CL2021001803A1 - Pamoato de ketamina y su uso - Google Patents

Pamoato de ketamina y su uso

Info

Publication number
CL2021001803A1
CL2021001803A1 CL2021001803A CL2021001803A CL2021001803A1 CL 2021001803 A1 CL2021001803 A1 CL 2021001803A1 CL 2021001803 A CL2021001803 A CL 2021001803A CL 2021001803 A CL2021001803 A CL 2021001803A CL 2021001803 A1 CL2021001803 A1 CL 2021001803A1
Authority
CL
Chile
Prior art keywords
pamoate
ketamine
salts
ketamine pamoate
anesthetic
Prior art date
Application number
CL2021001803A
Other languages
English (en)
Inventor
Tong-Ho Lin
Yung-Shun Wen
Chia-Hsien Chen
Wei-Ju Chang
Original Assignee
Alar Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alar Pharmaceuticals Inc filed Critical Alar Pharmaceuticals Inc
Publication of CL2021001803A1 publication Critical patent/CL2021001803A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/35—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing only non-condensed rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
    • C07C65/11—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic with carboxyl groups on a condensed ring system containing two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se proporcionan sales de pamoato de ketamina que tienen una estequiometría de 2:1 de ketamina a pamoato, incluyendo pamoato de R, S-ketamina, pamoato de S-ketamina, o pamoato de R-ketamina, y formas cristalinas o amorfas de las sales de pamoato, y que tienen excelente seguridad y propiedades para aplicaciones farmacéuticas. También se proporcionan composiciones farmacéuticas que incluyen las sales de pamoato de la ketamina y sus usos en el tratamiento de una enfermedad del SNC o como anestésico.
CL2021001803A 2019-01-11 2021-07-07 Pamoato de ketamina y su uso CL2021001803A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962791058P 2019-01-11 2019-01-11
US201962871763P 2019-07-09 2019-07-09

Publications (1)

Publication Number Publication Date
CL2021001803A1 true CL2021001803A1 (es) 2021-12-24

Family

ID=71521952

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2021001803A CL2021001803A1 (es) 2019-01-11 2021-07-07 Pamoato de ketamina y su uso

Country Status (22)

Country Link
US (1) US11981617B2 (es)
EP (1) EP3908570B1 (es)
JP (1) JP7451538B2 (es)
KR (1) KR20210116517A (es)
CN (1) CN113423686B (es)
AU (1) AU2020206826B2 (es)
BR (1) BR112021013340A2 (es)
CA (1) CA3118954A1 (es)
CL (1) CL2021001803A1 (es)
CO (1) CO2021006884A2 (es)
DK (1) DK3908570T3 (es)
FI (1) FI3908570T3 (es)
LT (1) LT3908570T (es)
MX (1) MX2021006029A (es)
PE (1) PE20211550A1 (es)
PH (1) PH12021551157A1 (es)
PT (1) PT3908570T (es)
RS (1) RS65271B1 (es)
SG (1) SG11202104792SA (es)
SI (1) SI3908570T1 (es)
TW (1) TWI827783B (es)
WO (1) WO2020143762A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2019160057A1 (ja) 2018-02-15 2021-02-04 国立大学法人千葉大学 炎症性疾患若しくは骨疾患の予防又は治療剤及び医薬組成物
MX2020011653A (es) 2018-05-04 2021-02-09 Perception Neuroscience Inc Métodos de tratamiento para el abuso de sustancias.
MX2022006596A (es) * 2019-12-20 2022-07-05 Alar Pharmaceuticals Inc Formulaciones inyectables de accion prolongada de sales de pamoato de ketamina.
US20210322669A1 (en) * 2020-04-16 2021-10-21 Invictus Health, Inc. Method for treatment of traumatic brain injuries
CN112263572A (zh) * 2020-11-17 2021-01-26 厦门大学附属翔安医院 右旋氯胺酮在制备治疗脱髓鞘疾病药物中的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003519698A (ja) 2000-01-07 2003-06-24 トランスフォーム ファーマスーティカルズ，インコーポレイテッド 多様な固体形態のハイスループットでの形成、同定および分析
US20080293695A1 (en) * 2007-05-22 2008-11-27 David William Bristol Salts of physiologically active and psychoactive alkaloids and amines simultaneously exhibiting bioavailability and abuse resistance
US9421266B2 (en) * 2007-05-22 2016-08-23 Pisgah Laboratories, Inc. Safety of pseudoephedrine drug products
JO2857B1 (en) 2008-06-16 2015-03-15 سانوفي أفينتس Vinyl pipers with modified activity of tumor-resistant TNF
JO3227B1 (ar) 2011-09-08 2018-03-08 Otsuka Pharma Co Ltd مشتقات بنزو ثيوفين بها استبدال ببرازين كعوامل مضادة للذهان
JP2014196292A (ja) 2013-03-07 2014-10-16 大塚製薬株式会社 医薬
CN106562952B (zh) 2015-10-09 2020-06-09 江阴安博生物医药有限公司 氯胺酮在治疗重性抑郁障碍中的应用
JP6669932B2 (ja) 2016-03-29 2020-03-18 シャンハイ・シナジー・ファーマシューティカル・サイエンシーズ・カンパニー・リミテッド ボルチオキセチンのパモ酸塩及びその結晶形
RU2021114918A (ru) 2016-12-26 2021-07-09 Целликс Био Прайвет Лимитед Композиции и способы лечения хронической боли
KR102556740B1 (ko) * 2018-01-10 2023-07-18 엑스더블유파마 리미티드 케타민의 전구약물, 및 이의 조성물 및 용도

Also Published As

Publication number Publication date
WO2020143762A1 (en) 2020-07-16
PH12021551157A1 (en) 2021-11-03
US20220119338A1 (en) 2022-04-21
US11981617B2 (en) 2024-05-14
AU2020206826A1 (en) 2021-06-03
SG11202104792SA (en) 2021-06-29
AU2020206826B2 (en) 2024-05-02
LT3908570T (lt) 2024-03-12
PT3908570T (pt) 2024-03-15
CN113423686B (zh) 2023-08-22
PE20211550A1 (es) 2021-08-16
EP3908570A1 (en) 2021-11-17
DK3908570T3 (da) 2024-02-26
BR112021013340A2 (pt) 2021-09-14
JP7451538B2 (ja) 2024-03-18
TWI827783B (zh) 2024-01-01
CO2021006884A2 (es) 2021-06-10
KR20210116517A (ko) 2021-09-27
MX2021006029A (es) 2021-09-23
JP2022518003A (ja) 2022-03-11
EP3908570A4 (en) 2022-10-19
EP3908570B1 (en) 2023-12-13
CN113423686A (zh) 2021-09-21
CA3118954A1 (en) 2020-07-16
FI3908570T3 (fi) 2024-02-13
SI3908570T1 (sl) 2024-04-30
RS65271B1 (sr) 2024-03-29
TW202042796A (zh) 2020-12-01

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