CL2024002124A1 - Formas sólidas cristalinas de inhibidores de la helicasa-primasa y proceso de preparación de las mismas - Google Patents
Formas sólidas cristalinas de inhibidores de la helicasa-primasa y proceso de preparación de las mismasInfo
- Publication number
- CL2024002124A1 CL2024002124A1 CL2024002124A CL2024002124A CL2024002124A1 CL 2024002124 A1 CL2024002124 A1 CL 2024002124A1 CL 2024002124 A CL2024002124 A CL 2024002124A CL 2024002124 A CL2024002124 A CL 2024002124A CL 2024002124 A1 CL2024002124 A1 CL 2024002124A1
- Authority
- CL
- Chile
- Prior art keywords
- helicase
- crystalline forms
- solid crystalline
- preparation process
- primase inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 239000007787 solid Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- 208000009889 Herpes Simplex Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP22151820 | 2022-01-17 | ||
| EP22170332 | 2022-04-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2024002124A1 true CL2024002124A1 (es) | 2024-11-22 |
Family
ID=84982261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2024002124A CL2024002124A1 (es) | 2022-01-17 | 2024-07-15 | Formas sólidas cristalinas de inhibidores de la helicasa-primasa y proceso de preparación de las mismas |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20250115565A1 (enExample) |
| EP (1) | EP4466255A1 (enExample) |
| JP (1) | JP2025502300A (enExample) |
| KR (1) | KR20240134979A (enExample) |
| AU (1) | AU2023206628A1 (enExample) |
| CA (1) | CA3246779A1 (enExample) |
| CL (1) | CL2024002124A1 (enExample) |
| IL (1) | IL314188A (enExample) |
| MX (1) | MX2024008821A (enExample) |
| PY (1) | PY2302301A (enExample) |
| TW (1) | TW202337444A (enExample) |
| UY (1) | UY40111A (enExample) |
| WO (1) | WO2023135303A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3265860A1 (en) * | 2022-08-29 | 2024-03-07 | Assembly Biosciences, Inc. | Pharmaceutical compositions against the herpes virus |
| CN121532378A (zh) | 2023-07-17 | 2026-02-13 | 创新分子股份有限公司 | 抗病毒解旋酶-引发酶抑制剂化合物的微粉化结晶盐酸盐 |
| WO2026078039A1 (en) | 2024-10-09 | 2026-04-16 | Innovative Molecules Gmbh | Oral administration forms of antiviral helicase-primase inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DOP2000000109A (es) | 1999-12-23 | 2002-08-30 | Gerald Kleymann | Derivados de tiazolilamida |
| DE10131128A1 (de) | 2001-06-28 | 2003-01-16 | Bayer Ag | Sekundäre Sulfonamide |
| GEP20207128B (en) | 2016-04-06 | 2020-07-10 | Molecules Gm Innovative | Aminothiazole derivatives useful as antiviral agents |
| DK3692039T3 (da) | 2017-10-05 | 2023-03-13 | Innovative Molecules Gmbh | Enantiomerer af substituerede thiazoler som antivirale forbindelser |
| TW202038947A (zh) | 2018-11-28 | 2020-11-01 | 德商創新分子有限責任公司 | 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑 |
| MX2023004955A (es) | 2020-10-29 | 2023-05-17 | Innovative Molecules Gmbh | Compuestos de aminotiazol deuterados como compuestos antiviricos. |
-
2023
- 2023-01-16 IL IL314188A patent/IL314188A/en unknown
- 2023-01-16 KR KR1020247027250A patent/KR20240134979A/ko active Pending
- 2023-01-16 WO PCT/EP2023/050883 patent/WO2023135303A1/en not_active Ceased
- 2023-01-16 EP EP23700877.6A patent/EP4466255A1/en active Pending
- 2023-01-16 US US18/729,411 patent/US20250115565A1/en active Pending
- 2023-01-16 UY UY0001040111A patent/UY40111A/es unknown
- 2023-01-16 MX MX2024008821A patent/MX2024008821A/es unknown
- 2023-01-16 TW TW112101829A patent/TW202337444A/zh unknown
- 2023-01-16 PY PY202302302301A patent/PY2302301A/es unknown
- 2023-01-16 AU AU2023206628A patent/AU2023206628A1/en active Pending
- 2023-01-16 CA CA3246779A patent/CA3246779A1/en active Pending
- 2023-01-16 JP JP2024542125A patent/JP2025502300A/ja active Pending
-
2024
- 2024-07-15 CL CL2024002124A patent/CL2024002124A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2024008821A (es) | 2024-07-29 |
| IL314188A (en) | 2024-09-01 |
| PY2302301A (es) | 2023-10-31 |
| TW202337444A (zh) | 2023-10-01 |
| UY40111A (es) | 2023-08-15 |
| CA3246779A1 (en) | 2023-07-20 |
| JP2025502300A (ja) | 2025-01-24 |
| EP4466255A1 (en) | 2024-11-27 |
| US20250115565A1 (en) | 2025-04-10 |
| KR20240134979A (ko) | 2024-09-10 |
| WO2023135303A1 (en) | 2023-07-20 |
| AU2023206628A1 (en) | 2024-08-01 |
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