CL2022001516A1 - Compuesto y composición como inhibidor de quinasa del receptor pdgf - Google Patents

Compuesto y composición como inhibidor de quinasa del receptor pdgf

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Publication number
CL2022001516A1
CL2022001516A1 CL2022001516A CL2022001516A CL2022001516A1 CL 2022001516 A1 CL2022001516 A1 CL 2022001516A1 CL 2022001516 A CL2022001516 A CL 2022001516A CL 2022001516 A CL2022001516 A CL 2022001516A CL 2022001516 A1 CL2022001516 A1 CL 2022001516A1
Authority
CL
Chile
Prior art keywords
compound
diseases
receptor kinase
pdgf receptor
present
Prior art date
Application number
CL2022001516A
Other languages
English (en)
Inventor
ASADA Junshi
Haruta Yoshinari
YAKUSHIJI Hiroyuki
Tanaka Toru
KURAMOTO Kazuya
KOSUGI Keiji
FUCHIKAMI Chiaki
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of CL2022001516A1 publication Critical patent/CL2022001516A1/es

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    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Un objeto de la presente invención es proporcionar un compuesto que tiene una actividad inhibidora de la quinasa del receptor de PDGF. Los ejemplos de la presente invención pueden incluir, por ejemplo, un compuesto representado por la siguiente fórmula [I] o una sal farmacéuticamente aceptable de este, o un solvato de este. El compuesto de la presente invención tiene actividad inhibidora contra la quinasa del receptor de PDGF. Además, debido a que el compuesto de la presente invención tiene una actividad inhibidora contra el receptor quinasa de PDGF, es útil como agente terapéutico para enfermedades respiratorias, cánceres, enfermedades proliferativas del músculo liso, enfermedades vasoproliferativas, enfermedades autoinmunes/inflamatorias, enfermedades metabólicas, enfermedades vasooclusivas, y similares.
CL2022001516A 2019-12-13 2022-06-08 Compuesto y composición como inhibidor de quinasa del receptor pdgf CL2022001516A1 (es)

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ES2424642T3 (es) * 2004-02-14 2013-10-07 Irm Llc Compuestos y composiciones como inhibidores de la proteína quinasa
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