CL2021003525A1 - Ligandos de antígeno de membrana específico de próstata (psma) y sus usos - Google Patents

Ligandos de antígeno de membrana específico de próstata (psma) y sus usos

Info

Publication number
CL2021003525A1
CL2021003525A1 CL2021003525A CL2021003525A CL2021003525A1 CL 2021003525 A1 CL2021003525 A1 CL 2021003525A1 CL 2021003525 A CL2021003525 A CL 2021003525A CL 2021003525 A CL2021003525 A CL 2021003525A CL 2021003525 A1 CL2021003525 A1 CL 2021003525A1
Authority
CL
Chile
Prior art keywords
psma
ligands
prostate
specific membrane
membrane antigen
Prior art date
Application number
CL2021003525A
Other languages
English (en)
Spanish (es)
Inventor
Maurizio F Mariani
Lorenza Fugazza
Daniela Chicco
Martin Gilbert Pomper
Sangeeta Ray
Original Assignee
Univ Johns Hopkins
Advanced Accelerator Applications Italy Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins, Advanced Accelerator Applications Italy Srl filed Critical Univ Johns Hopkins
Publication of CL2021003525A1 publication Critical patent/CL2021003525A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0497Organic compounds conjugates with a carrier being an organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0402Organic compounds carboxylic acid carriers, fatty acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0474Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
CL2021003525A 2019-07-02 2021-12-28 Ligandos de antígeno de membrana específico de próstata (psma) y sus usos CL2021003525A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19184015 2019-07-02

Publications (1)

Publication Number Publication Date
CL2021003525A1 true CL2021003525A1 (es) 2022-10-21

Family

ID=67145647

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2021003525A CL2021003525A1 (es) 2019-07-02 2021-12-28 Ligandos de antígeno de membrana específico de próstata (psma) y sus usos

Country Status (16)

Country Link
US (1) US20230226227A1 (enExample)
EP (1) EP3993837A1 (enExample)
JP (2) JP7805170B2 (enExample)
KR (1) KR20220044496A (enExample)
CN (3) CN120441497A (enExample)
AR (1) AR119331A1 (enExample)
AU (3) AU2020299974A1 (enExample)
BR (1) BR112021026812A2 (enExample)
CA (1) CA3144557A1 (enExample)
CL (1) CL2021003525A1 (enExample)
CO (1) CO2021017708A2 (enExample)
IL (1) IL289039A (enExample)
MX (1) MX2022000136A (enExample)
PH (1) PH12021553284A1 (enExample)
TW (1) TW202114742A (enExample)
WO (1) WO2021001360A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021219719A1 (en) * 2020-04-29 2021-11-04 Advanced Accelerator Applications (Italy) Srl Methods for radiolabelling psma binding ligands and their kits
CN121604981A (zh) 2023-07-21 2026-03-03 诺华公司 靶向psma的放射性配体治疗方案
WO2025125469A1 (en) 2023-12-13 2025-06-19 Swiss Rockets Ag Combination therapy using psma-targeted radiopharmaceuticals and an inhibitor of pi3k, akt, and/or mtor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001271026A1 (en) 2000-07-11 2002-01-21 Bml, Inc. Remedies for bone diseases
HUE045028T2 (hu) * 2011-08-05 2019-12-30 Molecular Insight Pharm Inc Radiojelzett prosztataspecifikus membrán antigén inhibitorok
GEP20237479B (en) * 2013-10-18 2023-03-27 Deutsches Krebsforsch Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
KR20250057132A (ko) 2016-03-22 2025-04-28 더 존스 홉킨스 유니버시티 전립선 암의 내부방사선요법을 위한 전립선-특이적 막 항원 표적화된 고-친화성 제제
US11478558B2 (en) * 2017-05-30 2022-10-25 The Johns Hopkins University Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer
IL276528B2 (en) * 2018-02-06 2024-11-01 Univ Johns Hopkins PSMA Targeted Radiohalogenated Urea-Polyaminocarboxylates For Cancer Radiotherapy
WO2020028323A1 (en) * 2018-07-30 2020-02-06 The Johns Hopkins Universtiy Competitive prostate-specific membrane antigen (psma) binding agents for the reduction of non-target organ uptake of radiolabeled psma inhibitors for psma positive tumor imaging and radiopharmaceutical therapy

Also Published As

Publication number Publication date
PH12021553284A1 (en) 2022-08-01
JP2025165975A (ja) 2025-11-05
CO2021017708A2 (es) 2022-05-20
BR112021026812A2 (pt) 2022-02-22
CN120441497A (zh) 2025-08-08
WO2021001360A1 (en) 2021-01-07
EP3993837A1 (en) 2022-05-11
JP2022538478A (ja) 2022-09-02
MX2022000136A (es) 2022-04-27
AU2020299974A1 (en) 2022-01-27
AR119331A1 (es) 2021-12-09
TW202114742A (zh) 2021-04-16
US20230226227A1 (en) 2023-07-20
AU2024200850A1 (en) 2024-02-29
CN114341118A (zh) 2022-04-12
AU2024200850B2 (en) 2025-09-04
IL289039A (en) 2022-02-01
CN120441498A (zh) 2025-08-08
KR20220044496A (ko) 2022-04-08
AU2025271182A1 (en) 2025-12-18
CA3144557A1 (en) 2021-01-07
JP7805170B2 (ja) 2026-01-23

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