CN1823838B - Medicine and food dual purpose vitamin micro element mineral calcium nutritive product for preventing myopia and its manufacturing method - Google Patents
Medicine and food dual purpose vitamin micro element mineral calcium nutritive product for preventing myopia and its manufacturing method Download PDFInfo
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- CN1823838B CN1823838B CN2005101365668A CN200510136566A CN1823838B CN 1823838 B CN1823838 B CN 1823838B CN 2005101365668 A CN2005101365668 A CN 2005101365668A CN 200510136566 A CN200510136566 A CN 200510136566A CN 1823838 B CN1823838 B CN 1823838B
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Abstract
The invention discloses a nutritive product used as both medicine and food for preventing myopia, the product is prepared from vitamins, trace elements and mineral Ca. Its preparing process is also disclosed. The present invention has the advantages of low cost,pollution-free,good taste,small amount,certainty effects, and the product is easily accepted by patients for all patients with no age distinction. Eyes are the window of the soul, which is the number one of the facial features. Everyone wants a pair of healthy eyes and good insight, but almost half of persons have eye problems globally, wherein more than forty million persons lose their sight. And the number of persons troubled by eye problem will increased doubled, if no effective treasures are adopted. Then eye problem will threaten everyone, for example short sight in primary and secondary school population, the percent of poor sight in national primary school students is 18.57%, the percent of short sight is 13.35%; the percent of poor sight in secondary school students is 45.04%, the percent of short sight is 37.44%; the percent of poor sight in high school students is 67.29%, the percent of short sight is 61.5%. The eye problem is generally concerned by the whole society. Thus,the present invention has specially important practical value and positive meaning for present and the long ever in improving and increasing condition of eye and sight health.
Description
The eyes are the windows of the mind, occupy first of the face, everybody thirsts for having a pair of healthy eye and good vision, but whole world nearly half people suffers from variety classes and ophthalmic in various degree, wherein more than 4,000 ten thousand people are blind, as not adopting an effective measure, the crowd who encroached on by ophthalmic will be doubled and redoubled, ophthalmic will threaten everyone.Therefore, prevention of blindness, effectively controlling ophthalmic infringement, is one of human challenge that faces in 21 century.China of new century need a large amount of high-quality talents, body and mind especially eye health be the basis, but China youngsters and children student's physical health situation is troubling at present, the vision health problem is outstanding especially.Show that according to national students in middle and primary schools' myopic eye preventing and treating work sampling monitoring result in 1999 national pupil's poor eyesight rate is 18.57%, rate of myopia is 13.35%; Junior school student's poor eyesight rate is 45.04%, and rate of myopia is 37.44%; High school student's poor eyesight rate is 67.29%, and rate of myopia is 61.5%; How effectively to reduce the rate of myopia of youngsters and children, the control ophthalmic stops the development trend of bad vision in youngsters and children and all groups to the infringement of vision, becomes the problem that the whole society generally is concerned about.What " Sight first China Act " was that Ministry of Public Health and China Disabled Federation etc. carry out both at home and abroad hand in hand is the large-scale international cooperative project of main task and target with prevention and health care and curing cataract, has obtained remarkable achievement since the execution.This project is implemented the policy of putting prevention first from start to finish, with outreach eye care and prevention of blindness knowledge, improves eye care consciousness, as the important content of this action; The Ministry of Education, Ministry of Public Health, SARFT(The State Administration of Radio and Television), the Central Committee of the Communist Young League and China Disabled Persons' Federation's joint signature file in 2000, the education of disease prevention and health protection activity of " cherishing our eyes " of national teenager is carried out in decision in " Sight first China Act ".
In recent years, improvement because of the living condition, many children even comprise that a large amount of adults have the custom of monophagia, as have a sweet tooth and rich food dish, do not eat vegetable or edible variety and amount very little, and various vegetables are above-mentioned nutrient substance main sources, so that the nutrient substance that even if the long-term above-mentioned not monophagia of famine also very easily lacks in the body, and these nutrient substance are very important to improving whole body premunition level and ability, must influence eye health and vision level and progressively increase the weight of the state of an illness, the fact is also as this, just be enough to make us startling as above-mentioned national students in middle and primary schools' myopic eye preventing and treating work sampling monitoring result, this also does not comprise adult data! What change is exactly " custom " and the well-known people of being are the most difficult, the Chinese idiom maxim that this just has " rivers and mountains easily changes, nature difficulty move " is therefore look to changing deviation food habit by all crowds especially child comprehensively and is reached balanced nutritious purpose of preventing and treating ophthalmic and vision care huge, its probability of difficulty, feasibility and operability are obviously all unrealistic undoubtedly.
The present invention is exactly for solving this difficult problem and more, the vitamin micro element mineral calcium agent pre-myopia prevention medicine-food two-purpose nutrient product and the manufacture method that design of operability and embodiment widely being provided for above-mentioned Sight first China Act activity, product does not have crowd restriction, to pre-myopia prevention, improve eyes and the vision health situation has the practical value of particular importance and positive now and far-reaching significance.Be to strengthen the understanding of the present invention, the main scientific and technological principle and the innovation that below continue to introduce the present invention and foundation thereof are advantage.
Reasonably nutrient substance not only promotes teenager health normal growth to grow and to improve premunition such as booster immunization proteic synthetic etc., also is the Fundamentals of safeguarding eye health, prevention and the various oculopathy of treatment simultaneously, complements each other between them, promotes mutually.Nutritional imbalance, deficiency or superfluous, body interior all can go wrong.For ophthalmics such as pre-myopia preventions, following GB2760 and GB14880 officinal food dual purpose product and function become more important and outstanding, spy further are described below one by one.
Vitamin A can be prevented and treated nyctalopia, conjunctival xerosis and keratomalacia: nyctalopia is exactly in night or the dark phenomenon of locating cannot see thing.Nyctalopia has two types, and a kind of is that the people of congenital night blindness, most of congenital night blindnesses is just blind after 40-50 year, and this nyctalopia does not also have effective Therapeutic Method at present.Another kind is the acquired night blindness of vitamin A deficiency.The people is at the dark place or see thing night, what lean on is rod cell on the retina, because containing, rod cell inside experiences material---the rhodopsin that the low light level stimulates, and one of primary raw material of synthetic rhodopsin is a vitamin A, so be understood that, if be deficient in vitamin in the diet A or gastrointestinal tract can not absorb vitamin A, cause rod cell not synthesize or synthetic rhodopsin not enough and cause nyctalopia, if in time replenish intravital vitamin A, acquired night blindness just can very fast healing; Vitamin A is to keep all epithelial tissue to perfect necessary nutrient substance, during shortage, epithelium drying, hypertrophy and keratinization are wherein influenced remarkable with the epithelium of eye etc.Because epithelial tissue is unsound, the ability of body opposing microbiological attack reduces, and catches easily; Because the lachrymal gland epithelium is unsound, secretion stops, so easily produce xerophthalmia; So vitamin A claims antixerophthalmic vitamin again.The symptom of xerophthalmia is cornea and conjunctival xerosis, inflammation, even keratomalacia and boring a hole.β-Hu square-bottomed bamboo basket Bu Su not only can change into vitamin A, again do not have the toxicity of VA and can accumulate in vivo and to the people harmless (as accumulate too much also only show skin slightly yellowing that is all, need only short-term stop using and can recover the former colour of skin rapidly), so the present invention is with its alternative part of V A, and when lacking, VA transforms rapidly with compensation VA, so tool regulate supplies double effects automatically.The bone in children abnormal development of vitamin D deficiency can cause narrow, the exophthalmos of a frame, causes ametropia.Vitamin B
1Lack and cause conjunctiva and corneal epithelium infringement causing xerophthalmia, retrobulbar neuritis, optic atrophy.Vitamin B
2Lack and to cause eyes many places inflammation such as keratitis (blood vessel hyperplasia, muddiness, fester), conjunctivitis, iritis, optic neuritis, scleral injection, even crystalline lens and vitreous opacity occur.Vitamin PP (nicotinic acid is that nicotinic acid and niacin amide are nicotiamide) lacks and causes neural malnutrition and neuritis, makes optic atrophy.Hypovitaminosis C cause intercellular substance such as collagen protein synthetic generation obstacle, wound appears and ulcer is difficult for healing; Capillary permeability increases, cause vitamin C deficiency such as subcutaneous, mucosa, hemorrhage of muscle, so can bring out eyeball and the accessory organs of eye official is hemorrhage, as serious consequences such as subretinal choroidal hemorrhage will cause losing one's sight, also can influence the healing of eye inflammation, macular hole etc.(it is a lot of that nucleic acid contains chromium for mineral calcium (bone strengthening) and trace element chromium, nucleic acid lacks and causes growth inhibited, chromium deficiency also causes insulin active low, concurrent hyperglycemia and the glycosuria on an empty stomach of comprising, because of energy shortage makes premunition that various ophthalmics lowly easily take place and looks disease, comprising also wherein that the direct harm of hyperglycemia such as retinal degeneration etc. are serious reduces vision and blinding pathological changes and is on the rise and extensively, especially old people Geng Yi lacks chromium, should pay much attention to especially) lack wall of eyeball elasticity is weakened, eye frame and optical fundus framework deformation and eye (looking) axle is elongated myopia takes place, and can not increase atrophy because of retina and choroid, be elongated, distortion, attenuation, finally cause retina to be pulled open and split formation macular hole (stating as follows), or choroidal rupture is hemorrhage cause losing one's sight (seeing above-mentioned), not only cause and deepen true myopia, vitreous opacity and liquefaction are shunk and cause also being pulled open and split and form macular hole by its retina that involves, grievous injury patient central vision dwindles as looking thing, distortion, even central vision complete obiteration, make many occupations that must rely on central vision and work as drive (because of central light loss can't be seen traffic signal, or because of image replacement or covering around the center image quilt, central vision is seen be in fact peripheral image be false center image and very easily lead to serious traffic safety accident), read and (seriously dwindle distortion, even cannot see any literal or the image of being watched attentively at all, all the other are identical with above-mentioned driving situation) etc. can't carry out at all, the vitreous humor of liquefaction that What is more leaks under the disruptive retina and constantly and enlarges, cause retina part even come off fully, as give treatment to untimely then blinding fully.Trace element-selenium is the same with vitamin C to be activated plurality of enzymes and enzyme system and is beneficial to element and vitamin Bs such as calcium (as the acidity of VC), chromium
1And vitamin B
2With the absorbing and bring into play effect, and strengthen effect mutually, of vitamin PP etc. as vitamin B
1Lack and cause vitamin B
2Output, increase, make the vitamin B in the in-vivo tissue in the urine
2Descend, vitimin supplement PP has prevented again because of vitimin supplement B
1The shortage of aggravation vitamin PP, thus make vitamin B group dosage keep balance etc., the improvement of vision is all had very great help mutually, so the helpfulness degree of association is very high.
Product of the present invention is made up of legal dietotherapeutic compound vitamin 1-3 part, compound microelement 0.01-0.1 part, composite mineral matter calcium preparation 1-3 part; Wherein:
Compound vitamin is by vitamin A 0.01-0.1 part, β-Hu square-bottomed bamboo basket Bu Su 0.01-0.1 part, vitamin D 0.001-0.01 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part and vitamin C 1-3 part are formed;
Compound microelement is made up of chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part;
The composite mineral matter calcium preparation is made up of calcium gluconate 3-5 part and calcium citrate 3-5 part;
Above material adopts other kind of GB2760 and GB14880 approval to convert consumption by active substance.
The manufacture method of product of the present invention is as follows:
The preparation of compound vitamin: in sterilizing room, get vitamin A 0.01-0.1 part, β-Hu square-bottomed bamboo basket Bu Su 0.01-0.1 part, vitamin D 0.001-0.01 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part and vitamin C 1-3 part, join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB1488 approval to convert consumption by active substance;
The preparation of compound microelement: in sterilizing room, get chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part, join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB14880 approval to convert consumption by active substance;
The preparation of composite mineral matter calcium preparation: in sterilizing room, get calcium gluconate 3-5 part and calcium citrate 3-5 part, join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB14880 approval to convert consumption by active substance;
The preparation of product of the present invention: in sterilizing room, get compound vitamin 1-3 part, compound microelement 0.01-0.1 part, composite mineral matter calcium preparation 1-3 part, join and ground well in the nonmetal mortar 3-5 minute, raw produce; Product 3-5 part of the present invention is added the Any shape such as sheet, grain, ball that 1-3 part lactose mixing, compacting (lactose is compression moulding very easily) become the 0.2-0.4 gram, must product.
The purposes of product of the present invention, usage and consumption: as food, nutriment, health product and medicine, oral every day 2-3 time, each 0.4-0.8 restrain, and need not the branch of crowd and dosage; As the host or the additive of food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP.
Embodiment:
In sterilizing room, get 2 parts of compound vitamines, 0.03 part of compound microelement, 3 parts of composite mineral matter calcium preparation, join and ground well in the nonmetal mortar 3-5 minute, raw produce; With Any shape such as 3 parts of sheets that add 1 part of lactose mixing, are pressed into the 0.2-0.4 gram of product of the present invention, grain, balls, get product.
Supplementary copy inventive principle and advantage are as follows:
1, the present invention adopts the low lactose of water absorption to do complexion changed and easy preservation that filler can reduce duration of storage, so storage life is that the commodity shelf life is long, economic worth is high; And form particularly favourite " acid is sour-sweet sweet " the popular taste products of children and easily being accepted of most crowds jointly with the acescency of the low sweet taste of lactose and calcium gluconate and calcium citrate, so service face and service group are the most extensive, its society and economic benefit are also just apparent naturally, and these also are the great novelty and the practicality of the legal approval of Patent Law.
2, medicine variety and function all are legal medicine-food two-purposes and simple and clear and do not have a dispute, the multiple state of an illness of prescription adaptation versatile and flexible and select medication properer.
3, all medical materials all are conventional varieties and have no side effect, so quality, the source is secure and aboundresources is cheap, product of the present invention can be consumed by vast general patient because of no patient crowd's branch event and obtain and afford to consume, and the realization new and high technology is served lofty aim for the most numerous common people.
4, become the favorable factor of the defective of China and Asia average 80% above population Lactose enzyme indigestibility absorption for want of (as milk) lactose into disease preventing and treating, because adopt lactose to replace the starch of easily digesting and assimilating and dextrin is made adsorbent and filler can significantly slow down the medicine slow release speed, thereby significantly prolong the efficacy of a drug persistent period and improve curative effect and possible medicine irritation is relieved to bottom line.
Test method, data and presentation of results and prompting:
Disease that product of the present invention is controlled belongs to common frdquently encountered disease so tool is extensively representative, experimenter's voluntary participation.Product of the present invention because of good effect and have no side effect and crowd's branch, so treatment cycle is short and cure rate is high, make test be easy to just satisfactorily be finished, now further be explained as follows (only for reference) under the prerequisite of necessary KNOW-HOW and business secret and please understand allow keeping in Patent Law about situation: different sexes, age 12-17 the year totally 80 of teenager experimenters, it is 4 groups that 20 people are divided into for one group.Two groups of visions normal (more than 1.0), wherein one group near-sighted with product of the present invention and usage and dosage control, another organizes not medication and compares; Two groups of visions undesired (1.0 below) in addition, wherein one group simultaneously with product of the present invention and usage and dosage prevent and treat near-sighted, another organizes not medication and compares; Test period be from the new term begins one week of back before have a holiday or vacation January so that observation and avoid reviewing examination and influence to alleviate the fulminant pseudomyopia with the extreme stage of eye.Test number and time on test reach 4 first quarter moons, tool statistical significance so suitable representativeness and credibility are arranged.The result is as follows: no matter myopia whether when the experimenter begins to test, only there are 5 people to find visual deterioration but none routine fall surpasses 0.2 with two test group personnel of product of the present invention, 15 people's vision no changes are arranged, 20 people's eyesight improvings are arranged, go up not down, and increasing degree reaches 0.1-0.3 and do not wait; No matter whether myopia when the matched group experimenter began to test, find that visual deterioration 32 people and 23 people decrease by 0.2-0.3, only 8 people's vision no changes, none eyesight improving, the person of going up not down arranged.
Prompting: over-burden and myopia takes place by the age and the objective reality fact of the general trend that more and more becomes younger and more and more huger near-sighted crowd's ratio according to China's adolescents with learning, it is (no matter true with regard to having proved absolutely product control myopia of the present invention not descend as vision after 12 years old, pseudomyopia, can prevent or alleviate its intensification to true myopia, principle is seen below and is stated) effectively, the explanation product of the present invention control myopia that goes up not down especially easily develops into true myopia and to deepen the pseudomyopia of true myopia degree effective equally, and increasing degree (illustrate that pseudomyopia is able to effective alleviation) and number explanation to prevent and treat near-sighted effect remarkable.
Claims (2)
1. near-sighted medicine-food two-purpose nutrient product is treated in the vitamin micro element mineral calcium agent, and its feature is as follows:
Raw produce is made up of legal dietotherapeutic compound vitamin 1-3 part, compound microelement 0.01-0.1 part, composite mineral matter calcium preparation 1-3 part, wherein,
Compound vitamin is by vitamin A 0.01-0.1 part, beta-carotene 0.01-0.1 part, vitamin D 0.001-0.01 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part and vitamin C 1-3 part are formed;
Compound microelement is made up of chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part;
The composite mineral matter calcium preparation is made up of calcium gluconate 3-5 part and calcium citrate 3-5 part;
Product adds 1-3 part lactose by raw produce 3-5 part and forms.
2. the manufacture method of near-sighted medicine-food two-purpose nutrient product is treated in the vitamin micro element mineral calcium agent, and is as follows:
A. the preparation of compound vitamin: in sterilizing room, get vitamin A 0.01-0.1 part, beta-carotene 0.01-0.1 part, vitamin D 0.001-0.01 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part and vitamin C 1-3 part, join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB1488 approval to convert consumption by active substance;
B. the preparation of compound microelement: in sterilizing room, get chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part, join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB14880 approval to convert consumption by active substance;
C. the preparation of composite mineral matter calcium preparation: in sterilizing room, get calcium gluconate 3-5 part and calcium citrate 3-5 part, join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB14880 approval to convert consumption by active substance;
D. the preparation of product: in sterilizing room, get compound vitamin 1-3 part, compound microelement 0.01-0.1 part, composite mineral matter calcium preparation 1-3 part, join and ground well in the nonmetal mortar 3-5 minute, raw produce; Raw produce is added 1-3 part lactose mixing, is pressed into sheet, grain, ball that 0.2-0.4 restrains by 3-5 part, get product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2005101365668A CN1823838B (en) | 2005-12-29 | 2005-12-29 | Medicine and food dual purpose vitamin micro element mineral calcium nutritive product for preventing myopia and its manufacturing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005101365668A CN1823838B (en) | 2005-12-29 | 2005-12-29 | Medicine and food dual purpose vitamin micro element mineral calcium nutritive product for preventing myopia and its manufacturing method |
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| CN1823838A CN1823838A (en) | 2006-08-30 |
| CN1823838B true CN1823838B (en) | 2011-06-08 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100376237C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Vitamin micro element mineral calcium nutritive product for preventing pseudomyopia and roal myopia and its manufacturing method |
| CN100376241C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Medicine and food dual purpose product for preventing true myopia and its manufacturing method |
| CN100376252C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Medicine and food dual purpose compound vitamin microelement mineral nutritive product for preventing true myopia and its manufacturing method |
| CN100376238C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Medicine and food dual purpose nutritive product for preventing pseudomyopia and real myopia and its manufacturing method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1319402A (en) * | 2000-01-31 | 2001-10-31 | 邹燕 | Eye nutrient |
| CN1334097A (en) * | 2000-07-17 | 2002-02-06 | 上海交大昂立股份有限公司 | Health-care product for improving visual function |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1319402A (en) * | 2000-01-31 | 2001-10-31 | 邹燕 | Eye nutrient |
| CN1334097A (en) * | 2000-07-17 | 2002-02-06 | 上海交大昂立股份有限公司 | Health-care product for improving visual function |
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