CL2017002420A1 - Detección de lesión cerebral - Google Patents
Detección de lesión cerebralInfo
- Publication number
- CL2017002420A1 CL2017002420A1 CL2017002420A CL2017002420A CL2017002420A1 CL 2017002420 A1 CL2017002420 A1 CL 2017002420A1 CL 2017002420 A CL2017002420 A CL 2017002420A CL 2017002420 A CL2017002420 A CL 2017002420A CL 2017002420 A1 CL2017002420 A1 CL 2017002420A1
- Authority
- CL
- Chile
- Prior art keywords
- tbi
- brain injury
- victims
- cte
- neuronal damage
- Prior art date
Links
- 208000029028 brain injury Diseases 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 title 1
- 208000030886 Traumatic Brain injury Diseases 0.000 abstract 4
- 230000009529 traumatic brain injury Effects 0.000 abstract 4
- 208000004051 Chronic Traumatic Encephalopathy Diseases 0.000 abstract 3
- 208000017004 dementia pugilistica Diseases 0.000 abstract 3
- 230000003961 neuronal insult Effects 0.000 abstract 2
- 230000003542 behavioural effect Effects 0.000 abstract 1
- 230000005779 cell damage Effects 0.000 abstract 1
- 208000037887 cell injury Diseases 0.000 abstract 1
- 230000008809 cell oxidative stress Effects 0.000 abstract 1
- 230000002596 correlated effect Effects 0.000 abstract 1
- 238000011156 evaluation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108091027963 non-coding RNA Proteins 0.000 abstract 1
- 102000042567 non-coding RNA Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- Psychiatry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/669,454 US9605315B2 (en) | 2014-03-26 | 2015-03-26 | Detection of traumatic brain injury |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2017002420A1 true CL2017002420A1 (es) | 2018-07-13 |
Family
ID=56979279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017002420A CL2017002420A1 (es) | 2015-03-26 | 2017-09-26 | Detección de lesión cerebral |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9605315B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3274008B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2018518147A (cg-RX-API-DMAC7.html) |
| CN (1) | CN107427614B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2015387481B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2976347A1 (cg-RX-API-DMAC7.html) |
| CL (1) | CL2017002420A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES3014311T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL253889A0 (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201707332XA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016153549A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6021893B2 (ja) | 2011-04-18 | 2016-11-09 | ディアミール, エルエルシーDiamir, Llc | 軽度認知機能障害（ＭＣＩ）およびアルツハイマー病（ＡＤ）の早期検出ならびにモニタリングのために体液からのｍｉＲＮＡを使用する方法 |
| ES2813699T3 (es) | 2013-11-18 | 2021-03-24 | Diamir Llc | Métodos de uso de miARN de fluidos corporales para la detección y monitoreo de la enfermedad de Parkinson (PD) |
| WO2017087726A1 (en) * | 2015-11-18 | 2017-05-26 | Dignity Health | Methods of diagnosing epilepsy |
| US10975436B2 (en) | 2016-01-05 | 2021-04-13 | Diamir, Llc | Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders |
| GB201603967D0 (en) * | 2016-03-08 | 2016-04-20 | Univ Birmingham | Biomarkers of traumatic brain injury |
| WO2017165458A1 (en) | 2016-03-21 | 2017-09-28 | Diamir, Llc | Methods of using mirnas from bodily fluids for detection and differentiation of neurodegenerative diseases |
| CN108300788B (zh) * | 2017-01-13 | 2021-07-09 | 中国人民解放军南京军区南京总医院 | 一种用于检测轻型脑外伤的微小核糖核酸组合及其应用 |
| KR102621064B1 (ko) * | 2017-03-23 | 2024-01-03 | 콰드런트 바이오사이언시즈 인코포레이티드 | 외상성 뇌 손상 및 뇌진탕 증상의 분석 및 예측 |
| US10781487B2 (en) | 2017-07-24 | 2020-09-22 | Diamir, Llc | miRNA-based methods for detecting and monitoring aging |
| MA52796A (fr) * | 2018-05-31 | 2021-04-14 | Amydis Inc | Compositions et procédés de détection d'une lésion cérébrale traumatique |
| WO2025039033A1 (en) * | 2023-08-21 | 2025-02-27 | Glia Diagnostics Pty Ltd | Methods and reagents for diagnosis and/or prognosis of traumatic brain injury |
| CN118314963B (zh) * | 2023-11-13 | 2024-10-29 | 中国人民解放军空军特色医学中心 | 一种基于lasso回归的血小板储存损伤风险预测模型及其构建方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL145209A0 (en) * | 2000-09-06 | 2002-06-30 | Pfizer Prod Inc | Pharmaceutical combinations for the treatment of stroke and traumatic brain injury |
| AU2003237379A1 (en) | 2002-06-10 | 2003-12-22 | Oklahoma Medical Research Foundation | A method for using tethered bis(polyhydroxyphenyls) and o-alkyl derivatives thereof in treating inflammatory conditions of the central nervous system |
| WO2009132273A2 (en) * | 2008-04-25 | 2009-10-29 | Merck & Co., Inc. | Microrna biomarkers of tissue injury |
| WO2011032155A2 (en) * | 2009-09-14 | 2011-03-17 | Banyan Biomarkers, Inc. | Micro-rna, autoantibody and protein markers for diagnosis of neuronal injury |
| EP2611918A1 (en) * | 2010-05-28 | 2013-07-10 | Vereniging Voor Christelijk Hoger Onderwijs, Weten | Mirnas involved in the blood brain barrier function |
| TW201231671A (en) * | 2011-01-28 | 2012-08-01 | Univ Kaohsiung Medical | Method and kit for in vitro diagnosis of atherosclerosis |
| WO2013032962A2 (en) | 2011-08-28 | 2013-03-07 | The Board Of Trustees Of The Leland Stanford Junior University | Micro rnas to treat stroke, ischemic brain injury, traumatic brain injury, and neurodegenerative disease |
| EP2756102B1 (en) * | 2011-09-13 | 2019-04-24 | Commonwealth Scientific and Industrial Research Organisation | Detection of viral infection |
| AU2013219799C1 (en) * | 2012-02-15 | 2017-12-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of treating and preventing diseases and disorders of the central nervous system |
| US9101580B2 (en) * | 2012-12-18 | 2015-08-11 | Matthew Bennett | Compositions and methods for treating traumatic brain injury |
-
2015
- 2015-03-26 US US14/669,454 patent/US9605315B2/en active Active
- 2015-09-22 ES ES15886700T patent/ES3014311T3/es active Active
- 2015-09-22 JP JP2017541658A patent/JP2018518147A/ja active Pending
- 2015-09-22 CN CN201580077882.4A patent/CN107427614B/zh active Active
- 2015-09-22 WO PCT/US2015/051518 patent/WO2016153549A1/en not_active Ceased
- 2015-09-22 AU AU2015387481A patent/AU2015387481B2/en active Active
- 2015-09-22 CA CA2976347A patent/CA2976347A1/en active Pending
- 2015-09-22 SG SG11201707332XA patent/SG11201707332XA/en unknown
- 2015-09-22 EP EP15886700.2A patent/EP3274008B1/en active Active
-
2017
- 2017-02-14 US US15/432,172 patent/US10202649B2/en active Active
- 2017-08-07 IL IL253889A patent/IL253889A0/en unknown
- 2017-09-26 CL CL2017002420A patent/CL2017002420A1/es unknown
-
2018
- 2018-12-17 US US16/222,864 patent/US10815529B2/en active Active
-
2021
- 2021-10-29 AU AU2021258088A patent/AU2021258088B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2015387481A1 (en) | 2017-08-03 |
| EP3274008A4 (en) | 2018-10-24 |
| IL253889A0 (en) | 2017-10-31 |
| CN107427614A (zh) | 2017-12-01 |
| EP3274008C0 (en) | 2024-12-04 |
| US9605315B2 (en) | 2017-03-28 |
| AU2021258088A1 (en) | 2021-11-25 |
| SG11201707332XA (en) | 2017-10-30 |
| AU2021258088B2 (en) | 2024-11-28 |
| US20170268058A1 (en) | 2017-09-21 |
| CA2976347A1 (en) | 2016-09-29 |
| WO2016153549A1 (en) | 2016-09-29 |
| US10815529B2 (en) | 2020-10-27 |
| US20190352716A1 (en) | 2019-11-21 |
| ES3014311T3 (en) | 2025-04-21 |
| US10202649B2 (en) | 2019-02-12 |
| CN107427614B (zh) | 2021-10-15 |
| JP2018518147A (ja) | 2018-07-12 |
| EP3274008A1 (en) | 2018-01-31 |
| AU2015387481B2 (en) | 2021-08-05 |
| US20150344954A1 (en) | 2015-12-03 |
| EP3274008B1 (en) | 2024-12-04 |
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