CL2023003003A1 - Tratamiento y diagnóstico de trastornos inflamatorios - Google Patents

Tratamiento y diagnóstico de trastornos inflamatorios

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Publication number
CL2023003003A1
CL2023003003A1 CL2023003003A CL2023003003A CL2023003003A1 CL 2023003003 A1 CL2023003003 A1 CL 2023003003A1 CL 2023003003 A CL2023003003 A CL 2023003003A CL 2023003003 A CL2023003003 A CL 2023003003A CL 2023003003 A1 CL2023003003 A1 CL 2023003003A1
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CL
Chile
Prior art keywords
subject
inflammatory disorder
diagnosis
treatment
inflammatory disorders
Prior art date
Application number
CL2023003003A
Other languages
English (en)
Inventor
Zhu Zhenglun
Gao Hong
Original Assignee
Zhu Zhenglun
Gao Hong
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhu Zhenglun, Gao Hong filed Critical Zhu Zhenglun
Publication of CL2023003003A1 publication Critical patent/CL2023003003A1/es

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4614—Monocytes; Macrophages
    • A—HUMAN NECESSITIES
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    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
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    • A61K39/4643—Vertebrate antigens
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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Abstract

Método para tratar un trastorno inflamatorio en un sujeto, que comprende administrar al sujeto que lo necesita una molécula de ácido nucleico para inhibir la expresión de Hom-1. Específicamente, la molécula de ácido nucleico es un agente de ARNi o un oligonucleótido morfolino antisentido. Además, se describe un método para seleccionar un agente terapéutico para un trastorno inflamatorio en un sujeto, o monitorear la eficacia de un agente terapéutico para un trastorno inflamatorio en un sujeto, que comprende detectar el nivel de expresión de Hom-1 en una muestra de tejido inflamado obtenida del sujeto.
CL2023003003A 2016-02-04 2023-10-06 Tratamiento y diagnóstico de trastornos inflamatorios CL2023003003A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662291271P 2016-02-04 2016-02-04

Publications (1)

Publication Number Publication Date
CL2023003003A1 true CL2023003003A1 (es) 2024-04-19

Family

ID=59499992

Family Applications (3)

Application Number Title Priority Date Filing Date
CL2018002097A CL2018002097A1 (es) 2016-02-04 2018-08-03 Tratamiento y diagnóstico de desórdenes inflamatorios
CL2021003543A CL2021003543A1 (es) 2016-02-04 2021-12-29 Tratamiento y diagnóstico de desórdenes inflamatorios (divisional de la solicitud no. 201802097)
CL2023003003A CL2023003003A1 (es) 2016-02-04 2023-10-06 Tratamiento y diagnóstico de trastornos inflamatorios

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CL2018002097A CL2018002097A1 (es) 2016-02-04 2018-08-03 Tratamiento y diagnóstico de desórdenes inflamatorios
CL2021003543A CL2021003543A1 (es) 2016-02-04 2021-12-29 Tratamiento y diagnóstico de desórdenes inflamatorios (divisional de la solicitud no. 201802097)

Country Status (13)

Country Link
US (2) US11268095B2 (es)
EP (1) EP3411479A4 (es)
JP (2) JP2019512018A (es)
KR (1) KR20180109985A (es)
CN (1) CN108779461A (es)
AU (2) AU2017213744B2 (es)
CA (1) CA3013898A1 (es)
CL (3) CL2018002097A1 (es)
IL (2) IL260987B1 (es)
MX (2) MX2018009542A (es)
MY (1) MY194135A (es)
SG (2) SG11201806636SA (es)
WO (1) WO2017136322A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111528842B (zh) * 2020-05-26 2023-01-03 复嶂环洲生物科技(上海)有限公司 基于生理和行为指标的帕金森病症状定量化评估方法
CA3225436A1 (en) * 2021-06-23 2022-12-29 Enclear Therapies, Inc. Method of regulating gene expression

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030035790A1 (en) 1999-01-15 2003-02-20 Shu-Hsia Chen Combination therapy for the prevention or treatment of cancer, inflammatory disorders or infectious diseases in a subject
JPWO2005070964A1 (ja) 2004-01-27 2008-01-17 株式会社医学生物学研究所 単球の単離方法
US7994126B2 (en) * 2006-02-22 2011-08-09 Zhenglun Zhu Treatment of cellular proliferative disorders with compositions comprising Hom polypeptide (also known as Xom, VENTX2)
US8741865B2 (en) * 2009-07-15 2014-06-03 Zhenglun Zhu Treatment of immune disorders with Hom-1 inhibitors
WO2012071513A2 (en) * 2010-11-24 2012-05-31 Hong Gao Expanding hematopoietic stem cells
WO2012170979A1 (en) * 2011-06-10 2012-12-13 Zhenglun Zhu Human homeobox gene ventx and macrophage terminal differentiation and activation, compositions and methods thereof
WO2014093773A1 (en) 2012-12-14 2014-06-19 The Brigham And Women's Hospital, Inc. Methods and assays relating to macrophage differentiation
CN105473710B (zh) * 2013-04-10 2019-08-23 朱正伦 同源盒转录因子VentX调控人树突状细胞的分化和成熟
US9428748B2 (en) * 2013-06-17 2016-08-30 Hong Gao Method of expanding hematopoietic stem cells

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Publication number Publication date
CL2021003543A1 (es) 2022-08-19
JP2019512018A (ja) 2019-05-09
US11268095B2 (en) 2022-03-08
MY194135A (en) 2022-11-14
SG10201913129QA (en) 2020-02-27
CL2018002097A1 (es) 2018-12-21
EP3411479A1 (en) 2018-12-12
US20220177892A1 (en) 2022-06-09
KR20180109985A (ko) 2018-10-08
WO2017136322A1 (en) 2017-08-10
CA3013898A1 (en) 2017-08-10
AU2023233180A1 (en) 2023-12-14
SG11201806636SA (en) 2018-09-27
AU2017213744A1 (en) 2018-08-30
IL311968A (en) 2024-06-01
EP3411479A4 (en) 2019-09-18
IL260987A (en) 2018-09-20
IL260987B1 (en) 2024-05-01
MX2022010890A (es) 2022-09-27
JP2022180437A (ja) 2022-12-06
AU2017213744B2 (en) 2023-06-22
US20190085336A1 (en) 2019-03-21
CN108779461A (zh) 2018-11-09
MX2018009542A (es) 2018-11-09

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