CL2017000582A1 - Nuevos compuestos derivados de piridopirimidinas - Google Patents

Nuevos compuestos derivados de piridopirimidinas

Info

Publication number
CL2017000582A1
CL2017000582A1 CL2017000582A CL2017000582A CL2017000582A1 CL 2017000582 A1 CL2017000582 A1 CL 2017000582A1 CL 2017000582 A CL2017000582 A CL 2017000582A CL 2017000582 A CL2017000582 A CL 2017000582A CL 2017000582 A1 CL2017000582 A1 CL 2017000582A1
Authority
CL
Chile
Prior art keywords
compounds derived
new compounds
pyridopyrimidines
inhibitor
synthesis
Prior art date
Application number
CL2017000582A
Other languages
English (en)
Inventor
Nucci Gilberto De
Original Assignee
Biolab Sanus Farmacêutica Ltda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biolab Sanus Farmacêutica Ltda filed Critical Biolab Sanus Farmacêutica Ltda
Publication of CL2017000582A1 publication Critical patent/CL2017000582A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

<p>LA PRESENTE INVENCIÓN DESCRIBE NUEVOS COMPUESTOS DERIVADOS DE PIRIDOPIRIMIDINA CON ESTRUCTURA REPRESENTADA POR LA FÓRMULA GENERAL (I) O SALES FARMACÉUTICAMENTE ACEPTABLES, O SUS MEZCLAS (EN CUALQUIER PROPORCIÓN), UNA COMPOSICIÓN FARMACÉUTICA QUE LOS CONTIENE, UN MÉTODO DE USO DE LOS NUEVOS COMPUESTOS DERIVADOS DE PIRIDOPIRIMIDINA COMO INHIBIDOR DE LA SÍNTESIS DE NUCLEÓTIDOS CÍCLICOS O COMO INHIBIDOR DE LA SÍNTESIS DE cAMP y cGMP, Y SUS USOS EN EL TRATAMIENTO PROFILÁCTICO O CURATIVO DE LA DIARREA, COLITIS Y SÍNDROME DEL INTESTINO IRRITABLE.</p>
CL2017000582A 2014-09-12 2017-03-09 Nuevos compuestos derivados de piridopirimidinas CL2017000582A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462049506P 2014-09-12 2014-09-12

Publications (1)

Publication Number Publication Date
CL2017000582A1 true CL2017000582A1 (es) 2017-11-24

Family

ID=55454107

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017000582A CL2017000582A1 (es) 2014-09-12 2017-03-09 Nuevos compuestos derivados de piridopirimidinas

Country Status (18)

Country Link
US (2) US10280162B2 (es)
EP (1) EP3191099B1 (es)
JP (1) JP6661606B2 (es)
KR (1) KR20170054408A (es)
CN (2) CN107074847A (es)
AR (1) AR101813A1 (es)
AU (1) AU2015316120B2 (es)
BR (1) BR112017004919A2 (es)
CA (1) CA2958331C (es)
CL (1) CL2017000582A1 (es)
CO (1) CO2017001709A2 (es)
ES (1) ES2701273T3 (es)
HU (1) HUE040387T2 (es)
IL (1) IL250968B (es)
MX (1) MX2017003067A (es)
PL (1) PL3191099T3 (es)
PT (1) PT3191099T (es)
WO (1) WO2016037255A2 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170204089A1 (en) 2014-08-04 2017-07-20 Drexel University Novel compounds and methods of treating or ameliorating an il-1r-mediated disease or disorder using same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02012659A (es) 2000-06-26 2003-09-22 Lilly Icos Llc Derivados de pirazindiona condensados.
CN1275964C (zh) 2000-08-31 2006-09-20 霍夫曼-拉罗奇有限公司 作为细胞增殖抑制剂的7－氧代吡啶并嘧啶
CA2427608C (en) * 2000-11-08 2010-05-04 Lilly Icos Llc Condensed pyradizindione derivatives as pde inhibitors
FR2896246B1 (fr) * 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
DE602007006947D1 (de) * 2006-05-23 2010-07-15 Hoffmann La Roche Pyridopyrimidinonderivate
US20100035867A1 (en) * 2006-07-11 2010-02-11 Guerrant Richard L Inhibitors of Cyclic Nucleotide Synthesis and Their Use for Therapy of Various Diseases
US7474231B2 (en) * 2006-07-12 2009-01-06 Alcatel-Lucent Usa Inc. Radio communications for vehicle speed adjustment
UY33535A (es) * 2010-08-13 2011-12-01 Biolab Sanus Farmaceutuca Limitada Derivados de 6,7-dihidro-3h-oxazolo[3,4]pirazin-5,8-diona
US20150152101A1 (en) * 2012-06-06 2015-06-04 L'oreal Active compounds for combating greasy skin

Also Published As

Publication number Publication date
BR112017004919A2 (pt) 2017-12-12
KR20170054408A (ko) 2017-05-17
CN114751905A (zh) 2022-07-15
AU2015316120B2 (en) 2018-05-17
IL250968A0 (en) 2017-04-30
CA2958331A1 (en) 2016-03-17
WO2016037255A2 (en) 2016-03-17
US20180111926A2 (en) 2018-04-26
HUE040387T2 (hu) 2019-03-28
AU2015316120A1 (en) 2017-01-12
PT3191099T (pt) 2018-12-18
CN107074847A (zh) 2017-08-18
US10280162B2 (en) 2019-05-07
CA2958331C (en) 2019-12-17
EP3191099A2 (en) 2017-07-19
US10822333B2 (en) 2020-11-03
US20160075702A1 (en) 2016-03-17
JP6661606B2 (ja) 2020-03-11
WO2016037255A3 (en) 2016-06-30
MX2017003067A (es) 2017-06-14
IL250968B (en) 2020-03-31
AR101813A1 (es) 2017-01-11
PL3191099T3 (pl) 2019-07-31
ES2701273T3 (es) 2019-02-21
CO2017001709A2 (es) 2017-03-31
EP3191099B1 (en) 2018-11-14
JP2017526666A (ja) 2017-09-14
US20190218216A1 (en) 2019-07-18

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