CL2023002667A1 - Síntesis de omecamtiv mecarbil. - Google Patents
Síntesis de omecamtiv mecarbil.Info
- Publication number
- CL2023002667A1 CL2023002667A1 CL2023002667A CL2023002667A CL2023002667A1 CL 2023002667 A1 CL2023002667 A1 CL 2023002667A1 CL 2023002667 A CL2023002667 A CL 2023002667A CL 2023002667 A CL2023002667 A CL 2023002667A CL 2023002667 A1 CL2023002667 A1 CL 2023002667A1
- Authority
- CL
- Chile
- Prior art keywords
- synthesis
- omecamtiv mecarbil
- omecamtiv
- mecarbil
- preparation
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- RFUBTTPMWSKEIW-UHFFFAOYSA-N omecamtiv mecarbil Chemical compound C1CN(C(=O)OC)CCN1CC1=CC=CC(NC(=O)NC=2C=NC(C)=CC=2)=C1F RFUBTTPMWSKEIW-UHFFFAOYSA-N 0.000 title abstract 2
- 229950001617 omecamtiv mecarbil Drugs 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000010189 synthetic method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/08—Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/10—Preparation of nitro compounds by substitution of functional groups by nitro groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/16—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
- C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
En el presente documento se proporcionan métodos sintéticos para la preparación de productos intermedios que se utilizan en la síntesis de diclorhidrato de omecamtiv mecarbil.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163159227P | 2021-03-10 | 2021-03-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2023002667A1 true CL2023002667A1 (es) | 2024-02-02 |
Family
ID=80937110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2023002667A CL2023002667A1 (es) | 2021-03-10 | 2023-09-07 | Síntesis de omecamtiv mecarbil. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11702380B2 (es) |
| EP (1) | EP4305018A2 (es) |
| JP (1) | JP2024509797A (es) |
| KR (1) | KR20240006498A (es) |
| CN (1) | CN117157274A (es) |
| AU (1) | AU2022232919A1 (es) |
| BR (1) | BR112023018095A2 (es) |
| CA (1) | CA3212491A1 (es) |
| CL (1) | CL2023002667A1 (es) |
| IL (1) | IL305751A (es) |
| MX (1) | MX2023010558A (es) |
| TW (1) | TW202300479A (es) |
| WO (1) | WO2022192414A2 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108785265A (zh) | 2013-03-14 | 2018-11-13 | 美国安进公司 | 杂环化合物和其用途 |
| MA49508A (fr) | 2017-06-30 | 2020-05-06 | Amgen Inc | Procédés de traitement d'une insuffisance cardiaque avec des activateurs de sarcomères cardiaques |
| BR112019028205A2 (pt) | 2017-06-30 | 2020-10-06 | Amgen Inc. | síntese de omecamtiv mecarbil |
| MX2021001792A (es) | 2018-08-17 | 2021-05-27 | Amgen Inc | Sales y formas cristalinas de omecamtiv mecarbil. |
| AU2022232919A1 (en) | 2021-03-10 | 2023-10-19 | Amgen Inc. | Synthesis of omecamtiv mecarbil |
| US11986474B1 (en) | 2023-06-27 | 2024-05-21 | Cytokinetics, Incorporated | Methods for treating heart failure by administering cardiac sarcomere activators |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI359812B (en) | 2004-06-17 | 2012-03-11 | Cytokinetics Inc | Compounds, compositions and methods |
| TW200808321A (en) | 2005-12-15 | 2008-02-16 | Cytokinetics Inc | Certain chemical entities, compositions and methods |
| CN101177400A (zh) | 2006-11-06 | 2008-05-14 | 吕铁环 | 一种生产2-氟-3-硝基甲苯的方法 |
| WO2014152198A1 (en) | 2013-03-14 | 2014-09-25 | Amgen Inc. | Heterocyclic compounds and their uses |
| CN108785265A (zh) | 2013-03-14 | 2018-11-13 | 美国安进公司 | 杂环化合物和其用途 |
| AU2016282985B2 (en) | 2015-06-26 | 2021-07-29 | Amgen Inc. | Combination therapy of cardiac myosin activator and sinus node if current inhibitor |
| BR112019028205A2 (pt) | 2017-06-30 | 2020-10-06 | Amgen Inc. | síntese de omecamtiv mecarbil |
| MA49508A (fr) | 2017-06-30 | 2020-05-06 | Amgen Inc | Procédés de traitement d'une insuffisance cardiaque avec des activateurs de sarcomères cardiaques |
| LT3594199T (lt) | 2018-07-09 | 2020-11-10 | F.I.S.- Fabbrica Italiana Sintetici S.P.A. | Kristalinis 2-fluor-3-nitroluenas ir jo paruošimo būdas |
| US11608318B2 (en) | 2018-07-12 | 2023-03-21 | Assia Chemical Industries Ltd. | Solid state forms of Omecamtiv mecarbil and Omecamtiv mecarbil diHCl |
| MX2021001792A (es) | 2018-08-17 | 2021-05-27 | Amgen Inc | Sales y formas cristalinas de omecamtiv mecarbil. |
| WO2020131574A1 (en) | 2018-12-18 | 2020-06-25 | Amgen Inc. | Method of reducing aromatic nitro compounds |
| WO2021053175A1 (en) | 2019-09-19 | 2021-03-25 | Synthon B.V. | Salts of omecamtiv mecarbil and solid forms thereof |
| WO2021053189A1 (en) | 2019-09-19 | 2021-03-25 | Synthon B.V. | Salts of omecamtiv mecarbil and solid forms thereof |
| WO2021070123A1 (en) | 2019-10-09 | 2021-04-15 | Dr. Reddy’S Laboratories Limited | Solid forms of omecamtiv mecarbil dihydrochloride and processes thereof |
| US20220411374A1 (en) | 2019-10-09 | 2022-12-29 | Dr. Reddy's Laboratories Limited | Alternate processes for the preparation of omecamtiv mecarbil |
| WO2021136477A1 (zh) | 2020-01-03 | 2021-07-08 | 苏州科睿思制药有限公司 | 化合物i二盐酸盐的共晶及其制备方法和用途 |
| CA3168513A1 (en) | 2020-02-10 | 2021-08-19 | Amgen Inc. | Omecamtiv mecarbil tablet |
| MX2023005455A (es) | 2020-11-12 | 2023-07-27 | Amgen Inc | Metodos de tratamiento de la insuficiencia cardiaca mediante la administracion de omecamtiv mecarbil. |
| AU2022232919A1 (en) | 2021-03-10 | 2023-10-19 | Amgen Inc. | Synthesis of omecamtiv mecarbil |
-
2022
- 2022-03-09 AU AU2022232919A patent/AU2022232919A1/en active Pending
- 2022-03-09 MX MX2023010558A patent/MX2023010558A/es unknown
- 2022-03-09 EP EP22712763.6A patent/EP4305018A2/en active Pending
- 2022-03-09 KR KR1020237033048A patent/KR20240006498A/ko unknown
- 2022-03-09 CA CA3212491A patent/CA3212491A1/en active Pending
- 2022-03-09 WO PCT/US2022/019573 patent/WO2022192414A2/en active Application Filing
- 2022-03-09 CN CN202280017907.1A patent/CN117157274A/zh active Pending
- 2022-03-09 IL IL305751A patent/IL305751A/en unknown
- 2022-03-09 TW TW111108611A patent/TW202300479A/zh unknown
- 2022-03-09 JP JP2023552300A patent/JP2024509797A/ja active Pending
- 2022-03-09 BR BR112023018095A patent/BR112023018095A2/pt unknown
- 2022-03-09 US US17/690,729 patent/US11702380B2/en active Active
-
2023
- 2023-09-07 CL CL2023002667A patent/CL2023002667A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US11702380B2 (en) | 2023-07-18 |
| KR20240006498A (ko) | 2024-01-15 |
| IL305751A (en) | 2023-11-01 |
| WO2022192414A3 (en) | 2022-10-27 |
| CN117157274A (zh) | 2023-12-01 |
| US20220298099A1 (en) | 2022-09-22 |
| JP2024509797A (ja) | 2024-03-05 |
| MX2023010558A (es) | 2023-11-24 |
| EP4305018A2 (en) | 2024-01-17 |
| AU2022232919A1 (en) | 2023-10-19 |
| TW202300479A (zh) | 2023-01-01 |
| CA3212491A1 (en) | 2022-09-15 |
| WO2022192414A2 (en) | 2022-09-15 |
| BR112023018095A2 (pt) | 2023-12-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2023002667A1 (es) | Síntesis de omecamtiv mecarbil. | |
| AR122790A2 (es) | Inhibidores de kras g12c y métodos para su uso | |
| ECSP19050049A (es) | Anticuerpos anti-ox40 y sus usos | |
| CU20180152A7 (es) | Pirimidin-2-ilamino-1h-pirazoles útiles como inhibidores de lrrk2 | |
| AR067779A1 (es) | Profarmacos dipeptoides y su uso | |
| UY38806A (es) | Compuestos inhibidores tricíclicos de kars dependientes de akr1c3, composiciones y sus usos | |
| NI202000087A (es) | Anticuerpos ant-tmeff2 monoespecíficos y multiespecíficos y sus usos | |
| CL2021002331A1 (es) | Formulaciones de anticuerpo anti-il-36r | |
| AR116790A1 (es) | PROCEDIMIENTO PARA LA PREPARACIÓN DE 3a-HIDROXI-5a-PREGNAN-20-ONA (BREXANOLONA) | |
| CL2022000093A1 (es) | Imidazopirimidinas como inhibidores de eed y uso de estas | |
| UY33565A (es) | Compuestos de tetrahidrofuranilo disustituidos como antagonistas de bradiquinina-B1 | |
| CL2019001804A1 (es) | Activador de nrf2. | |
| BR112022022984A2 (pt) | Intermediários e síntese para compostos de quinolona do tipo endoquina | |
| CL2021000580A1 (es) | Uso de inhibidores de la caseina quinasa 1 para el tratamiento de enfermedades vasculares. | |
| CL2023002907A1 (es) | Anticuerpos anti-nectina-4 y usos de los mismos | |
| CL2022001456A1 (es) | Tiofenocarboxamidas sustituidas y sus derivados | |
| CL2022002589A1 (es) | Tratamiento de trastornos respiratorios | |
| CO2022009068A2 (es) | Composición para la inhibición de la producción de hmf que comprende disacárido de alulosa | |
| UY38759A (es) | Tienilhidroxiisoxazolinas y derivados de las mismas | |
| CO2019013718A2 (es) | Anticuerpos anti-trkb | |
| CO2022001860A2 (es) | Derivados quinolina como inhibidores de proteína quinasa | |
| AR098879A1 (es) | Síntesis de ent-progesterona y sus productos intermedios | |
| CL2023001137A1 (es) | Procedimiento para la purificación de pleuromutilinas | |
| CO2020006542A2 (es) | Profármacos de creatina, composiciones y métodos de uso de estos | |
| CL2022001594A1 (es) | Tiofenocarboxamidas sustituidas y sus derivados |