CL2017003427A1 - Anticuerpos para cd40 - Google Patents

Anticuerpos para cd40

Info

Publication number
CL2017003427A1
CL2017003427A1 CL2017003427A CL2017003427A CL2017003427A1 CL 2017003427 A1 CL2017003427 A1 CL 2017003427A1 CL 2017003427 A CL2017003427 A CL 2017003427A CL 2017003427 A CL2017003427 A CL 2017003427A CL 2017003427 A1 CL2017003427 A1 CL 2017003427A1
Authority
CL
Chile
Prior art keywords
antibodies
rllb
tnvention
administrating
union
Prior art date
Application number
CL2017003427A
Other languages
English (en)
Inventor
Aaron P Yamniuk
Bryan C Barnhart
Brigitte Devaux
Brenda L Stevens
Shannon L Okada
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56322325&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2017003427(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CL2017003427A1 publication Critical patent/CL2017003427A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

<p>LA PRESENTE INVENCIÓN SE REFIERE ANTICUERPOS AGONISTAS, O PORCIONES DE UNIÓN AL ANTÍGENO DEL MISMO QUE SE UNEN A CD40 HUMANO. TALES ANTICUERPOS COMPRENDEN OPCIONALMENTE REGIONES FC CON ESPECIFICIDAD MEJORADA PARA FC?RLLB. LA INVENCIÓN TAMBIÉN PROPORCIONA MÉTODOS PARA EL TRATAMIENTO DE CÁNCER O INFECCIÓN CRÓNICA ADMINISTRANDO LOS ANTICUERPOS DE LA TNVENCIÓN A UN SUJETO EN NECESIDAD DEL MISMO.</p>
CL2017003427A 2015-06-29 2017-12-28 Anticuerpos para cd40 CL2017003427A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562186076P 2015-06-29 2015-06-29
US201562252615P 2015-11-09 2015-11-09

Publications (1)

Publication Number Publication Date
CL2017003427A1 true CL2017003427A1 (es) 2018-05-04

Family

ID=56322325

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2017003427A CL2017003427A1 (es) 2015-06-29 2017-12-28 Anticuerpos para cd40
CL2022001189A CL2022001189A1 (es) 2015-06-29 2022-05-04 Anticuerpos para cd40. (divisional de solicitud n° 2017003427)

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2022001189A CL2022001189A1 (es) 2015-06-29 2022-05-04 Anticuerpos para cd40. (divisional de solicitud n° 2017003427)

Country Status (16)

Country Link
US (3) US20180142030A1 (es)
EP (1) EP3313880A1 (es)
JP (2) JP7350467B2 (es)
CN (2) CN107771184B (es)
AU (2) AU2016285913B2 (es)
BR (1) BR112017027549A2 (es)
CA (1) CA2990012A1 (es)
CL (2) CL2017003427A1 (es)
CO (1) CO2018000809A2 (es)
EA (1) EA035268B1 (es)
HK (1) HK1252666A1 (es)
IL (1) IL256499B (es)
MX (2) MX2017016253A (es)
PE (1) PE20180315A1 (es)
WO (1) WO2017004006A1 (es)
ZA (1) ZA201708704B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3556774T (pt) 2011-03-11 2024-02-29 Beth Israel Deaconess Medical Ct Inc Anticorpos anti-cd40 e suas utilizações
SG11201701070WA (en) 2014-08-12 2017-03-30 Alligator Bioscience Ab Combination therapies with anti cd40 antibodies
JP2018526977A (ja) * 2015-06-29 2018-09-20 ザ ロックフェラー ユニヴァーシティ アゴニスト活性が増強されたｃｄ４０に対する抗体
MX2018002708A (es) 2015-09-04 2018-08-01 Primatope Therapeutics Inc Anticuerpos anti-cd40 humanizados y usos de los mismos.
IL261602B1 (en) 2016-03-04 2024-02-01 Univ Rockefeller CD40 antibodies with increased agonistic activity
EP4371570A2 (en) 2016-06-08 2024-05-22 Xencor, Inc. Treatment of igg4-related diseases with anti-cd19 antibodies crossbinding to cd32b
CN109475603B (zh) 2016-06-20 2023-06-13 科马布有限公司 抗pd-l1抗体
EP3630831B1 (en) 2017-05-25 2022-06-15 Bristol-Myers Squibb Company Antagonistic cd40 monoclonal antibodies and uses thereof
EP3632932A4 (en) 2017-06-01 2021-08-18 Jiangsu Hengrui Medicine Co. Ltd. ANTI-CD40 ANTIBODIES, ANTIGEN BINDING FRAGMENT OF THIS ANTIGEN AND ASSOCIATED MEDICAL USE
KR20200103761A (ko) 2017-12-27 2020-09-02 브리스톨-마이어스 스큅 컴퍼니 항-cd40 항체 및 그의 용도
JP7212138B2 (ja) 2018-07-20 2023-01-24 ヨウキュア（ベイジン）バイオファーマ カンパニー リミテッド 抗ｃｄ４０抗体及びその使用
AR117091A1 (es) * 2018-11-19 2021-07-07 Bristol Myers Squibb Co Anticuerpos monoclonales antagonistas contra cd40 y sus usos
MX2021006360A (es) 2018-11-30 2021-08-11 Jiangsu Hengrui Medicine Co Composicion farmaceutica de anticuerpo cd40 y uso de la misma.
WO2020108611A1 (zh) 2018-11-30 2020-06-04 江苏恒瑞医药股份有限公司 抗cd40抗体、其抗原结合片段及其医药用途
US10570210B1 (en) * 2019-03-04 2020-02-25 Beijing Mabworks Biotech Co.Ltd Antibodies binding CD40 and uses thereof
US20220324988A1 (en) 2019-04-10 2022-10-13 Nankai University Anti-CD40 antibodies and uses thereof
JP2023516459A (ja) 2020-03-09 2023-04-19 ブリストル－マイヤーズ スクイブ カンパニー 増強されたアゴニスト活性を有するｃｄ４０に対する抗体
IL296880A (en) * 2020-05-06 2022-12-01 Navicure Biopharmaceuticals Ltd Fusion proteins for immunotherapy against cancer and infectious diseases
CN115403670A (zh) * 2021-05-26 2022-11-29 安徽瀚海博兴生物技术有限公司 抗cd40抗体及其用途
WO2023019129A1 (en) * 2021-08-10 2023-02-16 Apexigen, Inc. Biomarkers for cd40 agonist therapy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR039067A1 (es) * 2001-11-09 2005-02-09 Pfizer Prod Inc Anticuerpos para cd40
US8188231B2 (en) 2002-09-27 2012-05-29 Xencor, Inc. Optimized FC variants
CA2824278C (en) * 2010-12-20 2022-09-20 The Rockefeller University Modulating agonistic tnfr antibodies
KR20230005405A (ko) 2011-02-25 2023-01-09 추가이 세이야쿠 가부시키가이샤 ＦｃγＲＩＩｂ 특이적 Ｆｃ 항체
CN105611944A (zh) 2013-12-20 2016-05-25 豪夫迈·罗氏有限公司 抗ang2抗体和cd40激动剂的组合疗法
US11059898B2 (en) 2014-03-24 2021-07-13 Cancer Research Technology Limited Modified antibodies containing modified IGG2 domains which elicit agonist or antagonistic properties and use thereof
US20170233485A1 (en) * 2014-08-18 2017-08-17 Biogen Ma Inc. Anti-cd40 antibodies and uses thereof
JP2018526977A (ja) * 2015-06-29 2018-09-20 ザ ロックフェラー ユニヴァーシティ アゴニスト活性が増強されたｃｄ４０に対する抗体
IL261602B1 (en) * 2016-03-04 2024-02-01 Univ Rockefeller CD40 antibodies with increased agonistic activity

Also Published As

Publication number Publication date
CN115838427A (zh) 2023-03-24
EA035268B1 (ru) 2020-05-22
CL2022001189A1 (es) 2023-01-20
CN107771184A (zh) 2018-03-06
KR20180021834A (ko) 2018-03-05
JP2022028666A (ja) 2022-02-16
US20210054091A1 (en) 2021-02-25
EP3313880A1 (en) 2018-05-02
MX2022002504A (es) 2022-04-06
ZA201708704B (en) 2019-08-28
CN107771184B (zh) 2022-11-01
US10844130B2 (en) 2020-11-24
PE20180315A1 (es) 2018-02-09
WO2017004006A1 (en) 2017-01-05
HK1252666A1 (zh) 2019-05-31
AU2016285913B2 (en) 2022-06-16
IL256499B (en) 2021-12-01
CO2018000809A2 (es) 2018-04-19
JP7350467B2 (ja) 2023-09-26
BR112017027549A2 (pt) 2018-09-11
AU2022228155A1 (en) 2022-11-10
MX2017016253A (es) 2018-04-20
JP2018526978A (ja) 2018-09-20
AU2016285913A1 (en) 2018-02-15
EA201890175A1 (ru) 2018-06-29
US20180142030A1 (en) 2018-05-24
US20190248911A1 (en) 2019-08-15
IL256499A (en) 2018-02-28
CA2990012A1 (en) 2017-01-05

Similar Documents

Publication Publication Date Title
CL2017003427A1 (es) Anticuerpos para cd40
UY36757A (es) Anticuerpos monoclonales murinos contra cd40 con actividad agonista mejorada
CY1124033T1 (el) Δοσολογια και χορηγηση μη φουκοζυλιωμενων αντισωματων anti-cd40
BR112018014016A2 (pt) combinação de um agonista de ox40 e um agonista de anticorpo monoclonal 4-1bb para tratamento de câncer
EA201790545A1 (ru) Антитела и иммуноконъюгаты против her2
EA201790984A1 (ru) Анти-cd79b антитела и способы их применения
ECSP17011657A (es) Conjugados de fármacos con anticuerpos anti-cdh6
EA201691974A1 (ru) Антитела против ox40 и способы их применения
EA201790569A1 (ru) Антитела и иммуноконъюгаты против cll-1
EA201791310A1 (ru) Химерные антигенные рецепторы к bcma
EA201691991A1 (ru) Мультиспецифические антитела
AR104847A1 (es) Formulación de anticuerpo anti-cgrp
EA201791884A1 (ru) Химерные антигенные рецепторы против dll3 и способы применения
EA201692201A1 (ru) Соединения и композиции в качестве агонистов toll-подобного рецептора 7
EA201890530A1 (ru) Конъюгаты антитела к dll3 и лекарственного средства и способы их применения
EA201691610A1 (ru) Анти-jagged1 антитела и способы применения
CL2017002983A1 (es) Terapia combinada de un anticuerpo anti-cd-20 con un inhibidor de bcl-2 y un inhibidor de mdm2
CL2017003147A1 (es) Moduladores de receptor nuclear
EA201691541A1 (ru) Новые анти-baff антитела
CL2018000597A1 (es) Métodos para tratar enfermedades inflamatorias
BR112017012381A2 (pt) imunoterapia para doença angiogênica
EA201791454A1 (ru) Лекарственные формы для трансдермального введения
EA201790529A1 (ru) Новые антитела против mfi2 и способы их применения
CU24407B1 (es) Moduladores de pirrolopiridina de rorc2 sustituidos con metilo y trifluorometilo
EA201790312A1 (ru) Комбинации лекарственных средств для лечения множественной миеломы