ECSP22054240A - Compuesto y composici?n como inhibidor de quinasa del receptor pdgf - Google Patents

Compuesto y composici?n como inhibidor de quinasa del receptor pdgf

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Publication number
ECSP22054240A
ECSP22054240A ECSENADI202254240A ECDI202254240A ECSP22054240A EC SP22054240 A ECSP22054240 A EC SP22054240A EC SENADI202254240 A ECSENADI202254240 A EC SENADI202254240A EC DI202254240 A ECDI202254240 A EC DI202254240A EC SP22054240 A ECSP22054240 A EC SP22054240A
Authority
EC
Ecuador
Prior art keywords
compound
diseases
receptor kinase
pdgf receptor
present
Prior art date
Application number
ECSENADI202254240A
Other languages
English (en)
Inventor
Junshi Asada
Yoshinari Haruta
Hiroyuki Yakushiji
Kazuya Kuramoto
Keiji Kosugi
Chiaki Fuchikami
Toru Tanaka
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of ECSP22054240A publication Critical patent/ECSP22054240A/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Un objeto de la presente invenci?n es proporcionar un compuesto que tiene una actividad inhibidora de la quinasa del receptor de PDGF. Los ejemplos de la presente invenci?n pueden incluir, por ejemplo, un compuesto representado por la siguiente f?rmula [I] o una sal farmac?uticamente aceptable de este, o un solvato de este. El compuesto de la presente invenci?n tiene actividad inhibidora contra la quinasa del receptor de PDGF. Adem?s, debido a que el compuesto de la presente invenci?n tiene una actividad inhibidora contra el receptor quinasa de PDGF, es ?til como agente terap?utico para enfermedades respiratorias, c?nceres, enfermedades proliferativas del m?sculo liso, enfermedades vasoproliferativas, enfermedades autoinmunes/inflamatorias, enfermedades metab?licas, enfermedades vasooclusivas, y similares.
ECSENADI202254240A 2019-12-13 2022-07-12 Compuesto y composici?n como inhibidor de quinasa del receptor pdgf ECSP22054240A (es)

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AU2021405620A1 (en) * 2020-12-23 2023-06-29 Actelion Pharmaceuticals Ltd Pyrazolothiazole carboxamides and their uses as pdgfr inhibitors

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US20050014753A1 (en) * 2003-04-04 2005-01-20 Irm Llc Novel compounds and compositions as protein kinase inhibitors
US7259164B2 (en) * 2003-08-11 2007-08-21 Cgi Pharmaceuticals, Inc. Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity
US7968557B2 (en) * 2004-02-14 2011-06-28 Novartis Ag Substituted pyrrolo[2,3-2]pyrimidines as protein kinase inhibitors
US20100286211A1 (en) 2004-10-08 2010-11-11 Biswajit Das Oxazolidinone derivatives as antimicrobials
EP2937345B1 (en) * 2009-12-29 2018-03-21 Dana-Farber Cancer Institute, Inc. Type ii raf kinase inhibitors
EA201490542A1 (ru) * 2011-09-01 2014-08-29 АйАрЭм ЭлЭлСи Соединения и композиции в качестве pdgfr киназных ингибиторов
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