CL2023002274A1 - Compuestos tricíclicos y usos de los mismos - Google Patents
Compuestos tricíclicos y usos de los mismosInfo
- Publication number
- CL2023002274A1 CL2023002274A1 CL2023002274A CL2023002274A CL2023002274A1 CL 2023002274 A1 CL2023002274 A1 CL 2023002274A1 CL 2023002274 A CL2023002274 A CL 2023002274A CL 2023002274 A CL2023002274 A CL 2023002274A CL 2023002274 A1 CL2023002274 A1 CL 2023002274A1
- Authority
- CL
- Chile
- Prior art keywords
- tricyclic compounds
- preparing
- variable
- formula
- tricyclic
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se relaciona con compuestos tricíclicos de la fórmula (I), composiciones farmacéuticas que los comprenden, métodos para preparar los mismos, y usos de los mismos, en donde cada variable es como se define en la descripción.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110166021 | 2021-02-05 | ||
CN202210069346 | 2022-01-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2023002274A1 true CL2023002274A1 (es) | 2024-01-26 |
Family
ID=82740848
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2023002274A CL2023002274A1 (es) | 2021-02-05 | 2023-08-01 | Compuestos tricíclicos y usos de los mismos |
Country Status (13)
Country | Link |
---|---|
US (1) | US20240140931A1 (es) |
EP (1) | EP4288436A1 (es) |
JP (1) | JP2024506886A (es) |
KR (1) | KR20230167347A (es) |
CN (1) | CN116940573A (es) |
AU (1) | AU2022217319A1 (es) |
CA (1) | CA3206933A1 (es) |
CL (1) | CL2023002274A1 (es) |
IL (1) | IL304819A (es) |
MX (1) | MX2023009190A (es) |
PE (1) | PE20240634A1 (es) |
TW (1) | TW202241904A (es) |
WO (1) | WO2022166844A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023114954A1 (en) * | 2021-12-17 | 2023-06-22 | Genzyme Corporation | Pyrazolopyrazine compounds as shp2 inhibitors |
WO2023172940A1 (en) | 2022-03-08 | 2023-09-14 | Revolution Medicines, Inc. | Methods for treating immune refractory lung cancer |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3094690A1 (en) * | 2018-03-21 | 2019-09-26 | Relay Therapeutics, Inc. | Shp2 phosphatase inhibitors and methods of use thereof |
CN111138412B (zh) * | 2018-11-06 | 2023-09-15 | 上海奕拓医药科技有限责任公司 | 一种螺芳环化合物及其应用 |
JP2022506887A (ja) * | 2018-11-07 | 2022-01-17 | シャンハイ リンジーン バイオファーマ カンパニー リミテッド | 窒素含有縮合複素環系shp2阻害剤化合物、製造方法及び使用 |
EP3889153A4 (en) * | 2018-11-30 | 2022-09-07 | Tuojie Biotech (Shanghai) Co., Ltd. | PYRIMIDINE AND PENTAGONAL HETEROCYCLE DERIVATIVE OF NITROGEN, METHOD FOR THE PREPARATION AND MEDICAL APPLICATIONS |
AU2020306124A1 (en) * | 2019-06-28 | 2022-02-03 | Tuojie Biotech (Shanghai) Co., Ltd. | Pyrimidine five-membered nitrogen heterocyclic derivative, preparation method thereof and pharmaceutical use thereof |
CN113754683A (zh) * | 2020-06-05 | 2021-12-07 | 上海奕拓医药科技有限责任公司 | 同位素取代的螺芳环化合物及其应用 |
-
2022
- 2022-01-28 AU AU2022217319A patent/AU2022217319A1/en active Pending
- 2022-01-28 JP JP2023547520A patent/JP2024506886A/ja active Pending
- 2022-01-28 WO PCT/CN2022/074753 patent/WO2022166844A1/en active Application Filing
- 2022-01-28 PE PE2023002241A patent/PE20240634A1/es unknown
- 2022-01-28 KR KR1020237030016A patent/KR20230167347A/ko unknown
- 2022-01-28 MX MX2023009190A patent/MX2023009190A/es unknown
- 2022-01-28 CA CA3206933A patent/CA3206933A1/en active Pending
- 2022-01-28 EP EP22749123.0A patent/EP4288436A1/en active Pending
- 2022-01-28 TW TW111104077A patent/TW202241904A/zh unknown
- 2022-01-28 US US18/264,386 patent/US20240140931A1/en active Pending
- 2022-01-28 CN CN202280012558.4A patent/CN116940573A/zh active Pending
-
2023
- 2023-07-30 IL IL304819A patent/IL304819A/en unknown
- 2023-08-01 CL CL2023002274A patent/CL2023002274A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2022217319A1 (en) | 2023-08-17 |
PE20240634A1 (es) | 2024-03-26 |
MX2023009190A (es) | 2023-08-21 |
IL304819A (en) | 2023-09-01 |
EP4288436A1 (en) | 2023-12-13 |
TW202241904A (zh) | 2022-11-01 |
JP2024506886A (ja) | 2024-02-15 |
CN116940573A (zh) | 2023-10-24 |
CA3206933A1 (en) | 2022-08-11 |
WO2022166844A1 (en) | 2022-08-11 |
KR20230167347A (ko) | 2023-12-08 |
US20240140931A1 (en) | 2024-05-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UY38070A (es) | Derivados de quinazolina y piridopirimidina sustituidos útiles como agentes anticáncer | |
UY38076A (es) | Derivados de tetrahidroquinazolina útiles como agentes anticáncer | |
CL2023002274A1 (es) | Compuestos tricíclicos y usos de los mismos | |
CL2023002090A1 (es) | Inhibidores de kras tricíclicos fusionados | |
ECSP20033467A (es) | Compuestos macrocíclicos para tratar enfermedades | |
DOP2011000361A (es) | Nuevos derivados de pirimidina y sus usos en el tratamiento del cancer y otras enfermedades | |
CR20180578A (es) | Derivados de carbonucleósidos sustituidos útiles como agentes antineoplásicos | |
CU20190101A7 (es) | Imidazopirimidinas diazabicíclicas sustituidas | |
UY35409A (es) | 2-azabiciclos sustituidos y su uso como moduladores del receptor de orexina | |
UY35408A (es) | 7-azabiciclos sustituidos y su uso como moduladores del receptor de orexina | |
CO2020007044A2 (es) | Derivados de pirrol como inhibidores de acc | |
DOP2019000290A (es) | Inhibidores de quinasa y usos de los mismos | |
UY37015A (es) | Inhibidores de la tirosina quinasa de bruton y métodos de su uso | |
CO2021005509A2 (es) | Derivados de piridinil sulfonamida, composiciones farmacéuticas y usos de estos | |
BR112017018643A2 (pt) | "derivados de tetra-hidrotiazepina bicíclicos úteis, composição farmacêutica compreendendo os mesmos, seu uso, e método in vitro ou ex vivo para a produção de células imunes ativadas" | |
CL2023000772A1 (es) | Compuestos heterocíclicos de heteroarilo y usos de los mismos | |
UY37016A (es) | Inhibidores de la tirosina quinasa de bruton y métodos de su uso | |
CL2019003213A1 (es) | Compuestos plaguicidas bicíclicos. | |
CL2022002255A1 (es) | Compuestos heterocíclicos de heteroarilo y usos de los mismos | |
UY35128A (es) | Derivados de oxazolidin-2-ona-pirimidina | |
CO2022018636A2 (es) | Moduladores de il-17a | |
CO2022016899A2 (es) | Moduladores de il-17a | |
CO2021004553A2 (es) | Nuevos derivados amino-pirimidonil-piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen | |
ECSP099481A (es) | Compuestos de piridina y su uso como antagonistas de p2y12 | |
CL2022002574A1 (es) | Compuestos de amida y usos de los mismos |