CN1823826A - Medicine and food dual purpose nutritive product for preventing and treating keratomalacid and its manufacturing method - Google Patents
Medicine and food dual purpose nutritive product for preventing and treating keratomalacid and its manufacturing method Download PDFInfo
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Abstract
A Western medicine used as both medicine and food for preventing and treating keratomalacia is prepared from vitamins and trace elements. Its preparing process is also disclosed.
Description
The eyes are the windows of the mind, occupy first of the face, everybody thirsts for having a pair of healthy eye and good vision, but whole world nearly half people suffers from variety classes and ophthalmic in various degree, wherein more than 4,000 ten thousand people are blind, as not adopting an effective measure, the crowd who encroached on by ophthalmic will be doubled and redoubled, ophthalmic will threaten everyone.Therefore, prevention of blindness, effectively controlling ophthalmic infringement, is one of human challenge that faces in 21 century.
Keratomalacia, ulcer, perforation are one of main diseases causing blindnesses of China, account for critical role in prevention of blindness work.Nutrition of whole body and metabolism are bad to be this sick essence, so with multiple ophthalmic such as nyctalopia, conjunctiva and bitot's patches, cornea ulcer with perforation at last, only carry out the general nutrition treatment and just can effect a permanent cure.If at present at the drug main artificial tears of bitot's patches phase or cod-liver oil drop eye drip to replenish moisture content and VA mitigate the disease, but obviously can't solve the nutrition of whole body fundamental issue, nature can only take stopgap measures and can not effect a permanent cure, and the medication number of times frequently very bothers, also easily contaminated or use because of the impatient excess of patient and to cause the excessive poisoning of VA, the keratomalacia phase is many with secondary infection, use antibiotic eye drip and atropine mydriasis, same because of failing to solve trophopathy because of also being the act that takes stopgap measures, medical apparatus and instruments is mainly wears soft corneal contact lens to prevent perforation of cornea, we can say to be not only and cure the symptoms, not the disease, and be " beyond cure " this moment, final perforation is blind to settle substantially, prevent and treat day after the fair, do transplant operation unless can in time seek the cornea that is fit to, even the rebirth of great doctor Hua Tuo also difficulty has the power capable of saving a desperate situation, as long as can well-knownly be that operation all is difficult to avoid operation (reaching postoperative in the art) various risks and misery, in addition it is easier said than done again in time to seek the cornea that is fit to! Even if very lucky can seeking (China's legal provisions human organ can only be contributed, not allow to buy and sell so expense is low), though corneal transplantation is that the operation that success rate is the highest in organ and the tissue transplantation is (because of cornea does not have blood vessel, lymphatic vessel, cornea central authorities epithelium does not have the Langerhans cell yet, be in " absolution zone " relatively on the immunology), however, its surgery cost also high, non-everybody can both afford.So be that the morbidity essence reason that descends according to primary disease pantatrophia, opposing (disease) power of the present invention is carried out systemic treatment and is only unique correct wise selection of primary disease only according to the essence etiology of primary disease, can present several no similar schemes reports or product come out.So far, the key i.e. problem of effecting a permanent cure of preventing and treating this disease is that the supply and the metabolism of the corresponding nutrient substance how the full-scope safeguards general is enough and stable is abundantly clear.
The present invention is exactly for solving western modern medicine control keratomalacia medicine-food two-purpose nutriment and the manufacture method that this difficult problem designs, product does not have crowd restriction, to preventing and treating xerophthalmia, improving eyes and the vision health situation has the practical value of particular importance and positive now and far-reaching significance.Be to strengthen the understanding of the present invention, the main scientific and technological principle and the innovation that below continue to introduce the present invention and foundation thereof are advantage.
Reasonably nutrient substance not only promotes teenager health normal growth to grow and to improve premunition such as booster immunization proteic synthetic etc., also is the Fundamentals of safeguarding eye health, prevention and the various oculopathy of treatment simultaneously, complements each other between them, promotes mutually.Nutritional imbalance, deficiency or superfluous, body interior all can go wrong.For ophthalmic such as control keratomalacia etc., following health promulgated by the ministries or commissions of the Central Government and GB2760 and GB14880 officinal food dual purpose product and function becomes more important and outstanding, spy further are described below one by one:
Vitamin A can be prevented and treated xerophthalmia, and this is because VA keeps the sound necessary disposition nutrient substance and influenced the most remarkable and classify that VA lacks and the top priority of harm as with the epithelium of eye of supporting one's family of all epithelial tissue, so VA is called antixerophthalmic vitamin again.Keratomalacia is exactly because the long-term lacking vitamin A makes the lachrymal gland epithelium unsound, even tear secretion minimizing stops and the pathological changes of cornea own sees that especially for a long time computer, TV make retina consume energy too high and light (poisoning) infringement that produce a large amount of free radicals, and these crowds make the tear film rupture withered because of excessively absorbed, nictation very little, add that nictation makes cornea and atmosphere time of contact also significantly be prolonged very little the tear evaporation is strengthened, again because of the same very little reason of nictation be difficult to timely and effective refresh and rebuild the tear film take place with additional tear; As a same reason, aqueous humor is by ophthalmic corpus ciliare secretion displacement, just can obviously not feel within the eye that because of it resembling the outer tear of eye lets out loss because of for a long time direct ingress of air with through tear (little) bank of tubes, but still be understood that, A or gastroenteropathy such as enteritis, diarrhea are digested and assimilated bad and can not be absorbed enough vitamin A if be deficient in vitamin in the diet, also will inevitably cause blood VA not enough and cause VA in the tear of excretory aqueous humor of corpus ciliare and lacrimal secretion and various nutrition especially the free radical resisting oxidation material reduce and metabolism slows down, make and directly from aqueous humor and tear, obtain the cornea chain-react of nutrition and easily bring out malnutrition as anterior drying, muddy, softening, ulcer even perforation are blind.Beta-carotene not only can change into vitamin A, again do not have the toxicity of VA and can accumulate in vivo and to the people harmless (as accumulate too much also only show skin slightly yellowing that is all, need only short-term stop using and can recover the former colour of skin rapidly), so the present invention is with its alternative part of V A, and when lacking, VA transforms rapidly with compensation VA, so tool regulate supplies double effects automatically.Vitamin B1 deficiency causes conjunctiva and corneal epithelium infringement causing xerophthalmia, retrobulbar neuritis, optic atrophy.Vitamin B2 deficiency causes eyes many places inflammation such as keratitis (muddy, fester), conjunctivitis, iritis, optic neuritis, scleral injection, even crystalline lens and vitreous opacity occur.Vitamin PP (nicotinic acid is that nicotinic acid and niacin amide are nicotiamide) can form energy and many substance metabolismes are the hydrogen acceptor NAD+ (CoI-nadide) and the NADP+ (CoII-is coenzyme II) of biological oxidation respiratory chain and supply (passing) hydrogen body NADH and NADPH, reversible hydrogenation of niacin amide part tool and dehydrogenation characteristic in these two kinds of coenzyme structures, in biological oxidation process, form hydrogen carrier system or electron transport system, play a part to pass hydrogen, so shortage causes neural malnutrition and neuritis, makes optic atrophy.Vitamin C is an antioxidant in the aqueous humor, lack and not only make cornea, crystalline lens, the oxidated thing of vitreous body is quinoid oxidation material severe oxidation and outside the grievous injury transparency especially, the synthetic generation obstacle that also can directly cause intercellular substancies such as collagen protein, wound and ulcer occur and be difficult for healing, capillary permeability increases, cause subcutaneous, mucosa, vitamin C deficiency such as hemorrhage of muscle, event can bring out eyeball and the accessory organs of eye official is hemorrhage, as serious consequences such as subretinal choroidal hemorrhage will cause losing one's sight, also can influence eye inflammation, the healing of macular hole etc., whether normal relation is close and these factors are all with aqueous humor composition and metabolism thereof.The vitamin E anti-oxidation function is same powerful and be fatsoluble vitamin, can form a complete aqueous humor antioxidant vitamins system with water solublity antioxidant vitamins C because of it, and the oxidation resistance and the effect that mutual coordination are arranged and strengthen function and strengthened single application greatly because of these two kinds of antioxidant mechanism and effect thereof, so the two and vitamin A share that not only the antioxidation mode is more perfect and control cornea, the oxide oxidation of crystallin matter and the power of degeneration muddiness is also more powerful and thorough, consumption is still less saved cost on the contrary.(it is a lot of that nucleic acid contains chromium for trace element chromium, nucleic acid lacks and causes growth inhibited, chromium deficiency also causes insulin active low, concurrent hyperglycemia and the glycosuria on an empty stomach of comprising, because of energy shortage makes premunition that various ophthalmics lowly easily take place and looks disease, comprising also wherein that the direct harm of hyperglycemia such as retinal degeneration etc. are serious reduces vision and blinding pathological changes and is on the rise and extensively, especially old people Geng Yi lacks chromium, should pay much attention to especially, shortage can make wall of eyeball elasticity weaken distortion and eye (looking) axle is changed, and force cornea, crystalline lens, the long-term gross distortion of retina and choroid with adapt to and regulate this variation and make its elasticity and regulating power serious descend and be difficult to recover, because of retina and choroid distortion degeneration causes self atrophy, break, break away from, cell death, finally cause losing one's sight, also easily make cornea because of influencing the aqueous humor composition, lenticular opacity generation cataract, vitreous opacity shrinks with liquefaction and causes also being pulled open by its retina that involves and split and form macular hole, grievous injury patient central vision dwindles as looking thing, distortion, even central vision complete obiteration, make many occupations that must rely on central vision and work as drive (because of central light loss can't be seen traffic signal, or because of image replacement or covering around the center image quilt, central vision is seen be in fact peripheral image be false center image and very easily lead to serious traffic safety accident), read and (seriously dwindle distortion, even cannot see any literal or the image of being watched attentively at all, all the other are identical with above-mentioned driving situation) etc. can't carry out at all, the vitreous humor of liquefaction that What is more leaks under the disruptive retina and constantly and enlarges, cause retina part even come off fully, as give treatment to untimely then blinding fully.Trace element-selenium is the same with vitamin C to be activated plurality of enzymes and enzyme system and is beneficial to absorbing and bring into play effect, and strengthening effect mutually of element such as calcium (as the acidity of VC), chromium and vitamin B1 and vitamin B2 and vitamin PP etc., cause output increase in the vitamin B2 urine, the vitamin B2 in the in-vivo tissue is descended as Vitamin B1 deficiency, vitimin supplement PP has prevented the shortage because of vitimin supplement B1 aggravation vitamin PP again, thereby make vitamin B group dosage keep balance etc., the improvement of vision is all had very great help mutually.In addition; vitamin A, C and E also have and the collaborative antioxidation of the glutathion that powerful anti-oxidative damage function is arranged equally: the increase of glutathione content makes cornea, crystalline lens, vitreous body be tending towards transparent; corneal nutrition, thickness and intensity are increased and prevent and treat its drying, muddiness, softening, ulcer, perforation is blind, so glutathion is another key factor of vision protection and material base.Glutathion be one natural in the destructive antioxidant of opposing free radical; not only ensure cornea, crystalline lens, vitreous body transparency and can reverse muddiness and make it to recover transparent again and improve vision, also help the liver protecting to avoid the infringement of poisonous substance and some drugs; and Chinese medicine is thought " the liver being in charge of the eyes "; western modern medicine equally also proved liver function quality directly decision eyes health degree, as storage all fixed and concrete runnings of vitamin A, D, E and B with release, inversion quantity and time etc. by extreme miosis, determine directly whether the health had in mind to be so the health of liver is whether also inevitable.Yet directly take glutathion is not a wise move because its to belong to peptide class be the protein amino acid substance, most ofly during through digestive tract can seldom can be entered blood by gastric acid and digestive tract proteolytic enzyme digest.Therefore pharmacy seldom has the glutathion tonic to sell, but as taking the effect that the tonic that can make body produce more glutathion then can reach the compensation glutathion equally and remove free radical.Therefore the method for best raising body glutathion inside level is to take in enough synthetic glutathiones and promote its raw material synthetic and its effect of raising, comprises vitamin A, C, E and trace element-selenium, lactalbumin.Selenium and vitamin A, C, E and cystine play synergism, it is the essential composition (every mole enzyme contains 4 gram atom selenium) of glutathion peroxidase, the oxidation of this enzyme catalysis glutathion, make reduced glutathion change oxidized form of glutathione into, reduced glutathion destroys and consumes peroxide, the generation oxidized form of glutathione of hydrogen peroxide (is raw material with the hydrogen peroxide) and unsaturated fatty acid in this process, even if scarce selenium promptly lacks enzyme enough glutathion (GSH) are arranged, the destruction that nature can not prevent these peroxide.Taking lactalbumin also is to increase the synthetic effective ways of body glutathion inside: scientist has compared the influence to glutathion inside of 20 gram lactalbumins, placebo and 20 gram caseins in 20 health volunteers, found that lactalbumin can make glutathione level rising 20% in the blood, shows and can improve antioxidant status.One of them explanation is because contain a kind of sulfur-containing amino acid---cysteine in the milk surum, replenishes the glutathione level that nitrogen acetylcysteine (NAC) can improve human body.But the nitrogen acetylcysteine of long-term overdose might bring side effect, shows that because of experiment is arranged exacting practice (producing a large amount of free radicals) back takes the nitrogen acetylcysteine in conjunction with vitamin C and can make on the contrary that the interior free yl level raises, and the remarkable infringement degree of increase muscle! So the effect about it is also not too clear and definite, does not recommend to be used for improving glutathione level.Therefore, lactalbumin is taken in recommendation rather than the nitrogen acetylcysteine stimulates body glutathion inside level, and that milk powder contains abundant lactalbumin, other nutrient substance is also very abundant, is undoubtedly superior choosing, adopts one of milk powder major reason so this also is the present invention.
To sum up state, it is all very high that product of the present invention and raw material belong to total inventive concept, helpfulness and a degree of association.
Product of the present invention is made up of legal dietotherapeutic compound vitamin 1-3 part, compound microelement 0.01-0.1 part; Wherein:
Compound vitamin is by vitamin A 0.01-0.1 part, β-Hu square-bottomed bamboo basket Bu Su 0.01-0.1 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part and vitamin C 1-3 part and vitamin e1-3 part composition;
Compound microelement is made up of chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part;
Above material adopts other kind of GB2760 and GB14880 approval to convert consumption by active substance.
The manufacture method of product of the present invention is as follows:
The preparation of compound vitamin: in sterilizing room, get vitamin A 0.01-0.1 part, β-Hu square-bottomed bamboo basket Bu Su 0.01-0.1 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part, vitamin C 1-3 part and vitamin e1-3 part join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB1488 approval to convert consumption by active substance;
The preparation of compound microelement: in sterilizing room, get chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part, join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB14880 approval to convert consumption by active substance;
The preparation of product of the present invention: in sterilizing room, get compound vitamin 1-3 part, compound microelement 0.01-0.1 part, join and ground well in the nonmetal mortar 3-5 minute, raw produce; Raw produce 3-5 part of the present invention and milk powder 3-5 part and lactose 1-3 part part by weight mixing are pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.
The purposes of product of the present invention, usage and consumption: as food, nutriment, health product and medicine, oral every day 2-3 time, each 0.4-0.8 restrain, and need not the branch of crowd and dosage; As the host or the additive of food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP.
Embodiment:
In sterilizing room, get 1 part of compound vitamin, 0.01 part of compound microelement, join and ground well in the nonmetal mortar 3-5 minute, raw produce; 3 parts of 3 parts of raw produce of the present invention and milk powder and 1 part of part by weight mixing of lactose are pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.
Supplementary copy inventive principle and advantage are as follows:
1, the present invention adopts the low lactose of water absorption to do complexion changed and easy preservation that filler can reduce duration of storage, so storage life is that the commodity shelf life is long, economic worth is high.
2, medicine variety and function all are legal medicine-food two-purposes and simple and clear and do not have a dispute, the multiple state of an illness of prescription adaptation versatile and flexible and select medication properer.
3, all medical materials all are conventional varieties and have no side effect, so quality, the source is secure and aboundresources is cheap, product of the present invention can be consumed by vast general patient because of no patient crowd's branch event and obtain and afford to consume, and the realization new and high technology is served lofty aim for the most numerous common people.
4, become the favorable factor of the defective of China and Asia average 80% above population Lactose enzyme indigestibility absorption for want of (as milk) lactose into disease preventing and treating, because adopt lactose to replace the starch of easily digesting and assimilating and dextrin is made adsorbent and filler can significantly slow down the medicine slow release speed, thereby significantly prolong the efficacy of a drug persistent period and improve curative effect and possible medicine irritation is relieved to bottom line.
Test method, data and presentation of results and prompting:
Disease that product of the present invention is controlled belongs to common frdquently encountered disease so tool is extensively representative, experimenter's voluntary participation.Product of the present invention because of good effect and have no side effect and crowd's branch, so treatment cycle is short and cure rate is high, make test be easy to just satisfactorily be finished, now further be explained as follows (only for reference) with allow keeping in Patent Law about situation under the prerequisite of necessary KNOW-HOW and business secret and please understand: it is 2 groups that totally 40 of the test patients at different sexes, age, 20 people are divided into for one group: one group with compound Chinese medicine product of the present invention and usage and dosage prevent and treat, one group of not medication compares; Test number and time on test reach 4 first quarter moons, tool statistical significance so suitable representativeness and credibility are arranged.The result is as follows: none the routine symptom of two test group personnel with product of the present invention is deepened, and 5 people's no changes are arranged, and has 15 people to improve; The matched group experimenter finds 17 people's sxs, 3 people's no changes, none improver.
Prompting: symptom does not deepen promptly to have proved absolutely that the state of an illness is controlled, is that product of the present invention is effective, and the direction that the doing well,improving explanation state of an illness is become better reverses, is that product efficacy of the present invention is remarkable.
Claims (3)
1, western modern medicine control keratomalacia medicine-food two-purpose nutriment is made up of dietotherapeutic compound vitamin 1-3 part, compound microelement 0.01-0.1 part; Wherein:
Compound vitamin is by vitamin A 0.01-0.1 part, β-Hu square-bottomed bamboo basket Bu Su 0.01-0.1 part, vitamin D 0.001-0.01 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part, vitamin C 1-3 part and vitamin e1-3 part composition;
Compound microelement is made up of chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part;
Above material adopts other kind of GB2760 and GB14880 approval to convert consumption by active substance.
2, the manufacture method of western modern medicine control keratomalacia medicine-food two-purpose nutriment is as follows:
1) preparation of compound vitamin: in sterilizing room, get vitamin A 0.01-0.1 part, β-Hu square-bottomed bamboo basket Bu Su 0.01-0.1 part, vitamin B
10.01-0.1 part, vitamin B
20.01-0.1 part, vitamin PP 0.1-1 part, vitamin C 1-3 part and vitamin e1-3 part join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB1488 approval to convert consumption by active substance;
2) preparation of compound microelement: in sterilizing room, get chromic anhydride 0.001-0.01 part and sodium selenite 0.001-0.01 part, join and ground well in the nonmetal mortar 3-5 minute, airtight black out is preserved standby; Adopt other kind of GB2760 and GB14880 approval to convert consumption by active substance;
3) preparation of western modern medicine control keratomalacia medicine-food two-purpose nutriment: in sterilizing room, get compound vitamin 1-3 part, compound microelement 0.01-0.1 part, join and ground well in the nonmetal mortar 3-5 minute, raw produce; Raw produce 3-5 part of the present invention and milk powder 3-5 part and lactose 1-3 part part by weight mixing are pressed into sheet, grain, the ball of 0.2-0.4 gram, must product.
3, the purposes of western modern medicine control keratomalacia medicine-food two-purpose nutriment: as food, nutriment, health product and medicine, oral every day 2-3 time, each 0.4-0.8 restrain, and need not the branch of crowd and dosage; As food, nutriment, health product and medicine host or additive, consumption is that ordinary production needs an amount of use, no dose limitation by GMP.
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| CN100376236C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Medicine and food vitamin and microelement nutritive product for preventing and treating keratomalacia and its manufacturing method |
| CN100376239C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Medicine and food dual purpose nutritive product for preventing and treating cataract and its manufacturing method |
| CN100376240C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Medicine and fool dual purpose vitamin microelement nutritive product for preventing ane treating cataract and its manufacturing method |
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2005
- 2005-12-29 CN CN 200510136533 patent/CN1823826A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100376233C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Food and medicine dual purpose product for preventing and treating vision injury syndrome duo to TV and computer display light and its manufacturing method |
| CN100376235C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Medicine and food dual purpose nutritive product for preventing and treating synchysis and its manufacturing method |
| CN100376236C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Medicine and food vitamin and microelement nutritive product for preventing and treating keratomalacia and its manufacturing method |
| CN100376239C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Medicine and food dual purpose nutritive product for preventing and treating cataract and its manufacturing method |
| CN100376240C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | Medicine and fool dual purpose vitamin microelement nutritive product for preventing ane treating cataract and its manufacturing method |
| CN100376234C (en) * | 2005-12-29 | 2008-03-26 | 颜怀伟 | medicine and food dual purpose vitamin microelement nutritive product for preventing and treating synchysis and its manufacturing method |
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Open date: 20060830 |