CL2018002523A1 - Profármacos del modulador selectivo del receptor de la progesterona (msrp) (11.beta.,17.beta.)-17-hidroxi-11-[4- (metilsulfonil)fenil]-17-(pentafluoroetil)estra-4,9-dien-3-ona - Google Patents
Profármacos del modulador selectivo del receptor de la progesterona (msrp) (11.beta.,17.beta.)-17-hidroxi-11-[4- (metilsulfonil)fenil]-17-(pentafluoroetil)estra-4,9-dien-3-onaInfo
- Publication number
- CL2018002523A1 CL2018002523A1 CL2018002523A CL2018002523A CL2018002523A1 CL 2018002523 A1 CL2018002523 A1 CL 2018002523A1 CL 2018002523 A CL2018002523 A CL 2018002523A CL 2018002523 A CL2018002523 A CL 2018002523A CL 2018002523 A1 CL2018002523 A1 CL 2018002523A1
- Authority
- CL
- Chile
- Prior art keywords
- beta
- msrp
- estra
- dien
- pentafluoroethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
ESTA INVENCIÓN SE RELACIONA CON LOS MODULADORES SELECTIVOS DEL RECEPTOR DE LA PROGESTERONA (MSRP) EN FORMA DE PROFÁRMACO ASÍ COMO TAMBIÉN CON SU APLICACIÓN EN TERAPIA. (3A,11ß,17ß)-11-[4-(METILSULFONIL)FENIL]-17-(PENTAFLUOROETIL)ESTRA-4,9-DIEN-3,17- DIOL (COMPUESTO 1) ES UNO DE LOS PROFÁRMACOS DE LA INVENCIÓN.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16158598.9A EP3214092A1 (en) | 2016-03-04 | 2016-03-04 | Prodrugs of the selective progesterone receptor modulator (sprm) (11.beta.,17.beta.)-17-hydroxy-11-[4-(methylsulphonyl)phenyl]-17-(pentafluoroethyl)estra-4,9-dien-3-one |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2018002523A1 true CL2018002523A1 (es) | 2018-12-21 |
Family
ID=55486547
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2018002523A CL2018002523A1 (es) | 2016-03-04 | 2018-09-04 | Profármacos del modulador selectivo del receptor de la progesterona (msrp) (11.beta.,17.beta.)-17-hidroxi-11-[4- (metilsulfonil)fenil]-17-(pentafluoroetil)estra-4,9-dien-3-ona |
Country Status (16)
Country | Link |
---|---|
US (1) | US10894805B2 (es) |
EP (2) | EP3214092A1 (es) |
JP (1) | JP2019511486A (es) |
KR (1) | KR20180118135A (es) |
CN (1) | CN108779142A (es) |
AU (1) | AU2017226922A1 (es) |
BR (1) | BR112018067517A2 (es) |
CA (1) | CA3016369A1 (es) |
CL (1) | CL2018002523A1 (es) |
CO (1) | CO2018009264A2 (es) |
CR (1) | CR20180426A (es) |
MA (1) | MA43691A (es) |
MX (1) | MX2018010658A (es) |
RU (1) | RU2018134045A (es) |
SG (1) | SG11201806771RA (es) |
WO (1) | WO2017148977A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3214092A1 (en) | 2016-03-04 | 2017-09-06 | Bayer Pharma Aktiengesellschaft | Prodrugs of the selective progesterone receptor modulator (sprm) (11.beta.,17.beta.)-17-hydroxy-11-[4-(methylsulphonyl)phenyl]-17-(pentafluoroethyl)estra-4,9-dien-3-one |
EP3384913A1 (en) | 2017-04-03 | 2018-10-10 | Bayer Pharma Aktiengesellschaft | Selective progesterone receptor modulators and stabilized estrogen level in patient |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA8231B (en) | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
DE69500542T2 (de) * | 1994-05-19 | 1998-01-02 | Akzo Nobel Nv | 11,21-Bisphenyl-19-nor-pregnan Derivate |
DE19706061A1 (de) | 1997-02-07 | 1998-08-13 | Schering Ag | Antigestagen wirksame Steroide mit fluorierter 17alpha-Alkylkette |
EP1068338A2 (en) * | 1998-03-06 | 2001-01-17 | Oxford Biomedica (UK) Limited | Enhanced prodrug activation |
CA2433776A1 (en) | 2001-01-09 | 2002-09-06 | Schering Aktiengesellschaft | The use of antigestagens for inhibiting accelerated endometrial maturation during infertility treatment |
JP2002233378A (ja) * | 2001-02-07 | 2002-08-20 | Nihon Nosan Kogyo Kk | ヒト由来のチトクロムp450分子種を認識する抗体 |
DE102006054535A1 (de) * | 2006-11-15 | 2008-05-21 | Bayer Schering Pharma Aktiengesellschaft | Progesteronrezeptorantagonisten |
EP2448422A1 (en) | 2009-07-02 | 2012-05-09 | University College Cork, National University Of Irland Cork | Method for the production of a gum base |
DE102009034362A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102010007722A1 (de) * | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
DE102010007719A1 (de) * | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
DE102011088270A1 (de) * | 2011-12-12 | 2013-06-13 | Bayer Intellectual Property Gmbh | (11ß ,17ß)-17-hydroxy-11-[4-(methylsulfonyl)phenyl]-17-(pentafluorethyl)estra-4,9-dien-3-on zur Behandlung von Morbus Charcot Marie Toot |
SI2983671T1 (sl) | 2013-04-11 | 2020-06-30 | Bayer Pharma Aktiengesellschaft | Dozirna oblika antagonista receptorja progesterona |
EP3417863A1 (en) * | 2015-05-18 | 2018-12-26 | Bayer Pharma Aktiengesellschaft | Selective progesterone receptor modulator (sprm) for use in the treatment of heavy menstrual bleeding |
EP3214092A1 (en) | 2016-03-04 | 2017-09-06 | Bayer Pharma Aktiengesellschaft | Prodrugs of the selective progesterone receptor modulator (sprm) (11.beta.,17.beta.)-17-hydroxy-11-[4-(methylsulphonyl)phenyl]-17-(pentafluoroethyl)estra-4,9-dien-3-one |
JP7086395B2 (ja) | 2016-03-04 | 2022-06-20 | ヴァンダービルト ユニバーシティー | 置換インドールMcl-1阻害剤 |
-
2016
- 2016-03-04 EP EP16158598.9A patent/EP3214092A1/en not_active Withdrawn
-
2017
- 2017-03-01 CN CN201780014127.0A patent/CN108779142A/zh active Pending
- 2017-03-01 RU RU2018134045A patent/RU2018134045A/ru not_active Application Discontinuation
- 2017-03-01 AU AU2017226922A patent/AU2017226922A1/en not_active Abandoned
- 2017-03-01 CR CR20180426A patent/CR20180426A/es unknown
- 2017-03-01 EP EP17707881.3A patent/EP3423466A1/en not_active Withdrawn
- 2017-03-01 WO PCT/EP2017/054704 patent/WO2017148977A1/en active Application Filing
- 2017-03-01 BR BR112018067517A patent/BR112018067517A2/pt not_active IP Right Cessation
- 2017-03-01 CA CA3016369A patent/CA3016369A1/en not_active Abandoned
- 2017-03-01 CO CONC2018/0009264A patent/CO2018009264A2/es unknown
- 2017-03-01 SG SG11201806771RA patent/SG11201806771RA/en unknown
- 2017-03-01 JP JP2018546493A patent/JP2019511486A/ja active Pending
- 2017-03-01 KR KR1020187025053A patent/KR20180118135A/ko not_active Application Discontinuation
- 2017-03-01 MA MA043691A patent/MA43691A/fr unknown
- 2017-03-01 US US16/082,025 patent/US10894805B2/en active Active
- 2017-03-01 MX MX2018010658A patent/MX2018010658A/es unknown
-
2018
- 2018-09-04 CL CL2018002523A patent/CL2018002523A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
US10894805B2 (en) | 2021-01-19 |
MA43691A (fr) | 2021-03-17 |
US20190367555A1 (en) | 2019-12-05 |
SG11201806771RA (en) | 2018-09-27 |
CN108779142A (zh) | 2018-11-09 |
RU2018134045A (ru) | 2020-04-06 |
CR20180426A (es) | 2018-11-21 |
KR20180118135A (ko) | 2018-10-30 |
CO2018009264A2 (es) | 2018-09-20 |
EP3214092A1 (en) | 2017-09-06 |
BR112018067517A2 (pt) | 2019-01-02 |
WO2017148977A1 (en) | 2017-09-08 |
EP3423466A1 (en) | 2019-01-09 |
CA3016369A1 (en) | 2017-09-08 |
AU2017226922A1 (en) | 2018-08-23 |
JP2019511486A (ja) | 2019-04-25 |
RU2018134045A3 (es) | 2020-04-27 |
MX2018010658A (es) | 2019-01-17 |
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