CN100384856C (zh) 2008-04-30

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EP (1) EP1622916A4 (https=)
JP (1) JP2006523704A (https=)
CN (1) CN100384856C (https=)
AU (1) AU2004232939A1 (https=)
CA (1) CA2521625A1 (https=)
WO (1) WO2004094371A2 (https=)

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EP2588197B1 (en) 2010-07-02 2014-11-05 Gilead Sciences, Inc. Fused heterocyclic compounds as ion channel modulators
KR20140033377A (ko) * 2011-05-10 2014-03-18 길리애드 사이언시즈, 인코포레이티드 나트륨 채널 조절제로서의 융합된 헤테로시클릭 화합물
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UY34171A (es) 2011-07-01 2013-01-31 Gilead Sciences Inc Compuestos heterocíclicos fusionados como moduladores del canal iónico
DK3297438T3 (da) 2015-05-21 2022-01-17 Chemocentryx Inc Ccr2-modulatorer
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WO2018026798A1 (en) 2016-08-01 2018-02-08 Aptinyx Inc. Spiro-lactam nmda modulators and methods of using same
KR102465758B1 (ko) 2016-08-01 2022-11-09 앱티닉스 인크. 스피로-락탐 nmda 수용체 조정제 및 그의 용도
CA3293051A1 (en) 2017-09-25 2026-03-02 Chemocentryx, Inc. Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor
CN112105353B (zh) 2018-01-08 2024-04-19 凯莫森特里克斯股份有限公司 Ccr2拮抗剂治疗实体瘤的方法
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
PE20210455A1 (es) * 2018-01-31 2021-03-08 Aptinyx Inc Moduladores del receptor nmda espiro-lactama y usos de los mismos
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