CL2019003589A1 - Derivado de n2,n4-difenilpirimidin-2,4-diamina, método para la preparación del mismo, y una composición farmacéutica que contiene el mismo como ingrediente activo para la prevención o tratamiento de cáncer. - Google Patents

Derivado de n2,n4-difenilpirimidin-2,4-diamina, método para la preparación del mismo, y una composición farmacéutica que contiene el mismo como ingrediente activo para la prevención o tratamiento de cáncer.

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Publication number
CL2019003589A1
CL2019003589A1 CL2019003589A CL2019003589A CL2019003589A1 CL 2019003589 A1 CL2019003589 A1 CL 2019003589A1 CL 2019003589 A CL2019003589 A CL 2019003589A CL 2019003589 A CL2019003589 A CL 2019003589A CL 2019003589 A1 CL2019003589 A1 CL 2019003589A1
Authority
CL
Chile
Prior art keywords
cancer
same
derivative
treatment
diamine
Prior art date
Application number
CL2019003589A
Other languages
English (en)
Inventor
Gildon Choi
Kwangho Lee
Inji Shin
Chong Hak Chae
Hyeon Jeong Choe
Myoung Eun Jung
Byeong Uk Jeon
Byoung Chul Cho
Chae Won Park
Hwan Kim
Krishna Babu Duggirala
Original Assignee
Korea Res Inst Chemical Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Res Inst Chemical Tech filed Critical Korea Res Inst Chemical Tech
Publication of CL2019003589A1 publication Critical patent/CL2019003589A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/308—Foods, ingredients or supplements having a functional effect on health having an effect on cancer prevention

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A UN DERIVADO DE N2,N4-DIFENILPIRIMIDIN2,4-DIAMINA, UN MÉTODO PARA PREPARAR EL MISMO Y UNA COMPOSICIÓN FARMACÉUTICA PARA LA PREVENCIÓN O EL TRATAMIENTO DEL CÁNCER, QUE CONTIENE EL MISMO COMO INGREDIENTE ACTIVO. EL DERIVADO MUESTRA UN EFECTO INHIBIDOR DE LA ACTIVIDAD DE EGFR RELATIVAMENTE DÉBIL SOBRE EL EGFR DE TIPO SALVAJE, UNA ALTA CAPACIDAD INHIBITORIA EN LA MUTACIÓN DE EGFR Y UNA ALTA CAPACIDAD INHIBITORIA INCLUSO EN LA MUTACIÓN FLT3 Y FLT3, Y POR LO TANTO, PUEDE USARSE EFICAZMENTE PARA EL TRATAMIENTO DEL CÁNCER CON EGFR MUTACIÓN O CÁNCER CON FLT3 O UNA MUTACIÓN DEL MISMO, Y EL DERIVADO MUESTRA UN EFECTO DE SINERGIA EN EL MOMENTO DE LA ADMINISTRACIÓN COMBINADA Y, POR LO TANTO, PUEDE USARSE EFICAZMENTE PARA EL TRATAMIENTO DE LA ADMINISTRACIÓN COMBINADA.
CL2019003589A 2017-06-13 2019-12-06 Derivado de n2,n4-difenilpirimidin-2,4-diamina, método para la preparación del mismo, y una composición farmacéutica que contiene el mismo como ingrediente activo para la prevención o tratamiento de cáncer. CL2019003589A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20170073907 2017-06-13
KR1020170146241A KR20180135781A (ko) 2017-06-13 2017-11-03 N2,n4-디페닐피리미딘-2,4-디아민 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물

Publications (1)

Publication Number Publication Date
CL2019003589A1 true CL2019003589A1 (es) 2020-07-03

Family

ID=70972831

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019003589A CL2019003589A1 (es) 2017-06-13 2019-12-06 Derivado de n2,n4-difenilpirimidin-2,4-diamina, método para la preparación del mismo, y una composición farmacéutica que contiene el mismo como ingrediente activo para la prevención o tratamiento de cáncer.

Country Status (19)

Country Link
US (2) US11253516B2 (es)
EP (1) EP3640246B1 (es)
JP (1) JP6945015B2 (es)
KR (2) KR20180135781A (es)
CN (1) CN110740999A (es)
AU (1) AU2018286361B2 (es)
BR (1) BR112019026253A2 (es)
CA (1) CA3066083C (es)
CL (1) CL2019003589A1 (es)
EA (1) EA201992722A1 (es)
ES (1) ES2969701T3 (es)
IL (1) IL271291B2 (es)
JO (1) JOP20190281A1 (es)
MX (1) MX2019014548A (es)
NZ (1) NZ760089A (es)
PL (1) PL3640246T3 (es)
SA (1) SA519410722B1 (es)
WO (1) WO2018230934A1 (es)
ZA (1) ZA201908241B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101992621B1 (ko) 2017-12-07 2019-09-27 주식회사 온코빅스 암세포 성장 억제 효과를 나타내는 신규한 피리미딘 유도체 및 그를 포함하는 약제학적 조성물
EP3941463A1 (en) 2019-03-22 2022-01-26 Sumitomo Dainippon Pharma Oncology, Inc. Compositions comprising pkm2 modulators and methods of treatment using the same
AU2020296620B2 (en) * 2019-06-20 2023-07-13 Oncobix Co.Ltd. Pyrimidine derivative inhibiting growth of cancer cell and medicinal use thereof
WO2020257385A1 (en) * 2019-06-20 2020-12-24 Dana-Farber Cancer Institute, Inc. Small molecule inhibitors of src tyrosine kinase
KR20220028075A (ko) 2019-07-03 2022-03-08 스미토모 다이니폰 파마 온콜로지, 인크. 티로신 키나제 비-수용체 1 (tnk1) 억제제 및 그의 용도
WO2021125758A1 (ko) * 2019-12-16 2021-06-24 주식회사 온코빅스 신규한 중수소 치환 피리미딘 유도체 및 이를 포함하는 약제학적 조성물
CN113896744B (zh) * 2020-07-06 2024-04-16 成都先导药物开发股份有限公司 一种选择性egfr抑制剂
CN112390760B (zh) * 2020-10-15 2022-07-29 北京师范大学 靶向fak的化合物及其制备方法和应用
CN112239422B (zh) * 2020-10-16 2022-07-22 河北化工医药职业技术学院 一种布格替尼中间体、其盐、其制备方法以及布格替尼的制备方法
EP4274567A1 (en) * 2021-01-05 2023-11-15 Sumitomo Pharma Oncology, Inc. Forms and formulations of a tyrosine kinase non-receptor 1 (tnk1) inhibitor
US20240051940A1 (en) * 2021-02-08 2024-02-15 Accutar Biotechnology Inc. Sulfonamides with egfr inhibition activities and their use thereof
EP4286376A1 (en) * 2021-04-01 2023-12-06 Therapex Co., Ltd. Pyrimidine derivative having protein kinase inhibitory activity, and therapeutic pharmaceutical composition comprising same
EP4371983A1 (en) * 2021-07-13 2024-05-22 Korea Research Institute of Chemical Technology Novel pyrimidine-2,4-diamine derivatives, preparation method therefor, and pharmaceutical composition containing same as active ingredient for prevention or treatment of cancer
WO2023201024A1 (en) * 2022-04-15 2023-10-19 Bridge Biotherapeutics, Inc. Composition and treatment for cancer with mutations
WO2024106979A1 (ko) * 2022-11-17 2024-05-23 (주)팜캐드 피페리딘 유도체, 이의 염 및 이를 유효성분으로 포함하는 약학적 조성물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4607879B2 (ja) * 2003-08-15 2011-01-05 ノバルティス アーゲー 新生物疾患、炎症および免疫障害の処置に有用な２，４−ピリミジンジアミン
EA019966B1 (ru) 2006-12-08 2014-07-30 АйАрЭм ЭлЭлСи Соединения и композиции в качестве ингибиторов протеинкиназы
WO2009127642A2 (en) * 2008-04-15 2009-10-22 Cellzome Limited Use of lrrk2 inhibitors for neurodegenerative diseases
MX2010012703A (es) 2008-05-21 2010-12-21 Ariad Pharma Inc Derivados fosforosos como inhibidores de cinasa.
CN104284584B (zh) * 2012-03-15 2019-06-04 西建卡尔有限责任公司 表皮生长因子受体激酶抑制剂的盐
KR101656382B1 (ko) 2014-02-28 2016-09-09 한국화학연구원 피리미딘-2,4-디아민 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물
WO2015176010A1 (en) * 2014-05-15 2015-11-19 The United States Of America, As Represented By The Secretary, Departmentof Health & Human Services Treatment or prevention of an intestinal disease or disorder
KR101733733B1 (ko) 2014-06-17 2017-05-11 한국화학연구원 피리미딘-2,4-디아민 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물
BR112017003186A2 (pt) 2014-08-22 2017-11-28 Fujifilm Corp composição farmacêutica para tratamento de cancer positivo para mutação em flt3, inibidor de flt3 mutante e usos dos mesmos
KR101789934B1 (ko) 2015-07-31 2017-10-26 중앙대학교 산학협력단 상피세포성장인자수용체 변이체를 가진 종양 진단 및 종양 성장 억제 활성을 갖는 신규 화합물 및 이를 포함하는 의학적 용도

Also Published As

Publication number Publication date
ZA201908241B (en) 2021-04-28
MX2019014548A (es) 2020-02-07
SA519410722B1 (ar) 2023-03-15
US20220249482A1 (en) 2022-08-11
JOP20190281A1 (ar) 2019-12-02
KR20180135815A (ko) 2018-12-21
EP3640246A4 (en) 2020-08-05
KR20180135781A (ko) 2018-12-21
AU2018286361A1 (en) 2020-01-16
ES2969701T3 (es) 2024-05-22
IL271291A (en) 2020-01-30
WO2018230934A1 (ko) 2018-12-20
NZ760089A (en) 2022-10-28
CA3066083C (en) 2021-11-30
KR102023156B1 (ko) 2019-09-19
IL271291B2 (en) 2023-02-01
EP3640246A1 (en) 2020-04-22
JP2020523360A (ja) 2020-08-06
CN110740999A (zh) 2020-01-31
EP3640246C0 (en) 2023-11-01
CA3066083A1 (en) 2018-12-20
BR112019026253A2 (pt) 2020-06-23
EP3640246B1 (en) 2023-11-01
JP6945015B2 (ja) 2021-10-06
PL3640246T3 (pl) 2024-04-22
US20200179384A1 (en) 2020-06-11
IL271291B (en) 2022-10-01
EA201992722A1 (ru) 2020-04-02
AU2018286361B2 (en) 2020-11-19
US11253516B2 (en) 2022-02-22

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