CL2021001433A1 - Terapia de combinación de radioinmunoconjugados con inhibidor del punto de control - Google Patents

Terapia de combinación de radioinmunoconjugados con inhibidor del punto de control

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Publication number
CL2021001433A1
CL2021001433A1 CL2021001433A CL2021001433A CL2021001433A1 CL 2021001433 A1 CL2021001433 A1 CL 2021001433A1 CL 2021001433 A CL2021001433 A CL 2021001433A CL 2021001433 A CL2021001433 A CL 2021001433A CL 2021001433 A1 CL2021001433 A1 CL 2021001433A1
Authority
CL
Chile
Prior art keywords
radioimmunoconjugate
combination therapy
checkpoint inhibitor
inhibitor combination
checkpoint
Prior art date
Application number
CL2021001433A
Other languages
English (en)
Inventor
Meiduo Hu
John Fitzmaurice Valliant
Julie Metcalf
Natalie Grinshtein
Eric Steven Burak
Original Assignee
Fusion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fusion Pharmaceuticals Inc filed Critical Fusion Pharmaceuticals Inc
Publication of CL2021001433A1 publication Critical patent/CL2021001433A1/es

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    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • AHUMAN NECESSITIES
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    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A61K51/1036Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants against hormone receptors
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/502Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K51/0482Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
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    • A61K51/103Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants against receptors for growth factors or receptors for growth regulators
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    • A61K51/04Organic compounds
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    • A61K51/1093Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A61K51/1096Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

Terapias de combinación que comprenden la administración de radioinmunoconjugados y uno o más inhibidores de puntos de control.
CL2021001433A 2018-12-03 2021-06-01 Terapia de combinación de radioinmunoconjugados con inhibidor del punto de control CL2021001433A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862774847P 2018-12-03 2018-12-03

Publications (1)

Publication Number Publication Date
CL2021001433A1 true CL2021001433A1 (es) 2021-12-03

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Family Applications (2)

Application Number Title Priority Date Filing Date
CL2021001432A CL2021001432A1 (es) 2018-12-03 2021-06-01 Terapia de combinación de radioinmunoconjugados con inhibidores de daños y reparaciones del adn
CL2021001433A CL2021001433A1 (es) 2018-12-03 2021-06-01 Terapia de combinación de radioinmunoconjugados con inhibidor del punto de control

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2021001432A CL2021001432A1 (es) 2018-12-03 2021-06-01 Terapia de combinación de radioinmunoconjugados con inhibidores de daños y reparaciones del adn

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Country Link
US (5) US11446401B2 (es)
EP (2) EP3890789A4 (es)
JP (2) JP2022511471A (es)
KR (2) KR20210099074A (es)
CN (3) CN113474014A (es)
AU (2) AU2019394888A1 (es)
BR (2) BR112021010670A2 (es)
CA (2) CA3119917A1 (es)
CL (2) CL2021001432A1 (es)
EA (2) EA202191556A1 (es)
IL (2) IL283613A (es)
MA (2) MA54401A (es)
MX (2) MX2021006407A (es)
PE (2) PE20211961A1 (es)
PH (2) PH12021551282A1 (es)
SG (2) SG11202105112RA (es)
WO (2) WO2020115556A1 (es)
ZA (1) ZA202103429B (es)

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WO2020169537A1 (en) * 2019-02-21 2020-08-27 Bayer Aktiengesellschaft Combination of pd-1/pd-l1 inhibitors and targeted thorium conjugates

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