CL2022000050A1 - Formas polimórficas de (r)-4- (1-((3- (difluorometil)-1-metil-1h-pirazol-4-il)sulfonil) -1-fluoroetil)-n-(isoxazol-3-il)piperidina -1-carboxamida - Google Patents
Formas polimórficas de (r)-4- (1-((3- (difluorometil)-1-metil-1h-pirazol-4-il)sulfonil) -1-fluoroetil)-n-(isoxazol-3-il)piperidina -1-carboxamidaInfo
- Publication number
- CL2022000050A1 CL2022000050A1 CL2022000050A CL2022000050A CL2022000050A1 CL 2022000050 A1 CL2022000050 A1 CL 2022000050A1 CL 2022000050 A CL2022000050 A CL 2022000050A CL 2022000050 A CL2022000050 A CL 2022000050A CL 2022000050 A1 CL2022000050 A1 CL 2022000050A1
- Authority
- CL
- Chile
- Prior art keywords
- fluoroethyl
- difluoromethyl
- pyrazol
- carboxamide
- piperidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962874855P | 2019-07-16 | 2019-07-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2022000050A1 true CL2022000050A1 (es) | 2022-10-14 |
Family
ID=71895284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2022000050A CL2022000050A1 (es) | 2019-07-16 | 2022-01-10 | Formas polimórficas de (r)-4- (1-((3- (difluorometil)-1-metil-1h-pirazol-4-il)sulfonil) -1-fluoroetil)-n-(isoxazol-3-il)piperidina -1-carboxamida |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20210053939A1 (enExample) |
| EP (1) | EP3999504A1 (enExample) |
| JP (2) | JP2022540678A (enExample) |
| KR (1) | KR20220035176A (enExample) |
| CN (1) | CN114127061A (enExample) |
| AU (1) | AU2020315605A1 (enExample) |
| BR (1) | BR112022000474A2 (enExample) |
| CA (1) | CA3143965A1 (enExample) |
| CL (1) | CL2022000050A1 (enExample) |
| CO (1) | CO2022000117A2 (enExample) |
| IL (1) | IL289817A (enExample) |
| MX (1) | MX2022000606A (enExample) |
| PE (1) | PE20220645A1 (enExample) |
| WO (1) | WO2021011586A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116082326B (zh) * | 2022-12-16 | 2024-12-27 | 药康众拓(江苏)医药科技有限公司北京分公司 | 一种氘代吡唑磺酰甲基-哌啶异噁唑脲类化合物及其用途 |
| CN117865941B (zh) * | 2024-03-13 | 2024-06-28 | 上海方予健康医药科技有限公司 | 取代哌啶化合物及其制备方法和应用 |
| WO2025244956A1 (en) | 2024-05-20 | 2025-11-27 | MyoKardia, Inc. | Methods of manufacturing danicamtiv |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6358980B1 (en) | 1999-01-27 | 2002-03-19 | American Cyanamid Company | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors |
| US20050250789A1 (en) | 2004-04-20 | 2005-11-10 | Burns David M | Hydroxamic acid derivatives as metalloprotease inhibitors |
| ES2522579T3 (es) | 2004-06-17 | 2014-11-17 | Cytokinetics, Inc. | Compuestos, composiciones y métodos |
| NZ590148A (en) | 2004-12-30 | 2012-04-27 | Janssen Pharmaceutica Nv | Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase |
| EP1866285A1 (en) | 2005-03-03 | 2007-12-19 | F. Hoffmann-Roche AG | 1-sulfonyl-piperdine-3-carboxylic acid amide derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase for the treatment of type ii diabetes mellitus |
| WO2008120759A1 (ja) | 2007-03-30 | 2008-10-09 | Japan Tobacco Inc. | ウレア化合物およびその用途 |
| RU2462454C2 (ru) | 2007-06-20 | 2012-09-27 | Мицубиси Танабе Фарма Корпорейшн | Новое сульфонамидное производное малоновой кислоты и его фармацевтическое применение |
| WO2009011850A2 (en) | 2007-07-16 | 2009-01-22 | Abbott Laboratories | Novel therapeutic compounds |
| BRPI0817211A2 (pt) | 2007-09-20 | 2017-05-16 | Irm Llc | composto composições como moduladores da atividade de gpr119 |
| RU2010116821A (ru) | 2007-10-01 | 2011-11-10 | Ф.Хоффманн-Ля Аг (Ch) | N-гетероциклические биарильные карбоксамиды в качестве антагонистов рецептора ccr |
| RU2487127C2 (ru) | 2007-10-09 | 2013-07-10 | Ф.Хоффманн-Ля Рош Аг | Хиральные цис-имидазолины |
| NZ600238A (en) | 2008-06-19 | 2014-04-30 | Takeda Pharmaceutical | Heterocyclic compound and use thereof |
| US8324178B2 (en) | 2008-10-31 | 2012-12-04 | The Regents Of The University Of California | Method of treatment using alpha-1-adrenergic agonist compounds |
| WO2010113377A1 (ja) | 2009-04-01 | 2010-10-07 | パナソニック株式会社 | デジタル周波数／位相ロックドループ |
| TWI472331B (zh) | 2009-11-11 | 2015-02-11 | Sumitomo Dainippon Pharma Co Ltd | ８－氮雙環〔３‧２‧１〕辛烷－８－羧醯胺衍生物 |
| US9771357B2 (en) | 2013-07-09 | 2017-09-26 | Ono Pharmaceutical Co., Ltd. | ALXR agonist compound |
| KR102249564B1 (ko) | 2013-08-07 | 2021-05-07 | 메르크 파텐트 게엠베하 | 피페리딘 우레아 유도체 |
| ES2933350T3 (es) | 2014-01-24 | 2023-02-06 | Turning Point Therapeutics Inc | Macrociclos de diarilo como moduladores de proteína quinasas |
| EP4234017B1 (en) * | 2015-01-22 | 2026-04-15 | MyoKardia, Inc. | Preparation of 4-methylsulfonyl-substituted piperidine urea compounds useful for the treatment of cardiac disorders such as dilated cardiomyopathy (dcm) |
| KR20220009440A (ko) | 2019-05-19 | 2022-01-24 | 미요카디아, 인크. | 화합물 (r)-4-(1-((3-(디플루오로메틸)-1-메틸-1h-피라졸-4-일)술포닐)-1-플루오로에틸)-n-(이속사졸-3-일)피페리딘-1-카르복스아미드를 사용한 수축기 기능장애 및 감소된 박출 계수를 가진 심부전의 치료 |
-
2020
- 2020-07-15 CN CN202080051794.8A patent/CN114127061A/zh active Pending
- 2020-07-15 US US16/929,230 patent/US20210053939A1/en not_active Abandoned
- 2020-07-15 EP EP20750115.6A patent/EP3999504A1/en active Pending
- 2020-07-15 JP JP2022502486A patent/JP2022540678A/ja active Pending
- 2020-07-15 CA CA3143965A patent/CA3143965A1/en active Pending
- 2020-07-15 WO PCT/US2020/042028 patent/WO2021011586A1/en not_active Ceased
- 2020-07-15 MX MX2022000606A patent/MX2022000606A/es unknown
- 2020-07-15 KR KR1020227004725A patent/KR20220035176A/ko active Pending
- 2020-07-15 BR BR112022000474A patent/BR112022000474A2/pt unknown
- 2020-07-15 PE PE2022000049A patent/PE20220645A1/es unknown
- 2020-07-15 AU AU2020315605A patent/AU2020315605A1/en active Pending
-
2022
- 2022-01-10 CL CL2022000050A patent/CL2022000050A1/es unknown
- 2022-01-12 IL IL289817A patent/IL289817A/en unknown
- 2022-01-12 CO CONC2022/0000117A patent/CO2022000117A2/es unknown
- 2022-02-23 US US17/678,569 patent/US12459919B2/en active Active
-
2025
- 2025-07-04 JP JP2025113468A patent/JP2025148397A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2022000606A (es) | 2022-03-11 |
| JP2025148397A (ja) | 2025-10-07 |
| US20220289709A1 (en) | 2022-09-15 |
| US20210053939A1 (en) | 2021-02-25 |
| PE20220645A1 (es) | 2022-04-28 |
| IL289817A (en) | 2022-03-01 |
| EP3999504A1 (en) | 2022-05-25 |
| CA3143965A1 (en) | 2021-01-21 |
| TW202116765A (zh) | 2021-05-01 |
| AU2020315605A1 (en) | 2022-03-03 |
| KR20220035176A (ko) | 2022-03-21 |
| WO2021011586A1 (en) | 2021-01-21 |
| BR112022000474A2 (pt) | 2022-05-17 |
| CO2022000117A2 (es) | 2022-01-17 |
| CN114127061A (zh) | 2022-03-01 |
| JP2022540678A (ja) | 2022-09-16 |
| US12459919B2 (en) | 2025-11-04 |
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