CN100362992C - Nutritional composition for oral use - Google Patents
Nutritional composition for oral use Download PDFInfo
- Publication number
- CN100362992C CN100362992C CNB2003801075382A CN200380107538A CN100362992C CN 100362992 C CN100362992 C CN 100362992C CN B2003801075382 A CNB2003801075382 A CN B2003801075382A CN 200380107538 A CN200380107538 A CN 200380107538A CN 100362992 C CN100362992 C CN 100362992C
- Authority
- CN
- China
- Prior art keywords
- branched
- amino acid
- chain amino
- vitamin
- isoleucine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000000203 mixture Substances 0.000 title claims abstract description 114
- 235000016709 nutrition Nutrition 0.000 title abstract description 5
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- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims abstract description 52
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims abstract description 49
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- 229940024606 amino acid Drugs 0.000 claims abstract description 10
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- 235000021542 oral nutrition Nutrition 0.000 claims description 58
- 229960003136 leucine Drugs 0.000 claims description 47
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- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 24
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- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 16
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 claims description 12
- 238000007873 sieving Methods 0.000 claims description 12
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- BVHLGVCQOALMSV-JEDNCBNOSA-N L-lysine hydrochloride Chemical compound Cl.NCCCC[C@H](N)C(O)=O BVHLGVCQOALMSV-JEDNCBNOSA-N 0.000 claims description 10
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- IWXAZSAGYJHXPX-BCEWYCLDSA-N Bisbentiamine Chemical compound C=1C=CC=CC=1C(=O)OCC/C(SS\C(CCOC(=O)C=1C=CC=CC=1)=C(/C)N(CC=1C(=NC(C)=NC=1)N)C=O)=C(/C)N(C=O)CC1=CN=C(C)N=C1N IWXAZSAGYJHXPX-BCEWYCLDSA-N 0.000 claims description 8
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- QZNNVYOVQUKYSC-JEDNCBNOSA-N (2s)-2-amino-3-(1h-imidazol-5-yl)propanoic acid;hydron;chloride Chemical compound Cl.OC(=O)[C@@H](N)CC1=CN=CN1 QZNNVYOVQUKYSC-JEDNCBNOSA-N 0.000 claims description 6
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- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
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Abstract
A nutritional composition for oral use which contains a mixture of (a) three branched amino acids including valine, leucine and isoleucine, or (b) three branched amino acids including valine, leucine and isoleucine together with an amino acid other than branched amino acids, and in which the branched amino acids are not granulated and the branched amino acids have such a grain size as passing a 106 mum-sieve at a ratio of 10% by weight or less.
Description
Technical field
The present invention relates to oral nutrition composition, especially the downtrod alimentation composition of bitterness.
Background technology
Oral nutrition composition is used to improve the nutritional condition of patient or healthy individual and in extensive uses such as field of medicaments.Oral nutrition composition often is present in solvent such as the water with dissolving or suspensions.
Yet the solution or the suspension of this oral nutrition composition present bitterness, and when taking patient being waited is a trouble.
As the oral nutrition composition that bitterness when taking in is suppressed, knownly announce No.3 in the Japanese granted patent, granular preparation is disclosed in 211,824.This granted patent has openly been instructed the method that is used for by granulating material production pharmacy granular preparation, this material mainly comprises three kinds of branched-amino granulates, that is, isoleucine, leucine and valine granule, wherein each isoleucine and leucic granular size are adjusted to 20 to 700 μ m.Described in 0002 joint of above-mentioned announcement that the taste of hour preparation is unhappy and be difficult to take when the granule of branched-chain amino acid.In addition, when the taking in downtrod granular preparation of bitterness can be by regulating the branched-chain amino acid material granule in pelletization size has been described to obtain in above-mentioned disclosed 0005 joint greater than material granule usually.
Yet as described in above-mentioned patent disclosure 0034 joint, as the absorption method, granule is put in the mouth and with water and swallows.Subsequently, bitterness and aftertaste after check is taken in soon.According to the inventor's research, by the granular preparation dissolving described in will be above-mentioned open or the suspend in water solution that obtains or the bitterness of suspension be not suppressed.
In addition, for producing the above-mentioned open middle granular preparation of describing, need granulation workshop and granulating process, it has improved production cost.
Summary of the invention
An object of the present invention is to provide the oral nutrition composition that comprises branched-chain amino acid and its simple production method, wherein be suppressed taking by the bitterness that is partly dissolved or taste when solution that the said composition that suspends obtains or suspension.
For the inventor that achieves the above object has carried out extensive studies and found that the downtrod oral nutrition composition of bitterness can be by a kind of three class branched-chain amino acid of regulating when taking in particular range, that is the straightforward procedure of the granular size of valine, leucine and isoleucine and obtaining.In addition, the inventor finds that also the oral nutrition composition that bitterness is subjected to further to suppress when taking in can be by not losing its easy-to-swallow characteristic, in particular range, regulate every kind of branched-chain amino acid, that is, and the granular size of valine, leucine and isoleucine and obtaining.
The present invention finishes on the basis of the above, and following oral nutrition composition, its production method are provided, or the like.
Project 1. oral nutrition compositions comprise: (a) three kinds of branched-chain amino acid, and branched-chain amino acid is valine, leucine and isoleucine; Or (b) mixture of three kinds of branched-chain amino acid of non-branched-chain amino acid and valine, leucine and isoleucine; Branched-chain amino acid granulating not wherein, and its granular size is: wherein 10wt% or the still less screen cloth by 106 μ m (preferred 105 μ m).
Project 2. is according to this oral nutrition composition of project 1, and the granular size that is stranded in the branched-chain amino acid of (preferred 105 μ m) the hole sizer net that has 106 μ m after wherein sieving is that 106 (preferred 105) are to 710 μ m.
Project 3. is according to the oral nutrition composition of project 2, the granular size that is stranded in the valine of (preferred 105 μ m) the hole sizer net that has 106 μ m after wherein sieving is 180 to 500 μ m, the leucic granular size that is stranded in (preferred 105 μ m) the hole sizer net that has 106 μ m after sieving is 180 to 500 μ m, and the granular size that is stranded in the isoleucine of (preferred 105 μ m) the hole sizer net that has 106 μ m after sieving is 180 to 500 μ m.
Project 4. is according to the oral nutrition composition of project 1,2 or 3, the mixture that comprises three kinds of branched-chain amino acid of non-branched-chain amino acid and valine, leucine and isoleucine, wherein granulating and granular size are not 10wt% or still less by having the screen cloth in 106 μ m (preferred 105 μ m) hole wherein to branched-chain amino acid.
Project 5. is according to the oral nutrition composition of project 4, and wherein with respect to the branched-chain amino acid of 100 weight portions, the content of non-branched-chain amino acid is 10 to 25 parts.
Project 6. is according to the oral nutrition composition of project 5, wherein said composition comprises 2 to 5wt% valines, 3 to 6wt% leucines, 3 to 6wt% isoleucine, 0.3 to the 0.7wt% lysine hydrochloride, 0.1 to the 0.4wt% threonine, 0.4 to 0.8wt% arginine monohydrochloride, 0.2 to 0.5% histidine hydrochloride and 0.05 to 0.2wt% tryptophan.
Project 7. is according to the oral nutrition composition of project 6, wherein the 50g said composition comprises 1.2 to 2gL-valines, 1.6 to the 2.2gL-leucine, 1.6 to the 2.2gL-isoleucine, 0.1 to the 0.3g lysine hydrochloride, 0.1 to the 0.2gL-threonine, 0.2 to the 0.4gL-arginine monohydrochloride, 0.1 to 0.3gL-histidine hydrochloride, 50 to 90mgL-tryptophans, 5 to 8g gel hydrolyzate, 2 to 5g crop oil, 25 to 40g dextrin, 300 to 600I.U. vitamin A palmitates, 30 to 60I.U. vitamin D-2s, 0.1 to the 0.2mg bisbentiamine, 0.1 to 0.2mg vitamin B-2,0.1 to 0.3mg vitamin B-6 hydrochlorate, 0.3 to 0.7 μ g vitamin B-12,30 to 70 μ g folic acid, 5 to 9mgL-sodium ascorbates, 7 to 12mg vitamin E acetate, 4 to 7 μ g vitamin K1s, 1 to 1.5mg calcium pantothenate, 1 to 2mg nicotinamide, 15 to 40 μ g biotins, 9 to 16mg adipokinetic hormones, 0.15 to 0.25g magnesium sulfate, 0.25 to 0.35g calcium glycerophosphate, 0.15 to 0.25g crystallization sodium dihydrogen phosphate, 10 to 15mg tetrasodium biscitrate ferrates, 0.3 to 0.7mg copper sulfate, 3 to 4.5mg zinc sulfate, 10 to 15 μ g potassium iodide, 0.6 to the 1mg manganese sulfate, and 0.15 to 0.23g potassium chloride.
Project 8. is according to the oral nutrition composition of project 7, wherein the 50g said composition comprises the 1.602gL-valine, 2.037gL-leucine, 1.9225gL-isoleucine, 0.2425g lysine hydrochloride, 0.133gL-threonine, 0.302gL-arginine monohydrochloride, 0.1875gL-histidine hydrochloride, 73.5mgL-tryptophan, 6.5g gel hydrolyzate, 3.5g crop oil, 31.05g dextrin, 466I.U. vitamin A palmitate, 46.6I.U. vitamin D-2,0.145mg bisbentiamine, 0.155mg vitamin B-2,0.245mg vitamin B-6 hydrochlorate, 0.5 μ g vitamin B-12,50 μ g folic acid, 6.9mgL-sodium ascorbate, 9.3mg vitamin E acetate, 5.5 μ g vitamin K1,1.19mg calcium pantothenate, 1.515mg nicotinamide, 25 μ g biotins, 12.3mg adipokinetic hormone, 0.205g magnesium sulfate, 0.305g calcium glycerophosphate, 0.195g crystallization sodium dihydrogen phosphate, 12.5mg tetrasodium biscitrate ferrate, 0.515g copper sulfate, 3.755g zinc sulfate, 12.5 μ g potassium iodide, 0.815mg manganese sulfate, and 0.1875g potassium chloride.
Project 9. is used for the method for composite inhibiting bitterness, and said composition comprises: a) three kinds of branched-chain amino acid, and branched-chain amino acid is valine, leucine and isoleucine; Or (b) chemical compound of three kinds of branched-chain amino acid of non-branched-chain amino acid and valine, leucine and isoleucine; Wherein granulating and granular size are not 10wt% or still less by having the screen cloth in 106 μ m (preferred 105 μ m) hole wherein to branched-chain amino acid.
Project 10. is used to produce the method for oral nutrition composition, comprising: mix valine, leucine and isoleucine, wherein every kind not granulating and granular size for 10wt% wherein or still less by having the screen cloth in 106 μ m (preferred 105 μ m) hole; The non-branched-chain amino acid of additional mixing when needing.
Project 11. oral nutrition compositions comprise: (a) three kinds of branched-chain amino acid, and branched-chain amino acid is valine, leucine and isoleucine; Or (b) mixture of three kinds of branched-chain amino acid of non-branched-chain amino acid and valine, leucine and isoleucine; Wherein branched-chain amino acid not granulating and granular size for 10wt% wherein or still less by having the screen cloth in 105 μ m holes.
The invention provides a kind of oral nutrition composition, wherein be suppressed taking by the bitterness that is partly dissolved or taste when solution that the said composition that suspends obtains or suspension.This oral nutrition composition of the present invention does not influence the absorbance of body.
The invention provides a kind of being used for by not needing special operational as granulating the method that the simple production method cheaply of bag quilt or the like is produced above-mentioned oral nutrition composition.
Detailed Description Of The Invention
To describe the present invention in detail below.
(1)
Oral nutrition composition of the present invention
1-1)
Oral nutrition composition
Basic composition
Oral nutrition composition according to the present invention comprises: (a) three class branched-chain amino acid, that is, and valine, leucine and isoleucine; Or (b) mixture of non-branched-chain amino acid and three kinds of branched-chain amino acid (that is, valine, leucine and isoleucine); Wherein branched-chain amino acid not granulating and granular size for 10wt% wherein or still less by having the screen cloth in 106 μ m holes.
Said composition is generally solid composite (as, the compositions of powder type).
Branched-chain amino acid
Among the present invention, " not granulated branched-chain amino acid " refer to by, for example, that fermentation process or synthetic method are produced and do not use excipient or adhesive to be fixed to particulate branched-chain amino acid.The example of excipient or adhesive comprises cellulose derivative, starch, synthetic polymer, natural polymer or the like.Even not granulated branched-chain amino acid comprises above-mentioned excipient or adhesive in the present composition, this branched-chain amino acid still is included in " not granulated branched-chain amino acid ", as long as the amount of excipient or adhesive can not cause particulate formation.
The not granulated branched-chain amino acid granular size that the present invention uses is for wherein generally being 10wt% or still less, preferred 5wt% or still less, and more preferably 3wt% or still less by having the screen cloth in 106 μ m holes.
When this not granulated branched-chain amino acid sieves when having the screen cloth in 106 μ m holes, be trapped in the granular size of the branched-chain amino acid of screen cloth can be preferably about 106 to about 710 μ m, more preferably from about 125 to about 600 μ m, further preferred about 180 to about 500 μ m.When granular size in above-mentioned scope, bitterness is subjected to fully suppressing and following state can not occurring: when solution or suspension prepare precipitation, in the mouth non-experiences, is stuck between tooth naturally, clings artificial tooth when taking in, or when the production of this oral nutrition composition and other component separating.
For this oral nutrition composition, importantly be trapped in every kind of branched-chain amino acid on the screen cloth with 106 μ m holes, valine, leucine or isoleucine have the granular size in the particular range.Under such situation, bitterness can be suppressed more.Particularly, when valine, leucine or isoleucine sieve respectively when having the screen cloth in 106 μ m holes, be trapped in valine, leucine or the isoleucine granular size of screen cloth can be preferably about 106 to about 710 μ m, more preferably from about 125 to about 600 μ m, and further preferred about 180 to about 500 μ m.
These branched-chain amino acid can be L-, D-or DL-type.Preferred branched-chain amino acid is the L-type.
Non-branched-chain amino acid
Be included in aminoacid in the oral nutrition composition of the present invention and can only be branched-chain amino acid or branched-chain amino acid and non-branched-chain amino acid together.Preferably comprise non-branched-chain amino acid and branched-chain amino acid.
This branched-chain amino acid refers to do not have the aminoacid of branched carbon skeleton beyond valine, leucine and isoleucine.As non-branched-chain amino acid, be generally comprised within can use without restriction in the oral nutrition composition.The example of branched-chain amino acid comprises lysine, threonine, arginine, histidine, tryptophan or the like.These non-branched-chain amino acid can be L-, D-or DL-type.Preferably, non-branched-chain amino acid is the L-type.These aminoacid can be acid-addition salts form, for example hydrochloric acid.
Content ratio
Comprise in the situation of non-branched-chain amino acid at oral nutrition composition of the present invention, the ratio of branched-chain amino acid and non-branched-chain amino acid does not have specific limited and can select suitably in a big scope.For example, the branched-chain amino acid of preferred per 100 weight portions, the content of non-branched-chain amino acid is about 10 to 25 weight portion, especially about weight portion of 15 to 20.
Preferred compositions
The preferred oral nutrition composition of the present invention comprises, proportional meter by gross weight: about 2 to about 5wt% valine, about 3 to about 6wt% leucine, about 3 to about 6wt% isoleucine, about 0.3 to about 0.7wt% lysine hydrochloride, about 0.1 to about 0.4wt% threonine, and about 0.4 to about 0.8wt% arginine monohydrochloride, about 0.2 to about 0.5% histidine hydrochloride and about 0.05 to about 0.2wt% tryptophan.
Except branched-chain amino acid and non-branched-chain amino acid, this oral nutrition composition can comprise the normally used compounding ingredient in multiple this area.The example of described compounding ingredient can comprise gel hydrolyzate, crop oil, dextrin, vitamin A palmitate, vitamin D-2, bisbentiamine, vitamin B-2, vitamin B-6 hydrochlorate, vitamin B-12, folic acid, L-sodium ascorbate, vitamin E acetate, vitamin K1, calcium pantothenate, nicotinamide, biotin, adipokinetic hormone, magnesium sulfate, calcium glycerophosphate, crystallization sodium dihydrogen phosphate, tetrasodium biscitrate ferrate, copper sulfate, zinc sulfate, potassium iodide, manganese sulfate, potassium chloride, or the like.
In the instantiation of the preferred chemical constituent of this oral nutrition composition, the 50g said composition can comprise: about 1.2 to about 2gL-valine, about 1.6 to about 2.2gL-leucine, about 1.6 to about 2.2gL-isoleucine, about 0.1 to about 0.3g lysine hydrochloride, about 0.1 to about 0.2gL-threonine, about 0.2 to about 0.4gL-arginine monohydrochloride, about 0.1 to about 0.3gL-histidine hydrochloride, about 50 to about 90mgL-tryptophan, about 5 to about 8g gel hydrolyzate, about 2 to about 5g crop oil, about 25 to about 40g dextrin, about 300 to about 600I.U. vitamin A palmitate, about 30 to about 60I.U. vitamin D-2, about 0.1 to about 0.2mg bisbentiamine, about 0.1 to about 0.2mg vitamin B-2, about 0.1 to about 0.3mg vitamin B-6 hydrochlorate, about 0.3 to about 0.7 μ g vitamin B-12, about 30 to about 70 μ g folic acid, and about 5 to about 9mgL-sodium ascorbate, and about 7 to about 12mg vitamin E acetate, about 4 to about 7 μ g vitamin K1s, about 1 to about 1.5mg calcium pantothenate, and about 1 to about 2mg nicotinamide, and about 15 to about 40 μ g biotins, about 9 to about 16mg adipokinetic hormone, about 0.15 to about 0.25g magnesium sulfate, and about 0.25 to about 0.35g calcium glycerophosphate, and about 0.15 to about 0.25g crystallization sodium dihydrogen phosphate, about 10 to about 15mg tetrasodium biscitrate ferrate, about 0.3 to about 0.7mg copper sulfate, and about 3 to about 4.5mg zinc sulfate, and about 10 to about 15 μ g potassium iodide, about 0.6 to about 1mg manganese sulfate, and about 0.15 to about 0.23g potassium chloride.
In the instantiation of the preferred chemical constituent of this oral nutrition composition, the 50g said composition can comprise: the 1.602gL-valine, 2.037gL-leucine, 1.9225gL-isoleucine, 0.2425g lysine hydrochloride, 0.133gL-threonine, 0.302gL-arginine monohydrochloride, 0.1875gL-histidine hydrochloride, 73.5mgL-tryptophan, 6.5g gel hydrolyzate, 3.5g crop oil, 31.05g dextrin, 466I.U. vitamin A palmitate, 46.6I.U. vitamin D-2,0.145mg bisbentiamine, 0.155mg vitamin B-2,0.245mg vitamin B-6 hydrochlorate, 0.5 μ g vitamin B-12,50 μ g folic acid, 6.9mgL-sodium ascorbate, 9.3mg vitamin E acetate, 5.5 μ g vitamin K1,1.19mg calcium pantothenate, 1.515mg nicotinamide, 25 μ g biotins, 12.3mg adipokinetic hormone, 0.205g magnesium sulfate, 0.305g calcium glycerophosphate, 0.195g crystallization sodium dihydrogen phosphate, 12.5mg tetrasodium biscitrate ferrate, 0.515g copper sulfate, 3.755g zinc sulfate, 12.5 μ g potassium iodide, 0.815mg manganese sulfate, and 0.1875g potassium chloride.
1-2)
Be used to produce the method for this oral nutrition composition
The method that the present invention is used to produce this oral nutrition composition comprises: mix not granulated and granular size and be the 10wt% wherein or the valine of the screen cloth by having 106 μ m holes still less, not granulated and granular size is for 10wt% wherein or still less the leucine of the screen cloth by having 106 μ m holes and not granulated and granular size are the 10wt% wherein or the isoleucine of the screen cloth by having 106 μ m holes still less; Mix non-branched-chain amino acid when needing.
The approach that acquisition has not granulating valine, leucine and the isoleucine of above-mentioned granular size does not have specific limited.For example, they can obtain by screening business-like not granulating valine powder, leucine powder and isoleucine powder respectively.This commercialization valine, leucine and isoleucine are usually by fermentation process or synthetic method production.
The not granulated branched-chain amino acid of Shi Yonging in the present invention, 10wt% or still less usually wherein, preferred 5wt% or still less, more preferably 3wt% or still less by having the screen cloth in 106 μ m holes.
When branched-chain amino acid sieves when having 106 μ m hole sizer nets, be trapped in the branched-chain amino acid granular size of screen cloth can be preferably about 106 to about 710 μ m, more preferably from about 125 to about 600 μ m, further preferred about 180 to about 500 μ m.
When valine, leucine or isoleucine sieve respectively when having 106 μ m hole sizer nets, be trapped in valine, leucine or the isoleucine granular size of screen cloth can be preferably about 106 to about 710 μ m, more preferably from about 125 to about 600 μ m, and further preferred about 180 to about 500 μ m.The result is that bitterness further is suppressed in the oral nutrition composition.
These branched-chain amino acid can be L-, D-or DL-type.Preferred branched-chain amino acid is the L-type.
In the methods of the invention, can comprise or do not comprise non-branched-chain amino acid, but preferably comprise.Available non-branched-chain amino acid as mentioned above.In using non-branched-chain amino acid situation, the ratio of branched-chain amino acid and non-branched-chain amino acid also as mentioned above.
1-3)
Be used to suppress comprise the method for the oral nutrition composition bitterness of branched-chain amino acid
The present invention is used to suppress comprise that the method for the oral nutrition composition bitterness of branched-chain amino acid is: be used for the method for composite inhibiting bitterness, said composition comprises (a) three kinds of branched-chain amino acid, and branched-chain amino acid is valine, leucine and isoleucine; Or (b) chemical compound of three kinds of branched-chain amino acid of non-branched-chain amino acid and valine, leucine and isoleucine; Wherein branched-chain amino acid not granulating and granular size for 10wt% wherein or still less by having the screen cloth in 106 μ m holes.
The adjusting of the acquisition of granulating branched-chain amino acid and granular size is not as mentioned above.
1-4)
Be used to use the method for oral nutrition composition
In using oral nutrition composition of the present invention, can bestow patient or healthy individual by the present composition being partly dissolved or being suspended in the suspension or the solution that obtain in suitable quantity of water or the similar solvent.The bitterness of solution or suspension is suppressed when taking immediately after preparation.
Because oral nutrition composition of the present invention comprises oarse-grained branched-chain amino acid, the dissolution rate of this branched-chain amino acid low and when being suspended in solvent meltage few.Therefore, even the dissolving of part branched-chain amino acid is arranged, the low bitterness of consequently can not tasting substantially of the concentration of branched-chain amino acid in the solution.In addition, though solution or suspension in the low-temperature preservation a very long time, bitterness does not almost increase, in other words, bitterness is suppressed always.Perhaps, can directly take the invention described above oral nutrition composition.
Oral nutrition composition of the present invention can preferably be bestowed liver failure, as patient with liver cirrhosis, provides nutrition thus.
Embodiment
Provide preparation embodiment and test implementation example below further describing the present invention in detail, but they do not attempt to limit the scope of the invention.
Preparation embodiment 1
The oral nutrition composition of the present invention of total amount 50g is by mixing following component preparation.
L-valine 1.602g
L-leucine 2.037g
L-isoleucine 1.9225g
Lysine hydrochloride 0.2425g
L-threonine 0.133g
L-arginine monohydrochloride 0.302g
L-histidine hydrochloride 0.1875g
L-tryptophan 73.5mg
Gel hydrolyzate 6.5g
Crop oil 3.5g
Dextrin 31.05g
Vitamin A palmitate 466I.U.
Vitamin D-2 46.6I.U.
Bisbentiamine 0.145mg
Vitamin B-2 0.155mg
Vitamin B-6 hydrochlorate 0.245mg
Vitamin B-12 0.5 μ g
Folic acid 50 μ g
L-sodium ascorbate 6.9mg
Vitamin E acetate 9.3mg
Vitamin K1 5.5 μ g
Calcium pantothenate 1.19mg
Nicotinamide 1.515mg
Biotin 25 μ g
Adipokinetic hormone 12.3mg
Magnesium sulfate 0.205g
Calcium glycerophosphate 0.305g
Crystallization sodium dihydrogen phosphate 0.195g
Tetrasodium biscitrate ferrate 12.5mg
Copper sulfate 0.515g
Zinc sulfate 3.755g
Potassium iodide 12.5 μ g
Manganese sulfate 0.815mg
Potassium chloride 0.1875g
Wherein used by having L-valine, L-leucine and the L-isoleucine after 710 μ m hole patterns sieve.The L-valine that uses has such distribution of particles, and wherein its 3wt% has the granular size of 106 to 710 μ m by the granule that the mesh screen with 106 μ m holes is trapped in mesh screen.The L-leucine that uses has such distribution of particles, and wherein its 3wt% has the granular size of 106 to 710 μ m by the granule that the mesh screen with 106 μ m holes is trapped in mesh screen.The L-isoleucine that uses has such distribution of particles, and wherein 3wt% has the granular size of 106 to 710 μ m by the granule that the mesh screen with 106 μ m holes is trapped in mesh screen.
Contrast preparation embodiment 1
Prepare similar compositions in same mode among the preparation embodiment 1, have the branched-chain amino acid of following granular size except use.
The L-valine that uses has such distribution of particles, and wherein mean particle size is 72 μ m to 90wt% by the mesh screen with 106 μ m holes.The L-leucine that uses has such distribution of particles, and wherein mean particle size is 66 μ m to its 90wt% by the mesh screen with 106 μ m holes.The L-isoleucine that uses has such distribution of particles, and wherein mean particle size is 58 μ m to its 95wt% by the mesh screen with 106 μ m holes.Mean particle size is determined according to the mesh analysis of routine.Use is identical among other component beyond L-valine, L-leucine and the L-isoleucine and the preparation embodiment 1.
Mix the contrast alimentation composition that makes total amount 50g with the compositions of preparation embodiment 1 same amount.
Test implementation example 1
To 50g prepare among the embodiment 1 and contrast preparation embodiment 1 in every kind of alimentation composition producing, add the vibration of 180ml water mixed alimentation composition solution or suspension.
These two kinds of alimentation composition solution or suspension are accepted 20 participants' (adult) sensory evaluation, easy degree of swallowing with assessment and every kind bitterness.
The result who estimates, 20 philtrums, 19 people answer and to swallow simple according among the preparation embodiment 1 of the alimentation composition solution comparison that makes among the preparation embodiment 1, and all 20 people to answer the alimentation composition solution that makes among the contrast preparation embodiment 1 more bitter than tasting of making among the preparation embodiment 1.
Test implementation example 2
To 50g prepare among the embodiment 1 and contrast preparation embodiment 1 in every kind of alimentation composition producing, add the vibration of 100ml water mixed alimentation composition solution or suspension.
These two kinds of alimentation composition solution or suspension in refrigerator 10 ℃ the storage 24 hours, in time the sampling and by using following standard to accept simplification and bitterness that sensory evaluation is swallowed with assessment.
Being used to estimate the standard of taking in easy degree is:
◎ is highly susceptible to swallowing; Zero, easy-to-swallow; △, more easy-to-swallow; *, be difficult to swallow.
The standard that is used to estimate bitterness is:
◎ does not feel bitter; Zero, feel a bit bitter; △ feels bitter; *, feel very bitter.
The result of sensory evaluation shows in the following Table 1.
Table 1
| Elapsed time (hour) | Preparation embodiment 1 | Contrast preparation embodiment 1 | ||
| Swallow easy degree | Bitterness | Swallow easy degree | Bitterness | |
| 0 (after the preparation immediately) | ◎ | ◎ | × | × |
| 4 | ○ | ○ | × | × |
| 8 | ○ | ○ | × | × |
| 24 | ○ | ○ | × | × |
Test implementation example 1 and 2 result show that bitterness is suppressed and easy-to-swallow oral nutrition composition can obtain for 10wt% wherein or when still less the screen cloth by having 106 μ m holes and valine, leucine and isoleucine granular size are 106 to 710 μ m in the granular size of branched-chain amino acid.In addition, but described characteristic stable maintenance, even store at low temperatures when these oral nutrition compositions.
Test implementation example 3
To 50g prepare among the embodiment 1 and contrast preparation embodiment 1 in every kind of alimentation composition producing, add the vibration of 180ml water mixed alimentation composition solution.
These two kinds of alimentation composition solution or suspension 10 ℃ of storages in refrigerator, in time the sampling and by using following standard to accept easy degree and bitterness that sensory evaluation is swallowed with assessment.Sampled and took in 4 and 8 hours at solution and suspension preparation back.Time representation: supposition alimentation composition solution is 4 hours in the preparation of breakfast time from breakfast to lunch; And supposition alimentation composition solution is 8 hours in the preparation of breakfast time from breakfast to dinner.
Being used to estimate the standard of taking in easy degree is:
◎ is highly susceptible to swallowing; Zero, easy-to-swallow; △, more easy-to-swallow; *, be difficult to swallow.
The standard that is used to estimate bitterness is:
◎ does not feel bitter; Zero, feel a bit bitter; △ feels bitter; *, feel very bitter.
The result of sensory evaluation shows in the following Table 2.Value representation participant number in the table 2.
Table 2
| Preparation embodiment 1 | Contrast preparation embodiment 1 | |||||||||||||||
| Swallow easy degree | Bitterness | Swallow easy degree | Bitterness | |||||||||||||
| ◎ | ○ | △ | × | ◎ | ○ | △ | × | ◎ | ○ | △ | × | ◎ | ○ | △ | × | |
| 0 the preparation after immediately | 10 | 0 | 0 | 0 | 10 | 0 | 0 | 0 | 0 | 0 | 1 | 9 | 0 | 0 | 1 | 9 |
| 4 hours | 9 | 1 | 0 | 0 | 7 | 3 | 0 | 0 | 0 | 0 | 1 | 9 | 0 | 0 | 1 | 9 |
| 8 hours | 8 | 2 | 0 | 0 | 6 | 4 | 0 | 0 | 0 | 0 | 1 | 9 | 0 | 0 | 1 | 9 |
The result of test implementation example 3, many participants represent to contrast the alimentation composition solution that obtains among the preparation embodiment 1 and taste more bitter and be difficult to and take immediately after preparation, have also provided similar feedback to preparing 4 and 8 hours the liquid in back.On the contrary, all participants represent to prepare among the embodiment 1 the alimentation composition solution that obtains or suspension and do not feel bitterness and be highly susceptible to taking.After having spent a period of time, some participants taste little hardship, but this bitterness is negligible.Even all participants represent conveniently to take and prepare back 8 hours solution or suspension.
The result of test implementation example 3 shows when the solution of alimentation composition of the present invention or suspension and is stored in refrigerator in the preparation of breakfast time, and this solution or suspension can be taken and do not have a bitterness at lunchtime or date for dinner.
Industrial applicibility
Oral nutrition composition according to the present invention is when taking as solution in water and similar solvent or suspension, and the bitter taste that can taste has been subject to inhibition. Even this solution or suspension are in the cryopreservation a very long time, bitter taste does not almost increase, and in other words, bitter taste continues to be suppressed. Alimentation composition of the present invention can preferably be bestowed the patient of hepatic failure such as cirrhosis, and nutrition is provided thus.
Claims (10)
1. oral nutrition composition comprises: (a) three kinds of branched-chain amino acid, and wherein branched-chain amino acid is valine, leucine and isoleucine; Or (b) mixture of non-branched-chain amino acid and valine, leucine and three kinds of branched-chain amino acid of isoleucine;
Wherein granulating and granular size be not for 10wt% wherein or still less by having the screen cloth in 106 μ m holes for branched-chain amino acid, and the granular size that is stranded in the branched-chain amino acid in the screen cloth with 106 μ m holes after sieving is 106 to 710 μ m.
2. according to the oral nutrition composition of claim 1, the granular size that is stranded in the valine in the screen cloth with 106 μ m holes after wherein sieving is 180 to 500 μ m, the leucic granular size that is stranded in after sieving in the screen cloth with 106 μ m holes is 180 to 500 μ m, and the granular size that is stranded in the isoleucine in the screen cloth with 106 μ m holes after sieving is 180 to 500 μ m.
3. according to the oral nutrition composition of claim 1 or 2, comprise the mixture of non-branched-chain amino acid and valine, leucine and three kinds of branched-chain amino acid of isoleucine,
Wherein granulating and granular size be not for 10wt% wherein or still less by having the screen cloth in 106 μ m holes for branched-chain amino acid, and the granular size that is stranded in the branched-chain amino acid in the screen cloth with 106 μ m holes after sieving is 106 to 710 μ m.
4. according to the oral nutrition composition of claim 3, wherein with respect to the branched-chain amino acid of 100 weight portions, the content of non-branched-chain amino acid is 10 to 25 weight portions.
5. according to the oral nutrition composition of claim 4, wherein said composition comprises 2 to 5wt% valine, 3 to 6wt% leucine, 3 to 6wt% isoleucine, 0.3 lysine hydrochloride to 0.7wt%, 0.1 to the threonine of 0.4wt%, 0.4 to 0.8wt% arginine monohydrochloride, 0.2 to 0.5% histidine hydrochloride and 0.05 to 0.2wt% tryptophan.
6. according to the oral nutrition composition of claim 5, wherein every 50g said composition comprises 1.2 to 2g L-valines, 1.6 to 2.2g L-leucine, 1.6 to 2.2g L-isoleucine, 0.1 to the 0.3g lysine hydrochloride, 0.1 to 0.2g L-threonine, 0.2 to 0.4g L-arginine monohydrochloride, 0.1 to 0.3g L-histidine hydrochloride, 50 to 90mg L-tryptophans, 5 to 8g gel hydrolyzate, 2 to 5g crop oil, 25 to 40g dextrin, 300 to 600 I.U. vitamin A palmitates, 30 to 60 I.U. vitamin D-2s, 0.1 to the 0.2mg bisbentiamine, 0.1 to 0.2mg vitamin B-2,0.1 to 0.3mg vitamin B-6 hydrochlorate, 0.3 to 0.7 μ g vitamin B-12,30 to 70 μ g folic acid, 5 to 9mg L-sodium ascorbates, 7 to 12mg vitamin E acetate, 4 to 7 μ g vitamin K1s, 1 to 1.5mg calcium pantothenate, 1 to 2mg nicotinamide, 15 to 40 μ g biotins, 9 to 16mg adipokinetic hormones, 0.15 to 0.25g magnesium sulfate, 0.25 to 0.35g calcium glycerophosphate, 0.15 to 0.25g crystallization sodium dihydrogen phosphate, 10 to 15mg tetrasodium biscitrate ferrates, 0.3 to 0.7mg copper sulfate, 3 to 4.5mg zinc sulfate, 10 to 15 μ g potassium iodide, 0.6 to the 1mg manganese sulfate, and 0.15 to 0.23g potassium chloride.
7. according to the oral nutrition composition of claim 6, wherein every 50g said composition comprises 1.602g L-valine, 2.037g L-leucine, 1.9225g L-isoleucine, 0.2425g lysine hydrochloride, 0.133g L-threonine, 0.302g the L-arginine monohydrochloride, 0.1875g L-histidine hydrochloride, 73.5mg L-tryptophan, 6.5g gel hydrolyzate, 3.5g crop oil, 31.05g dextrin, 466I.U. vitamin A palmitate, 46.6 I.U. vitamin D-2,0.145mg bisbentiamine, 0.155mg vitamin B-2,0.245mg vitamin B-6 hydrochlorate, 0.5 μ g vitamin B-12,50 μ g folic acid, 6.9mg L-sodium ascorbate, 9.3mg vitamin E acetate, 5.5 μ g vitamin K1,1.19mg calcium pantothenate, 1.515mg nicotinamide, 25 μ g biotins, 12.3mg adipokinetic hormone, 0.205g magnesium sulfate, 0.305g calcium glycerophosphate, 0.195g crystallization sodium dihydrogen phosphate, 12.5mg tetrasodium biscitrate ferrate, 0.515g copper sulfate, 3.755g zinc sulfate, 12.5 μ g potassium iodide, 0.815mg manganese sulfate, and 0.1875g potassium chloride.
8. be used for the method for composite inhibiting bitterness, wherein said composition comprises: a) three kinds of branched-chain amino acid, and branched-chain amino acid is valine, leucine and isoleucine; Or (b) mixture of non-branched-chain amino acid and valine, leucine and three kinds of branched-chain amino acid of isoleucine;
Wherein granulating and granular size be not for 10wt% wherein or still less by having the screen cloth in 106 μ m holes for branched-chain amino acid, and the granular size that is stranded in the branched-chain amino acid in the screen cloth with 106 μ m holes after sieving is 106 to 710 μ m.
9. be used to produce the method for oral nutrition composition, comprise: mix valine, leucine and isoleucine, wherein every kind granulating and granular size be not for 10wt% wherein or still less by having the screen cloth in 106 μ m holes, and the described amino acid whose granular size that is stranded in after sieving in the screen cloth with 106 μ m holes is 106 to 710 μ m; The non-branched-chain amino acid of additional mixing when needing.
10. oral nutrition composition comprises: (a) three kinds of branched-chain amino acid, and wherein branched-chain amino acid is valine, leucine and isoleucine; Or (b) mixture of non-branched-chain amino acid and valine, leucine and three kinds of branched-chain amino acid of isoleucine;
Wherein branched-chain amino acid not granulating and granular size be 10wt% or wherein still less by having the screen cloth in 105 μ m holes, and the granular size that is stranded in the branched-chain amino acid in the screen cloth with 105 μ m holes after sieving is 105 to 710 μ m.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3783082002 | 2002-12-26 | ||
| JP2002378308A JP4989836B2 (en) | 2002-12-26 | 2002-12-26 | Oral nutrition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1731990A CN1731990A (en) | 2006-02-08 |
| CN100362992C true CN100362992C (en) | 2008-01-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2003801075382A Expired - Fee Related CN100362992C (en) | 2002-12-26 | 2003-12-16 | Nutritional composition for oral use |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JP4989836B2 (en) |
| KR (1) | KR101189932B1 (en) |
| CN (1) | CN100362992C (en) |
| EG (1) | EG25065A (en) |
| HK (1) | HK1083600A1 (en) |
| MY (1) | MY146246A (en) |
| TW (1) | TWI285533B (en) |
| WO (1) | WO2004058242A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009063230A2 (en) * | 2007-11-16 | 2009-05-22 | Statoilhydro Asa | Process |
| WO2009104696A1 (en) | 2008-02-19 | 2009-08-27 | 株式会社アーネストメディスン | Oral or enteral composition useful for recovery of physical functions |
| JP5383244B2 (en) * | 2008-02-19 | 2014-01-08 | 株式会社アーネストメディスン | Nutritional agent suitable for improving symptoms or nutritional status of cancer patients |
| CN101524155B (en) * | 2009-04-20 | 2012-10-10 | 北京康比特体育科技股份有限公司 | Amino acid composition |
| JOP20190146A1 (en) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | Amino acid compositions and methods for the treatment of liver diseases |
| JP7266581B2 (en) | 2017-08-14 | 2023-04-28 | アクセラ・ヘルス・インコーポレイテッド | Amino acid composition for treatment of liver disease |
| US10596136B2 (en) | 2018-06-20 | 2020-03-24 | Axcella Health Inc. | Compositions and methods for the treatment of fat infiltration in muscle |
| WO2019246256A1 (en) | 2018-06-20 | 2019-12-26 | Axcella Health Inc. | Compositions for therapy and health containing amino acids with bitter taste |
| CN114423419A (en) * | 2019-09-20 | 2022-04-29 | 株式会社明治 | Amino acid-containing granules |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58216118A (en) * | 1982-06-11 | 1983-12-15 | Morishita Seiyaku Kk | Amino acid pharmaceutical preparation composition and its preparation |
| JP2002114674A (en) * | 2000-10-10 | 2002-04-16 | Ajinomoto Co Inc | Suspending agent for medicine containing branched-chain amino acid |
| JP2002145769A (en) * | 2000-11-07 | 2002-05-22 | Ajinomoto Co Inc | Branched-chain amino acid-containing pharmaceutical granular preparation |
-
2002
- 2002-12-26 JP JP2002378308A patent/JP4989836B2/en not_active Expired - Lifetime
-
2003
- 2003-12-16 WO PCT/JP2003/016072 patent/WO2004058242A1/en active Application Filing
- 2003-12-16 KR KR1020057011938A patent/KR101189932B1/en not_active IP Right Cessation
- 2003-12-16 CN CNB2003801075382A patent/CN100362992C/en not_active Expired - Fee Related
- 2003-12-19 TW TW092136196A patent/TWI285533B/en not_active IP Right Cessation
- 2003-12-26 MY MYPI20034995A patent/MY146246A/en unknown
-
2005
- 2005-06-26 EG EGNA2005000357 patent/EG25065A/en active
-
2006
- 2006-05-22 HK HK06105852A patent/HK1083600A1/en not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58216118A (en) * | 1982-06-11 | 1983-12-15 | Morishita Seiyaku Kk | Amino acid pharmaceutical preparation composition and its preparation |
| JP2002114674A (en) * | 2000-10-10 | 2002-04-16 | Ajinomoto Co Inc | Suspending agent for medicine containing branched-chain amino acid |
| JP2002145769A (en) * | 2000-11-07 | 2002-05-22 | Ajinomoto Co Inc | Branched-chain amino acid-containing pharmaceutical granular preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| MY146246A (en) | 2012-07-31 |
| WO2004058242A1 (en) | 2004-07-15 |
| JP4989836B2 (en) | 2012-08-01 |
| EG25065A (en) | 2011-07-26 |
| TW200412864A (en) | 2004-08-01 |
| JP2004210639A (en) | 2004-07-29 |
| KR20050095833A (en) | 2005-10-04 |
| KR101189932B1 (en) | 2012-10-12 |
| CN1731990A (en) | 2006-02-08 |
| TWI285533B (en) | 2007-08-21 |
| HK1083600A1 (en) | 2006-07-07 |
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