CN100376266C - Medicated composition with wt.-reducing and hypolipidemic functions - Google Patents
Medicated composition with wt.-reducing and hypolipidemic functions Download PDFInfo
- Publication number
- CN100376266C CN100376266C CNB2005100110604A CN200510011060A CN100376266C CN 100376266 C CN100376266 C CN 100376266C CN B2005100110604 A CNB2005100110604 A CN B2005100110604A CN 200510011060 A CN200510011060 A CN 200510011060A CN 100376266 C CN100376266 C CN 100376266C
- Authority
- CN
- China
- Prior art keywords
- powder
- folium camelliae
- fat
- reducing
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
A medical composition in the form of tablet and capsule for losing weight, regulating blood fat and moistening intestine is prepared from phyllanthus emblica powder (40-70 Wt%), tea powder (25-60) and powdered extract of notoginseng (4-10).
Description
Technical field
The present invention relates to a kind of functional composition that combines by plant material, have the compositions of fat-reducing and lipid-reducing function especially simultaneously.
Background technology
Chinese patent application number 01112533.0 discloses a kind of " medicine ' Sanqi Houshuang ' for relieving throat disease ", relate to a kind of buccal tablet that is refined into by Radix Notoginseng extract, Yunnan Fructus Canrii Albi extract, starch and other excipient, minty note, the little bitter Hui Tian of mouthfeel, color is light brown, detect through relevant department, harmless.As everyone knows, Fructus Phyllanthi is that the effect of Yunnan Fructus Canarii albi mainly is to have moistening and cleaning throat and wet one's whistle, and does not see that Fructus Phyllanthi has the report of antiobesity action.
Summary of the invention
The object of the present invention is to provide a kind of edible safety to have the compositions of fat-reducing, effect for reducing fat reliably, simultaneously.
Compositions with fat reducing and weight reducing function of the present invention is made up of following raw materials by weight percent: Fructus Phyllanthi powder 40-70%, Folium Camelliae sinensis powder 25-60%, Radix Notoginseng extract powder 4-10%.
Compositions with fat reducing and weight reducing function of the present invention is made up of following raw materials by weight percent: Fructus Phyllanthi powder 45-60%, Folium Camelliae sinensis powder 30-50%, Radix Notoginseng extract powder 4-10%.
Above-mentioned Fructus Phyllanthi powder is a Fructus Phyllanthi fruit drink concentrated dry powder; Above-mentioned Folium Camelliae sinensis powder is any powder through the superfine grinding gained in Folium camelliae assamicae (processed) or Pu'er raw tea or the green tea; Described Folium Camelliae sinensis powder can be a Folium Camelliae sinensis extract dry powder also, is any water solution extract in Folium camelliae assamicae (processed) or Pu'er raw tea or the green tea, the spray-dried or direct dry powder that becomes of oven dry back mechanical activation comminution; The Radix Notoginseng extract powder is dry Radix Notoginseng, through clean, broken back is with the 50-70% alcohol reflux more than 3 times, filter cleaner, filtrate merges, reclaim spray drying is made behind the ethanol powder or 80 ℃ dry after the powder made of mechanical activation comminution.
Fructus Phyllanthi of the present invention (it is sweet to have another name called Yunnan Fructus Canarii albi, phyllanthus emblica, emblic leafflower fruit, pyhllanth usemhlica L., poplar) is the fruit that Euphorbiaceae leaf pearl belongs to (phyllanthus emblica genus) deciduous tree or shrub, it is a kind of fine wild fruit and medicinal plants, be again a kind of fine tree species with water and soil conservation, planting trees on barren hills, still a kind of landscape of grace is set.Fructus Phyllanthi is rich in natural complex C, every 100g fresh fruit content up to more than the 400mg, is the king who is only second to the another fruit dimension C of Fructus Rosae Normalis.The main medicinal ingredient of Fructus Phyllanthi is a tannin, its content at 30-35%, separate ten surplus kind of tannin composition.Effects such as that known Fructus Phyllanthi has is antibacterial, blood fat reducing, blood sugar regulation, antitumor are traditional raw material of Chinese medicine.Folium Camelliae sinensis of the present invention is the leaf class beverage that a kind of arbor or shrub leaf are made.China is the country of gathering and processing and drinking Folium Camelliae sinensis the earliest, the history of drinking tea in existing several thousand.Modern age, Folium Camelliae sinensis was divided into green tea, black tea, oolong tea, Ramulus et Folium Mussaendae Pubescentis, yellow tea and postfermented tea six big classes by the processing technology difference, was divided into daye tea and Camellia sinensis var. viridis again by tea kinds.Contain 12 more than 500 kind of organic principle of big class and 28 kinds of mineral elements in the present known Folium Camelliae sinensis, wherein topmost active component has tea polyphenols, caffeine, polysaccharide, lipoid, alkaloid, protein, aminoacid, vitamin, Saponin, organic acid, cellulose etc., and is wherein abundant with daye tea content.Drink tea that good for health, history records record Folium Camelliae sinensis makes eye bright, refreshment, diuresis detoxifcation, antiphlogistic antibacterial, smelly effect such as aid digestion disappears; modern study shows: Folium Camelliae sinensis has various health-care such as protection cardiovascular system, blood lipid regulation, blood glucose, enhancing immunity, radioprotective, defying age, mutation, antitumor, anti-caries, blood pressure lowering; simultaneously can replenish body multivitamin and mineral, daye tea is the optimal natural material of developing new drug and health food.Radix Notoginseng of the present invention (having another name called Radix Notoginseng, mountain lacquer, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), Herba Wedeliae Wallichii) is the dry root of panax araliaceae plant; main component is various active compositions such as arasaponin, polysaccharide and flavone in the Radix Notoginseng after deliberation; the tradition Chinese medicine studies show that effects such as Radix Notoginseng has invigorating blood circulation, stops blooding, detumescence, dissipating blood stasis, analgesia, and recent studies shows, Radix Notoginseng has efficacy effects such as protection cardiovascular and cerebrovascular vessel, blood sugar regulation, calmness, raise immunity, defying age, anoxia enduring, antitumor.The Radix Notoginseng extract powder that makes with said method contains Radix Notoginseng total arasaponins more than 60%.
Three kinds of its nature and flavor of raw material of the present invention are cold partially, all have the effect of protection cardiovascular and cerebrovascular vessel, blood lipid regulation, antiinflammatory heat clearing away.Simple Obesity is owing to due to significant quantities of fat is piled up in the body, infer thus that three kinds of raw materials may have the antiobesity action that reduces body fat, reduces body weight.For this reason, we have carried out rat fat-reducing, blood fat reducing test separately to Fructus Phyllanthi powder and two kinds of raw materials of tea powder respectively, its result shows: Fructus Phyllanthi powder or the independent rat feeding of tea powder with same dose compare with fat, hyperlipidemia model group rat, weight loss not obvious (P＞0.05), Fructus Phyllanthi powder only has effect (P＜0.05) to reducing TC (cholesterol), and tea powder then only has effect (P＜0.05) to reducing TG (triglyceride).To feed rat behind Fructus Phyllanthi powder and tea powder, the Radix Notoginseng extract powder mixing prescription, under the identical condition of accumulated dose, compare with fat, hyperlipidemia model group rat, its weight loss fairly obvious (P＜0.01), and can reduce TC, TG level (P＜0.05) simultaneously.Illustrate between each selected composition of the present invention to have good synergism, reached the purpose that reduces consumption, strengthens the Weight-reducing and lipid-lowering effect.
The present invention has the effect of blood lipid regulation, loosening bowel to relieve constipation and fat-reducing.Can be made into tablet, two kinds of dosage forms of capsule, its pharmacology and health-care effect are unaffected.The present invention makes full use of the Chinese medicine traditional theory and the modern medicine study achievement is carried out scientific composition, confirms to have tangible fat-reducing, effect for reducing fat through animal experiment.Compositions of the present invention has pharmacology and health-care effect, can be used as medicine, also can be used as health food.
Fat-reducing of the present invention, effect for reducing fat and edible safety reliability obtain by following test:
1, rat fat-reducing test: male rat fat-reducing test shows, this sample all has significant effect to treatment obese rat and prevention rat obesity.
1.1 the fat modelling of rat: to the fat model feedstuff of bull rat feeding 40 days, compare with the normal control group of equal body weight feed rat normal feedstuff, fat model group rat average weight is higher than more than the normal control group 100g, learn check by statistics highly significant difference (P＜0.01) is arranged, the fat modelling of rat is described, on this basis, carry out the fat-reducing test of sample of the present invention.
With rat normal feedstuff feed normal control group, the fat model control group of fat model feedstuff feed and experimental group, the while per os gives experimental group sample of the present invention and repeatedly tests, and each administration time is 35 days.The result shows: sample of the present invention can significantly reduce obese rat body weight, minimizing rat kidney and testis fat weight on every side, with its weight loss rate of fat model control group comparison be that 40-25%, body fat slip are 25-18%, highly significant and significant difference (P＜0.01, P＜0.05) are arranged.
1.2 rat prevention of obesity modelling: after the grouping of bull rat, directly with normal feedstuff feed bull rat normal control group, fat model control group of fat model feedstuff feed and experimental group, per os gives experimental group sample of the present invention and repeatedly tests each administration time 35 days simultaneously.The result shows: the effectively increase of fat around rat body weight and kidney and the testis due to the controlling obesity model feedstuff of sample of the present invention, its body weight and body fat rate of increase are starkly lower than fat model control group, are respectively 47-70% (P＜0.01), the 41-57% (P＜0.01) of fat model control group.
2, rat hypolipemic function test: male rat blood fat reducing test shows that this sample all has significant effect to treating the rat hyperlipidemia and preventing rat fat to increase.
2.1, rat disorders of lipid metabolism modelling-therapeutic is given given the test agent: the bull rat is got tail blood survey TC (serum total cholesterol), TG (serum levels of triglyceride), HDL-C (serum high-density LP cholesterol) level, feed hyperlipidemia model feedstuff 30 days, get tail blood again and survey TC, TG, the HDL-C level, carry out feed high lipid food front and back TC, TG, HDL-C level self relatively, rat TC average level significantly raises, learn check by statistics highly significant difference (P＜0.01) is arranged, the foundation of rat hyperlipidemia model is described, carries out the blood fat reducing test of sample of the present invention on this basis.
With high lipid food feed hyperlipidemia model matched group and experimental group, the while per os gives experimental group sample of the present invention and repeatedly tests, and each administration time is 35 days.The result shows: sample of the present invention can significantly reduce high fat rat TC, TG level and hyperlipidemia model matched group relatively highly significant difference (P＜0.01).
2.2 the rat disorders of lipid metabolism modelling-preventative given the test agent of giving: the bull rat is got tail blood survey TC (serum total cholesterol), TG (serum levels of triglyceride), HDL-C (serum high-density LP cholesterol) level, with high lipid food feed hyperlipidemia model matched group and experimental group, the while per os gives experimental group sample of the present invention and repeatedly tests, and each administration time is 35 days.The result shows: sample of the present invention can significantly be controlled rat TC due to the hyperlipidemia model feedstuff, the TG level raises and the hyperlipidemia model matched group relatively there were significant differences (P＜0.05).
3, edible safety evaluation test: product of the present invention has been carried out safe toxicological evaluation, and the result shows: sample edible safety of the present invention is reliable.
3.1, acute toxicity test: adopt the maximum tolerated dose method respectively large and small Mus to be experimentized, the result shows: the large and small Mus per os of sample of the present invention median lethal dose(LD 50) (LD50)＞10g/kg.bw, it is nontoxic to press the true border of toxicity grading standard.
3.2, rat 35 days feeds experiment: with daily dose 100 multiple doses of referrer of the present invention, per os feed health, from breast, the young Mus of SD 35 days, not seeing has harmful effect to rat growthing development, feed and food utilization, blood parameters, main organs etc., and its maximum is not observed illeffects dosage 100 times for the daily dose of referrer.
The specific embodiment
Embodiment 1:
Get Fructus Phyllanthi powder 450g, Folium camelliae assamicae (processed) powder 490g, Radix Notoginseng extract powder 50g, add that 70% ethanol is granulated in right amount, dry, granulate, add magnesium stearate 10g, be pressed into tablet.
Described Fructus Phyllanthi powder for the Fructus Phyllanthi fresh fruit clean, broken, squeeze the juice, get the powder that filtrate is spray dried to behind the filter cleaner; Described Folium camelliae assamicae (processed) powder is dry Folium camelliae assamicae (processed), removes impurity, the powder that machinery or comminution by gas stream, mistake 200 orders are made; Described Radix Notoginseng extract powder for get dry Radix Notoginseng, cleaning, broken back with 50-70% alcohol reflux more than 3 times, filter cleaner, filtrate merge, reclaim behind the ethanol spraying drying powder-forming or 80 ℃ dry after mechanical activation comminution become powder.
Embodiment 2:
Get Fructus Phyllanthi powder 600g, Folium camelliae assamicae (processed) extract powder 340g, Radix Notoginseng extract powder 60g, in the hard capsule of fully packing into behind the mixing, make hard capsule.Described Fructus Phyllanthi powder and Radix Notoginseng extract powder craft are the same; Described Folium camelliae assamicae (processed) extract powder is Folium camelliae assamicae (processed), remove the water solution extract behind the impurity, the spray-dried or direct dry powder that becomes of oven dry back mechanical activation comminution.
Embodiment 3:
Get Fructus Phyllanthi powder 430g, green tea powder 470g, Radix Notoginseng extract powder 90g, make tablet with common process.Described Fructus Phyllanthi powder and Radix Notoginseng extract powder craft are the same; Described green tea powder is dry big leaf green tea, removes impurity, machinery or comminution by gas stream, mistake 200 orders and the above powder of making.
Embodiment 4:
Get Fructus Phyllanthi powder 500g, Pu'er raw tea powder 430g, Radix Notoginseng extract powder 70g, in the hard capsule of fully packing into behind the mixing, make hard capsule, its technique for producing raw material is with embodiment 1.
Claims (9)
1. compositions with fat reducing and weight reducing function, by it is characterized in that following raw materials by weight percent forms: Fructus Phyllanthi powder 40-70%, Folium Camelliae sinensis powder 25-60%, Radix Notoginseng extract powder 4-10%, described Fructus Phyllanthi powder are Fructus Phyllanthi fruit drink concentrated dry powder.
2. according to the described compositions of claim 1, by it is characterized in that described Folium Camelliae sinensis powder is the powder of Folium camelliae assamicae (processed) through the superfine grinding gained with fat reducing and weight reducing function.
3. according to the described compositions of claim 1, by it is characterized in that described Folium Camelliae sinensis powder is the powder of Pu'er raw tea through the superfine grinding gained with fat reducing and weight reducing function.
4. according to the described compositions of claim 1, by it is characterized in that described Folium Camelliae sinensis powder is the powder of green tea through the superfine grinding gained with fat reducing and weight reducing function.
5. according to the described compositions of claim 1 with fat reducing and weight reducing function, by it is characterized in that described Folium Camelliae sinensis powder is the water solution extract of Folium camelliae assamicae (processed) or Pu'er raw tea or green tea, the spray-dried or direct dry powder that becomes of oven dry back mechanical activation comminution.
6. according to the described compositions of claim 1 with fat reducing and weight reducing function, by it is characterized in that described Radix Notoginseng extract powder is dry Radix Notoginseng, after cleaning, fragmentation, use the 50-70% alcohol reflux more than 3 times, filter cleaner, filtrate merges, the powder that spray drying is made behind the recovery ethanol or 80 ℃ of powder that dry back mechanical activation comminution is made.
7. according to the described compositions of claim 1, by it is characterized in that following raw materials by weight percent forms: Fructus Phyllanthi powder 45-60%, Folium Camelliae sinensis powder 30-50%, Radix Notoginseng extract powder 4-10% with fat reducing and weight reducing function.
8. has application in the medicine of fat reducing and weight reducing function according to any described compositions among the claim 1-7 in preparation.
9. has application in the health food of fat reducing and weight reducing function according to any described compositions among the claim 1-7 in preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100110604A CN100376266C (en) | 2005-10-12 | 2005-10-12 | Medicated composition with wt.-reducing and hypolipidemic functions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100110604A CN100376266C (en) | 2005-10-12 | 2005-10-12 | Medicated composition with wt.-reducing and hypolipidemic functions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1947762A CN1947762A (en) | 2007-04-18 |
| CN100376266C true CN100376266C (en) | 2008-03-26 |
Family
ID=38017450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100110604A Expired - Fee Related CN100376266C (en) | 2005-10-12 | 2005-10-12 | Medicated composition with wt.-reducing and hypolipidemic functions |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100376266C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102106539B (en) * | 2011-01-25 | 2012-12-12 | 洛阳国颜食品科技有限公司 | Blood lipid reducing health-care food |
| CN102204602B (en) * | 2011-05-18 | 2012-09-26 | 徐杏昌 | Lipid-lowering and antihypertensive health tea and preparation method thereof |
| CN105265637A (en) * | 2014-05-27 | 2016-01-27 | 李建峰 | Beautifying Pu'er tea composition |
| CN106072586A (en) * | 2016-07-15 | 2016-11-09 | 侯小芳 | A kind of health food of slimming and preparation method thereof |
| CN108157544A (en) * | 2017-12-28 | 2018-06-15 | 防城港圣保堂制药有限公司 | A kind of konjaku tea powder and preparation method thereof for dietotherapy of reducing weight |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1385205A (en) * | 2002-06-04 | 2002-12-18 | 孟昭强 | Soft-extract for treating hepatitis B and preparation process thereof |
-
2005
- 2005-10-12 CN CNB2005100110604A patent/CN100376266C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1385205A (en) * | 2002-06-04 | 2002-12-18 | 孟昭强 | Soft-extract for treating hepatitis B and preparation process thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1947762A (en) | 2007-04-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100376266C (en) | Medicated composition with wt.-reducing and hypolipidemic functions | |
| CN103203008A (en) | Pharmaceutical composition for sobering up and preparation method thereof | |
| CN103749776B (en) | Sweet broomwort herbal tea and making method thereof | |
| CN101485861B (en) | Chinese medicament preparation with sobering-up, blood fat-reducing, liver-protecting and cardio-cerebrovascular-protecting functions | |
| CN109498785A (en) | Invigorating the spleen to clear away damp pathogen Chinese medicine composition | |
| CN104126705A (en) | Heart nourishing tea | |
| CN101199347A (en) | Pb excluding health care product and its preparation method | |
| CN101715914A (en) | Polygonatum polysaccharide buccal tablets and preparation method thereof | |
| CN104013845A (en) | Formula of blood sugar reducing traditional Chinese medicinal preparation and preparation method | |
| CN104984210A (en) | Amomum kravanh and galangal alcohol effect dispelling honey and preparing method thereof | |
| CN107897414A (en) | A kind of clearing lung type tea of relieving cough and diminishing inflammation and its preparation and application | |
| KR20160000695A (en) | Herbal-medicine containing dha for recovering fatigue and enhancing memory, and method of manufacturing the same | |
| CN105994840A (en) | Antihypertensive health-care tea containing dendrobium officinale and preparation method of tea | |
| KR101783549B1 (en) | Health supplement food containing dha for recovering fatigue, and method of manufacturing the same | |
| CN1298251C (en) | Health food with fat-reducing function | |
| CN100475049C (en) | Green tea product and preparation method thereof | |
| CN104274568A (en) | Anti-fatigue compound preparation and preparation method thereof | |
| CN100998787B (en) | Traditional Chinese medicine effervescent tablets for treating gastrointestinal disease and its preparing method | |
| CN1947770A (en) | Medicinal composition with wt.-reducing function | |
| CN102485263B (en) | Medicinal composition for treating chronic cough of children and its preparation method | |
| CN106036344A (en) | Lotus root weight-loss beverage and preparation method thereof | |
| CN100422199C (en) | Extractive from specific part of skullcap, preparation method and application | |
| CN105831512A (en) | Lepidium-meyenii-containing traditional Chinese medicine or food having tonification function without dryness, and preparation method and application of lepidium-meyenii-containing traditional Chinese medicine or food | |
| CN102485264A (en) | Pharmaceutical composition for treating children's long-term cough and preparation method thereof | |
| CN104013696A (en) | Plant medicine composition for preventing and treating metabolic syndrome and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080326 Termination date: 20101012 |