CN100353188C - Improved apparatus, system and method for applying optical gradient forces - Google Patents
Improved apparatus, system and method for applying optical gradient forces Download PDFInfo
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- CN100353188C CN100353188C CNB028099915A CN02809991A CN100353188C CN 100353188 C CN100353188 C CN 100353188C CN B028099915 A CNB028099915 A CN B028099915A CN 02809991 A CN02809991 A CN 02809991A CN 100353188 C CN100353188 C CN 100353188C
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Abstract
The present invention relates generally to generating and controlling optical trap arrays for manipulating particles. In particular, the invention relates to a dual function optical element able to both diffract laser light into beamlets and converge the beamlets (acting as a virtual lens for laser light), thereby eliminating the need for multiple physical lenses to transfer the diffracted laser beams to a focusing lens. The invention also relates to improved monitoring of optical traps by limiting the amount of noise reflected and scattered resulting from un-diffracted, laser light.
Description
Run through the application, with reference to many publications.The disclosed content of these publications is all introduced among the application as reference, so that more intactly describe the state of the art in the affiliated field of the present invention.
Technical field
The present invention relates in general to the optics trap.Particularly, the present invention relates to be used to apply optical gradient forces and operate equipment, the system and method for small particle to form a plurality of optics traps.
Background technology
Optical tweezers is the optical tooling that a kind of gradient force that utilizes focused beam is operated the high particulate of permittivity ratio surrounding medium.In order to make its energy minimization, this particulate will be to the strongest regional movement of electric field.With regard to momentum, the light beam of focusing produces radiation pressure, by absorption, reflection, diffraction or the refraction generation small power of a particulate by light.Basically can ignore by the power that radiation pressure produces, light source, for example only produce several slight newton's power with the diode pumping Nd:YAG laser instrument of 10mW work.Yet several slight newton's power is enough to operate small particle.
Other optical tooling that can be used to operate small particle includes but not limited to optical vortex, optical bottle, optical rotator and light cage.Although optical vortex is similar with the optical tweezers purposes, principle of work is opposite.Optical vortex produces a gradient around the zone of zero electric field, this is lower than the particulate of surrounding medium or has reflective particles or be useful by the particulate of other type that optical tweezers repelled for handling specific inductive capacity.In order to make its energy minimization, this particulate will be to the minimum zone of electric field, promptly to moving at suitable zero electric field region at the focus place of the laser beam of shape.Optical vortex provides a zero electric field region that is very similar to the room in the doughnut (microtron chamber).Around doughnut, optical gradient is with the strongest electric field radiation.Optical vortex is trapped in small particle in the room of doughnut.This delay slips over along zero electric field line on small particle by eddy current and realizes.
The difference of optical bottle and optical vortex is that it only has zero electric field at the focus place, and has a non-zero electric field at an end of eddy current.Optical bottle can be used to catch that those are too little or have very much absorbability and atom and the nanocluster that can not catch with optical vortex or optical tweezers.J.Arlt?andM.J.Padgett.“Generation?of?a?beam?with?a?dark?focus?surrounded?by?regionsof?higher?intensity：The?optical?bottle?beam”，Opt.Lett.25，191-193，2000。
Optical rotator is nearest disclosed optical tooling, and it provides a kind of spiral arm pattern of catching object.Pattern conversion can make captive object rotation.L.Paterson，M.P.MacDonald，J.Arlt，W.Sibbett，P.E.Bryant，and?K.Dholakia，“Controlled?rotation?ofoptically?trapped?microscopic?particles，”Science?292，912-914，2001。Such instrument can be used to handle aspheric particulate and driving MEMs device or nano-machine.
Neal is in U.S. Patent No. 5,939, and disclosed smooth cage is a kind of wide in range optical vortex kind equipment that can be visual in 716.The light cage forms round an optical vortex ring that too greatly, too has reflectivity or have the particulate of the specific inductive capacity that is lower than surrounding medium.If optical vortex is similar to a doughnut, then this light cage is similar to one and fills paste (jelly-filled) doughnut.The doughnut room
(for eddy current) is zero electric field region, and filling paste then is low electric field region.In general, form doughnut a plurality of optical tweezers gradient force towards also can be considered between a plurality of optical tweezers not clear clear zone fill the particulate that paste " promotion " has the specific inductive capacity lower than surrounding medium.Yet, different with eddy current, produced a non-zero electric field district.
In the U.S. Patent No. 6,055,106 of the Grier and Dufresne that describes optics trap array, can know that the single beam laser that a kind of employing has a diffraction optical element forms the diffracted laser beam that a plurality of focusing form optics trap arrays.This patent proposes to adopt the back aperture of physical transfer lens with the laser beam direction condenser lens of a diffraction.A plurality of real lens are used to guide and laser beam is overlapped the back aperture place of condenser lens, make laser beam fully overlapping to obtain to be at least 0.8 effective numerical aperture (NA), U.S. Patent No. 5 as Chu and Kronis, 079,169 is described, and 0.8 is considered to be in and catches and handle the required minimum NA of particulate in the three dimensions.U.S. Patent No. 6,055, the shortcoming of disclosed equipment is in 106, each lens needs a large amount of relatively physical spaces operating, and each lens must be maintained, cleaning and alignment.The people who is familiar with the transmission lens system will recognize that the lens number in system is many more, then out-of-alignment possibility is big more, and has other maintenance problem.Therefore, needs reduce the lens number in the transmission lens system that is used to form optics trap array.The present invention can satisfy these needs.
In U.S. Patent No. 6,055, the common form that being used for of describing in 106 monitored the activity of optics trap is to place a beam splitter at laser beam path, thereby and produces an optical data stream.The limitation of this form is that noise is for the deleterious effect of optical data stream.Aspect the optics trap, noise refers to the imaging of optics trap, measurement and/or observation, their content or peripheral region is impacted, this be because lens are imperfect, dust, dirt or because of unjustifiedly cause not that the focused beam or the energy of diffraction are present in the system, light disperses and the lens of light from the physical transfer lens combination are reflected or diffraction causes from the optics trap.As U.S. Patent No. 6,055,106 is described, and a kind of approach that reduces noise is with respect to the angle guided laser bundle of diffraction element with an inclination, thereby the light beam that impels diffraction not is away from object lens.Although for its desired purpose that reaches is useful, still there is other noise source.Therefore need reduce or eliminate owing to produce the caused noise of not diffracted laser beam, dispersion and reflection lasering beam that the parts of the system of optics trap array form.The present invention can satisfy these needs and other needs equally, is listed as and provides associated advantages.
Summary of the invention
The invention provides a kind of novel and improved method, system and equipment that only adopts the single one physical transmission lens to produce, monitor and control optics trap array.By filtering or mask by the scattering in the system, not diffraction and reflected light " noise " that causes, the present invention has also improved the monitoring and the control of optics trap.
In producing the system of a plurality of optics traps, by with a lens function compiling (encoding) in a diffraction optical element, eliminate or reduced a plurality of transmission lenses.This diffraction optical element can also change the phase place of any light beam.By the compiling diffraction optical element assembling a plurality of light beams, the invention adopt single real lens to transmit a plurality of light beams and they overlapped on the back aperture of object lens, and form the advantage of the optics trap that runs through.
In a citation form, the present invention (Figure 1A) is the light or the beam of a branch of focusing, and for example by the single laser beam of diffraction optical element diffraction, described diffraction optical element has the coding lens function.This laser beam is diffracted into a plurality of light beams, and the also diffracted optical elements focused of each light beam also guides to single transmission lens subsequently, this single transmission lens guides a plurality of light beams and overlap onto on the back aperture of condenser lens (for example microscopical object lens) again, thereby forms a plurality of optics traps.In order to change the position of given optics trap, the light beam that forms this optics trap can be adjusted to a new position by diffraction optical element, thereby changes consequent optics trap position.Can increase the catoptron (Fig. 1 D, 1E, 2 and 4) of a motion, so that integrally change the position of all optics traps.In some cases, the motion of single transmission lens also can be used to change the position of given optics trap satisfactorily.
Producing and control optics trap array selectively with the simple lens mobile system is useful for many commercial application, for example the manufacturing of the structure of optical circuit design and manufacturing, nano composite material, electronic unit, photoelectron, chemistry and biosensor array, holographic data storage matrix component, the energy that drives MEMS or light motor, to the check of the concentrating of the examination of the control of the popularization of the promotion of combinatorial chemistry, colloid self assembly, biomaterial, biomaterial, selected biomaterial, biomaterial The Characteristic Study and biomaterial etc.
(Fig. 2 and 4) in some embodiments of the invention, by before condenser lens, a beam splitter placed beam path and introduce subsequently a light filter with the light that limits diffraction, scattering or reflection along optical data stream by, and therefore reduce and can upset the image of optical data stream or the noise of other monitoring, can carry out Real Time Observation to the activity of optics trap array.The catoptron and the beam splitter of the motion of a position that is used for regulating whole optics trap array can also be combined (Fig. 2 and 3) or adds system (Fig. 4) to.
By periodically cutting off laser (Fig. 3) and monitoring optical data stream and/or, can reduce noise by when laser instrument is opened, cutting off optical data stream.For example, can when optical data stream is monitored, block first optical gate of laser beam selectively; And second optical gate that when laser beam is opened, blocks optical data stream selectively and when laser beam is closed, do not stop optical data stream.
In the reference the description of the drawings, will partly mention other features and advantages of the present invention, in this explanation and accompanying drawing, describe and represented the preferred embodiments of the present invention, and experimentize by the detailed description of following below in conjunction with accompanying drawing, it will be appreciated by those skilled in the art that these feature and advantage, perhaps can understand by putting into practice the present invention.Can realize and obtain advantage of the present invention by measure and the combination of specifically noting in the claims.
Description of drawings
Figure 1A represents a system that is used to handle the small particle array.
Figure 1B represents to be used to handle first alternative system of small particle array.
Fig. 1 C represents to handle with a reflectivity diffraction optical element second alternative system of small particle array.
Fig. 1 D represents to have the 3rd alternative system that is used to handle the small particle array of moving reflector.
Fig. 1 E represents to have the 4th alternative system that is used to handle the small particle array of moving reflector.
Fig. 2 represents to be suitable for carrying out the 5th alternative system that is used to handle the small particle array that real-time and no noise is observed.
Fig. 3 represents to be suitable for carrying out the 6th alternative system that is used to handle the small particle array that real-time and no noise is observed.
Fig. 4 represents to be suitable for carrying out the 7th alternative system that is used to handle the small particle array of Real Time Observation.
Embodiment
To adopt specific term in the following description,, provide the simple and clear definition of indefiniteness below for more convenient and help reference:
A. " beam " refers to the child bundle of focused light or other energy source, and it is that the focused beam acts of the light that for example produces by laser instrument or from the parallel output that light emitting diode sends by guiding or other energy source is passed the media that this focused beam acts is diffracted into two or more son bundles and produced.An example of beam is the higher order laser beam from optical grating diffraction.
B. " PHASE DISTRIBUTION " refers to the phase place of in the xsect of light beam light or other energy source.
C. " phase pattern form (phase patterning) " refers to that the phase shift with a pattern changes the focused beam acts or the beam of the light of its PHASE DISTRIBUTION, other energy source, includes but not limited to that phase modulation (PM), pattern form, divide, assemble, disperse, shaping and to the focused beam acts of light or other energy source or other manipulation of beam.
Shown in Figure 1A, 1B and 1C, the various embodiment that are used to form the equipment of the present invention of a plurality of movable optics traps totally are denoted as 8.In the embodiment shown in Figure 1A,, form a movable optics trap array by producing the focused beam acts of an energy, for example electromagnetic wave energy.In a preferred embodiment, electromagnetic wave is a light wave, and this light wave preferably has the wavelength from about 400nm to about 1060nm, the wavelength that more preferably has green spectrum.Shown in Figure 1A-E, this light beam is formed by directional light, for example parallel output that comes from the light emitter, is preferably laser beam 10.
Along optical axis 500 guided focused light beams pass a phase pattern with variable optical surface form optical element, for example one be arranged on basically and condenser lens, diffraction optical element 12 on the plane of plane 15 conjugation of the back aperture 16 of object lens 18, that have the variable optical surface for example so that produce a plurality of beams 32 and 33 (illustrating two) with selected PHASE DISTRIBUTION.The optical surface that changes diffraction optical element will change this beam.
Empty lens are coded in the diffraction optical element 12, and these void lens are focused at a plurality of beams on the position of encoding between diffraction optical lens and the single transmission lens.From the beam that the coding diffraction optical element penetrates, after assembling, guided into a transmission lens fully, so that beam is overlapped on the back aperture of condenser lens, for example object lens 18.Then, utilize condenser lens that beam is assembled, so that in work focal region 2000, form a plurality of optics traps 1002 and 1004.Work focal region 2000 is zones that a placement comprises the medium that need utilize particulate 3000 that optics trap 1002 and 1004 tests, measures or handle or other material 3002.
Can adopt the light source of any suitable laser instrument as laser beam 10.Available laser instrument comprise solid-state laser, diode optically pumped laser, gas laser, dye laser, Alexanderite Lasers device, free electron laser, VCSEL laser instrument, diode laser, with collimating element form one light emitting diode, Ti-sapphire laser, doped yttrium aluminium garnet laser, mix YLF Lasers device, diode pumping yttrium-aluminum garnet laser and flash lamp pumping yttrium-aluminum garnet laser.The diode pumping Nd:YAG laser instrument of working between 10mW and 5W is preferred.
When focused beam 10 was conducted through coding diffraction optical element 12, this coding diffraction optical element produced a plurality of diffracted beams 32 and 33 of the PHASE DISTRIBUTION with variation.Type according to required optics trap, described variation can comprise wave front shaping, phase shift, turn to, disperses and assemble, and comprises the optics trap that optical tweezers, optical vortex, optical bottle, optical rotator, light cage etc. are dissimilar and the combination of dissimilar optics traps with formation.For the sake of clarity, only expressed two diffracted beams and two corresponding optical tweezers 1002 and 1004, but should be appreciated that and utilize the coding diffraction optical element can produce this beam array.
Utilize the coding diffraction optical element can control the position of each trap selectively.A notable feature of the present invention is, can selectively control the motion of each trap, be rotated on the fixed position, on the on-fixed position, be rotated, two and three dimensions motion, continuously and galloping motion.Thereby the converged position that changes the beam that penetrates from the coding diffraction optical element by the surface that changes the diffraction optical element that light beam passes can be realized this control.
How guided focused light beam decides its characteristic to suitable diffraction optical element is transmission or reflection according to them.Shown in Figure 1A and Figure 1B, the transmission diffraction optical element focuses on light beam, and shown in Fig. 1 C, reflective diffractive optical element reflects light beam.
In two total groups, diffraction optical element can be categorized as by static state or dynamic media and constitute.The example of suitable static diffraction optical element comprises the diffraction optical element with fixed surface, for example grating comprises diffraction grating, reflection grating, transmission grating, hologram (holograms), template, polishing shape holographic filter, multicolor hologram, lens, catoptron, prism, wave plate etc.
Static diffraction optical element can have different zones, and each regional structure gives beam a different PHASE DISTRIBUTION.In these embodiments, the surface of static diffraction optical element can change by moving described surface with respect to laser beam 10, so that select suitable zone to change the desirable characteristics of giving beam, promptly change the required PHASE DISTRIBUTION of the beam that at least one obtained.In certain embodiments, static surface comprises that this static surface of two or more discontinuous non-homogeneous zones can be reorientated so that the different piece alignment of static surface, thus receiving beam.In an alternate embodiment, this static surface changes basically continuously.
The example of the time dependent dynamic diffraction optical element suitably of function comprises: diffraction pattern, variable phase that variable computing machine produces move material, variable liquid crystal phase displacement array, micro reflector array, piston mode micro reflector array, spatial light modulator, electro-optic deflector, acousto-optic modulator, deformable mirror, reflection MEMS array etc.Adopt dynamic diffraction optical element, for example can change the feature of coded surface, so that change beam number, the PHASE DISTRIBUTION of at least one beam and the position of at least one beam by a computing machine.
The empty lens that are encoded on the diffraction optical element change the phase place that incides the light on the optical element.Typical empty lens are similar to the form of Fresnel lens, and Fresnel lens is for example encoded on the orientation of reflection grating or nematic crystal.These void lens are different with the real lens that integrally influence all beams 32 and 33, because should the void element can change the relative position of each light beam independently.
Diffraction optical element also is used to give laser a specific topological mode.Therefore, a beam 32 forms with Gauss-Laguerre pattern, and another beam 33 forms with gaussian model.
Preferred empty lens coding diffraction optical element comprises pure phase bit space photomodulator, for example " the PAL-SLM series of X 7665 " made by the Hamanmatsu of Japan, by Boulder NonlinearSystem of Layfette, " the SLM 512SA7 " that Colorado makes.These coding diffraction optical elements be can control with computing machine and be multi-functional, thereby they can produce beam 32 and 33 by laser beam 10 is carried out diffraction, and give the beam that is obtained required characteristic selectively.
Regional A from the front surface 13 of coding diffraction optical element launches each diffracted beam, and each beam also must pass through an area B on back aperture 16, thereby beam is overlapping on the back aperture 16 of object lens 18.In the embodiment shown in fig. 1, combine, can realize effectively near overlapping accurately by a single movable optical lens L1 with empty lens coding diffraction optical element and downstream.
Explain by mathematical way: if set up effective NA of the gradient force be enough to form the optics trap is 0.8, if and with formula NA=n*Sin φ/effective NA of 2 calculating, wherein n represents the refractive index of object lens lateral media and φ is the convergence angle of diffracted beam, if and the employing refractive index is 1.5 oil immersion objective, then in order to keep effective NA of 0.8, φ should keep at least 66 degree in optics trap motion process, so that form and remain on the optics trap of effectively handling particulate in the three-dimensional.
Perhaps, if employing with respect to the oversize condenser lens that laser beam 10 has the back aperture of oversize, then can form an effective optics trap and not need to fill up back aperture 16.Yet bigger physical space and the cost of this lens needs may be higher.
Forward the alternate embodiment shown in Figure 1B to, by making laser beam 10 form controlled optics trap array by a diffraction optical element 12 with an empty lens coding, described empty lens are disposed generally in the plane 14 ' with respect to optical axis 500 formation acute angles beta.In the present embodiment, the beam 32 and 33 that utilizes diffraction optical element guiding to penetrate from the regional A on the coding diffraction optical element front surface so that pass area B on object lens 18 back aperture 16, and forms optics trap 1002 and 1004 in work focal region 2000.By changing the position of laser beam 10 with respect to optical axis 500, the part of diffraction light 34 is not removed, and this has reduced again because the noise that caused of diffraction light 34 not, thereby has improved efficient and the effect that forms optics trap 1002 and 1004.In addition, when shown in Figure 1A and 1C,, can eliminate by one of the laser beam movable optics trap (not shown) that partly forms of diffraction not along optical axis guided laser bundle.
Fig. 1 C represents an alternate embodiment, wherein, by the diffraction optical element 12 that has the empty lens of coding with " reflection lasering beam 10, form controlled optics trap array.
Fig. 1 D and 1E represent to have the alternate embodiment of moving reflector 41, and moving reflector 41 is used for making before the overlapping beam in the back aperture place of condenser lens the beam that sends from phase pattern formation optical element integrally to turn to.Moving reflector 41 places the downstream of transmission lens L1, and its rotation center is arranged in zone C.The regional A of representational beam 32 from the front surface 13 of coding diffraction optical element 12 is by transmission lens L1 and shine on the zone C, and zone C reflexes to it on the area B at back aperture 16 places.Inclination moving reflector 41 will change the incident angle of beam 32 with respect to catoptron 41, and can be used for the array of translation optics trap 1002 and 1004.
This moving reflector both is used for accurately in a fixed substrate alignment optical trap array so that by small size quick oscillation displacement the optics trap is dynamically strengthened, catch effect by effective enhancing the in the position of accurate change optics trap array again, make the optics trap produce pulsation, form two or more alternating optical trap groups simultaneously with beam by similar number.
Embodiment shown in Fig. 1 D minimizes the dislocation of beam by comprising a traditional telescopic system 42 that is arranged between moving reflector 41 and the object lens 18.But, in another embodiment, can use beam splitter 51 to substitute moving reflector 41.In this alternate embodiment, this telescopic system is made of two the lens L2 and the L3 that are placed between conjugate plane 43 and 45, so that beam passes on the rotation center of the beam splitter 51 that shines zone C on the plane 43 from the regional A on the front surface 13 of coding diffraction optical element 12, and pass the area B on the back aperture 16 of the object lens 18 on the plane 44 subsequently.In the embodiment shown in Fig. 1 E, moving reflector 41 is placed on the position near back aperture 16, so that the dislocation of beam is minimized.
Adopt the embodiment shown in Fig. 2 and 3, can be in work focal region 2000 optical data stream of Real Time Observation and small particle 3000 interactional optics traps 1002 and 1004. Optics trap 1002 and 1004 movable array can utilize simple lens transmission eyeglass L1 to form.For the sake of clarity, only express a beam 32, still should be appreciated that and utilize optical element 12 can produce a plurality of this beams.
In order to produce optics trap array, laser beam 10 is passed diffraction optical element 12 to produce beam 32, and this beam 32 penetrates from the regional A on the front surface 13 of coding diffraction optical element 12, is delivered to zone C then.Zone C is to be positioned at object lens 18 beam splitter 51 lip-deep central areas before.This beam splitter 51 is made of a static state or movable dichroic mirror, a static state or movable photon band gap catoptron, a static state or movable omnidirectional reflector or other similar device.Beam splitter shown in Figure 2 is movable, and therefore plays moving reflector and two kinds of effects of beam splitter.In alternate embodiment shown in Figure 3, beam splitter 51 is fixed.
Perhaps, can obtain a spectrum 64b of optical data stream, analyze then and/or convert optical data stream to a vision signal and also monitor with a video monitor 64c.In certain embodiments, optical data stream passes a spectroscope, and changes the converged position of at least one beam according to spectral analysis or video monitoring, so that change the position of corresponding (one or more) optics trap.
By being applicable to the backscattered imaging illumination of non-resilient spectrum or polarized light, can realize the spectral analysis 64b of biologic material sample, non-resilient spectrum is used to assess chemical constitution, and the polarized light backscattering is applicable to measurement nucleon size.66 pairs of data of computing machine are analyzed, and discerning suspicious cancer, precancer or non-cancer cell, and the guided optical array is to separate and to concentrate the sample of selected cell type.Those skilled in the art adopt according to the special parameter of cancer cell and concentrate the method for cell can change without departing from the present invention with the cell according to other parameter recognition and/or concentrated other type as can be known.The wavelength that is used to form the laser beam 10 of handling the useful optics trap of biomaterial comprises: infrared, near infrared and the visible wavelength from about 400nm to about 1060nm.
In further embodiments, can receive this optical data stream by a computing machine 66 that is suitable for the recording optically data stream, optical data stream is analyzed, and/or one of accurately adjusted in (one or more) beam 32 or whole positions, the position of single transmission lens L1 and/or the position of movable beam splitter 51 via diffraction optical element 13.Perhaps, can utilize the photodetector of its intensity of monitoring or any appropriate device that optical data stream is converted to the digital data stream that is applicable to computing machine 66 that optical data stream is handled.
If noise is controlled, then the real-time optical data stream will provide Useful Information more.As shown in Figure 2, filter element 53, for example polarizer or the logical element of band are arranged in the path of optical data stream, to reduce the amount of the reflection, scattering or the art diffraction laser 10 that pass through along the axis of optical data stream.Filter element 53 filters out one or more presetted wavelengths, and in certain embodiments, with all wavelengths that filters out except that a predetermined wavelength of optical data stream.
Method of the noise of another restriction in optical data stream is to close or arteries and veins send optical data stream.Fig. 3 represents the system of controlled optical gate 62 and 63.An advantage of optical gate is to eliminate all noises or interference basically from optical data stream.Optical gate 62 to adjust its opening, stops or does not stop that optical data stream freely passes through this system by laser beam switching 10 selectively.When not producing laser beam, stop optical data stream, and when producing focused beam, do not stop optical data stream.When cutting off laser beam 10 (this causes (one or more) beam 32 to be switched " connection " and " disconnection " with (one or more) optics trap 1002 that is obtained again in turn), in order in the optics trap, to keep control, adjust the pulse repetition rate of optical gate according to the characteristic of being handled particulate to the small particle (not shown).Yet the particulate that ratio of pulse length to the total cycle length will cause catching too slowly drifts about.For the situation of needs drifts, ratio of pulse length to the total cycle length can be adjusted into and help drift.Replacedly, also can when optical data stream is monitored, block first optical gate of laser beam selectively; And second optical gate that when laser beam is opened, blocks optical data stream selectively and when laser beam is closed, do not stop optical data stream.
Perhaps, optical gate 63 stops that laser beam (not shown) or beam freely enter object lens.Coordinate the switch of optical gate 63 by " connection " and " disconnection " of optical data flow monitoring, noise is reduced.In some instances, may need two optical gates.An advantage of two optical gates is that laser beam 10 and supervising device can always keep " connection ".In this design, only need to coordinate the action of optical gate 62 and 63.Computing machine 66 can be used for controlling selectively optical gate 62 and 63.
Shown in Figure 4 is a useful embodiment, wherein, the serviceability of equipment, the restriction of physical space or other performance parameter will be from utilizing a traditional telescope transmission lens system 42 and are benefited, and traditional telescope transmission lens system 42 is arranged on to be positioned in this system with mobile mirror 41 and beam splitter 51 and combines with after the single transmission lens L1 that optical data stream is provided.
Produce a plurality of optics traps according to the present invention.In certain embodiments, the optics trap forms and handles the required gradient condition of biomaterial.
Do not break away from this related scope of the present invention owing in the said equipment, can carry out change to a certain degree, so as all the elements that comprised in the described above-mentioned explanation of accompanying drawing, instructions and claim all is exemplary, and does not have the qualification effect.
Claims (115)
1, a kind of method that is used to form a plurality of movable optics traps, this method comprises:
Produce and focus on beam;
Described focusing beam is guided to the phase pattern with variable optical surface form optical element, described variable optical surface has coding empty lens thereon, so that form from this phase pattern and form a plurality of beams that optical element sends, each beam has a PHASE DISTRIBUTION;
Forming optical element by phase pattern makes and forms beam that optical element sends from phase pattern and assemble in the position that phase pattern forms between optical element and the single transmission lens;
Guiding is passed through single transmission lens from the beam that phase pattern formation optical element sends, so that beam is overlapping at the back aperture place of a condenser lens; And
The beam that sends from this condenser lens is assembled to form a plurality of optics traps.
2, the method for claim 1 is characterized in that, further comprises: change the converged position that forms at least one beam that optical element sends from phase pattern by changing optical surface, thereby change the position of at least one optics trap.
3, the method for claim 1 is characterized in that, described optics trap is to select from optical tweezers, optical vortex, optical bottle, optical rotator, light cage and their group that combination constituted.
4, method as claimed in claim 3 is characterized in that, further comprises: by changing optical surface, to change the PHASE DISTRIBUTION that forms at least one beam that optical element sends from phase pattern.
5, the method for claim 1 is characterized in that, further comprises: handle biomaterial by the optics trap.
6, the method for claim 1 is characterized in that, focusing on beam is laser beam.
7, method as claimed in claim 6 is characterized in that, the wavelength of laser beam is in visible spectrum.
8, method as claimed in claim 6 is characterized in that, selects in the scope of the wavelength of laser beam from about 400nm to about 1060mm.
9, the method for claim 1 is characterized in that, further comprises: before the back aperture place of condenser lens is overlapping, by a moving reflector beam that sends from phase pattern formation optical element is integrally turned at beam.
10, the method for claim 1 is characterized in that, further comprises: form two or more dissimilar optics traps of selecting from the group that optical tweezers, optical vortex, optical bottle, optical rotator and light cage are constituted.
11, the method for claim 1 is characterized in that, focusing on beam is the electromagnetism wave energy.
12, a kind of method that forms and monitor a plurality of movable optics traps comprises:
Produce focused beam;
This focused beam is guided to phase pattern form optical element, so that form from phase pattern and form a plurality of beams that optical element sends with variable optical surface, described variable optical surface has coding empty lens thereon, and each beam has a PHASE DISTRIBUTION;
Forming optical element by phase pattern makes and forms beam that optical element sends from phase pattern and assemble in the position that phase pattern forms between optical element and the single transmission lens;
Guiding is passed through a single transmission lens from the beam that phase pattern formation optical element sends, so that beam is the surperficial overlapping of a beam splitter and produce two feam columns, beam splitter reflexes to the back aperture of a condenser lens with first feam column and reflects second feam column to form an optical data stream;
The beam that sends from this condenser lens is assembled to form a plurality of optics traps; And
With the described a plurality of optics traps of described optical data flow monitoring.
13, method as claimed in claim 12 is characterized in that, further comprises: change the convergence that forms at least one beam that optical element sends from phase pattern, so that change the position of at least one optics trap.
14, method as claimed in claim 12 is characterized in that, further comprises: form two or more dissimilar optics traps of selecting from the group that optical tweezers, optical vortex, optical bottle, optical rotator and light cage are constituted.
15, method as claimed in claim 14 is characterized in that, further comprises: form the PHASE DISTRIBUTION that optical element changes at least one beam by phase pattern.
16, method as claimed in claim 12 is characterized in that, further comprises: utilize the optics trap to handle biomaterial.
17, method as claimed in claim 12 is characterized in that, focused beam is a laser beam.
18, method as claimed in claim 17 is characterized in that, the wavelength of laser beam is in green spectrum.
19, method as claimed in claim 17 is characterized in that, selects in the scope of the wavelength of single laser beam from about 400nm to about 1060nm.
20, method as claimed in claim 12 is characterized in that, further comprises: before the back aperture place of condenser lens is overlapping, by a moving reflector beam that sends from phase pattern formation optical element is integrally turned at beam.
21, method as claimed in claim 12 is characterized in that, further comprises: convert optical data stream to vision signal.
22, method as claimed in claim 12 is characterized in that, further comprises: obtain the also spectrum of subsequent analysis optical data stream.
23, method as claimed in claim 12 is characterized in that, further comprises: receive optical data stream by a computing machine.
24, method as claimed in claim 12 is characterized in that, by the change of a computing machine commander optical surface.
25, method as claimed in claim 22 is characterized in that, further comprises: the analysis spectrum according to optical data stream changes optical surface, to change the position of at least one optics trap.
26, method as claimed in claim 21 is characterized in that, further comprises: change optical surface according to vision signal, to change the position of at least one optics trap.
27, method as claimed in claim 12 is characterized in that, further comprises: the light that filters all wavelengths except that the light of a preselected wavelength from optical data stream.
28, method as claimed in claim 12 is characterized in that, further comprises: the light that filters one or more preselected wavelength from optical data stream.
29, method as claimed in claim 12, it is characterized in that, further comprise: produce focused beam selectively, and stop and do not stop optical data stream selectively, so that when not producing focused beam, stop optical data stream, and when producing focused beam, do not stop optical data stream.
30, method as claimed in claim 12 is characterized in that, further comprises:
Stop selectively and do not stop that the beam that sends from phase pattern formation optical element is sent to beam splitter; And
When stopping beam, monitor optical data stream selectively.
31, a kind of equipment that is used to produce at least two optics traps comprises:
Phase pattern forms optical element, is used to receive a focused beam and it is diffracted at least two beams, and each beam has a PHASE DISTRIBUTION;
Be encoded in the empty lens that phase pattern forms optical element, be used to make form each beam that optical element sends from phase pattern and assemble in the position that phase pattern forms between optical element and the single transmission lens;
Single transmission lens is used to guide from phase pattern and forms beam that optical element sends so that beam is overlapping in the back aperture of a condenser lens;
Condenser lens is used to make each beam that sends from transmission lens to assemble to form the optics trap; And
Single transmission lens between phase pattern formation optical element and condenser lens, it makes beam overlapping at the back aperture place of condenser lens.
32, equipment as claimed in claim 31 is characterized in that, single transmission lens is movable.
33, equipment as claimed in claim 31 is characterized in that, phase pattern forms optical element and has a static surface.
34, equipment as claimed in claim 33 is characterized in that, this static surface can be reorientated so that the different piece of static surface is alignd, thus receiving beam.
35, equipment as claimed in claim 34 is characterized in that, static surface comprises two or more discontinuous non-homogeneous zones.
36, equipment as claimed in claim 34 is characterized in that, static surface changes basically continuously.
37, equipment as claimed in claim 32, it is characterized in that it is at least one that selects that phase pattern forms optical element from the group that is made of grating, diffraction grating, reflection grating, transmission grating, template, polishing shape holographic filter, multicolor hologram, lens, catoptron, prism, wave plate and hologram.
38, equipment as claimed in claim 31 is characterized in that, it is dynamic that phase pattern forms optical element.
39, equipment as claimed in claim 38 is characterized in that, changes the empty lens of coding selectively to change from its beam number that sends.
40, equipment as claimed in claim 38 is characterized in that, changes the empty lens of coding selectively to change the converged position by its at least one beam that sends.
41, equipment as claimed in claim 38 is characterized in that, changes phase pattern selectively and forms optical element to change the PHASE DISTRIBUTION of at least one beam that sends thus.
42, a kind of equipment that is used to produce at least two optics traps comprises:
Phase pattern forms optical element, is used for the collectiong focusing light beam and it is diffracted at least two beams, and each beam has a PHASE DISTRIBUTION;
Be encoded in the empty lens that phase pattern forms optical element, be used to make form each beam that optical element sends from phase pattern and assemble in the position that phase pattern forms between optical element and the single transmission lens;
Single transmission lens is used to guide from phase pattern and forms beam that optical element sends so that overlapping in the back aperture of condenser lens;
Beam splitter receives the beam that sends from single transmission lens, to produce two feam columns, then first feam column is reflexed to the back aperture of described condenser lens, and reflects second feam column to form an optical data stream; And
Wherein said condenser lens will be assembled to form two optics traps from each beam that beam splitter sends at least.
43, equipment as claimed in claim 42 is characterized in that, single transmission lens is movable.
44, equipment as claimed in claim 42 is characterized in that, phase pattern forms optical element and has a static surface.
45, equipment as claimed in claim 44 is characterized in that, this static surface can be reorientated so that the different piece of static surface is alignd, thus receiving beam.
46, equipment as claimed in claim 45 is characterized in that, static surface comprises two or more discontinuous non-homogeneous zones.
47, equipment as claimed in claim 45 is characterized in that, static surface changes basically continuously.
48, equipment as claimed in claim 44, it is characterized in that it is at least one that selects that phase pattern forms optical element from the group that is made of grating, diffraction grating, reflection grating, transmission grating, template, polishing shape holographic filter, multicolor hologram, lens, catoptron, prism, wave plate and hologram.
49, equipment as claimed in claim 42 is characterized in that, it is dynamic that phase pattern forms optical element.
50, equipment as claimed in claim 49 is characterized in that, the dynamic phasing pattern forms optical element and can change selectively, thereby can change the beam number that is sent by it.
51, equipment as claimed in claim 49 is characterized in that, the dynamic phasing pattern forms optical element and can change selectively, thereby can change the converged position of each the independent beam that is sent by it.
52, equipment as claimed in claim 49 is characterized in that, the dynamic phasing pattern forms optical element and can change selectively, thereby can change the PHASE DISTRIBUTION of each the independent beam that is sent by it.
53, equipment as claimed in claim 49, it is characterized in that it is at least one that selects that phase pattern forms optical element from the group that is made of variable computing machine generation diffraction pattern, variable phase shift material, variable liquid crystal phase displacement array, micro reflector array, piston mode micro reflector array, spatial light modulator, electro-optic deflector, acousto-optic modulator, deformable mirror and reflection MEMS array.
54, equipment as claimed in claim 42, it is characterized in that beam splitter is from by fixing omnidirectional reflector, fixedly select photon band gap catoptron, the group that fixedly dichroic mirror, movable omnidirectional reflector, movable photon band gap catoptron and movable dichroic mirror constitute at least one.
55, equipment as claimed in claim 42, it is characterized in that, further comprise the moving reflector that is arranged on the transmission lens downstream, be used for the beam that sends from phase pattern formation optical element integrally being turned at beam.
56, equipment as claimed in claim 55 is characterized in that, further is included in the telescopic system between moving reflector and the condenser lens.
57, a kind ofly be used to produce a plurality of systems that are used to handle the optics trap of small particle, comprise:
A plurality of small particles;
Be used to produce the light source of focused beam;
Focused beam;
Be used for the collectiong focusing light beam and its phase pattern that is diffracted at least two beams is formed optical element, each beam has a PHASE DISTRIBUTION;
Be encoded in the empty lens that phase pattern forms optical element, be used to make form each beam that optical element sends from phase pattern and assemble in the position that phase pattern forms between optical element and the single transmission lens;
Single transmission lens is arranged on phase pattern and forms between optical element and the condenser lens, and each beam is by described condenser lens and superimposed in the back aperture of condenser lens; And
Condenser lens is used to make each beam convergence and at least two the optics traps of formation that send from transmission lens, and each optics trap can be handled in a plurality of small particles.
58, system as claimed in claim 57 is characterized in that, single transmission lens is movable.
59, system as claimed in claim 57 is characterized in that, the optics trap moves according to moving of single transmission lens.
60, system as claimed in claim 57 is characterized in that, phase pattern forms optical element and has variable optical surface.
61, system as claimed in claim 60 is characterized in that, phase pattern forms optical element and has a static surface.
62, system as claimed in claim 61 is characterized in that, static surface is movable, so that focused beam is alignd with the selection area of static surface.
63, system as claimed in claim 62 is characterized in that, static surface is made of two or more discontinuous non-homogeneous zones.
As the described system of claim 63, it is characterized in that 64, static surface changes basically continuously.
65, as the described system of claim 63, it is characterized in that it is at least one that selects that phase pattern forms optical element from the group that is made of grating, diffraction grating, reflection grating, transmission grating, template, polishing shape holographic filter, multicolor hologram, lens, catoptron, prism, wave plate and hologram.
66, system as claimed in claim 57 is characterized in that, it is dynamic that phase pattern forms optical element.
67, system as claimed in claim 57, it is characterized in that it is at least one that selects that phase pattern forms optical element from the group that is made of variable computing machine generation diffraction pattern, variable phase shift material, variable liquid crystal phase displacement array, micro reflector array, piston mode micro reflector array, spatial light modulator, electro-optic deflector, acousto-optic modulator, deformable mirror and reflection MEMS array.
68, system as claimed in claim 57 is characterized in that, comprises that further is used for changing selectively the computing machine that phase pattern forms optical element.
69, system as claimed in claim 57 is characterized in that, at least some in a plurality of small particles are biomaterials.
70, system as claimed in claim 57 is characterized in that, light source is a laser, and focused beam is the laser beam of wavelength in green spectrum.
71, system as claimed in claim 57 is characterized in that, light source is a laser, and focused beam is the laser beam of the wavelength selected in having from about 400nm to about 1060nm scope.
72, system as claimed in claim 57 is characterized in that, further comprises a moving reflector, is used at beam the beam that sends from phase pattern formation optical element integrally being turned to.
73, system as claimed in claim 57 is characterized in that, comprises that further one is positioned at simple lens downstream and the telescopic system before condenser lens.
74, system as claimed in claim 57 is characterized in that, each optics trap is to select from the group that is made of optical tweezers, optical vortex, optical bottle, optical rotator and light cage.
75, a kind of system that utilizes the optics trap to handle small particle comprises:
A plurality of small particles;
Be used to produce the light source of focused beam;
Focused beam;
Be used for the collectiong focusing light beam and its phase pattern that is diffracted at least two beams is formed optical element, each beam has a PHASE DISTRIBUTION;
Be encoded in the empty lens that phase pattern forms optical element, these void lens make and form each beam that optical element sends from phase pattern and assemble in the position that phase pattern forms between optical element and the single transmission lens;
Beam splitter is used to receive from phase pattern and forms the beam that optical element sends and produce two feam columns, and is used to reflect first feam column so that overlapping in the back aperture of a condenser lens, and reflects second feam column to form an optical data stream;
Single transmission lens is arranged on phase pattern and forms between optical element and the condenser lens, and each beam is by condenser lens and superimposed in the back aperture of condenser lens;
Can handle at least two optics traps of one of a plurality of small particles respectively; And
Be used to monitor the watch-dog of optical data stream.
As the described system of claim 75, it is characterized in that 76, single transmission lens is movable.
As the described system of claim 75, it is characterized in that 77, the optics trap moves according to moving of single transmission lens.
As the described system of claim 75, it is characterized in that 78, phase pattern forms optical element and has a variable optical surface.
As the described system of claim 75, it is characterized in that 79, phase pattern forms optical element and has a static surface.
As the described system of claim 79, it is characterized in that 80, this static surface is movable, so that focused beam is alignd with the selection area of this static surface.
As the described system of claim 79, it is characterized in that 81, static surface is made of two or more discontinuous non-homogeneous zones.
As the described system of claim 79, it is characterized in that 82, static surface changes basically continuously.
83, as the described system of claim 75, it is characterized in that it is at least one that selects that phase pattern forms optical element from the group that is made of grating, diffraction grating, reflection grating, transmission grating, template, polishing shape holographic filter, multicolor hologram, lens, catoptron, prism, wave plate and hologram.
As the described system of claim 75, it is characterized in that 84, it is dynamic that phase pattern forms optical element.
85, as the described system of claim 75, it is characterized in that it is at least one that selects that phase pattern forms optical element from the group that is made of variable computing machine generation diffraction pattern, variable phase shift material, variable liquid crystal phase displacement array, micro reflector array, piston mode micro reflector array, spatial light modulator, electro-optic deflector, acousto-optic modulator, deformable mirror and reflection MEMS array.
86, as the described system of claim 75, it is characterized in that, further comprise being used for controlling selectively the computing machine that the dynamic phasing pattern forms optical element.
As the described system of claim 75, it is characterized in that 87, at least some in a plurality of small particles are biomaterials.
As the described system of claim 75, it is characterized in that 88, light source is a laser, and focused beam is the laser beam of wavelength in green spectrum.
As the described system of claim 75, it is characterized in that 89, light source is a laser, and focused beam is that wavelength is chosen in about 400nm to the interior laser beam of about 1060nm scope.
90, as the described system of claim 75, it is characterized in that, further comprise a moving reflector, be used for the beam that sends from phase pattern formation optical element integrally being turned at beam.
91, as the described system of claim 75, it is characterized in that, comprise that further one is positioned at simple lens downstream and the telescopic system before condenser lens.
As the described system of claim 75, it is characterized in that 92, described watch-dog is human supervisor.
As the described system of claim 75, it is characterized in that 93, described watch-dog is a video monitor.
94, as the described system of claim 75, it is characterized in that, further comprise converting optical data stream to digital data stream.
95, as the described system of claim 75, it is characterized in that, further comprise the spectroscope of the spectrum that is used to produce optical data stream.
96, as the described system of claim 75, it is characterized in that, comprise that further one is used to receive by optical data stream being converted to the computing machine of the digital data stream that digital data stream obtains.
97, as the described system of claim 75, it is characterized in that, comprise that further one is used for receiving optical data stream and with its computing machine that is processed into digital data stream and is used for changing according to the information of optical data stream the position of at least one optics trap.
98, as the described system of claim 75, it is characterized in that, further comprise a computing machine, this computing machine is used to command a moving reflector, so that at beam the beam that sends from phase pattern formation optical element is integrally turned to.
99, as the described system of claim 75, it is characterized in that, further comprise:
The computing machine that is used for spectral analysis; And
Form the computing machine that beam that optical element sends integrally turns to being used to command moving reflector so that before the back aperture place of condenser lens is overlapping, make from phase pattern at beam.
100, as the described system of claim 75, it is characterized in that, further comprise a polarizing filter or a bandpass optical filter that is arranged in the optical data flow path.
101, as the described system of claim 75, it is characterized in that, further comprise an optical gate, this optical gate stops optical data stream selectively and do not stop optical data stream when opening focused beam when turning off focused beam.
102, as the described system of claim 75, it is characterized in that, further comprise an optical gate, be used for when optical data stream is monitored, stopping selectively focused beam.
As the described system of claim 75, it is characterized in that 103, the light source that is used to produce focused beam is a laser, and focused beam is a laser beam.
104, as the described system of claim 75, it is characterized in that, further comprise:
When optical data stream is monitored, block first optical gate of laser beam selectively; And
Second optical gate that when laser beam is opened, blocks optical data stream selectively and when laser beam is closed, do not stop optical data stream.
As the described system of claim 75, it is characterized in that 105, each optics trap is to select from the group that is made of optical tweezers, optical vortex, optical bottle, optical rotator and light cage.
106, a kind of optical system that is used to monitor and handle small particle comprises:
The source of single focusing beam is provided;
Has empty lens coding dynamic diffraction optical element thereon;
Condenser lens;
Beam splitter; And
Be arranged on the movable simple lens between described dynamic diffraction optical element and the beam splitter;
Wherein produce a plurality of convergent beams, and assemble between described dynamic diffraction optical element and described movable simple lens to each beam of beam splitter from being directed of sending of described dynamic diffraction optical element by described single beam is guided to described dynamic diffraction optical element;
Wherein simple lens is directed to described beam splitter with each beam, and two feam columns of described beam splitter generation, and described beam splitter reflection first feam column is overlapping with the back aperture place at condenser lens, and reflects second feam column to form an optical data stream;
Wherein at least two optics traps form by assembling by the beam of condenser lens; And
Be used to monitor the watch-dog of optical data stream.
107, as the described system of claim 106, it is characterized in that, the source of single focusing beam be from by solid-state laser, diode optically pumped laser, gas laser, dye laser, Alexanderite Lasers device, free electron laser, VCSEL laser instrument, diode laser, Ti-sapphire laser, doped yttrium aluminium garnet laser, mix YLF Lasers device, diode pumping yttrium-aluminum garnet laser, flash lamp pumping yttrium-aluminum garnet laser, light emitting diode and form the group that the light emitting diode of one constitutes and select with collimating element.
As the described system of claim 106, it is characterized in that 108, the focusing beam is an electromagnetic energy.
As the described system of claim 106, it is characterized in that 109, the optics trap moves according to signal-lens moving.
As the described system of claim 106, it is characterized in that 110, the change in location of optics trap is produced by at least one variation of optical element.
As the described system of claim 106, it is characterized in that 111, each optics trap is to select from the group that is made of optical tweezers, optical vortex, optical bottle, optical rotator and light cage.
112, a kind of method that is used to form a plurality of movable optics traps, this method comprises:
Produce convergent beam;
Convergent beam is guided to the phase pattern with coding empty lens thereon form optical element, form a plurality of beams that optical element sends so that form from phase pattern, each beam has a PHASE DISTRIBUTION;
Forming optical element by phase pattern makes and forms beam that optical element sends from phase pattern and assemble in the position that phase pattern forms between optical element and the single transmission lens;
Pass through single transmission lens by a movable catoptron guiding from the beam that phase pattern formation optical element sends, so that beam is overlapping at the back aperture place of a condenser lens; And
Make the beam convergence of sending, to form a plurality of optics traps from condenser lens.
113, as the described method of claim 112, it is characterized in that, further comprise and move this catoptron to change the position of at least one optics trap.
As the described method of claim 112, it is characterized in that 114, the optics trap is to select from the group that is made of optical tweezers, optical vortex, optical bottle, optical rotator and light cage.
115, as the described method of claim 112, it is characterized in that, further comprise by the optics trap and handle biomaterial.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85599501A | 2001-05-14 | 2001-05-14 | |
| US09/855,995 | 2001-05-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1509415A CN1509415A (en) | 2004-06-30 |
| CN100353188C true CN100353188C (en) | 2007-12-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028099915A Expired - Fee Related CN100353188C (en) | 2001-05-14 | 2002-05-14 | Improved apparatus, system and method for applying optical gradient forces |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1395856A4 (en) |
| JP (2) | JP2004534661A (en) |
| CN (1) | CN100353188C (en) |
| CA (1) | CA2447472A1 (en) |
| WO (1) | WO2002093202A2 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ536283A (en) * | 2002-04-10 | 2006-11-30 | Arryx Inc | Apparatus and method to generate and control optical traps to manipulate small particles |
| EP1663460B1 (en) * | 2003-09-04 | 2015-07-08 | Premium Genetics (UK) Limited | Multiple laminar flow-based particle and cellular separation with laser steering |
| GB0416498D0 (en) | 2004-07-23 | 2004-08-25 | Council Cent Lab Res Councils | Optically controllable device |
| US20070160175A1 (en) * | 2005-09-23 | 2007-07-12 | Lang Matthew J | Systems and methods for force-fluorescence microscopy |
| JP5686408B2 (en) * | 2011-01-31 | 2015-03-18 | 独立行政法人産業技術総合研究所 | Fine particle array method and apparatus |
| CN102240848B (en) * | 2011-06-15 | 2013-10-23 | 中科中涵激光设备（福建）股份有限公司 | Method for adjusting laser beam to generate dynamic transverse displacement |
| JP2013098262A (en) * | 2011-10-28 | 2013-05-20 | Canon Inc | Optical device, position detection device, and microscope device |
| JP5979536B2 (en) * | 2012-05-09 | 2016-08-24 | 国立研究開発法人産業技術総合研究所 | Three-dimensional operation device for minute objects |
| WO2019116526A1 (en) | 2017-12-15 | 2019-06-20 | 日本電気株式会社 | Projection device, interface device, and projection method |
| CN110471187B (en) * | 2019-08-20 | 2021-07-30 | 济南大学 | Device and method for generating three-dimensional array bottle-shaped light beams in hexagonal close-packed distribution |
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| US5445011A (en) * | 1993-09-21 | 1995-08-29 | Ghislain; Lucien P. | Scanning force microscope using an optical trap |
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| JP4487324B2 (en) * | 1998-08-31 | 2010-06-23 | 株式会社ニコン | Microscope equipment |
| JP3102523B2 (en) * | 1992-10-12 | 2000-10-23 | 日本電信電話株式会社 | Fine particle array control method |
| JPH06160728A (en) * | 1992-11-17 | 1994-06-07 | Nikon Corp | Microlaser equipment |
| JP3311083B2 (en) * | 1993-05-26 | 2002-08-05 | オリンパス光学工業株式会社 | Fine adjustment device for microscope observation |
| JP3489646B2 (en) * | 1996-05-21 | 2004-01-26 | 日本電信電話株式会社 | Measurement method of particle displacement by light radiation pressure |
| JP3346374B2 (en) * | 1999-06-23 | 2002-11-18 | 住友電気工業株式会社 | Laser drilling machine |
| US6416190B1 (en) * | 2001-04-27 | 2002-07-09 | University Of Chicago | Apparatus for using optical tweezers to manipulate materials |
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2002
- 2002-05-14 CN CNB028099915A patent/CN100353188C/en not_active Expired - Fee Related
- 2002-05-14 CA CA002447472A patent/CA2447472A1/en not_active Abandoned
- 2002-05-14 WO PCT/US2002/015351 patent/WO2002093202A2/en active Application Filing
- 2002-05-14 JP JP2002589827A patent/JP2004534661A/en active Pending
- 2002-05-14 EP EP02734431A patent/EP1395856A4/en not_active Withdrawn
-
2008
- 2008-02-15 JP JP2008034706A patent/JP5134389B2/en not_active Expired - Fee Related
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5445011A (en) * | 1993-09-21 | 1995-08-29 | Ghislain; Lucien P. | Scanning force microscope using an optical trap |
| US5717667A (en) * | 1993-11-11 | 1998-02-10 | Sony Corporation | Optical pickup apparatus including an optical rotation device |
| US5939716A (en) * | 1997-04-02 | 1999-08-17 | Sandia Corporation | Three-dimensional light trap for reflective particles |
| US6055106A (en) * | 1998-02-03 | 2000-04-25 | Arch Development Corporation | Apparatus for applying optical gradient forces |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1395856A4 (en) | 2006-01-18 |
| CA2447472A1 (en) | 2002-11-21 |
| WO2002093202A3 (en) | 2003-02-27 |
| JP2004534661A (en) | 2004-11-18 |
| JP5134389B2 (en) | 2013-01-30 |
| JP2008229837A (en) | 2008-10-02 |
| WO2002093202A2 (en) | 2002-11-21 |
| CN1509415A (en) | 2004-06-30 |
| EP1395856A2 (en) | 2004-03-10 |
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