CL2022002081A1 - Moduladores de kv3 - Google Patents
Moduladores de kv3Info
- Publication number
- CL2022002081A1 CL2022002081A1 CL2022002081A CL2022002081A CL2022002081A1 CL 2022002081 A1 CL2022002081 A1 CL 2022002081A1 CL 2022002081 A CL2022002081 A CL 2022002081A CL 2022002081 A CL2022002081 A CL 2022002081A CL 2022002081 A1 CL2022002081 A1 CL 2022002081A1
- Authority
- CL
- Chile
- Prior art keywords
- modulators
- compound
- formula
- related aspects
- aspects
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Gyroscopes (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Amplifiers (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2020/050268 WO2021156584A1 (en) | 2020-02-06 | 2020-02-06 | Kv3 modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2022002081A1 true CL2022002081A1 (es) | 2023-05-26 |
Family
ID=69591671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2022002081A CL2022002081A1 (es) | 2020-02-06 | 2022-08-02 | Moduladores de kv3 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP4100402A1 (ja) |
| JP (1) | JP2023523501A (ja) |
| KR (1) | KR20220139923A (ja) |
| CN (1) | CN115066424A (ja) |
| AU (1) | AU2020427632A1 (ja) |
| BR (1) | BR112022013339A2 (ja) |
| CA (1) | CA3169057A1 (ja) |
| CL (1) | CL2022002081A1 (ja) |
| IL (1) | IL295027A (ja) |
| MX (1) | MX2022009702A (ja) |
| WO (1) | WO2021156584A1 (ja) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024121552A1 (en) | 2022-12-06 | 2024-06-13 | Autifony Therapeutics Limited | Compounds for the treatment of centra nervous system disorders |
| CN117448440A (zh) * | 2023-10-23 | 2024-01-26 | 中国人民解放军空军军医大学 | Kv3在制备诊断或治疗创伤后应激障碍异常恐惧记忆消退产品中的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102753533B (zh) | 2009-12-11 | 2014-07-30 | 奥蒂福尼疗法有限公司 | 咪唑烷二酮衍生物 |
| AU2011340258C1 (en) * | 2010-12-06 | 2016-10-20 | Autifony Therapeutics Limited | Hydantoin derivatives useful as Kv3 inhibitors |
| GB201209986D0 (en) | 2012-06-06 | 2012-07-18 | Autifony Therapeutics Ltd | Novel compounds |
| CN103596943B (zh) | 2011-06-07 | 2016-10-12 | 奥蒂福尼疗法有限公司 | 用作kv3抑制剂的乙内酰脲衍生物 |
| DK2788339T3 (en) | 2011-12-06 | 2016-05-23 | Autifony Therapeutics Ltd | HYDANTOIN DERIVATIVES, USEFUL AS QU3 INHIBITORS |
| US9669030B2 (en) | 2012-05-22 | 2017-06-06 | Autifony Therapeutics Limited | Hydantoin derivatives as Kv3 inhibitors |
| EP2852589B1 (en) | 2012-05-22 | 2021-04-28 | Autifony Therapeutics Limited | Triazoles as kv3 inhibitors |
| WO2013182851A1 (en) | 2012-06-06 | 2013-12-12 | Autifony Therapeutics Limited | Prophylaxis or treatment of diseases where a modulator of kv3.3 channels is required |
| GB201521751D0 (en) | 2015-12-10 | 2016-01-27 | Autifony Therapeutics Ltd | Novel uses |
| GB201522179D0 (en) | 2015-12-16 | 2016-01-27 | Autifony Therapeutics Ltd | Novel compounds |
| GB201613163D0 (en) | 2016-07-29 | 2016-09-14 | Autifony Therapeutics Ltd | Novel compounds |
| US20200039970A1 (en) | 2016-12-16 | 2020-02-06 | Autifony Therapeutics Limited | Hydantoin modulators of kv3 channels |
| JP2022502370A (ja) | 2018-09-21 | 2022-01-11 | バイオノミクス リミテッド | 置換ピリジニル化合物およびその使用 |
| IL282096B1 (en) * | 2018-10-16 | 2024-03-01 | Autifony Therapeutics Ltd | History of 3-[5-[(3,3-dialkyl-2H-benzofuran-4-yl]oxy]pyrazin-2-yl]-5,5-dialkyl-imidazolidine-2,4-dione and pharmaceutical preparations containing them |
| JP2022528631A (ja) | 2019-03-25 | 2022-06-15 | バイオノミクス リミテッド | 置換ｎ－ヘテロアリール化合物及びその使用 |
-
2020
- 2020-02-06 EP EP20705484.2A patent/EP4100402A1/en active Pending
- 2020-02-06 WO PCT/GB2020/050268 patent/WO2021156584A1/en unknown
- 2020-02-06 IL IL295027A patent/IL295027A/en unknown
- 2020-02-06 AU AU2020427632A patent/AU2020427632A1/en active Pending
- 2020-02-06 JP JP2022547757A patent/JP2023523501A/ja active Pending
- 2020-02-06 BR BR112022013339A patent/BR112022013339A2/pt unknown
- 2020-02-06 KR KR1020227030594A patent/KR20220139923A/ko unknown
- 2020-02-06 CN CN202080095972.7A patent/CN115066424A/zh active Pending
- 2020-02-06 CA CA3169057A patent/CA3169057A1/en active Pending
- 2020-02-06 MX MX2022009702A patent/MX2022009702A/es unknown
-
2022
- 2022-08-02 CL CL2022002081A patent/CL2022002081A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL295027A (en) | 2022-09-01 |
| CN115066424A (zh) | 2022-09-16 |
| MX2022009702A (es) | 2022-09-07 |
| CA3169057A1 (en) | 2021-08-12 |
| JP2023523501A (ja) | 2023-06-06 |
| AU2020427632A1 (en) | 2022-08-18 |
| EP4100402A1 (en) | 2022-12-14 |
| WO2021156584A1 (en) | 2021-08-12 |
| BR112022013339A2 (pt) | 2022-09-13 |
| KR20220139923A (ko) | 2022-10-17 |
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