CN100382814C - Chinese medicine preparation for invigorating liver and kidney and its preparing method - Google Patents
Chinese medicine preparation for invigorating liver and kidney and its preparing method Download PDFInfo
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- CN100382814C CN100382814C CNB2004100467725A CN200410046772A CN100382814C CN 100382814 C CN100382814 C CN 100382814C CN B2004100467725 A CNB2004100467725 A CN B2004100467725A CN 200410046772 A CN200410046772 A CN 200410046772A CN 100382814 C CN100382814 C CN 100382814C
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- 238000000034 method Methods 0.000 title abstract description 12
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- QUQPHWDTPGMPEX-QJBIFVCTSA-N hesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@@H]([C@H](O)[C@@H](O)[C@H](C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-QJBIFVCTSA-N 0.000 description 4
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a traditional Chinese medicine preparation for invigorating the liver and the kidney, and a preparing method thereof. The traditional Chinese medicine preparation comprises the following components: 150 to 170g of poolyrhachis vicina roger, 90 to 110g of lucid ganoderma, 140 to 160g of mulberry fruit, 140 to 160 g of Chinese date, 40 to 60g of orange peel, and 30 to 50g of radices dipsaci. After extracted, effective composition of the six kinds of the traditional Chinese medicine are mixed and added with a right amount of honey and food preservative. Then, the mixture is mixed, precipitated, filtered, filled and sterilized to obtain finished products. The traditional Chinese medicine preparation of the present invention has the functions of invigorating the liver and the kidney, and strengthening bone and muscle. The present invention is suitable for a patient who suffers from intractable diseases, such as hepatitis B, tumor, etc., which are caused by soreness and weakness of waist and knee, dizziness, adynamia and anorexia or insomnia because of liver qi /kidney qi deficiency and the weak bone and muscle. By clinical verification results, the medicine has good therapeutic effect, and the clinical cure rate, the marked effect rate and the effective rate respectively reach 12.3%, 47.1% and 98.1%. Compared with medicine (Guhanyangshengjing), the present invention has obvious advantages, and adverse reaction is not discovered in the process of clinical observation.
Description
Technical field
The present invention relates to a kind of Chinese medicine of invigorating the liver and kidney, especially relate to a kind of treatment because of the hold concurrently compound Chinese medicinal preparation of multiple chronic diseases such as sleep disorder of soreness of the waist and knees, dizziness and blurred vision, fatigue and asthenia, lack of appetite due to deficiency of both the liver and kidney, muscle bone no hard, the immunocompromised.
Background technology
According to incompletely statistics, the people of chronic fatigue syndrome and all kinds of chronic difficult disease diseases is suffered from the whole world, accounts for more than 25% of total population.These are all not normal relevant with deficiency of both the liver and kidney, hypoimmunity or immunity, show as body void, weak clinically mostly, easily catch a cold, patient's body itself can not be eliminated the body inner virus maybe can not end the reflection of antibody autoimmune, liver,kidney,spleen void is vital QI being weakened and pathogen being violent, easily brings out difficult disease such as hepatitis B, tumor.At present, the double Chinese medicine preparation a great variety of controlling above-mentioned symptom, but how imprecise curative effect is, and specially controlling the Chinese medicine preparation of above-mentioned symptom, we do not find as yet.
Summary of the invention
The object of the present invention is to provide a kind of treatment soreness of the waist and knees, dizziness and blurred vision, fatigue and asthenia, compound Chinese medicinal preparation of difficult disease such as lack of appetite or double sleep disorder and the hepatitis B that causes thus, tumor and preparation method thereof.
The present invention's compound Chinese medicinal preparation is made by following crude drug: Formica fusca 150g-170g, Ganoderma 90g-110g, Fructus Mori 140g-160g, Fructus Jujubae 140g-160g, Pericarpium Citri Reticulatae 40g-60g, Radix Dipsaci 30g-50g.Also can add Mel an amount of (for example 150-300g) and can allow the food preservative of addition.
Its preparation method may further comprise the steps: (1) each component crude drug extracts active ingredients is doubly measured soaking in Chinese liquor 6-8 days of 45-55 (v/v) with Formica fusca with 4-6, filters filtrate for later use; Medicinal residues add 7-9 times of water gaging and decocted 0.5-1.5 hour, filter, and filtrate and above-mentioned filtrate merge, and is centrifugal, gets supernatant and be concentrated into the clear paste that relative density is 1.0-1.2 under 80-85 ℃ of condition, standby; Ganoderma is used twice of 70-90 ℃ of warm macerating of 40-60% (v/v) ethanol, for the first time adding 5-7 doubly measures, warm macerating 1.5-2.5 hour, for the second time adding 3-5 doubly measures, warm macerating 1.5-2.5 hour, merge impregnation liquid, filter, filtrate recycling ethanol also is concentrated into the clear paste that relative density is about 1.0-1.2 under 80-85 ℃ of condition, standby; Pericarpium Citri Reticulatae adds 5-7 times of water gaging, distills 4-6 hour, extracts volatile oil, and the aqueous solution after distillation device is in addition preserved; Three flavors such as all the other Fructus Moris decoct with water secondary, adding for the first time 9-11 times of water gaging decocted 1.5-2.5 hour, adding for the second time 7-9 times of water gaging decocted 0.5-1.5 hour, merge impregnation liquid, filter, filtrate adds the aqueous solution after Pericarpium Citri Reticulatae adds the water distillation, stir evenly, cold preservation 22-26 hour, centrifugal, get supernatant and under 80-85 ℃ of condition, be concentrated into the clear paste that relative density is 1.0-1.2; (2) Formica fusca, Ganoderma, Fructus Mori, Fructus Jujubae, Pericarpium Citri Reticulatae, the Radix Dipsaci clear paste that extracts merged, stir evenly, add above-mentioned Pericarpium Citri Reticulatae volatile oil again; Also can add an amount of Mel seasoning, and admissible food preservative, stir evenly again, leave standstill, filter, fill, sterilization is finished product.
This product is a bronzing liquid; Feeble QI perfume (or spice), little hardship; Be added with Mel, it is sweet to distinguish the flavor of, little hardship.
The present invention's Chinese medicine preparation invigorating the liver and kidney, bone and muscle strengthening.Be applicable to deficiency of both the liver and kidney, muscle bone no hard and cause soreness of the waist and knees, dizziness and blurred vision, fatigue and asthenia, difficult patients such as lack of appetite or double sleep disorder and the hepatitis B that causes thus, tumor.Clinical results shows, this medicine disease determined curative effect, and clinical cure rate, obvious effective rate, effective percentage can reach 12.3%, 47.1%, 98.1% respectively, significantly are better than contrasting Yaoguhan health cultivation essence, do not find bad reflection in the clinical observation process, take safety.
The specific embodiment
Below the invention will be further described by an embodiment.
Take by weighing Formica fusca 160g, Ganoderma 100g, Fructus Mori 150g, Fructus Jujubae 150g, Pericarpium Citri Reticulatae 50g, Radix Dipsaci 40g; Mel 200g and potassium sorbate 2g.
Its preparation method is as follows: (1) Formica fusca, Ganoderma, Fructus Mori, Fructus Jujubae, Pericarpium Citri Reticulatae, Radix Dipsaci extracts active ingredients with the soaking in Chinese liquor of 5 times of amounts 50 ° (v/v) 7 days, filter filtrate for later use with Formica fusca; Medicinal residues add 8 times of water gagings and decocted 1 hour, filter, and filtrate and the merging of above-mentioned filtrate, centrifugal, get supernatant and under 80-85 ℃ of condition, be concentrated into relative density and be about 1.10 clear paste, standby; Ganoderma adds 6 times of amounts, warm macerating 2 hours for the first time with 80 ℃ of warm macerating twice of 50% (v/v) ethanol, for the second time add 4 times of amounts, warm macerating 2 hours merges impregnation liquid, filter, filtrate recycling ethanol also is concentrated into relative density and is about 1.10 clear paste under 80-85 ℃ of condition, standby; Pericarpium Citri Reticulatae adds 6 times of water gagings, distills 5 hours, extracts volatile oil, and the aqueous solution after distillation device is in addition preserved; Three flavors such as all the other Fructus Moris decoct with water secondary, adding for the first time 10 times of water gagings decocted 2 hours, adding for the second time 8 times of water gagings decocted 1 hour, merge impregnation liquid, filter, filtrate adds the aqueous solution after Pericarpium Citri Reticulatae adds the water distillation, stir evenly, cold preservation 24 hours, centrifugal, get supernatant and under 80-85 ℃ of condition, be concentrated into relative density and be about 1.1 clear paste; (2) Formica fusca, Ganoderma, Fructus Mori, Fructus Jujubae, the Radix Dipsaci clear paste with said extracted merges, and stirs evenly, and adds above extracted Pericarpium Citri Reticulatae volatile oil again; Add Mel and potassium sorbate then, the adjustment total amount is 1000ml, stirs evenly, and leaves standstill, filter, and fill, sterilization is finished product.
This product is a bronzing liquid; Feeble QI perfume (or spice), little hardship, it is sweet to distinguish the flavor of.
Discrimination method:
(1) get this product 10ml, put evaporate to dryness in the water-bath, residue adds ethanol 20ml, makes dissolving, filters, and filtrate is put and is concentrated into about 2ml in the water-bath, as need testing solution.Other gets Pericarpium Citri Reticulatae control medicinal material 0.5g, adds ethanol 10ml warm macerating 1 hour, filters, and filtrate is put and is concentrated into about 5ml in the water-bath, in contrast the medical material body lotion.Get the Hesperidin reference substance again and add ethanol and make saturated solution, in contrast product solution.Test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2000), draw above-mentioned need testing solution 10 μ l, each 5 μ l of control medicinal material solution and reference substance solution, put respectively on the silica gel g thin-layer plate that same usefulness 0.1% sodium hydroxide solution is made, with ethyl acetate-methanol-water (10: 1.7: 1.3) is developing solvent, exhibition is taken out apart from about 3cm, dries; (20: 10: 1: upper solution 1) was developing solvent, and exhibition is taken out to about 8cm place, dries, and spray is with 0.5% aluminum chloride alcoholic solution, and hot blast drying is put under the ultra-violet lamp (365nm) and inspected with toluene-ethyl acetate-formic acid-water again.In the test sample chromatograph, with control medicinal material and contrast chromatograph corresponding position on, show the fluorescence speckle of same color.
(2) get this product 20ml, add ethyl acetate 30ml, supersound process 30 minutes, branch is got ethyl acetate extraction liquid and is concentrated into about 2ml, and as need testing solution, other gets Formica fusca medical material 1g, shines medical material solution in pairs with legal system.Test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2000), draw above-mentioned need testing solution 10 μ l, control medicinal material solution 5 μ l, put respectively on same silica gel g thin-layer plate, with benzene-ethyl acetate (9: 2) is developing solvent, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, and 105 ℃ were dried by the fire about 10 minutes.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show identical rose speckle.
(3) get this product 30ml, add petroleum ether 50ml, supersound process 30 minutes discards petroleum ether liquid, and water liquid adds ethyl acetate 50ml, supersound process 30 minutes.Divide and get ethyl acetate liquid, put evaporate to dryness in the water-bath, residue adds ethanol 2ml, makes dissolving, as need testing solution.Other gets Ganoderma control medicinal material 29, adds ethanol 30ml, and reflux 40 minutes is filtered, and filtrate evaporate to dryness, residue add methanol 1ml makes dissolving, in contrast medical material solution.Test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2000), draw above-mentioned need testing solution 10 μ l, control medicinal material solution 5 μ l, put respectively on same silica gel g thin-layer plate, (60 ℃-90 ℃)-ethyl acetate-formic acid (15: 10: 1) is developing solvent with petroleum ether, exhibition is taken out apart from about 8cm, dries, spray is with 15% phosphomolybdic acid ethanol solution, and 105 ℃ to be heated to the speckle colour developing clear.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show identical blue spot.
Check that relative density should be not less than 1.10 (an appendix VII of Chinese Pharmacopoeia version in 2000 A).
PH value should be 4.0-6.0 (an appendix VII of Chinese Pharmacopoeia version in 2000 G).
The nitrogen content precision is measured this product 5ml, measures according to N2 method (appendix LXL first method of Chinese Pharmacopoeia version in 2000).Nitrogen content is no less than 18.0mg among this product 10ml.
Other meet every regulation relevant under the mixture item (appendix IJ of Chinese Pharmacopoeia version in 2000).
Assay is measured according to high-efficient phase chromatogram method (an appendix VI of Chinese Pharmacopoeia version in 2000 D).
Chromatographic condition and system suitability test: with octadecylsilane chemically bonded silica is filler: methanol-water-acetic acid (35: 61: 4) is mobile phase: detect wavelength 283nm.Number of theoretical plate calculates by the Hesperidin peak should be not less than 2000.
The preparation of reference substance solution: it is an amount of that precision takes by weighing the Hesperidin reference substance, adds methanol and become to contain 0.053mg solution among every 1ml, at once.
The preparation of need testing solution: precision is measured this product 5ml, puts in the 50ml measuring bottle, adds methanol 30ml, supersound process 30 minutes, puts coldly, adds methanol and is diluted to scale, shakes up, and filters, and gets continuous liquid 5ml, puts 10ml and puts in the bottle, adds methanol and is diluted to scale, promptly.
Algoscopy: accurate respectively reference substance solution and each 10 μ l of need testing solution of drawing, inject chromatograph of liquid, measure, promptly.
The every 10ml of this product contains Hesperidin (C
28H
11O
15) be no less than 7.0mg.
Instructions about how to take medicine and consumption: oral, general every day three times, each 10ml.
The present embodiment product is verified through the man clinical verification of specified number hospital of National Drug Administration, the result shows, its disease determined curative effect, clinical cure rate, obvious effective rate, effective percentage reach 12.3%, 47.1%, 98.1% respectively, significantly be better than contrasting Yaoguhan health cultivation essence, do not find bad reflection in the clinical observation process.The above results shows, product of the present invention be a kind of treatment its adapt to the disease safe and effective medicine.
Case 1: Lee * * (retired employees of Agricultural University Of Hunan), man, 69 years old.Be advanced lung cancer by Hunan Medical University's Annex II hospital diagnosis in October, 2000, adheres to taking a month ant Ling oral liquid (being the invention described above embodiment product), every day three times, each 10ml, the state of an illness takes a turn for the better miraculously, obeys four months again, the pulmonary carcinoma lump disappears and fully recovers, so far not recurrence.
Case 2: Cao * * (Hengyang, Hunan railway retired employees), woman, 72 years old.Calendar year 2001 is diagnosed as advanced lung cancer in county Affiliated Hospital of Hengyang Medical College, hospital and kith and kin are considered as and can not have rescued, the funeral affairs of going home to prepare to do, they change clothes ant Ling oral liquid (being the invention described above embodiment product), every day three times, each 10ml, the state of an illness progressively takes a turn for the better, take cancer condition of illness disappearance after three months, it is normal that daily life recovers, and fully recovers after half a year.
Case 3: Liu * * (the Hunan state China worker of pharmaceutical factory), man, 29 years old.Have a delicate constitution, suffer from chronic enterogastritis, hepatitis B, fatigue and asthenia, dizziness and blurred vision, poor sleep, can not adhere to normal working, adhered to taking ant Ling oral liquid (being the invention described above embodiment product) in June, 1,999 three months, every day three times, each 10ml, hepatitis B, chronic enterogastritis recovery from illness, the very fast recovery of body constitution is normal.
Case 4: the king * * (worker of Changsha Highway Administration), woman, 34 years old.Body void, body are thin, insomnia, soreness of the waist and knees, malaise, and it is all ineffective to have eaten multiple tonic, and in JIUYUE, 1999 is taken ant Ling oral liquid (being the invention described above embodiment product), every day three times, each 10ml is after three months, of pink and healthy-looking, body constitution strengthens, and whole body condition of illness disappears.
Claims (6)
1. the Chinese medicine preparation of an invigorating the liver and kidney is characterized in that, is made by following crude drug: Formica fusca 150g-170g, Ganoderma 90g-110g, Fructus Mori 140g-160g, Fructus Jujubae 140g-160g, Pericarpium Citri Reticulatae 40g-60g, Radix Dipsaci 30g-50g.
2. the Chinese medicine preparation of invigorating the liver and kidney according to claim 1 is characterized in that, is made by following crude drug: Formica fusca 160g, Ganoderma 100g, Fructus Mori 150g, Fructus Jujubae 150g, Pericarpium Citri Reticulatae 50g, Radix Dipsaci 40g.
3. the Chinese medicine preparation of invigorating the liver and kidney according to claim 1 and 2 is characterized in that, also is added with Mel 150-300g, and can allow the food preservative of addition.
4. the preparation method of Chinese herbs for tonifying liver and kidney preparation according to claim 1 and 2 is characterized in that, may further comprise the steps:
(1) each crude drug extracts active ingredients is doubly measured 45-55 ° soaking in Chinese liquor 6-8 days with Formica fusca with 4-6, filters filtrate for later use; Medicinal residues add 7-9 times of water gaging and decocted 0.5-1.5 hour, filter, and filtrate and above-mentioned filtrate merge, and is centrifugal, gets supernatant and be concentrated into the clear paste that relative density is 1.0-1.2 under 80-85 ℃ of condition, standby; Ganoderma with 40-60% ethanol twice of 70-90 ℃ of warm macerating, for the first time adding 5-7 doubly measures, warm macerating 1.5-2.5 hour, for the second time adding 3-5 doubly measures, warm macerating 1.5-2.5 hour, merge impregnation liquid, filter, filtrate recycling ethanol also is concentrated into the clear paste that relative density is 1.0-1.2 under 80-85 ℃ of condition, standby; Pericarpium Citri Reticulatae adds 5-7 times of water gaging, distills 4-6 hour, extracts volatile oil, and the aqueous solution after distillation device is in addition preserved; Three flavors such as all the other Fructus Moris decoct with water secondary, adding for the first time 9-11 times of water gaging decocted 1.5-2.5 hour, adding for the second time 7-9 times of water gaging decocted 0.5-1.5 hour, merge impregnation liquid, filter, filtrate adds the aqueous solution after Pericarpium Citri Reticulatae adds the water distillation, stir evenly, cold preservation 22-26 hour, centrifugal, get supernatant and under 80-85 ℃ of condition, be concentrated into the clear paste that relative density is 1.0-1.2;
(2) Formica fusca, Ganoderma, Fructus Mori, Fructus Jujubae, the Radix Dipsaci clear paste that extracts merged, stir evenly, add above-mentioned Pericarpium Citri Reticulatae volatile oil again, stir evenly, leave standstill, filter, fill, sterilization.
5. the preparation method of Chinese herbs for tonifying liver and kidney preparation according to claim 4 is characterized in that, may further comprise the steps:
(1) Formica fusca, Ganoderma, Fructus Mori, Fructus Jujubae, Pericarpium Citri Reticulatae, Radix Dipsaci extracts active ingredients with the soaking in Chinese liquor of 50 ° of 5 times of amounts 7 days, filter filtrate for later use with Formica fusca; Medicinal residues add 8 times of water gagings and decocted 1 hour, filter, and filtrate and the merging of above-mentioned filtrate, centrifugal, getting supernatant, to be concentrated into relative density under 80-85 ℃ of condition be 1.1 clear paste, standby; Ganoderma adds 6 times of amounts for the first time with 80 ℃ of warm macerating twice of 50% ethanol, and warm macerating 2 hours adds 4 times of amounts for the second time, and warm macerating 2 hours merges impregnation liquid, filters, and filtrate recycling ethanol also is concentrated into relative density and is about 1.1 clear paste under 80-85 ℃ of condition, standby; Pericarpium Citri Reticulatae adds 6 times of water gagings, distills 5 hours, extracts volatile oil, and the aqueous solution after distillation device is in addition preserved; Three flavors such as all the other Fructus Moris decoct with water secondary, adding for the first time 10 times of water gagings decocted 2 hours, adding for the second time 8 times of water gagings decocted 1 hour, merge impregnation liquid, filter, filtrate adds the aqueous solution after Pericarpium Citri Reticulatae adds the water distillation, stir evenly, cold preservation 24 hours, centrifugal, get supernatant and under 80-85 ℃ of condition, be concentrated into the clear paste that relative density is about 1: 1;
(2) Formica fusca, Ganoderma, Fructus Mori, Fructus Jujubae, the Radix Dipsaci clear paste with said extracted merges, and stirs evenly, and adds the Pericarpium Citri Reticulatae volatile oil that is extracted again, stirs evenly, and leaves standstill, and filters fill, sterilization.
6. according to the preparation method of claim 4 or 5 described Chinese herbs for tonifying liver and kidney preparations, it is characterized in that, merge at the Formica fusca that will extract, Ganoderma, Fructus Mori, Fructus Jujubae, Radix Dipsaci clear paste, stir evenly, and after adding Pericarpium Citri Reticulatae volatile oil, add Mel again and can allow the food preservative of addition, stir evenly then, leave standstill, filter, fill, sterilization.
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| CN117288870B (en) * | 2023-11-27 | 2024-02-09 | 湖南迪诺制药股份有限公司 | Method for establishing fingerprint of Yiling oral liquid |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1141138A (en) * | 1995-10-28 | 1997-01-29 | 孙宏 | Traditional Chinese medicine "Yangshengdan" for keeping sb. in good health |
| CN1154862A (en) * | 1996-01-19 | 1997-07-23 | 何有缘 | Body-building medicinal liquor |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1141138A (en) * | 1995-10-28 | 1997-01-29 | 孙宏 | Traditional Chinese medicine "Yangshengdan" for keeping sb. in good health |
| CN1154862A (en) * | 1996-01-19 | 1997-07-23 | 何有缘 | Body-building medicinal liquor |
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