CN100339862C - 测试口腔和类似上皮病损的最低侵入性装置和方法 - Google Patents

测试口腔和类似上皮病损的最低侵入性装置和方法 Download PDF

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Publication number
CN100339862C
CN100339862C CNB008040230A CN00804023A CN100339862C CN 100339862 C CN100339862 C CN 100339862C CN B008040230 A CNB008040230 A CN B008040230A CN 00804023 A CN00804023 A CN 00804023A CN 100339862 C CN100339862 C CN 100339862C
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China
Prior art keywords
cells
epithelial tissue
body according
detecting abnormal
abnormal cells
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Expired - Fee Related
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CNB008040230A
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English (en)
Chinese (zh)
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CN1341244A (zh
Inventor
D·埃尔森
S·弗里斯特
J·雷希特
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Oralscan Laboratories Inc
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Oralscan Laboratories Inc
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Priority claimed from US09/298,219 external-priority patent/US6297044B1/en
Priority claimed from US09/298,218 external-priority patent/US6284482B1/en
Application filed by Oralscan Laboratories Inc filed Critical Oralscan Laboratories Inc
Publication of CN1341244A publication Critical patent/CN1341244A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B2010/0216—Sampling brushes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N2015/1472—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle with colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1488—Methods for deciding
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20084—Artificial neural networks [ANN]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Signal Processing (AREA)
  • Quality & Reliability (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Theoretical Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Testing Or Measuring Of Semiconductors Or The Like (AREA)
  • Sewage (AREA)
CNB008040230A 1999-02-23 2000-01-12 测试口腔和类似上皮病损的最低侵入性装置和方法 Expired - Fee Related CN100339862C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US12125599P 1999-02-23 1999-02-23
US60/121,255 1999-02-23
US09/298,219 1999-04-23
US09/298,219 US6297044B1 (en) 1999-02-23 1999-04-23 Minimally invasive apparatus for testing lesions of the oral cavity and similar epithelium
US09/298,218 1999-04-23
US09/298,218 US6284482B1 (en) 1999-04-23 1999-04-23 Method for detection of abnormal keratinization in epithelial tissue

Publications (2)

Publication Number Publication Date
CN1341244A CN1341244A (zh) 2002-03-20
CN100339862C true CN100339862C (zh) 2007-09-26

Family

ID=27382597

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008040230A Expired - Fee Related CN100339862C (zh) 1999-02-23 2000-01-12 测试口腔和类似上皮病损的最低侵入性装置和方法

Country Status (12)

Country Link
US (1) US20020012938A1 (https=)
EP (1) EP1155381B1 (https=)
JP (1) JP4748628B2 (https=)
CN (1) CN100339862C (https=)
AT (1) ATE472775T1 (https=)
AU (2) AU769471B2 (https=)
CA (1) CA2363833C (https=)
DE (1) DE60044604D1 (https=)
DK (1) DK1155381T3 (https=)
IL (2) IL144933A0 (https=)
PT (1) PT1155381E (https=)
WO (1) WO2000051066A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106570505A (zh) * 2016-11-01 2017-04-19 北京昆仑医云科技有限公司 对组织病理图像进行分析的方法和系统

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005064338A1 (en) * 2003-12-23 2005-07-14 University Of Florida Research Foundation, Inc. Microparticles for use in diagnostic methods
US8099600B2 (en) * 2004-08-23 2012-01-17 International Business Machines Corporation Content distribution site spoofing detection and prevention
KR101931899B1 (ko) 2005-05-09 2018-12-21 테라노스, 인코포레이티드 현장진료 유체 시스템 및 그 용도
JP2007114076A (ja) * 2005-10-21 2007-05-10 Pola Chem Ind Inc 角層細胞の画像の調整方法
CA3081708C (en) * 2009-10-19 2023-10-03 Theranos Ip Company, Llc Integrated health data capture and analysis system
CN108369161B (zh) * 2015-11-05 2021-10-01 株式会社资生堂 角质层采集工具和角质层采集检测用试剂盒
US12235272B2 (en) 2020-01-13 2025-02-25 New York University Screening and assessment of potentially malignant oral lesions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5257182A (en) * 1991-01-29 1993-10-26 Neuromedical Systems, Inc. Morphological classification system and method
US5740270A (en) * 1988-04-08 1998-04-14 Neuromedical Systems, Inc. Automated cytological specimen classification system and method

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2847990A (en) * 1956-03-20 1958-08-19 Ayre James Ernest Instrument for obtaining cells for cytodiagnosis
JPS5615731A (en) * 1979-07-20 1981-02-16 Olympus Optical Co Manufacture of cell diagnosing brush
US5623941A (en) * 1988-05-10 1997-04-29 Nils Stormby Cervical sampling velour brush
CA1340245C (en) * 1989-04-21 1998-12-15 John Samuel Monoclonal antibody for differentiation of squamous cell carcinoma antigens and method of use for same
US5184626A (en) * 1991-05-21 1993-02-09 Hicken William J Brush overlay Pap smear
EP0653920A1 (en) * 1992-08-07 1995-05-24 Genzyme Corporation Process for obtaining a non-liquid cell sample
US5733721A (en) * 1992-11-20 1998-03-31 The Board Of Regents Of The University Of Oklahoma Cell analysis method using quantitative fluorescence image analysis
JPH10506484A (ja) * 1994-09-20 1998-06-23 ネオパス，インク． 生物学分析系自己校正装置
US5713369A (en) * 1995-09-13 1998-02-03 Vance Products Inc. Uterine endometrial tissue sample brush
AU5223799A (en) * 1998-07-23 2000-02-14 Neal M. Lonky Apparatus and method for obtaining transepithelial specimen of a body surface using a non-lacerating technique

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5740270A (en) * 1988-04-08 1998-04-14 Neuromedical Systems, Inc. Automated cytological specimen classification system and method
US5257182A (en) * 1991-01-29 1993-10-26 Neuromedical Systems, Inc. Morphological classification system and method
US5257182B1 (en) * 1991-01-29 1996-05-07 Neuromedical Systems Inc Morphological classification system and method

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106570505A (zh) * 2016-11-01 2017-04-19 北京昆仑医云科技有限公司 对组织病理图像进行分析的方法和系统
CN106570505B (zh) * 2016-11-01 2020-08-21 北京昆仑医云科技有限公司 对组织病理图像进行分析的方法和系统

Also Published As

Publication number Publication date
IL144933A (en) 2006-07-05
AU2004201764A1 (en) 2004-05-27
JP4748628B2 (ja) 2011-08-17
AU2004201764B8 (en) 2004-05-27
CA2363833A1 (en) 2000-08-31
AU2004201764B2 (en) 2007-11-22
IL144933A0 (en) 2002-06-30
JP2002538441A (ja) 2002-11-12
ATE472775T1 (de) 2010-07-15
CN1341244A (zh) 2002-03-20
WO2000051066A1 (en) 2000-08-31
AU769471B2 (en) 2004-01-29
US20020012938A1 (en) 2002-01-31
DK1155381T3 (da) 2010-11-01
DE60044604D1 (de) 2010-08-12
EP1155381A4 (en) 2006-01-04
EP1155381B1 (en) 2010-06-30
EP1155381A1 (en) 2001-11-21
PT1155381E (pt) 2010-10-11
CA2363833C (en) 2007-04-03
AU2412000A (en) 2000-09-14

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