CL2020000384A1 - Métodos para tratar y/o prevenir la enfermedad de injerto contra huésped y/o hemorragia alveolar difusa y/o enfermedad veno-oclusiva asociada con trasplante de células madre hematopoyéticas. - Google Patents
Métodos para tratar y/o prevenir la enfermedad de injerto contra huésped y/o hemorragia alveolar difusa y/o enfermedad veno-oclusiva asociada con trasplante de células madre hematopoyéticas.Info
- Publication number
- CL2020000384A1 CL2020000384A1 CL2020000384A CL2020000384A CL2020000384A1 CL 2020000384 A1 CL2020000384 A1 CL 2020000384A1 CL 2020000384 A CL2020000384 A CL 2020000384A CL 2020000384 A CL2020000384 A CL 2020000384A CL 2020000384 A1 CL2020000384 A1 CL 2020000384A1
- Authority
- CL
- Chile
- Prior art keywords
- stem cell
- hematopoietic stem
- veno
- treating
- methods
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 208000017850 Diffuse alveolar hemorrhage Diseases 0.000 title 1
- 208000009329 Graft vs Host Disease Diseases 0.000 title 1
- 208000012346 Venoocclusive disease Diseases 0.000 title 1
- 208000024908 graft versus host disease Diseases 0.000 title 1
- 238000011134 hematopoietic stem cell transplantation Methods 0.000 title 1
- 102100026046 Mannan-binding lectin serine protease 2 Human genes 0.000 abstract 3
- 101710117460 Mannan-binding lectin serine protease 2 Proteins 0.000 abstract 3
- 208000032843 Hemorrhage Diseases 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 2
- 230000000295 complement effect Effects 0.000 abstract 2
- 230000001419 dependent effect Effects 0.000 abstract 2
- 238000009792 diffusion process Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21104—Mannan-binding lectin-associated serine protease-2 (3.4.21.104)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0381—Animal model for diseases of the hematopoietic system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0387—Animal model for diseases of the immune system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Environmental Sciences (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
EN UN ASPECTO, LA INVENCIÓN PROPORCIONA PROCEDIMIENTOS DE INHIBICIÓN DE LOS EFECTOS DE LA ACTIVACIÓN DEL COMPLEMENTO DEPENDIENTE DE MASP-2 EN UN SUJETO HUMANO QUE PADECE LA ENFERMEDAD DE INJERTO CONTRA HUÉSPED Y/O HEMORRAGIA ALVEOLAR DIFUSA Y/O ENFERMEDAD VENO-OCLUSIVA ASOCIADA CON UN TRASPLANTE DE CÉLULAS MADRE HEMATOPOYÉTICAS LOS MÉTODOS COMPRENDEN LA ETAPA DE ADMINISTRAR A UN SUJETO QUE LO NECESITA UNA CANTIDAD DE UN AGENTE INHIBIDOR DE MASP-2 EFECTIVA PARA INHIBIR LA ACTIVACIÓN DEL COMPLEMENTO DEPENDIENTE DE MASP-2.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762545864P | 2017-08-15 | 2017-08-15 | |
US201762574690P | 2017-10-19 | 2017-10-19 | |
US201862630756P | 2018-02-14 | 2018-02-14 | |
US201862637281P | 2018-03-01 | 2018-03-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2020000384A1 true CL2020000384A1 (es) | 2020-08-14 |
Family
ID=65362042
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2020000384A CL2020000384A1 (es) | 2017-08-15 | 2020-02-14 | Métodos para tratar y/o prevenir la enfermedad de injerto contra huésped y/o hemorragia alveolar difusa y/o enfermedad veno-oclusiva asociada con trasplante de células madre hematopoyéticas. |
CL2022000194A CL2022000194A1 (es) | 2017-08-15 | 2022-01-25 | Uso para tratar la enfermedad de hemorragia alveolar difusa asociada con trasplante de células madre hematopoyéticas (divisional de la solicitud no. 202000384) |
CL2022000195A CL2022000195A1 (es) | 2017-08-15 | 2022-01-25 | Usos para tratar la enfermedad veno-oclusiva asociada con trasplante de células madre hematopoyéticas (divisional de la solicitud no. 202000384) |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2022000194A CL2022000194A1 (es) | 2017-08-15 | 2022-01-25 | Uso para tratar la enfermedad de hemorragia alveolar difusa asociada con trasplante de células madre hematopoyéticas (divisional de la solicitud no. 202000384) |
CL2022000195A CL2022000195A1 (es) | 2017-08-15 | 2022-01-25 | Usos para tratar la enfermedad veno-oclusiva asociada con trasplante de células madre hematopoyéticas (divisional de la solicitud no. 202000384) |
Country Status (18)
Country | Link |
---|---|
US (2) | US11013772B2 (es) |
EP (1) | EP3668531A4 (es) |
JP (2) | JP2020531452A (es) |
KR (1) | KR20200040805A (es) |
CN (1) | CN111278449A (es) |
AU (1) | AU2018318982A1 (es) |
BR (1) | BR112020003207A2 (es) |
CA (1) | CA3072940A1 (es) |
CL (3) | CL2020000384A1 (es) |
GE (1) | GEP20237541B (es) |
IL (1) | IL272674A (es) |
JO (1) | JOP20200021A1 (es) |
MA (1) | MA49915A (es) |
MX (1) | MX2020001728A (es) |
PH (1) | PH12020500276A1 (es) |
SG (1) | SG11202001014WA (es) |
TW (2) | TW202402809A (es) |
WO (1) | WO2019036460A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11584714B2 (en) | 2018-05-29 | 2023-02-21 | Omeros Corporation | MASP-2 inhibitors and methods of use |
WO2021108447A1 (en) * | 2019-11-26 | 2021-06-03 | Omeros Corporation | Methods for treating and/or preventing idiopathic pneumonia syndrome (ips) and/or capillary leak syndrome (cls) and/or engraftment syndrome (es) and/or fluid overload (fo) associated with hematopoietic stem cell transplant |
CA3159159A1 (en) | 2019-12-04 | 2021-06-10 | Neil S. Cutshall | Masp-2 inhibitors and methods of use |
US11661418B2 (en) | 2019-12-04 | 2023-05-30 | Omeros Corporation | MASP-2 inhibitors and methods of use |
MX2022006750A (es) | 2019-12-04 | 2022-06-14 | Omeros Corp | Inhibidores de masp-2 y metodos de uso. |
CN115052604A (zh) | 2019-12-04 | 2022-09-13 | 奥默罗斯公司 | Masp-2抑制剂和使用方法 |
CN113057142B (zh) * | 2021-03-30 | 2022-12-09 | 四川大学华西医院 | 一种视网膜内和/或视网膜下纤维化动物模型的构建方法 |
CN114532982A (zh) * | 2022-01-12 | 2022-05-27 | 高谋 | 评价干细胞系统移植调控补体活化作用的体系 |
CN114686585B (zh) * | 2022-04-01 | 2023-06-30 | 中国人民解放军总医院 | Tmem65在预警和/或治疗高原病中的应用 |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
US4394370A (en) | 1981-09-21 | 1983-07-19 | Jefferies Steven R | Bone graft material for osseous defects and method of making same |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4526909A (en) | 1984-01-09 | 1985-07-02 | Regents Of The University Of California | Polymethylmethacrylate delivery system for bone morphogenetic protein |
US4563489A (en) | 1984-02-10 | 1986-01-07 | University Of California | Biodegradable organic polymer delivery system for bone morphogenetic protein |
JPH0662679B2 (ja) | 1985-06-21 | 1994-08-17 | 新田ゼラチン株式会社 | 組織親和性コラ−ゲンとその製法 |
US5453566A (en) | 1986-03-28 | 1995-09-26 | Calgene, Inc. | Antisense regulation of gene expression in plant/cells |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
NZ227332A (en) | 1987-12-15 | 1991-08-27 | Gene Shears Pty Ltd | Ribozymes, production and use |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
GB8822492D0 (en) | 1988-09-24 | 1988-10-26 | Considine J | Apparatus for removing tumours from hollow organs of body |
US5211657A (en) | 1988-11-07 | 1993-05-18 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5549910A (en) | 1989-03-31 | 1996-08-27 | The Regents Of The University Of California | Preparation of liposome and lipid complex compositions |
ATE149841T1 (de) | 1990-01-26 | 1997-03-15 | Immunomedics Inc | Impfstoffe gegen krebs und infektionskrankheiten |
JP3218637B2 (ja) | 1990-07-26 | 2001-10-15 | 大正製薬株式会社 | 安定なリポソーム水懸濁液 |
US5789573A (en) | 1990-08-14 | 1998-08-04 | Isis Pharmaceuticals, Inc. | Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2 |
JP2958076B2 (ja) | 1990-08-27 | 1999-10-06 | 株式会社ビタミン研究所 | 遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法 |
IL108367A0 (en) | 1993-01-27 | 1994-04-12 | Hektoen Inst For Medical Resea | Antisense polynzcleotide inhibition of human growth factor-sensitive cancer cells |
US5801154A (en) | 1993-10-18 | 1998-09-01 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of multidrug resistance-associated protein |
US5856121A (en) | 1994-02-24 | 1999-01-05 | Case Western Reserve University | Growth arrest homebox gene |
US5741516A (en) | 1994-06-20 | 1998-04-21 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
US5738868A (en) | 1995-07-18 | 1998-04-14 | Lipogenics Ltd. | Liposome compositions and kits therefor |
BR9509985A (pt) | 1995-12-12 | 1998-11-03 | Omeros Med Sys Inc | Solução para irrigação e método para inibição de dor inflamação e esparmo |
US5739119A (en) | 1996-11-15 | 1998-04-14 | Galli; Rachel L. | Antisense oligonucleotides specific for the muscarinic type 2 acetylcholine receptor MRNA |
WO2001007067A2 (en) | 1999-07-21 | 2001-02-01 | Omeros Medical Systems, Inc. | Solutions and methods for inhibition of pain, inflammation and cartilage degradation |
US6649592B1 (en) | 2000-01-14 | 2003-11-18 | Science & Technology Corporation @ Unm | Peptide inhibitors of LFA-1/ICAM-1 interaction |
SG98393A1 (en) | 2000-05-19 | 2003-09-19 | Inst Materials Research & Eng | Injectable drug delivery systems with cyclodextrin-polymer based hydrogels |
CA2474645C (en) | 2002-02-01 | 2011-08-09 | Omeros Corporation | Compositions and methods for systemic inhibition of cartilage degradation |
AU2003249317B2 (en) | 2002-07-19 | 2007-08-02 | Institute Of Materials Research And Engineering | Biodegradable triblock copolymers, synthesis methods therefor, and hydrogels and biomaterials made there from |
CN1798769A (zh) | 2003-05-12 | 2006-07-05 | 内蒂穆恩公司 | 抗masp-2抗体 |
US7919094B2 (en) | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
EP1879610A1 (en) * | 2005-05-06 | 2008-01-23 | Laboratoires Serono S.A. | Use of an immunoglobulin domain-containing cell surface recognition molecule for treating diseases |
US8906845B2 (en) | 2010-07-21 | 2014-12-09 | Eastern Virginia Medical School | Peptide compounds to regulate the complement system |
US20150166676A1 (en) * | 2011-04-08 | 2015-06-18 | Omeros Corporation | Methods for Treating Conditions Associated with MASP-2 Dependent Complement Activation |
US9644035B2 (en) * | 2011-04-08 | 2017-05-09 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
PT2704743T (pt) * | 2011-05-04 | 2020-06-17 | Omeros Corp | Composições para inibir a ativação de complemento dependente de masp-2 |
AU2014209350B8 (en) * | 2013-01-23 | 2019-04-18 | Department Of Veterans Affairs (Us) | Targeting constructs based on natural antibodies and uses thereof |
IL283373B1 (en) * | 2013-10-17 | 2024-04-01 | Omeros Corp | Pharmaceutical preparations containing MASP-2 suppressors to suppress MASP-2-dependent complement activation and related diseases |
CN106687123A (zh) | 2014-06-05 | 2017-05-17 | 科罗拉多州大学评议会 | Map44多肽和基于天然抗体的构建体及其用途 |
CA2988313A1 (en) * | 2015-06-08 | 2016-12-15 | Volution Immuno Pharmaceuticals Sa | Ornithodoros moubata complement inhibitor for use in the treatment of acute graft versus host disease |
CN117398458A (zh) * | 2015-11-09 | 2024-01-16 | 奥默罗斯公司 | 用于治疗与masp-2依赖性补体活化相关的病况的方法 |
-
2018
- 2018-08-13 TW TW112136719A patent/TW202402809A/zh unknown
- 2018-08-13 TW TW107128182A patent/TWI818919B/zh active
- 2018-08-14 JP JP2020508563A patent/JP2020531452A/ja active Pending
- 2018-08-14 AU AU2018318982A patent/AU2018318982A1/en active Pending
- 2018-08-14 WO PCT/US2018/046690 patent/WO2019036460A1/en active Application Filing
- 2018-08-14 SG SG11202001014WA patent/SG11202001014WA/en unknown
- 2018-08-14 CA CA3072940A patent/CA3072940A1/en active Pending
- 2018-08-14 BR BR112020003207-7A patent/BR112020003207A2/pt unknown
- 2018-08-14 US US16/103,332 patent/US11013772B2/en active Active
- 2018-08-14 EP EP18845831.9A patent/EP3668531A4/en active Pending
- 2018-08-14 CN CN201880052958.1A patent/CN111278449A/zh active Pending
- 2018-08-14 KR KR1020207006893A patent/KR20200040805A/ko not_active Application Discontinuation
- 2018-08-14 MX MX2020001728A patent/MX2020001728A/es unknown
- 2018-08-14 GE GEAP201815297A patent/GEP20237541B/en unknown
- 2018-08-14 JO JOP/2020/0021A patent/JOP20200021A1/ar unknown
- 2018-08-14 MA MA049915A patent/MA49915A/fr unknown
-
2020
- 2020-02-06 PH PH12020500276A patent/PH12020500276A1/en unknown
- 2020-02-13 IL IL272674A patent/IL272674A/en unknown
- 2020-02-14 CL CL2020000384A patent/CL2020000384A1/es unknown
-
2021
- 2021-04-09 US US17/226,987 patent/US11896621B2/en active Active
-
2022
- 2022-01-25 CL CL2022000194A patent/CL2022000194A1/es unknown
- 2022-01-25 CL CL2022000195A patent/CL2022000195A1/es unknown
-
2023
- 2023-06-21 JP JP2023101662A patent/JP2023123627A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN111278449A (zh) | 2020-06-12 |
BR112020003207A2 (pt) | 2020-10-06 |
US20190125802A1 (en) | 2019-05-02 |
PH12020500276A1 (en) | 2020-09-21 |
TW201920288A (zh) | 2019-06-01 |
MA49915A (fr) | 2021-03-24 |
CL2022000195A1 (es) | 2023-01-27 |
SG11202001014WA (en) | 2020-03-30 |
EP3668531A1 (en) | 2020-06-24 |
AU2018318982A1 (en) | 2020-03-19 |
TWI818919B (zh) | 2023-10-21 |
AU2018318982A2 (en) | 2020-03-26 |
EP3668531A4 (en) | 2021-03-24 |
WO2019036460A1 (en) | 2019-02-21 |
KR20200040805A (ko) | 2020-04-20 |
JOP20200021A1 (ar) | 2020-02-02 |
GEP20237541B (en) | 2023-09-25 |
US11013772B2 (en) | 2021-05-25 |
CL2022000194A1 (es) | 2023-01-27 |
TW202402809A (zh) | 2024-01-16 |
CA3072940A1 (en) | 2019-02-21 |
US20210290684A1 (en) | 2021-09-23 |
MX2020001728A (es) | 2020-09-25 |
JP2023123627A (ja) | 2023-09-05 |
IL272674A (en) | 2020-03-31 |
US11896621B2 (en) | 2024-02-13 |
JP2020531452A (ja) | 2020-11-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2020000384A1 (es) | Métodos para tratar y/o prevenir la enfermedad de injerto contra huésped y/o hemorragia alveolar difusa y/o enfermedad veno-oclusiva asociada con trasplante de células madre hematopoyéticas. | |
CL2018001258A1 (es) | Métodos para tratar las condiciones asociadas con la activación del complemento dependiente de masp-2 | |
CO2018012894A2 (es) | Derivados de pirazol como inhibidores de calicreína plasmática | |
CL2017000080A1 (es) | Métodos para tratar el cáncer con inhibidores de tigit y agentes contra el cáncer | |
UY38160A (es) | Partículas implantables y métodos relacionados | |
CL2017000317A1 (es) | Terapia adjuntiva con 25-hidroxi vitamina d | |
AR101312A1 (es) | Combinaciones de inhibidores de bet e inhibidores de tirosina quinasa de bruton | |
EA201591543A1 (ru) | Комбинированные терапии для лечения рака с применением микрорнк и ингибиторов egfr-tki | |
CO2021004141A2 (es) | Moduladores de la expresión de pnpla3 | |
CL2020002993A1 (es) | Terapias combinadas para la ateroesclerosis, incluyendo la enfermedad cardiovascular ateroesclerótica (divisional de solicitud no 1304-2019) | |
MX2020011817A (es) | Metodos para tratar el linfoma. | |
CL2019001014A1 (es) | Métodos de tratamiento de afecciones relacionadas con la inflamación utilizando moduladores metabólicos y anti inflamatorios pluripotentes. | |
CO2019011265A2 (es) | Moduladores de la expresión de pcsk9 | |
ECSP20082339A (es) | Moduladores de la expresión de apol1 | |
CO2021007006A2 (es) | Moduladores de la expresión de irf5 | |
ECSP20016283A (es) | Métodos para tratar y/o prevenir la enfermedad del injerto frente a hospedador y/o hemorragia alveolar y/o enfermedad veno-oclusiva asociada a trasplante de células madre hematopoyéticas | |
CL2019000919A1 (es) | Mejoras en el silenciamiento génico o relacionadas con este. | |
MX2020004731A (es) | Terapias de combinacion de inhibidor ezh2. | |
EA202090504A1 (ru) | Способы лечения и/или предотвращения реакции трансплантат против хозяина, и/или диффузного альвеолярного кровотечения, и/или веноокклюзионной болезни, связанных с трансплантатом гемопоэтических стволовых клеток | |
BR112022010078A2 (pt) | Métodos para tratar um sujeito humano sofrendo de síndrome da pneumonia idiopática, de síndrome do vazamento capilar, de sobrecarga de fluído e de síndrome do enxerto a seguir do transplante de célula tronco hematopoiética | |
AR113874A1 (es) | Terapias de combinación de inhibidor ezh2 | |
RU2014112839A (ru) | Способ лечения нагноившейся остаточной полости печени после эхинококкэктомии |