CN100376240C - Medicine and fool dual purpose vitamin microelement nutritive product for preventing ane treating cataract and its manufacturing method - Google Patents
Medicine and fool dual purpose vitamin microelement nutritive product for preventing ane treating cataract and its manufacturing method Download PDFInfo
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- CN100376240C CN100376240C CNB200510136548XA CN200510136548A CN100376240C CN 100376240 C CN100376240 C CN 100376240C CN B200510136548X A CNB200510136548X A CN B200510136548XA CN 200510136548 A CN200510136548 A CN 200510136548A CN 100376240 C CN100376240 C CN 100376240C
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Abstract
The present invention relates to a dietotherapeutic vitamin microelement nutritive product for preventing and treating the cataract and a manufacturing method of the product. The product is made of official dietotherapeutic composite vitamins and composite microelement. The present invention has the advantages of low production cost, no environment pollution, no difference on people and age, good taste, less dosage, certain effect and can be easily accepted by patients. Because eyes are windows of the soul and are the most important in five organs, all the people want a pair of healthy eyes and good eyesight. However, nearly half of people in the world have the eye diseases, and more than forty million people are blind. If effective measures are not adopted, the number of people having eye diseases can be multiplied, and each person can be threatened by the eye diseases. The cataract is one of the main diseases causing people to be blind, is the first eye disease causing blindness, has high morbidity and blindness causing rate and becomes a problem generally cared by the whole society. Although the cataract has many etiologies, malnutrition and bad metabolism are the essential and the fundamental reasons; hence, the present invention has very important practical value and positive present-day and long-term significance for preventing and treating the cataract and improving and enhancing the healthy conditions of eyes and eyesight.
Description
The eyes are the windows of the mind, occupy first of the face, everybody thirsts for having a pair of healthy eye and good vision, but whole world nearly half people suffers from variety classes and ophthalmic in various degree, wherein more than 4,000 ten thousand people are blind, as not adopting an effective measure, the crowd who encroached on by ophthalmic will be doubled and redoubled, ophthalmic will threaten everyone.Therefore, prevention of blindness, effectively controlling ophthalmic infringement, is one of human challenge that faces in 21 century.
Cataract is to cause one of human blind principal disease, is that the whole world first blinding ophthalmic, sickness rate and blind rate are all higher.Normal crystalline lens is transparent, but affects one's power of vision, then is called cataract because of its protein denaturation causes lenticular opacity as crystalline lens.Although cataractous reason takes place can be many-sided, but because of crystalline lens does not have blood vessel, is to carry out metabolic mode with the nutrient substance in the special absorption aqueous humor to keep its transparency, as the nutrient substance of aqueous humor particularly anti-oxidative damage material deficiency or composition change the especially increase of oxidation material, thereby all can make the crystallin qualitative change and cause muddiness and affect one's power of vision and produce cataract.Although have multiple but bad essence and the basic reasons of being only of nutrition and metabolism so cataractous reason takes place.Because crystalline lens does not have blood vessel, clearing all of the keeping of required all nutrition and metabolite done by aqueous humor fully, and the metabolism ability of aqueous humor itself and speed are supported far beyond blood flow and metabolic system is poor, the metabolism that is aqueous humor is periodically longer, so have only and contain enough nutrition in the aqueous humor, crystalline lens just may obtain enough and stable nutrition, have only the oxide that contains in the aqueous humor few more on the contrary, crystalline lens also can be kept its transparency, and these also only have blood to be that human body integral nutrition supply and metabolism are enough and stable could to realize.But although cataract operative treatment, but, lenticular opacity recovers transparent because of can reversing by the mode of improving nutrition, add that operation has many contraindications such as microphthalmia, microcornea, rubeosis of iris, the lore sky is unusual, congenital glaucoma, detachment of retina, proliferating diabetic retinopathy becomes and other proliferating diabetic retinopathy becomes, in the art or postoperative many complication such as artificial intraocular lenses's dystopy are also arranged, inflammation, hemorrhage, edema, ametropia etc., risk is more also big, the more important thing is that the artificial intraocular lenses is nonelastic and do not have the sighting distance of adjusting ability, to have a strong impact on many work and character as looking far away or looking nearly generation exceptional hardship etc., the result who weighs the advantages and disadvantages is not difficult to reach a conclusion: unless last resort, generally should at first adopt medical treatment, especially early, mid-term, lenticular opacity also was in the cataract under the reversible state, but prevent and treat all very single and thin catalin (catallin) that stops the Oxidation of quinoid material as unitary type of cataractous ingredient and effect at present, phacolin (phaconlysin), catalin (bernetin) eye drop, single anti-oxidative damage medicine glutathione (glutathione) eye drop etc., these all can only take stopgap measures and can not effect a permanent cure, because of crystalline lens is to obtain nutrition by the special aqueous humor metabolism mode of passing through, aqueous humor is then from capsulociliary juice and be what bring in constant renewal in to regenerate, and corpus ciliare and juice thereof and material composition wherein come autoblood, the nutrition of blood is frequent from food and nutrition thereof and the fast mass exchange of flowing velocity again, so final aqueous humor or say lenticular nutrition and morbid substance such as free radical etc. all from human body integral, as can not solve this fundamental issue of whole body health level comprehensively, above-mentioned all medicines and effect obviously all can only be just as short-lived, have a look at the cloud eye, promptly cure the symptoms, not the disease.Therefore, preventing and treating the cataractous key i.e. problem of effecting a permanent cure is that the supply and the metabolism of the corresponding nutrient substance how the full-scope safeguards general is enough and stable is abundantly clear.
The present invention is exactly for solving the application of a kind of compositions in preparation treatment cataract nutrition product that this difficult problem designs, product does not have crowd restriction, to preventing and treating cataract, improving eyes and the vision health situation has the practical value of particular importance and positive now and far-reaching significance.Be to strengthen the understanding of the present invention, the main scientific and technological principle and the innovation that below continue to introduce the present invention and foundation thereof are advantage.
Reasonably nutrient substance not only promotes teenager health normal growth to grow and to improve premunition such as booster immunization proteic synthetic etc., also is the Fundamentals of safeguarding eye health, prevention and the various oculopathy of treatment simultaneously, complements each other between them, promotes mutually.Nutritional imbalance, deficiency or superfluous, body interior all can go wrong.For preventing and treating ophthalmic such as cataract, following health promulgated by the ministries or commissions of the Central Government and GB2760 and GB14880 officinal food dual purpose product and function becomes more important and outstanding, spy further are described below one by one:
Vitamin A can be prevented and treated xerophthalmia, this is because VA keeps the sound necessary disposition nutrient substance and influenced the most remarkable and classify that VA lacks and the top priority of harm as with the epithelium of eye of supporting one's family of all epithelial tissue, xerophthalmia is exactly that the lachrymal gland epithelium is unsound, the tear secretion stops to take place owing to the long-term lacking vitamin A makes, so VA is called antixerophthalmic vitamin again; As a same reason, aqueous humor is by ophthalmic corpus ciliare secretion displacement, just can obviously not feel within the eye that because of it resembling the outer tear of eye lets out loss because of for a long time direct ingress of air with through tear (little) bank of tubes, but still be understood that, A or gastroenteropathy such as enteritis, diarrhea are digested and assimilated bad and can not be absorbed enough vitamin A if be deficient in vitamin in the diet, also will inevitably cause corpus ciliare VA not enough and cause the aqueous humor secretion to reduce and metabolism slows down, directly make crystalline lens that bad chain reaction takes place and easily bring out cataract.Beta-carotene not only can change into vitamin A, again do not have the toxicity of VA and can accumulate in vivo and to the people harmless (as accumulate too much also only show skin slightly yellowing that is all, need only short-term stop using and can recover the former colour of skin rapidly), so the present invention is with its alternative part of V A, and when lacking, VA transforms rapidly with compensation VA, so tool regulate supplies double effects automatically.Vitamin B1 deficiency causes conjunctiva and corneal epithelium infringement causing xerophthalmia, retrobulbar neuritis, optic atrophy.Vitamin B2 deficiency causes eyes many places inflammation such as keratitis (blood vessel hyperplasia, muddiness, fester), conjunctivitis, iritis, optic neuritis, scleral injection, even crystalline lens and vitreous opacity occur.Vitamin PP (nicotinic acid is that nicotinic acid and niacin amide are nicotiamide) can form energy and many substance metabolismes are the hydrogen acceptor NAD+ (CoI-nadide) and the NADP+ (CoII-is coenzyme II) of biological oxidation respiratory chain and supply (passing) hydrogen body NADH and NADPH, reversible hydrogenation of niacin amide part tool and dehydrogenation characteristic in these two kinds of coenzyme structures, in biological oxidation process, form hydrogen carrier system or electron transport system, play a part to pass hydrogen, so shortage causes neural malnutrition and neuritis, makes optic atrophy.Vitamin C is an antioxidant in the aqueous humor, lack and not only to make especially quinoid oxidation material severe oxidation and outside the grievous injury transparency of the oxidated thing of crystalline lens, the synthetic generation obstacle that also can directly cause intercellular substancies such as collagen protein, wound and ulcer occur and be difficult for healing, capillary permeability increases, cause subcutaneous, mucosa, vitamin C deficiency such as hemorrhage of muscle, event can bring out eyeball and the accessory organs of eye official is hemorrhage, as serious consequences such as subretinal choroidal hemorrhage will cause losing one's sight, also can influence eye inflammation, the healing of macular hole etc., whether normal relation is close and these factors are all with aqueous humor composition and metabolism thereof.The vitamin E anti-oxidation function is same powerful and be fatsoluble vitamin, can form a complete aqueous humor antioxidant vitamins system with water solublity antioxidant vitamins C because of it, and the oxidation resistance and the effect that mutual coordination are arranged and strengthen function and strengthened single application greatly because of these two kinds of antioxidant mechanism and effect thereof, so the two share that not only the antioxidation mode is more perfect and control crystallin matter oxide oxidation and the degeneration muddiness is that cataractous power is also more powerful, consumption is still less saved cost on the contrary.(it is a lot of that nucleic acid contains chromium for trace element chromium, nucleic acid lacks and causes growth inhibited, chromium deficiency also causes insulin active low, concurrent hyperglycemia and the glycosuria on an empty stomach of comprising, because of energy shortage makes premunition that various ophthalmics lowly easily take place and looks disease, comprising also wherein that the direct harm of hyperglycemia such as retinal degeneration etc. are serious reduces vision and blinding pathological changes and is on the rise and extensively, especially old people Geng Yi lacks chromium, should pay much attention to especially, shortage can make wall of eyeball elasticity weaken distortion and eye (looking) axle is changed, and force the long-term gross distortion of crystalline lens with adapt to and regulate this variation and make its elasticity and regulating power serious descend and be difficult to recover, because of retina and choroid distortion degeneration finally easily causes lose one's sight (seeing above-mentioned), also easily make lenticular opacity generation cataract because of influencing the aqueous humor composition, vitreous opacity shrinks with liquefaction and causes also being pulled open by its retina that involves and split and form macular hole, grievous injury patient central vision dwindles as looking thing, distortion, even central vision complete obiteration, make many occupations that must rely on central vision and work as drive (because of central light loss can't be seen traffic signal, or because of image replacement or covering around the center image quilt, central vision is seen be in fact peripheral image be false center image and very easily lead to serious traffic safety accident), read and (seriously dwindle distortion, even cannot see any literal or the image of being watched attentively at all, all the other are identical with above-mentioned driving situation) etc. can't carry out at all, the vitreous humor of liquefaction that What is more leaks under the disruptive retina and constantly and enlarges, cause retina part even come off fully, as give treatment to untimely then blinding fully.Trace element-selenium is the same with vitamin C to be activated plurality of enzymes and enzyme system and is beneficial to absorbing and bring into play effect, and strengthening effect mutually of element such as calcium (as the acidity of VC), chromium and vitamin B1 and vitamin B2 and vitamin PP etc., cause output increase in the vitamin B2 urine, the vitamin B2 in the in-vivo tissue is descended as Vitamin B1 deficiency, vitimin supplement PP has prevented the shortage because of vitimin supplement B1 aggravation vitamin PP again, thereby make vitamin B group dosage keep balance etc., the improvement of vision is all had very great help mutually.In addition, vitamin A, C and E also have and the collaborative antioxidation of the glutathion that powerful anti-oxidative damage function is arranged equally: because glutathione content is very high in the normal crystalline lens, its content obviously descends when senile cataract, and experimental cataract can make its crystalline lens be tending towards transparent because of the increase of glutathione content, so glutathione is to prevent and treat another key factor of cataract and material base.Glutathion be one natural in the destructive antioxidant of opposing free radical, not only ensure the crystalline lens transparency and can reverse muddy crystalline lens to make it to recover transparent again and prevent and treat cataract, also help the liver protecting to avoid the infringement of poisonous substance and some drugs.Yet directly take glutathion is not a wise move because its to belong to peptide class be the protein amino acid substance, most ofly during through digestive tract can seldom can be entered blood by gastric acid and digestive tract proteolytic enzyme digest.Therefore pharmacy seldom has the glutathion tonic to sell, but as taking the effect that the tonic that can make body produce more glutathion then can reach the compensation glutathion equally and remove free radical.Therefore the method for best raising body glutathion inside level is to take in enough synthesizing glutathions and promote its raw material synthetic and its effect of raising, comprises vitamin A, C, E and trace element-selenium, lactalbumin.Selenium and vitamin A, C, E and cystine play synergism, it is the essential composition (every mole enzyme contains 4 gram atom selenium) of glutathion peroxidase, the oxidation of this enzyme catalysis glutathion, make reduced glutathion change oxidized form of glutathione into, the peroxide of reduced glutathion destroying hydrogen peroxide and unsaturated fatty acid in this process has enough glutathion can not prevent the destruction of these peroxide naturally even if scarce selenium promptly lacks enzyme.Taking lactalbumin also is to increase the synthetic effective ways of body glutathion inside: scientist has compared the influence to glutathion inside of 20 gram lactalbumins, placebo and 20 gram caseins in 20 health volunteers, found that lactalbumin can make glutathione level rising 20% in the blood, shows and can improve antioxidant status.One of them explanation is because contain a kind of sulfur-containing amino acid---cysteine in the milk surum, replenishes the glutathione level that nitrogen acetylcysteine (NAC) can improve human body.But the nitrogen acetylcysteine of long-term overdose might bring side effect, shows that because of experiment is arranged exacting practice (producing a large amount of free radicals) back takes the nitrogen acetylcysteine in conjunction with vitamin C and can make on the contrary that the interior free yl level raises, and the remarkable infringement degree of increase muscle! So the effect about it is also not too clear and definite, does not recommend to be used for improving glutathione level.Therefore, lactalbumin is taken in recommendation rather than the nitrogen acetylcysteine stimulates body glutathion inside level, and that milk powder contains abundant lactalbumin, other nutrient substance is also very abundant, is undoubtedly superior choosing, adopts one of milk powder major reason so this also is the present invention.To sum up state, it is all very high that product of the present invention and raw material belong to total inventive concept, helpfulness and a degree of association.
Product of the present invention is made up of legal dietotherapeutic compound vitamin 1-3 part, compound microelement 0.01-0.1 part; Wherein:
Compound vitamin is by vitamin A 0.01-0.1 part, β-Hu square-bottomed bamboo basket Bu Su 0.01-0.1 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part, vitamin C 1-3 part and vitamin e1-3 part composition;
Compound microelement is made up of chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part;
Above material adopts other kind of GB2760 and GB14880 approval to convert consumption by active substance.
The manufacture method of product of the present invention is as follows:
The preparation of compound vitamin: in sterilizing room, get vitamin A 0.01-0.1 part, β-Hu square-bottomed bamboo basket Bu Su 0.01-0.1 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part, vitamin C 1-3 part and vitamin e1-3 part join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB1488 approval to convert consumption by active substance;
The preparation of compound microelement: in sterilizing room, get chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part, join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB14880 approval to convert consumption by active substance;
The preparation of product of the present invention: in sterilizing room, get compound vitamin 1-3 part, compound microelement 0.01-0.1 part, join and ground well in the nonmetal mortar 3-5 minute, raw produce; Product 3-5 part of the present invention is made Any shape such as sheet that filler and binding agent be pressed into the 0.2-0.4 gram, grain, ball of milk powder 3-5 part and lactose 1-3 part part by weight, must product.
The purposes of product of the present invention, usage and consumption: as food, nutriment, health product and medicine, oral every day 2-3 time, each 0.4-0.8 restrain, and need not the branch of crowd and dosage; As the host or the additive of food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP.
Embodiment:
In sterilizing room, get 1 part of compound vitamin, 0.01 part of compound microelement, join and ground well in the nonmetal mortar 3-5 minute, raw produce; 3 parts of products of the present invention are made Any shape such as sheet that filler and binding agent be pressed into the 0.2-0.4 gram, grain, ball with 1 part of 3 parts of milk powder and lactose, must product.
Supplementary copy inventive principle and advantage are as follows:
1, the present invention adopts the low lactose of water absorption to do complexion changed and easy preservation that filler can reduce duration of storage, so storage life is that the commodity shelf life is long, economic worth is high.
2, medicine variety and function all are legal medicine-food two-purposes and simple and clear and do not have a dispute, the multiple state of an illness of prescription adaptation versatile and flexible and select medication properer.
3, all medical materials all are conventional varieties and have no side effect, so quality, the source is secure and aboundresources is cheap, product of the present invention can be consumed by vast general patient because of no patient crowd's branch event and obtain and afford to consume, and the realization new and high technology is served lofty aim for the most numerous common people.
4, become China and Asia average 80% above population for want of the Lactose enzyme indigestibility defective that absorbs (as milk) lactose be the favorable factor of disease preventing and treating, thereby can significantly slow down the medicine slow release speed and significantly prolong efficacy of a drug persistent period and raising curative effect and possible medicine irritation is relieved to bottom line because adopt lactose to replace the starch easily digested and assimilated and dextrin to make adsorbent and filler.
Test method, data and presentation of results and prompting:
Disease that product of the present invention is controlled belongs to common frdquently encountered disease so tool is extensively representative, experimenter's voluntary participation.Product of the present invention because of good effect and have no side effect and crowd's branch, so treatment cycle is short and cure rate is high, make test be easy to just satisfactorily be finished, now further be explained as follows (only for reference) with allow keeping in Patent Law about situation under the prerequisite of necessary KNOW-HOW and business secret and please understand: it is 2 groups that totally 40 of the test patients at different sexes, age, 20 people are divided into for one group: one group with compound Chinese medicine product of the present invention and usage and dosage prevent and treat, one group of not medication compares; Test number and time on test reach 4 first quarter moons, tool statistical significance so suitable representativeness and credibility are arranged.The result is as follows: deepen with none routine cataract of the test group personnel of product of the present invention, 5 people's vision no changes are arranged, 15 people's eyesight improvings are arranged, go up not down, and increasing degree reaches 0.1-0.2 and do not wait; The matched group experimenter finds that visual deterioration 16 people and 12 people decrease by 0.1-0.2,4 people's vision no changes, none eyesight improving, the person of going up not down.
Prompting: it is that vision does not descend and just proves absolutely that the state of an illness control, is that product of the present invention is effective that cataract is not deepened, and the direction reverse that the explanation state of an illness that goes up not down is become better, is that product efficacy of the present invention is remarkable.
Claims (1)
1. the compositions application in preparation treatment cataract nutrition product is characterized in that said composition makes by following step:
1). the preparation of compound vitamin: in sterilizing room, get vitamin A 0.01-0.1 part, β-Hu square-bottomed bamboo basket Bu Su 0.01-0.1 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part, vitamin C 1-3 part and vitamin E 1-3 part join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby;
2). the preparation of compound microelement: in sterilizing room, get chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part, join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby;
3). the preparation of product: in sterilizing room, get compound vitamin 1-3 part, compound microelement 0.01-0.1 part, join and ground well in the nonmetal mortar 3-5 minute, raw produce; Raw produce 3-5 part is done sheet, grain, the ball that filler and binding agent are pressed into the 0.2-0.4 gram with milk powder 3-5 part and lactose 1-3 part part by weight, must product.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB200510136548XA CN100376240C (en) | 2005-12-29 | 2005-12-29 | Medicine and fool dual purpose vitamin microelement nutritive product for preventing ane treating cataract and its manufacturing method |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB200510136548XA CN100376240C (en) | 2005-12-29 | 2005-12-29 | Medicine and fool dual purpose vitamin microelement nutritive product for preventing ane treating cataract and its manufacturing method |
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| Publication Number | Publication Date |
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| CN1823832A CN1823832A (en) | 2006-08-30 |
| CN100376240C true CN100376240C (en) | 2008-03-26 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100376234C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | medicine and food dual purpose vitamin microelement nutritive product for preventing and treating synchysis and its manufacturing method |
| CN100376233C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Food and medicine dual purpose product for preventing and treating vision injury syndrome duo to TV and computer display light and its manufacturing method |
| CN100376235C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Medicine and food dual purpose nutritive product for preventing and treating synchysis and its manufacturing method |
| CN100376236C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Medicine and food vitamin and microelement nutritive product for preventing and treating keratomalacia and its manufacturing method |
| CN100376239C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Medicine and food dual purpose nutritive product for preventing and treating cataract and its manufacturing method |
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| CN1823832A (en) | 2006-08-30 |
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