CL2017000088A1 - Nueva combinación fija de adapaleno y peróxido de benzoílo para el tratamiento del acné grave. - Google Patents
Nueva combinación fija de adapaleno y peróxido de benzoílo para el tratamiento del acné grave.Info
- Publication number
- CL2017000088A1 CL2017000088A1 CL2017000088A CL2017000088A CL2017000088A1 CL 2017000088 A1 CL2017000088 A1 CL 2017000088A1 CL 2017000088 A CL2017000088 A CL 2017000088A CL 2017000088 A CL2017000088 A CL 2017000088A CL 2017000088 A1 CL2017000088 A1 CL 2017000088A1
- Authority
- CL
- Chile
- Prior art keywords
- adapalene
- treatment
- acne
- weight
- benzoyl peroxide
- Prior art date
Links
- 208000002874 Acne Vulgaris Diseases 0.000 title abstract 4
- 206010000496 acne Diseases 0.000 title abstract 4
- LZCDAPDGXCYOEH-UHFFFAOYSA-N adapalene Chemical compound C1=C(C(O)=O)C=CC2=CC(C3=CC=C(C(=C3)C34CC5CC(CC(C5)C3)C4)OC)=CC=C21 LZCDAPDGXCYOEH-UHFFFAOYSA-N 0.000 title abstract 3
- 229960002916 adapalene Drugs 0.000 title abstract 3
- 239000004342 Benzoyl peroxide Substances 0.000 title 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 title 1
- 235000019400 benzoyl peroxide Nutrition 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 2
- 230000006378 damage Effects 0.000 abstract 2
- 150000002978 peroxides Chemical class 0.000 abstract 2
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/327—Peroxy compounds, e.g. hydroperoxides, peroxides, peroxyacids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
<p>LA PRESENTE INVENCIÓN SE RELACIONA CON UNA COMPOSICIÓN FARMACÉUTICA QUE COMPRENDE 0,3 % POR PESO DE ADAPALENO, O ALGUNA DE SUS SALES FARMACÉUTICAMENTE ACEPTABLES, Y 2,5 % POR PESO DE PERÓXIDO DE BENZOÍLO, COMO INGREDIENTES ACTIVOS, DESTINADA AL USO EN LA ADMINISTRACIÓN TÓPICA EN EL TRATAMIENTO DE LAS LESIONES INFLAMATORIAS POR ACNÉ. LA PRESENTE INVENCIÓN TAMBIÉN SE RELACIONA CON UN RÉGIMEN DE TRATAMIENTO TERAPÉUTICO PARA LAS LESIONES POR ACNÉ DE UN SUJETO QUE SUFRE DE ACNÉ GRAVE. EL RÉGIMEN INCLUYE LA APLICACIÓN TÓPICA SOBRE LA PIEL DE DICHO SUJETO, COMO INGREDIENTES ACTIVOS, DE 0,3 % POR PESO DE ADAPALENO Y 2,5% POR PESO DE PERÓXIDO DE BENZOÍLO, COMBINADOS EN UNA FORMULA ÚNICA QUE LIBERA CONJUNTAMENTE DICHOS INGREDIENTES ACTIVOS. POR EJEMPLO, LA FÓRMULA ÚNICA SE PUEDE APLICAR UNA O DOS VECES AL DÍA POR UN PERÍODO DE 8 A 12 SEMANAS.</p>
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462029043P | 2014-07-25 | 2014-07-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2017000088A1 true CL2017000088A1 (es) | 2017-09-01 |
Family
ID=53540775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017000088A CL2017000088A1 (es) | 2014-07-25 | 2017-01-13 | Nueva combinación fija de adapaleno y peróxido de benzoílo para el tratamiento del acné grave. |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US20170216231A1 (es) |
| EP (1) | EP3171857B1 (es) |
| KR (1) | KR20170035916A (es) |
| CN (1) | CN107072939A (es) |
| AU (1) | AU2015294100A1 (es) |
| BR (1) | BR112017001434A2 (es) |
| CL (1) | CL2017000088A1 (es) |
| CY (1) | CY1124107T1 (es) |
| DK (1) | DK3171857T3 (es) |
| ES (1) | ES2828699T3 (es) |
| HR (1) | HRP20201787T1 (es) |
| HU (1) | HUE051351T2 (es) |
| IL (1) | IL250199A0 (es) |
| LT (1) | LT3171857T (es) |
| MA (1) | MA40179B1 (es) |
| MX (1) | MX2017000717A (es) |
| PT (1) | PT3171857T (es) |
| RS (1) | RS61017B1 (es) |
| RU (1) | RU2017105074A (es) |
| SG (1) | SG11201700449RA (es) |
| SI (1) | SI3171857T1 (es) |
| TW (1) | TW201609082A (es) |
| WO (1) | WO2016012352A1 (es) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2833841B1 (fr) | 2001-12-21 | 2005-07-22 | Galderma Res & Dev | Gel comprenant au moins un retinoide et du peroxyde de benzoyle |
| EP1485080B1 (en) * | 2002-03-12 | 2009-05-27 | Galderma Research & Development | Use of adapalene for the treatment of dermatological disorders |
| FR2903603B1 (fr) | 2006-07-13 | 2009-03-20 | Galderma Res & Dev S N C Snc | Combinaison d'adapalene et de peroxyde de benzole dans le traitement de l'acne |
| FR2909000B1 (fr) * | 2006-11-28 | 2009-02-06 | Galderma Res & Dev S N C Snc | Compositions comprenant du peroxyde de benzoyle, au moins un derive de l'acide naphtoique et au moins un compose de type polymeres de polyurethane ou des derives de celui-ci, et leurs utilisations. |
| FR2910321B1 (fr) * | 2006-12-21 | 2009-07-10 | Galderma Res & Dev S N C Snc | Gel creme comprenant au moins un retinoide et du peroxyde de benzole |
| EP2282731A1 (en) * | 2008-04-24 | 2011-02-16 | Galderma Research & Development | Combination therapy for acne vulgaris comprising adapalene 0.3% gel with clindamycin/benzoyl peroxide gel |
| WO2012129499A1 (en) * | 2011-03-23 | 2012-09-27 | The Regents Of The University Of California | Treatment of inflammatory and infectious skin disorders |
| JP2017500328A (ja) * | 2013-12-19 | 2017-01-05 | ガルデルマ・リサーチ・アンド・デヴェロップメント | 重度のざ瘡に関連した疾患を処置する治療レジメン |
-
2015
- 2015-07-16 DK DK15736304.5T patent/DK3171857T3/da active
- 2015-07-16 PT PT157363045T patent/PT3171857T/pt unknown
- 2015-07-16 BR BR112017001434A patent/BR112017001434A2/pt not_active Application Discontinuation
- 2015-07-16 US US15/329,170 patent/US20170216231A1/en not_active Abandoned
- 2015-07-16 SI SI201531367T patent/SI3171857T1/sl unknown
- 2015-07-16 KR KR1020177002234A patent/KR20170035916A/ko unknown
- 2015-07-16 EP EP15736304.5A patent/EP3171857B1/en active Active
- 2015-07-16 WO PCT/EP2015/066331 patent/WO2016012352A1/en active Application Filing
- 2015-07-16 MX MX2017000717A patent/MX2017000717A/es unknown
- 2015-07-16 LT LTEP15736304.5T patent/LT3171857T/lt unknown
- 2015-07-16 MA MA40179A patent/MA40179B1/fr unknown
- 2015-07-16 RS RS20201325A patent/RS61017B1/sr unknown
- 2015-07-16 HU HUE15736304A patent/HUE051351T2/hu unknown
- 2015-07-16 RU RU2017105074A patent/RU2017105074A/ru not_active Application Discontinuation
- 2015-07-16 SG SG11201700449RA patent/SG11201700449RA/en unknown
- 2015-07-16 AU AU2015294100A patent/AU2015294100A1/en not_active Abandoned
- 2015-07-16 CN CN201580040433.2A patent/CN107072939A/zh active Pending
- 2015-07-16 ES ES15736304T patent/ES2828699T3/es active Active
- 2015-07-24 TW TW104124153A patent/TW201609082A/zh unknown
-
2016
- 2016-12-19 US US15/383,675 patent/US20170095434A1/en not_active Abandoned
-
2017
- 2017-01-13 CL CL2017000088A patent/CL2017000088A1/es unknown
- 2017-01-19 IL IL250199A patent/IL250199A0/en unknown
-
2020
- 2020-10-13 CY CY20201100967T patent/CY1124107T1/el unknown
- 2020-11-09 HR HRP20201787TT patent/HRP20201787T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2017000717A (es) | 2017-05-01 |
| RU2017105074A3 (es) | 2019-01-15 |
| PT3171857T (pt) | 2020-11-19 |
| DK3171857T3 (da) | 2020-09-21 |
| HUE051351T2 (hu) | 2021-03-01 |
| CN107072939A (zh) | 2017-08-18 |
| BR112017001434A2 (pt) | 2017-12-05 |
| ES2828699T3 (es) | 2021-05-27 |
| US20170095434A1 (en) | 2017-04-06 |
| MA40179B1 (fr) | 2020-10-28 |
| EP3171857B1 (en) | 2020-08-19 |
| LT3171857T (lt) | 2021-01-11 |
| AU2015294100A1 (en) | 2017-01-12 |
| HRP20201787T1 (hr) | 2021-04-16 |
| RS61017B1 (sr) | 2020-12-31 |
| WO2016012352A1 (en) | 2016-01-28 |
| KR20170035916A (ko) | 2017-03-31 |
| SI3171857T1 (sl) | 2021-01-29 |
| TW201609082A (zh) | 2016-03-16 |
| IL250199A0 (en) | 2017-03-30 |
| SG11201700449RA (en) | 2017-02-27 |
| RU2017105074A (ru) | 2018-08-27 |
| EP3171857A1 (en) | 2017-05-31 |
| US20170216231A1 (en) | 2017-08-03 |
| CY1124107T1 (el) | 2022-03-24 |
| MA40179A (fr) | 2017-05-31 |
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