CN1824041A - Medicine and food dual purpose nutritive product for preventing and treating computer vision syndrome and its manufacturing method - Google Patents
Medicine and food dual purpose nutritive product for preventing and treating computer vision syndrome and its manufacturing method Download PDFInfo
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Abstract
A medical product used as both medicine and food for preventing and treating the vision syndrome caused by computer is prepared from composite medicine, vitamins and trace elements. Its preparing process is also disclosed.
Description
The eyes are the windows of the mind, occupy first of the face, everybody thirsts for having a pair of healthy eye and good vision, but whole world nearly half people suffers from variety classes and ophthalmic in various degree, wherein more than 4,000 ten thousand people are blind, as not adopting an effective measure, the crowd who encroached on by ophthalmic will be doubled and redoubled, ophthalmic will threaten everyone.Therefore, prevention of blindness, effectively controlling ophthalmic infringement, is one of human challenge that faces in 21 century.
Computer visual syndrome is proposed by U.S. ophthalmology association, comprise that the dry and astringent fatigue of eyes, forehead are heavy, clinical symptoms such as the dimness of vision, energy are not concentrated, hypomnesis, cervical vertebra ache, present 60% white collar has subhealth symptom and suffers from computer visual syndrome at the computer user of the U.S. 82.4%, is in first of occupation disease.Though its origin cause of formation is numerous, be after all because of due to the long-term serious overdraw of health factors such as muscle power, energy and closely-related nutrition.If drug main artificial tears in this respect or cod-liver oil drop eye drip are to replenish moisture content and VA mitigate the disease at present, but obviously can't solve the nutrition of whole body fundamental issue, nature can only take stopgap measures and can not effect a permanent cure, and the medication number of times frequently very bothers, also easily contaminated or use because of the impatient excess of patient and to cause the excessive poisoning of VA; It is that the what is called " green agitation " that this disease is advocated energetically must be born the new example who reclaims responsibility for catering to European Union 25 states approval " about scrapping the electronic and electrical equipment instruction " to a certain extent as " unleaded display " that what is called such as computermaker such as Philips overcomes " computer ' side-product ' "; " Yin Nami " material that LG releases just utilizes the distinctive adsorptivity of silver ion to enter antibacterial inside and the certain antibiosis and deodorization effects of tool; the collection anion of Samsung; the Trinitarian what is called of far infrared and photocatalyst " initiatively healthy solution "; its core is the photo-catalytic nano coating of display surface; also be that certain bactericidal action is only arranged, play the same tune on different musical instruments with the Yin Nami of LG.It is evident that these so-called green agitation or healthy scheme none relate to or solve that this disease is that eyes are dry and astringent, tired, the dimness of vision, dizziness, energy are not concentrated, hypomnesis or cervical vertebra ache problem, take stopgap measures all be far from being, with regard to let alone effected a permanent cure.So only to be the present invention descend according to its pantatrophia, opposing (disease) power is that the essential reason of subhealth state is carried out the general control and is only unique correct wise selection according to etiology, can present several no similar schemes reports or product come out.
The present invention is exactly for solving control computer visual syndrome medicine-food two-purpose dietetic product and the manufacture method that this difficult problem designs, product does not have crowd's restriction, has the practical value of particular importance and positive now and far-reaching significance to improving eyes and vision health situation.Be to strengthen the understanding of the present invention, the main scientific and technological principle and the innovation that below continue to introduce the present invention and foundation thereof are advantage.
Reasonably nutrient substance not only promotes teenager health normal growth to grow and to improve premunition such as booster immunization proteic synthetic etc., also be Fundamentals and the material base that all groups safeguard eye health, prevention and the various oculopathy of treatment simultaneously, complement each other between them, promote mutually.Nutritional imbalance, deficiency or superfluous, body interior all can go wrong.For ophthalmic such as control computer visual syndrome etc., following health promulgated by the ministries or commissions of the Central Government and GB2760 and GB14880 officinal food dual purpose product and function becomes more important and outstanding, spy further are described below one by one:
Chinese medicine food aspect: Radix Glycyrrhizae sweet in the mouth cold nature, can eliminating fire and detoxication and relax the bias of various medicines.Fructus Gardeniae bitter in the mouth cold in nature, heat clearing away also make heat from urine discharge thus effect rapidly, cooling blood for hemostasis, control the jaundice disease of conjunctival congestion and swelling pain, pyretic toxicity carbuncle, whole body jaundice, and the impaired disease of this main just hepato-biliary function that makes eye bright, involve the eyes function to some extent naturally.Semen Cassiae cold nature, suppressing the hyperactive liver and subsiding YANG, clearing away heat to improve acuity of vision, liver opening at eye, liver heat removing are apt to and can be made eye bright, so be to control oculopathy key medicines such as two blurred visions are dark, blurred vision, conjunctival congestion photophobia.Flos Chrysanthemi sweet in the mouth, detoxifcation, suppressing the hyperactive liver make eye bright and move back corneal nebula.Wisdom is nourished heart, strengthens in sweet flat, the spleen reinforcing of Arillus Longan, controls palpitation and restlessness and the hypomnesis that heart spleen blood deficiency causes and people's intelligence is strengthened.The sweet temperature of Fructus Lycii, grow kidney and replenishing marrow, nourishing the liver to improve visual acuity goes wind, cloudy emerging sun to rise, it can yin nourishing, can supporing yangly be maximum characteristics and advantage again, so can control the prosperous disease such as have a dizzy spell of deficiency of the kidney yin, liver-yang.The Semen Phaseoli sweet in the mouth is acid flat, heat-clearing and toxic substances removing, diuretic detumescent, the red swelling of the skin that the Zhi Fanyin pyretic toxicity the causes diseases such as hepato-biliary function damage such as (comprising eyes), carbuncle sore tumefacting virus, jaundice of having a pain, the another name Semen Phaseoli of the non-jequirity of these product, the two acts on complete difference and the latter is poisonous should not take orally, must distinguish clear, can not use with.The Herba Menthae acrid in the mouth is cool in nature, refresh oneself's wind heat, controls the conjunctival congestion headache.Cold in nature, the liver heat removing removing heat from blood that makes eye bright of Folium Mori sweet-bitter flavor controls that conjunctival congestion is dizzy, the lung moistening removing heat from blood.Milk powder sweet in the mouth saltiness is flat, nourishing YIN Yiyang, please that face makes eye bright, vigorate qi and replenish the blood, control the red and swollen puckery pain of binocular, make eye bright, curative effect is very good, can also promote the guarantee crystalline lens transparency that content in the normal crystalline lens is abundant and reverse the muddy cataractous important antioxidant glutathione of lenticular control synthetic, specifically ask for an interview western modern medicine described later and eat relevant elaboration in the content.Herba Portulacae acid is cold, heat-clearing and toxic substances removing, controls the blurring of vision that pyretic toxicity causes or gives birth to the nebula film and swell and ache.Folium Camelliae sinensis bitter in the mouth cold nature, resolving heat and reducing pathogenic fire are controlled diseases such as the vertigo, mental weariness.And above these just this disease be long-term excess eye-using, vision over loading and extremely tired, add all diseases due to the bad and accumulation of nutrition and environment such as light, reading habit etc.
Western modern medicine food aspect: vitamin A can be prevented and treated xerophthalmia, this is because VA keeps the sound necessary disposition nutrient substance and influenced the most remarkable and classify that VA lacks and the top priority of harm as with the epithelium of eye of supporting one's family of all epithelial tissue, so VA is called antixerophthalmic vitamin again.Computer visual syndrome is exactly owing to long-term excess eye-using causes supernutrition consumption to lack, make the lachrymal gland epithelium unsound as vitamin A deficiency, even tear secretion minimizing stops and the pathological changes of cornea own is seen computer especially for a long time, TV and books, make retina consume energy too high and light (poisoning) infringement that produce a large amount of free radicals, and because of these crowds excessively absorbed, twinkle very little (as reducing to below 10 times for about 25 times) and make the tear film rupture withered by normal per minute, adding twinkles makes cornea and atmosphere time of contact also significantly be prolonged the tear evaporation is strengthened very little, is difficult to timely and effectively refresh and rebuild the tear film with additional tear because of the same very little reason of twinkling again, make the very easily dry and astringent fatigue of eyes and take place; As a same reason, aqueous humor is by ophthalmic corpus ciliare secretion displacement, just can obviously not feel within the eye that because of it resembling the outer tear of eye lets out loss because of for a long time direct ingress of air with through tear (little) bank of tubes, but still be understood that, A or gastroenteropathy such as enteritis, diarrhea are digested and assimilated bad and can not be absorbed enough vitamin A if be deficient in vitamin in the diet, also will inevitably cause blood VA not enough and cause VA in the tear of excretory aqueous humor of corpus ciliare and lacrimal secretion and various nutrition especially the free radical resisting oxidation material reduce and metabolism slows down, make and directly from aqueous humor and tear, obtain the cornea chain-react of nutrition and easily bring out malnutrition as anterior dry, muddy, softening, ulcer and make extremely dry and astringent fatigue of eyes, vision seriously descends, even perforation is blind.Beta-carotene not only can change into vitamin A, again do not have the toxicity of VA and can accumulate in vivo and to the people harmless (as accumulate too much also only show skin slightly yellowing that is all, need only short-term stop using and can recover the former colour of skin rapidly), so the present invention is with its alternative part of V A, and when lacking, VA transforms rapidly with compensation VA, so tool regulate supplies double effects automatically.Vitamin B1 deficiency causes conjunctiva and corneal epithelium infringement causing xerophthalmia, retrobulbar neuritis, optic atrophy.Vitamin B2 deficiency causes eyes many places inflammation such as keratitis (muddy, fester), conjunctivitis, iritis, optic neuritis, scleral injection, even crystalline lens and vitreous opacity occur.Vitamin PP (nicotinic acid is that nicotinic acid and niacin amide are nicotiamide) can form energy and many substance metabolismes are the hydrogen acceptor NAD+ (CoI-nadide) and the NADP+ (CoII-is coenzyme II) of biological oxidation respiratory chain and supply (passing) hydrogen body NADH and NADPH, reversible hydrogenation of niacin amide part tool and dehydrogenation characteristic in these two kinds of coenzyme structures, in biological oxidation process, form hydrogen carrier system or electron transport system, play a part to pass hydrogen, so shortage causes neural malnutrition and neuritis, makes optic atrophy.Vitamin C is an antioxidant in the aqueous humor, lack and not only make cornea, crystalline lens, the oxidated thing of vitreous body is quinoid oxidation material severe oxidation and outside the grievous injury transparency especially, the synthetic generation obstacle that also can directly cause intercellular substancies such as collagen protein, wound and ulcer occur and be difficult for healing, capillary permeability increases, cause subcutaneous, mucosa, vitamin C deficiency such as hemorrhage of muscle, event can bring out eyeball and the accessory organs of eye official is hemorrhage, as serious consequences such as subretinal choroidal hemorrhage will cause losing one's sight, also can influence eye inflammation, the healing of macular hole etc., whether normal relation is close and these factors are all with aqueous humor composition and metabolism thereof.The vitamin E anti-oxidation function is same powerful and be fatsoluble vitamin, can form a complete aqueous humor antioxidant vitamins system with water solublity antioxidant vitamins C because of it, and the oxidation resistance and the effect that mutual coordination are arranged and strengthen function and strengthened single application greatly because of these two kinds of antioxidant mechanism and effect thereof, so the two and vitamin A share that not only the antioxidation mode is more perfect and control cornea, the oxide oxidation of crystallin matter and the power of degeneration muddiness is also more powerful and thorough, consumption is still less saved cost on the contrary.(it is a lot of that nucleic acid contains chromium for trace element chromium, nucleic acid lacks and causes growth inhibited, chromium deficiency also causes insulin active low, concurrent hyperglycemia and the glycosuria on an empty stomach of comprising, because of energy shortage makes premunition that various ophthalmics lowly easily take place and looks disease, comprising also wherein that the direct harm of hyperglycemia such as retinal degeneration etc. are serious reduces vision and blinding pathological changes and is on the rise and extensively, especially old people Geng Yi lacks chromium, should pay much attention to especially, shortage can make wall of eyeball elasticity weaken distortion and eye (looking) axle is changed, and force cornea, crystalline lens, the long-term gross distortion of retina and choroid with adapt to and regulate this variation and make its elasticity and regulating power serious descend and be difficult to recover, because of retina and choroid distortion degeneration causes self atrophy, break, break away from, cell death, finally cause losing one's sight, also easily make cornea because of influencing the aqueous humor composition, lenticular opacity generation cataract, vitreous opacity shrinks with liquefaction and causes also being pulled open by its retina that involves and split and form macular hole, grievous injury patient central vision dwindles as looking thing, distortion, even central vision complete obiteration, make many occupations that must rely on central vision and work as drive (because of central light loss can't be seen traffic signal, or because of image replacement or covering around the center image quilt, central vision is seen be in fact peripheral image be false center image and very easily lead to serious traffic safety accident), read and (seriously dwindle distortion, even cannot see any literal or the image of being watched attentively at all, all the other are identical with above-mentioned driving situation) etc. can't carry out at all, the vitreous humor of liquefaction that What is more leaks under the disruptive retina and constantly and enlarges, cause retina part even come off fully, as give treatment to untimely then blinding fully.Trace element-selenium is the same with vitamin C to be activated plurality of enzymes and enzyme system and is beneficial to absorbing and bring into play effect, and strengthening effect mutually of element such as calcium (as the acidity of VC), chromium and vitamin B1 and vitamin B2 and vitamin PP etc., cause output increase in the vitamin B2 urine, the vitamin B2 in the in-vivo tissue is descended as Vitamin B1 deficiency, vitimin supplement PP has prevented the shortage because of vitimin supplement B1 aggravation vitamin PP again, thereby make vitamin B group dosage keep balance etc., the improvement of vision is all had very great help mutually.In addition; vitamin A, C and E also have and the collaborative antioxidation of the glutathion that powerful anti-oxidative damage function is arranged equally: the increase of glutathione content makes cornea, crystalline lens, vitreous body be tending towards transparent; corneal nutrition, thickness and intensity are increased and prevent and treat its drying, muddiness, softening, ulcer, perforation is blind, so glutathion is another key factor of vision protection and material base.Glutathion be one natural in the destructive antioxidant of opposing free radical; not only ensure cornea, crystalline lens, vitreous body transparency and can reverse muddiness and make it to recover transparent again and improve vision, also help the liver protecting to avoid the infringement of poisonous substance and some drugs; and Chinese medicine is thought " the liver being in charge of the eyes "; western modern medicine equally also proved liver function quality directly decision eyes health degree, as storage all fixed and concrete runnings of vitamin A, D, E and B with release, inversion quantity and time etc. by extreme miosis, determine directly whether the health had in mind to be so the health of liver is whether also inevitable.Yet directly take glutathion is not a wise move because its to belong to peptide class be the protein amino acid substance, most ofly during through digestive tract can seldom can be entered blood by gastric acid and digestive tract proteolytic enzyme digest.Therefore pharmacy seldom has the glutathion tonic to sell, but as taking the effect that the tonic that can make body produce more glutathion then can reach the compensation glutathion equally and remove free radical.Therefore the method for best raising body glutathion inside level is to take in enough synthetic glutathiones and promote its raw material synthetic and its effect of raising, comprises vitamin A, C, E and trace element-selenium, lactalbumin.Selenium and vitamin A, C, E and cystine play synergism, it is the essential composition (every mole enzyme contains 4 gram atom selenium) of glutathion peroxidase, the oxidation of this enzyme catalysis glutathion, make reduced glutathion change oxidized form of glutathione into, reduced glutathion destroys and consumes peroxide, the generation oxidized form of glutathione of hydrogen peroxide (is raw material with the hydrogen peroxide) and unsaturated fatty acid in this process, even if scarce selenium promptly lacks enzyme enough glutathion (GSH) are arranged, the destruction that nature can not prevent these peroxide.Taking lactalbumin also is to increase the synthetic effective ways of body glutathion inside: scientist has compared the influence to glutathion inside of 20 gram lactalbumins, placebo and 20 gram caseins in 20 health volunteers, found that lactalbumin can make glutathione level rising 20% in the blood, shows and can improve antioxidant status.One of them explanation is because contain a kind of sulfur-containing amino acid---cysteine in the milk surum, replenishes the glutathione level that nitrogen acetylcysteine (NAC) can improve human body.But the nitrogen acetylcysteine of long-term overdose might bring side effect, shows that because of experiment is arranged exacting practice (producing a large amount of free radicals) back takes the nitrogen acetylcysteine in conjunction with vitamin C and can make on the contrary that the interior free yl level raises, and the remarkable infringement degree of increase muscle! So the effect about it is also not too clear and definite, does not recommend to be used for improving glutathione level.Therefore, lactalbumin is taken in recommendation rather than the nitrogen acetylcysteine stimulates body glutathion inside level, and that milk powder contains abundant lactalbumin, other nutrient substance is also very abundant, is undoubtedly superior choosing, adopts one of milk powder major reason so this also is the present invention.
To sum up state, it is all very high that product of the present invention and raw material belong to total inventive concept, helpfulness and a degree of association.
Product of the present invention is made up of legal dietotherapeutic compound Chinese medicine 3-10 part, compound vitamin 1-3 part, compound microelement 0.01-0.1 part; Wherein:
Compound Chinese medicine is made of in right amount Radix Glycyrrhizae 0.5-1.5 part, Fructus Gardeniae 0-3 part, Semen Cassiae 3-10 part, Flos Chrysanthemi 3-10 part, Arillus Longan 0-3 part, Fructus Lycii 2-4 part, Semen Phaseoli 0-10 part, Herba Menthae 0-1 part, Folium Mori 0-3 part, Herba Portulacae 0-3 part, Folium Camelliae sinensis 0-2 part and milk powder;
Compound vitamin is by vitamin A 0.01-0.1 part, β-Hu square-bottomed bamboo basket Bu Su 0.01-0.1 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part and vitamin C 1-3 part and vitamin e1-3 part composition;
Compound microelement is made up of chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part;
Above material adopts other kind of GB2760 and GB14880 approval to convert consumption by active substance.
The manufacture method of product of the present invention is as follows:
The preparation of compound Chinese medicine:
A. decoction pieces type Chinese crude drug Radix Glycyrrhizae 0.5-1.5 part, Fructus Gardeniae 0-3 part, Semen Cassiae 3-10 part, Flos Chrysanthemi 3-10 part, Arillus Longan 0-3 part, Fructus Lycii 2-4 part, Semen Phaseoli (fragmentation) 0-10 part, Herba Menthae 0-1 part, Folium Mori 0-3 part, Herba Portulacae 0-3 part, Folium Camelliae sinensis 0-2 part are on the waiting list in the choosing of raw material Chinese medicine, join in the nonmetallic surface such as containers such as fiberglass, enamel of belt stirrer, filter and water bath with thermostatic control heater;
Preparation b. organic and inorganic mixed solvent is got the above ethanol of food stage (solubilized many be insoluble in the material of water and significantly improve drug effect) and adds the dilution of room temperature drinking water that to make ethanol (dense) degree be that alcohol content is the organic mixed solvent (mixed solution for extraction object Chinese medicinal ingredients material different liquids still can be considered solvent) with inorganic two kinds of solvent compositions of the sterilization type of 55-75% (V/V is a volume ratio), and alcoholic strength is lower than 55% or be higher than 75% equal difficulty and reach optimum extraction and sterilization effect;
C. use the described solvent of b to the raw material medicine extract with the described mixed solvent of b join a described added get in the container of whole Chinese crude drugs, addition is advisable for flooding Chinese crude drug fully, hermetic container soaked 20-30 minute, turn on agitator and with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, open filter, 50-100 eye mesh screen isolated by filtration medicinal residues and solution, the centrifugal medicinal residues of 1000-3000 rev/min rotating speed, medicinal liquid is incorporated isolated by filtration solution into, open heating (evaporation) device medicinal residues and medicinal liquid accurately are heated to 78-80 ℃ of ethanol boiling point (to reduce evaporation of water and distillation as far as possible) vaporization ethanol respectively, collect vaporization ethanol and the alcohol gas liquid coolant is changed into liquid ethanol recycling use with in advance online water-cooled condenser with the room temperature cooling water, ensure that extracting solution utmost point low organic solvent is the high-quality of alcohol content, used cooling water extracts water as preheating, these measure and ensures the low energy consumption of production and product, low water consumption, low-cost, and avoided the pollution of organic solvent to environment and product, the airtight f merge extractive liquid, that is equipped with of medicinal liquid is used, medicinal residues add the following d step and proceed to handle;
D. inorganic solvent water to medicinal residues proceed extract at room temperature will the medicinal residues after c handles join in the described empty of a, with the described preheating water of c flood fully, hermetic container room temperature (because of contain the few breeding of bacterium limited guarantee not putrid and deteriorated) soaked Chinese crude drug 20-30 minute, turn on agitator was with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, 150-200 eye mesh screen isolated by filtration medicinal residues and solution add the airtight f merge extractive liquid, that is equipped with of medicinal liquid the following e step with, medicinal residues and proceed processing;
E. inorganic solvent is proceeded to add (height) warm extraction to medicinal residues the medicinal residues after d handles is joined in the described empty of a, flood fully with the described preheating water of c, hermetic container, turn on agitator also stirs with 20-60 rev/min of rotating speed, add simultaneously (height) temperature (so the time contain bacterium may be than d for high) lower the temperature slowly naturally after 3-5 minute to boiling that (summer high temperature was lowered the temperature and can suitably be aided with the room temperature water-cooled too slowly in about 20-30 minute, the same recyclable described preheating water of c of incorporating into of cooling water) continues stripping and energy-saving and water-saving to 60-70 ℃ in order to pharmaceutical compositions, extract and must high temperature could propose and low temperature is not carried most material composition, and make and heat rapidly and evenly, reduce material damage and loss, with further raising drug effect and recovery rate, open filter, 150-200 eye mesh screen isolated by filtration solution and medicinal residues, the medicinal residues that discard behind the centrifugal medicinal residues of 1000-3000 rev/min rotating speed are the acyclic dirts of agricultural soil high-quality fertilizer of returning crop stocks to the field, and medicinal liquid is incorporated isolated by filtration solution into and is equipped with f merge extractive liquid, usefulness;
F. extracting solution merges the medicinal liquid merging with c, d and e extraction, gets Chinese medicine extraction liquid;
G. the preparation of compound Chinese medicine is concentrated to 25-30% weight ratio concentration with Chinese medicine extraction liquid with triple effect or multi-effect evaporator, add Chinese medicine extraction liquid, be the solution dry matter content that concentration promotes and is 35-40% by milk powder 3-5 part and lactose 1-3 part part by weight, be spray dried into water content and get the compound Chinese medicine raw material below 3%, host or additive as food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP; Compacting (lactose and all very easily compression moulding of milk powder) becomes Any shape such as the sheet, grain, ball of 0.2-0.4 gram to get product, as food, nutriment, health product and medicine, advises oral every day 2-3 time, 0.4-0.8 restrains at every turn, need not the branch of crowd and dosage.
The preparation of compound vitamin: in sterilizing room, get vitamin A 0.01-0.1 part, β-Hu square-bottomed bamboo basket Bu Su 0.01-0.1 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part, vitamin C 1-3 part and vitamin e1-3 part join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB1488 approval to convert consumption by active substance;
The preparation of compound microelement: in sterilizing room, get chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part, join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB14880 approval to convert consumption by active substance;
The preparation of product of the present invention: in sterilizing room, get compound Chinese medicine 1-3 part, compound vitamin 1-3 part, compound microelement 0.01-0.1 part, join and ground well in the nonmetal mortar 3-5 minute, raw produce; Product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.
The purposes of product of the present invention, usage and consumption: as food, nutriment, health product and medicine, oral every day 2-3 time, each 0.4-0.8 restrain, and need not the branch of crowd and dosage; As the host or the additive of food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP.
Embodiment:
1, drinks 0.5 part of sheet type Chinese crude drug Radix Glycyrrhizae, 1.5 parts of Fructus Gardeniaes, 3 parts of Semen Cassiaes, 3 parts of Flos Chrysanthemis, 1.5 parts of Arillus Longans, 2 parts of Fructus Lyciis, make compound Chinese medicine by the manufacture method of compound Chinese medicine product of the present invention and get raw produce, product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.
2, drink 1.5 parts of sheet type Chinese crude drug Radix Glycyrrhizae, 10 parts of Semen Cassiaes, 4 parts of Fructus Lyciis, 5 parts of Flos Chrysanthemis, 3 parts of Semen Phaseolis (fragmentation), 0.5 part of Herba Menthae, 1 part on Folium Mori, 1 part of Herba Portulacae, 1 part of Folium Camelliae sinensis, make compound Chinese medicine by the manufacture method of compound Chinese medicine product of the present invention and get raw produce, product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.
3, drink 1 part of sheet type Chinese crude drug Radix Glycyrrhizae, 5 parts of Semen Cassiaes, 3 parts of Fructus Lyciis, 10 parts of Flos Chrysanthemis, 2 parts on Folium Mori, 3 parts of Herba Portulacaes, make compound Chinese medicine by the manufacture method of compound Chinese medicine product of the present invention and get raw produce, product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.
4, in sterilizing room, get 1 part of compound Chinese medicine, 1 part of compound vitamin, join and ground well in the nonmetal mortar 3-5 minute, raw produce; Product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.
5, in sterilizing room, get 2 parts of compound Chinese medicines, 1 part of compound vitamin, 0.01 part of compound microelement, join and ground well in the nonmetal mortar 3-5 minute, raw produce; Product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.
Supplementary copy inventive principle and advantage are as follows:
1, the present invention adopts the low lactose of water absorption to do complexion changed and easy preservation that filler can reduce duration of storage, so storage life is that the commodity shelf life is long, economic worth is high; And form particularly favourite " acid is sour-sweet sweet " the popular taste products of children and easily being accepted of most crowds jointly with the acescency of the sweet taste of lactose and Radix Glycyrrhizae and Fructus Lycii and Herba Portulacae, so service face and service group are the most extensive, its society and economic benefit are also just apparent naturally, and these also are the great novelty and the practicality of the legal approval of Patent Law.
2; the property of medicine of Chinese prescription medical material is with flat; cool; it is main and cold with flat rubber belting being slightly cold; also take into account simultaneously and liver (gallbladder); relevant other organ of order after one's own heart; lung; spleen; the protection of the function of kidney and coordination; make drug effect and function more comprehensive and mark; this double controlling; realized that Chinese medicine property of medicine general inclination is in gentle and promote the high boundary of drug effect mutually; potential side effect such as bringing " exceeding the proper limits in righting a wrong " impairment of YANG functional activities of the body fluid even new disease (traditional Chinese medical science is all understood this class situation in case occur often being difficult to control) have promptly been avoided controlling because of calentura is cold; especially can regulate simultaneously and of the application of Yin Yang balancing strength with the medicine of removing bias of medicine; thereby make the moon; sun balance of force and mutual regulating power all can reach balance and gentle; all kinds of diseases and ailments are spontaneous recovery; and because of the legal dietotherapeutic of all medical materials; effect certainly and do not have a toxic and side effects; be suitable for any crowd and serve wide, these just the present invention to the imbody of the wide main advantages of Chinese medicine adaptive surface.
3, medicine variety and function all are legal medicine-food two-purposes and simple and clear and do not have a dispute, and the multiple state of an illness of prescription adaptation versatile and flexible and select medication properer has been opened up out Chinese medicine and debated disease and execute tool body content and range of application.
4, all medical materials all are conventional varieties and have no side effect, so quality, the source is secure and aboundresources is cheap, product of the present invention can be consumed by vast general patient because of no patient crowd's branch event and obtain and afford to consume, and the realization new and high technology is served lofty aim for the most numerous common people.
5, innovate organic and inorganic mixed solvent and extract at room temperature and reclaim organic solvent and recycle molten and water-soluble substances and energy-conservation joint (cooling) water of Extraction oil with being beneficial to synchronously high-quality and high recovery rate, again with inorganic solvent and room temperature and high temperature combined extractive technique, scheme and technology, ensured extraction overall process asepticize, can carry substantially many to the greatest extent be insoluble in water or be insoluble in oil material and significantly improve drug effect and extract quality and content, and extraction ratio height, with short production cycle, energy-saving and water-saving, product cost is low, do not have (organic solvent) and pollute, its serial comprehensive advantage is traditional decocting and single with organic solvent or water or some other is because of expensive, highly difficult, the product of receiving single (fact proved and the generally acknowledged both at home and abroad compound composition extract of Chinese medicine than single composition extract good effect, this was exactly the essence and the inherent feature place of Chinese medicine originally and was determined by it), recovery rate low and short-term even long duration are difficult to that so-called modern Chinese medicine extractive technique that penetration and promotion uses is difficult to mention in the same breath.
6, become the favorable factor of the defective of China and Asia average 80% above population Lactose enzyme indigestibility absorption for want of (as milk) lactose into disease preventing and treating, because adopt lactose to replace the starch of easily digesting and assimilating and dextrin is made adsorbent and filler can significantly slow down the medicine slow release speed and avoid taking a very Peter Pans historic difficult problem beyond affordability of traditional decocting Chinese medicine amount, thereby significantly prolong the efficacy of a drug persistent period and improve curative effect and possible medicine irritation is relieved to bottom line.
Test method, data and presentation of results and prompting:
Disease that product of the present invention is controlled belongs to common frdquently encountered disease so tool is extensively representative, experimenter's voluntary participation.Product of the present invention is because of good effect and have no side effect and crowd's branch, so treatment cycle is short and cure rate is high, and make test be easy to just satisfactorily be finished, now further be explained as follows (only for reference) under the prerequisite of necessary KNOW-HOW and business secret and please understand: different sexes allow keeping in Patent Law about situation, totally 80 of the test patients at age, it is 4 groups that 20 people are divided into for one group: use compound Chinese medicine product of the present invention and usage and dosage control for one group, one group of not medication compares, and one group simultaneously with Chinese medicine and western medicine product of the present invention and usage and dosage control, one group of not medication compares; Test number and time on test reach 4 first quarter moons, tool statistical significance so suitable representativeness and credibility are arranged.The result is as follows: none the routine symptom of two test group personnel with product of the present invention is deepened, and 5 people's no changes are arranged, and has 35 people to improve; The matched group experimenter finds 32 people's sxs, 8 people's no changes, none improver.
Prompting: symptom does not deepen promptly to have proved absolutely that the state of an illness is controlled, is that product of the present invention is effective, and the direction that the doing well,improving explanation state of an illness is become better reverses, is that product efficacy of the present invention is remarkable.
Claims (3)
1, control computer visual syndrome medicine-food two-purpose dietetic product is made up of dietotherapeutic compound Chinese medicine 3-10 part, compound vitamin 1-3 part, compound microelement 0.01-0.1 part; Wherein:
Compound Chinese medicine is made of in right amount Radix Glycyrrhizae 0.5-1.5 part, Semen Cassiae 3-10 part, Fructus Lycii 2-4 part, Flos Chrysanthemi 3-10 part, Fructus Gardeniae 0-3 part, Arillus Longan 0-3 part, Semen Phaseoli 0-10 part, Herba Menthae 0-1 part, Folium Mori 0-3 part, Herba Portulacae 0-3 part, Folium Camelliae sinensis 0-2 part and milk powder;
Compound vitamin is by vitamin A 0.01-0.1 part, β-Hu square-bottomed bamboo basket Bu Su 0.01-0.1 part, vitamin D 0.001-0.01 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part, vitamin C 1-3 part and vitamin e1-3 part composition;
Compound microelement is made up of chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part;
Above material adopts other kind of GB2760 and GB14880 approval to convert consumption by active substance.
2, the manufacture method of control computer visual syndrome medicine-food two-purpose dietetic product is as follows:
A. the preparation of compound Chinese medicine:
A. decoction pieces type Chinese crude drug Radix Glycyrrhizae 0.5-1.5 part, Fructus Gardeniae 0-3 part, Semen Cassiae 3-10 part, Flos Chrysanthemi 3-10 part, Arillus Longan 0-3 part, Fructus Lycii 2-4 part, Semen Phaseoli (fragmentation) 0-10 part, Herba Menthae 0-1 part, Folium Mori 0-3 part, Herba Portulacae 0-3 part, Folium Camelliae sinensis 0-2 part are on the waiting list in the choosing of raw material Chinese medicine, join in the nonmetallic surface such as containers such as fiberglass, enamel of belt stirrer, filter and water bath with thermostatic control heater;
Preparation b. organic and inorganic mixed solvent is got the above ethanol of food stage (solubilized many be insoluble in the material of water and significantly improve drug effect) and adds the dilution of room temperature drinking water that to make ethanol (dense) degree be that alcohol content is the organic mixed solvent (mixed solution for extraction object Chinese medicinal ingredients material different liquids still can be considered solvent) with inorganic two kinds of solvent compositions of the sterilization type of 55-75% (V/V is a volume ratio), and alcoholic strength is lower than 55% or be higher than 75% equal difficulty and reach optimum extraction and sterilization effect;
C. use the described solvent of b to the raw material medicine extract with the described mixed solvent of b join a described added get in the container of whole Chinese crude drugs, addition is advisable for flooding Chinese crude drug fully, hermetic container soaked 20-30 minute, turn on agitator and with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, open filter, 50-100 eye mesh screen isolated by filtration medicinal residues and solution, the centrifugal medicinal residues of 1000-3000 rev/min rotating speed, medicinal liquid is incorporated isolated by filtration solution into, open heating (evaporation) device medicinal residues and medicinal liquid accurately are heated to 78-80 ℃ of ethanol boiling point (to reduce evaporation of water and distillation as far as possible) vaporization ethanol respectively, collect vaporization ethanol and the alcohol gas liquid coolant is changed into liquid ethanol recycling use with in advance online water-cooled condenser with the room temperature cooling water, ensure that extracting solution utmost point low organic solvent is the high-quality of alcohol content, used cooling water extracts water as preheating, these measure and ensures the low energy consumption of production and product, low water consumption, low-cost, and avoided the pollution of organic solvent to environment and product, the airtight f merge extractive liquid, that is equipped with of medicinal liquid is used, medicinal residues add the following d step and proceed to handle;
D. inorganic solvent water to medicinal residues proceed extract at room temperature will the medicinal residues after c handles join in the described empty of a, with the described preheating water of c flood fully, hermetic container room temperature (because of contain the few breeding of bacterium limited guarantee not putrid and deteriorated) soaked Chinese crude drug 20-30 minute, turn on agitator was with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, 150-200 eye mesh screen isolated by filtration medicinal residues and solution add the airtight f merge extractive liquid, that is equipped with of medicinal liquid the following e step with, medicinal residues and proceed processing;
E. inorganic solvent is proceeded to add (height) warm extraction to medicinal residues the medicinal residues after d handles is joined in the described empty of a, flood fully with the described preheating water of c, hermetic container, turn on agitator also stirs with 20-60 rev/min of rotating speed, add simultaneously (height) temperature (so the time contain bacterium may be than d for high) lower the temperature slowly naturally after 3-5 minute to boiling that (summer high temperature was lowered the temperature and can suitably be aided with the room temperature water-cooled too slowly in about 20-30 minute, the same recyclable described preheating water of c of incorporating into of cooling water) continues stripping and energy-saving and water-saving to 60-70 ℃ in order to pharmaceutical compositions, extract and must high temperature could propose and low temperature is not carried most material composition, and make and heat rapidly and evenly, reduce material damage and loss, with further raising drug effect and recovery rate, open filter, 150-200 eye mesh screen isolated by filtration solution and medicinal residues, the centrifugal medicinal residues of abandoning of 1000-3000 rev/min rotating speed, medicinal liquid are incorporated isolated by filtration solution into and are equipped with f merge extractive liquid, usefulness;
F. extracting solution merges the medicinal liquid merging with c, d and e extraction, gets Chinese medicine extraction liquid;
G. the preparation of compound Chinese medicine is concentrated to 25-30% weight ratio concentration with Chinese medicine extraction liquid with triple effect or multi-effect evaporator, add Chinese medicine extraction liquid, be the solution dry matter content that concentration promotes and is 35-40% by milk powder 3-5 part and lactose 1-3 part part by weight, be spray dried into water content and get the compound Chinese medicine raw material below 3%, host or additive as food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP; Compacting (lactose and all very easily compression moulding of milk powder) becomes Any shape such as the sheet, grain, ball of 0.2-0.4 gram to get product, as food, nutriment, health product and medicine, advises oral every day 2-3 time, 0.4-0.8 restrains at every turn, need not the branch of crowd and dosage.
B. the preparation of compound vitamin: in sterilizing room, get vitamin A 0.01-0.1 part, β-Hu square-bottomed bamboo basket Bu Su 0.01-0.1 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part, vitamin C 1-3 part and vitamin e1-3 part join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB1488 approval to convert consumption by active substance;
C. the preparation of compound microelement: in sterilizing room, get chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part, join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB14880 approval to convert consumption by active substance;
D. prevent and treat the preparation of computer visual syndrome medicine-food two-purpose dietetic product: in sterilizing room, get compound Chinese medicine 1-3 part, compound vitamin 1-3 part, compound microelement 0.01-0.1 part, join and ground well in the nonmetal mortar 3-5 minute, raw produce; Product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.
3, the purposes of control computer visual syndrome medicine-food two-purpose dietetic product: as food, nutriment, health product and medicine, oral every day 2-3 time, each 0.4-0.8 restrain, and need not the branch of crowd and dosage; As food, nutriment, health product and medicine host or additive, consumption is that ordinary production needs an amount of use, no dose limitation by GMP.
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