CL2019003091A1 - Terapia de combinación. - Google Patents
Terapia de combinación.Info
- Publication number
- CL2019003091A1 CL2019003091A1 CL2019003091A CL2019003091A CL2019003091A1 CL 2019003091 A1 CL2019003091 A1 CL 2019003091A1 CL 2019003091 A CL2019003091 A CL 2019003091A CL 2019003091 A CL2019003091 A CL 2019003091A CL 2019003091 A1 CL2019003091 A1 CL 2019003091A1
- Authority
- CL
- Chile
- Prior art keywords
- combination
- proliferative disease
- treatment
- subject
- same
- Prior art date
Links
- 238000002648 combination therapy Methods 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 230000002062 proliferating effect Effects 0.000 abstract 4
- 229940124647 MEK inhibitor Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A UNA COMBINACIÓN FARMACÉUTICA QUE COMPRENDE (A) UN INHIBIDOR DE RAF CONFORME LO DEFINIDO EN LA PRESENTE, O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DEL MISMO Y (B) UN INHIBIDOR DE MEK, PARTICULARMENTE TRAMETINIB, PARTICULARMENTE PARA USO EN EL TRATAMIENTO DE UNA ENFERMEDAD PROLIFERATIVA. LA PRESENTE INVENCIÓN ADEMÁS SE REFIERE A USOS DE ESTA COMBINACIÓN PARA LA PREPARACIÓN DE UN MEDICAMENTO PARA EL TRATAMIENTO DE UNA ENFERMEDAD PROLIFERATIVA; A MÉTODOS DE TRATAMIENTO DE UNA ENFERMEDAD PROLIFERATIVA EN UN SUJETO QUE LO NECESITE QUE COMPRENDEN ADMINISTRAR A DICHO SUJETO UNA CANTIDAD CONJUNTAMENTE TERAPÉUTICAMENTE EFECTIVA DE DICHA COMBINACIÓN; AL USO DE TAL COMBINACIÓN PARA EL TRATAMIENTO DE UNA ENFERMEDAD PROLIFERATIVA; A COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN TAL COMBINACIÓN Y A ENVASES COMERCIALES PARA LAS MISMAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762500108P | 2017-05-02 | 2017-05-02 | |
US201862656423P | 2018-04-12 | 2018-04-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2019003091A1 true CL2019003091A1 (es) | 2020-02-07 |
Family
ID=62218018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2019003091A CL2019003091A1 (es) | 2017-05-02 | 2019-10-28 | Terapia de combinación. |
Country Status (18)
Country | Link |
---|---|
US (2) | US11266653B2 (es) |
EP (2) | EP3618875B1 (es) |
JP (2) | JP7309614B2 (es) |
KR (2) | KR20240032157A (es) |
CN (1) | CN110494166B (es) |
AU (1) | AU2018262891B2 (es) |
BR (1) | BR112019022511A2 (es) |
CA (1) | CA3057969A1 (es) |
CL (1) | CL2019003091A1 (es) |
DK (1) | DK3618875T3 (es) |
ES (1) | ES2952265T3 (es) |
FI (1) | FI3618875T3 (es) |
IL (1) | IL270224B1 (es) |
MX (1) | MX2019012884A (es) |
PL (1) | PL3618875T3 (es) |
PT (1) | PT3618875T (es) |
TW (1) | TWI798218B (es) |
WO (1) | WO2018203219A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3665302A4 (en) * | 2017-08-11 | 2021-04-28 | Curematch, Inc. | COMBINED MEDICINAL PRODUCTS AGAINST MULTIPLE MUTATIONS IN CANCER |
KR20210105388A (ko) | 2018-12-20 | 2021-08-26 | 노파르티스 아게 | 암 치료에서 사용하기 위한 raf 저해제와 cdk4/6 저해제를 이용하는 병용요법 |
US20230226030A1 (en) * | 2020-02-18 | 2023-07-20 | Novartis Ag | Therapeutic combinations comprising a raf inhibitor for use in treating braf mutant nsclc |
EP4115907A1 (en) * | 2020-02-27 | 2023-01-11 | National University Corporation Hokkaido University | Method for screening anticancer agent and combination drug of kinase inhibitors for treatment of pancreatic cancer |
JP2023525100A (ja) * | 2020-05-12 | 2023-06-14 | ノバルティス アーゲー | Craf阻害剤を含む治療的組み合わせ |
US20230321110A1 (en) * | 2020-08-31 | 2023-10-12 | Novartis Ag | Combination therapy of a raf inhibitor and a mek inhibitor for the treatment of sarcoma |
WO2023145530A1 (ja) * | 2022-01-27 | 2023-08-03 | 国立大学法人東北大学 | 癌治療剤 |
WO2023166345A2 (en) | 2022-03-02 | 2023-09-07 | Novartis Ag | Precision therapy for the treatment of cancer |
US11957759B1 (en) | 2022-09-07 | 2024-04-16 | Arvinas Operations, Inc. | Rapidly accelerated fibrosarcoma (RAF) degrading compounds and associated methods of use |
WO2024088275A1 (zh) * | 2022-10-25 | 2024-05-02 | 中国科学院上海药物研究所 | 一种萘酰胺化合物治疗耐药性肿瘤的用途 |
CN117919235A (zh) * | 2022-10-25 | 2024-04-26 | 上海润石医药科技有限公司 | 一种萘酰胺化合物治疗kras突变相关疾病的用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1301472T1 (sl) | 2000-07-19 | 2014-05-30 | Warner-Lambert Company Llc | Oksigenirani estri 4-jodo fenilamino benzihidroksamskih kislin |
RS52670B (en) | 2004-06-11 | 2013-06-28 | Japan Tobacco Inc. | 5-AMINO-2,4,7-TRIOXO-3,4,7,8-TETRAHYDRO-2H-PIRIDO (2,3-D) PYRIMIDINE DERIVATIVES AND SIMILAR COMPOUNDS FOR CANCER TREATMENT |
TWI505828B (zh) | 2010-12-20 | 2015-11-01 | 葛蘭素史克智慧財產(第二)有限公司 | 新穎醫藥組成物 |
AR091876A1 (es) * | 2012-07-26 | 2015-03-04 | Novartis Ag | Combinaciones farmaceuticas para el tratamiento de enfermedades proliferativas |
EP3981408A1 (en) | 2012-09-04 | 2022-04-13 | Novartis AG | Dabrafenib and trametinib in a method of adjuvant cancer treatment |
US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
BR112019005046A2 (pt) * | 2016-09-19 | 2019-06-18 | Novartis Ag | combinações terapêuticas compreendendo um inibidor de raf e um inibidor de erk |
-
2018
- 2018-04-30 CA CA3057969A patent/CA3057969A1/en active Pending
- 2018-04-30 FI FIEP18726224.1T patent/FI3618875T3/fi active
- 2018-04-30 EP EP18726224.1A patent/EP3618875B1/en active Active
- 2018-04-30 IL IL270224A patent/IL270224B1/en unknown
- 2018-04-30 KR KR1020247006274A patent/KR20240032157A/ko active Search and Examination
- 2018-04-30 EP EP23166366.7A patent/EP4272740A1/en active Pending
- 2018-04-30 KR KR1020197031788A patent/KR102641827B1/ko active IP Right Grant
- 2018-04-30 WO PCT/IB2018/052989 patent/WO2018203219A1/en unknown
- 2018-04-30 JP JP2019558725A patent/JP7309614B2/ja active Active
- 2018-04-30 DK DK18726224.1T patent/DK3618875T3/da active
- 2018-04-30 PT PT187262241T patent/PT3618875T/pt unknown
- 2018-04-30 ES ES18726224T patent/ES2952265T3/es active Active
- 2018-04-30 US US16/610,482 patent/US11266653B2/en active Active
- 2018-04-30 PL PL18726224.1T patent/PL3618875T3/pl unknown
- 2018-04-30 MX MX2019012884A patent/MX2019012884A/es unknown
- 2018-04-30 AU AU2018262891A patent/AU2018262891B2/en active Active
- 2018-04-30 TW TW107114676A patent/TWI798218B/zh active
- 2018-04-30 CN CN201880023601.0A patent/CN110494166B/zh active Active
- 2018-04-30 BR BR112019022511-0A patent/BR112019022511A2/pt unknown
-
2019
- 2019-10-28 CL CL2019003091A patent/CL2019003091A1/es unknown
-
2022
- 2022-01-26 US US17/584,901 patent/US20220143036A1/en active Pending
-
2023
- 2023-07-05 JP JP2023110949A patent/JP2023145467A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN110494166A (zh) | 2019-11-22 |
JP7309614B2 (ja) | 2023-07-18 |
US20200246346A1 (en) | 2020-08-06 |
RU2019134757A3 (es) | 2021-08-17 |
CN110494166B (zh) | 2022-11-08 |
US11266653B2 (en) | 2022-03-08 |
AU2018262891A1 (en) | 2019-10-17 |
US20220143036A1 (en) | 2022-05-12 |
JP2020518568A (ja) | 2020-06-25 |
DK3618875T3 (da) | 2023-07-10 |
WO2018203219A1 (en) | 2018-11-08 |
IL270224B1 (en) | 2024-04-01 |
EP4272740A1 (en) | 2023-11-08 |
KR20240032157A (ko) | 2024-03-08 |
TW201842914A (zh) | 2018-12-16 |
CA3057969A1 (en) | 2018-11-08 |
RU2019134757A (ru) | 2021-06-02 |
EP3618875B1 (en) | 2023-04-05 |
BR112019022511A2 (pt) | 2020-05-12 |
IL270224A (es) | 2019-12-31 |
ES2952265T3 (es) | 2023-10-30 |
KR102641827B1 (ko) | 2024-03-04 |
PL3618875T3 (pl) | 2023-10-23 |
TWI798218B (zh) | 2023-04-11 |
KR20190141164A (ko) | 2019-12-23 |
JP2023145467A (ja) | 2023-10-11 |
EP3618875A1 (en) | 2020-03-11 |
AU2018262891B2 (en) | 2021-04-01 |
FI3618875T3 (fi) | 2023-07-04 |
PT3618875T (pt) | 2023-08-07 |
MX2019012884A (es) | 2020-01-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2019003091A1 (es) | Terapia de combinación. | |
CO2018012482A2 (es) | Formulaciones de un inhibidor de lsd1 | |
DOP2019000201A (es) | Compuestos inhibidores del vih | |
NI201700032A (es) | Uso de un agonista dual del receptor de glp-1/glucagón de acción prolongada para el tratamiento de la enfermedad del higado graso no alcohólico | |
CO2017000399A2 (es) | Inhibidores de cinasa de interacción con proteína cinasa activada por mitógeno (mnk) y métodos relacionados con los mismos | |
CO2017012381A2 (es) | Derivados de indol mono o disustituidos como inhibidores de la replicación viral del dengue | |
ECSP18073293A (es) | Derivados de indolina sustituidos como inhibidores de la replicación viral del dengue | |
NI201700101A (es) | Composiciones farmacéuticas que comprenden n - (3, 5 - dimetoxifenil) - n'- (1-metiletil) - n - [3-(1-metil-1h-pirazol-4-il) quinoxalina-6-il]etano-1,2-diamina | |
ECSP19083621A (es) | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue | |
ECSP19070369A (es) | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue | |
ECSP18073366A (es) | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue | |
CR20190447A (es) | Derivados de indolina sustituidos como inhibidores de la replicación viral de dengue | |
CL2017000782A1 (es) | Derivados de indol mono- o disustituidos como inhibidores de la replicación del virus del dengue | |
ECSP19083640A (es) | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue | |
DOP2016000254A (es) | Formulaciones farmeceuticas de inhibidor de la quinasa pan-raf, procedimientos para su preparacion, y metodos de uso. | |
CL2021000030A1 (es) | Uso de estimuladores de la sgc para el tratamiento de trastornos mitocondriales | |
CL2019003572A1 (es) | Combinaciones de brimonidina de dosis baja y usos de las mismas. | |
CO2019004004A2 (es) | Composición farmacéutica y método para el tratamiento de la enfermedad del hígado graso no alcohólico | |
ECSP16086247A (es) | (s)-pirlindole y sus sales farmacéuticamente aceptables para uso en medicina | |
EA201692111A1 (ru) | Фармацевтические композиции, содержащие данириксин, для лечения инфекционных заболеваний | |
CL2020000270A1 (es) | Combinación terapéutica de un inhibidor tirosina quinasa del egfr de tercera generación y un inhibidor raf. | |
ECSP16086232A (es) | (r) -pirlindole y sus sales farmacéuticamente aceptables para uso en medicina | |
EA201792314A1 (ru) | Фармацевтическая комбинация эверолимуса и дактолисиба | |
AR101901A1 (es) | Tratamiento de enfermedades neurodegenerativas con una combinación de laquinimod y fingolimod | |
AR099299A1 (es) | Inhibidor de la proteína de transferencia de éster de colesterilo (cetp) y composiciones farmacéuticas que comprenden dicho inhibidor para uso en el tratamiento o prevención de enfermedades cardiovasculares |