CN100376288C - T细胞介导的免疫的改善 - Google Patents
T细胞介导的免疫的改善 Download PDFInfo
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- CN100376288C CN100376288C CNB008089663A CN00808966A CN100376288C CN 100376288 C CN100376288 C CN 100376288C CN B008089663 A CNB008089663 A CN B008089663A CN 00808966 A CN00808966 A CN 00808966A CN 100376288 C CN100376288 C CN 100376288C
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AUPP9778A AUPP977899A0 (en) | 1999-04-15 | 1999-04-15 | Improvement of t cell mediated immunity |
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JP (1) | JP2002542174A (ja) |
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AUPR074500A0 (en) * | 2000-10-13 | 2000-11-09 | Monash University | Treatment of t cell disorders |
US20020086000A1 (en) * | 1999-04-15 | 2002-07-04 | Richard Boyd | Stimulation of thymus for vaccination development |
US20040258672A1 (en) * | 1999-04-15 | 2004-12-23 | Monash University | Graft acceptance through manipulation of thymic regeneration |
US20020071829A1 (en) * | 1999-04-15 | 2002-06-13 | Richard Boyd | Normalization of defective T cell responsiveness through manipulation of thymic regeneration |
AU2002216320C1 (en) * | 2000-10-13 | 2008-04-03 | Norwood Immunology Ltd | Hematopoietic stem cell gene therapy |
EP1345574A4 (en) * | 2000-10-13 | 2006-05-31 | Univ Monash | IMPROVING ACCEPTANCE OF TRANSPLANTS BY CONTROLLING THYME REGENERATION |
IL155414A0 (en) * | 2000-10-13 | 2003-11-23 | Univ Monash | Disease prevention by reactivation of the thymus |
AU2001295270B2 (en) * | 2000-10-13 | 2007-08-09 | Norwood Immunology Ltd | Treatment of T cell disorders |
IL155412A0 (en) * | 2000-10-13 | 2003-11-23 | Univ Monash | Diagnostic indicator of thymic function |
AU2002216323C1 (en) * | 2000-10-13 | 2008-05-29 | Norwood Immunology Ltd | Disease prevention by reactivation of the thymus |
AU2002225245C1 (en) * | 2000-10-13 | 2008-07-17 | Norwood Immunology Ltd | Improvement of graft acceptance through manipulation of thymic regeneration |
AP2003002800A0 (en) * | 2000-10-13 | 2003-06-30 | Richard Boyd | Hematopoietic stem cell gene therapy |
IL147138A0 (en) * | 2001-12-17 | 2002-08-14 | Yeda Res & Dev | Methods of and pharmaceutical compositions for modulating cell adhesion, migration and extravasation |
WO2004094599A2 (en) * | 2003-04-18 | 2004-11-04 | Norwood Immunology, Ltd. | Disease prevention and vaccination following thymic reactivation |
US20100204145A1 (en) * | 2007-09-11 | 2010-08-12 | Dorian Bevec | Use of a peptide as a therapeutic agent |
EP2726879B1 (en) * | 2011-07-01 | 2022-10-19 | Beckman Coulter, Inc. | Requlatory t cells and methods of identifying and isolating them using cd6 -expression or the combination of cd4, cd25 and cd127 |
CN103235135B (zh) * | 2013-04-26 | 2015-02-04 | 史其新 | 一种用于表征外周调节性t细胞抑制活性的特征细胞群的检测方法及其应用 |
TWI820753B (zh) * | 2016-11-11 | 2023-11-01 | 美商生命科學公司 | 使用人類間葉幹細胞以實現細胞性及體液性免疫的方法 |
EP3755346A4 (en) | 2018-02-23 | 2022-03-09 | Duke University & Medical Center | GRAFT OF CULTURED THYMUS TISSUE PROMOTING DONOR-SPECIFIC TOLERANCE TO ALLOGENIC SOLID ORGAN GRAFT |
US11819520B2 (en) | 2018-02-23 | 2023-11-21 | Duke University | Cultured thymus tissue transplantation promotes donor-specific tolerance to allogeneic solid organ transplants |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988001176A1 (en) * | 1986-08-18 | 1988-02-25 | Bunge (Australia) Pty. Ltd. | Regulating animal reproduction |
WO1992019746A1 (en) * | 1991-04-29 | 1992-11-12 | Csl Limited | Recombinant immunocastration vaccine and polypeptides useful for same |
-
1999
- 1999-04-15 AU AUPP9778A patent/AUPP977899A0/en not_active Abandoned
-
2000
- 2000-04-17 CA CA002370296A patent/CA2370296A1/en not_active Abandoned
- 2000-04-17 EP EP00916705A patent/EP1191975A4/en not_active Withdrawn
- 2000-04-17 WO PCT/AU2000/000329 patent/WO2000062657A2/en not_active Application Discontinuation
- 2000-04-17 KR KR1020017013148A patent/KR20020007371A/ko not_active Application Discontinuation
- 2000-04-17 AU AU37977/00A patent/AU779067B2/en not_active Ceased
- 2000-04-17 BR BR0009712-8A patent/BR0009712A/pt not_active Application Discontinuation
- 2000-04-17 CN CNB008089663A patent/CN100376288C/zh not_active Expired - Fee Related
- 2000-04-17 JP JP2000611797A patent/JP2002542174A/ja active Pending
- 2000-04-17 NZ NZ514975A patent/NZ514975A/xx unknown
-
2001
- 2001-10-15 ZA ZA200108451A patent/ZA200108451B/en unknown
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2002
- 2002-09-30 HK HK02107213.4A patent/HK1046249A1/zh unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988001176A1 (en) * | 1986-08-18 | 1988-02-25 | Bunge (Australia) Pty. Ltd. | Regulating animal reproduction |
WO1992019746A1 (en) * | 1991-04-29 | 1992-11-12 | Csl Limited | Recombinant immunocastration vaccine and polypeptides useful for same |
Also Published As
Publication number | Publication date |
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WO2000062657A3 (en) | 2001-01-11 |
CN1364093A (zh) | 2002-08-14 |
NZ514975A (en) | 2004-03-26 |
CA2370296A1 (en) | 2000-10-26 |
KR20020007371A (ko) | 2002-01-26 |
AUPP977899A0 (en) | 1999-05-13 |
JP2002542174A (ja) | 2002-12-10 |
HK1046249A1 (zh) | 2003-01-03 |
EP1191975A2 (en) | 2002-04-03 |
ZA200108451B (en) | 2003-01-15 |
AU779067B2 (en) | 2005-01-06 |
WO2000062657A2 (en) | 2000-10-26 |
BR0009712A (pt) | 2002-04-30 |
EP1191975A4 (en) | 2005-05-25 |
AU3797700A (en) | 2000-11-02 |
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