CL2015000886A1 - Compuestos derivados de azaindolinas sustituidas, inhibidores de la union de proteinas smac al inhibidor de proteinas de apoptosis (iap) y/o inhibidores de la union de proteina caspasa activada a los iap; composicion farmaceutica que los comprende; metodo para tratar o mejorar un cancer; y su uso para el tratamiento terapeutico y/o profilactico del cancer. - Google Patents

Compuestos derivados de azaindolinas sustituidas, inhibidores de la union de proteinas smac al inhibidor de proteinas de apoptosis (iap) y/o inhibidores de la union de proteina caspasa activada a los iap; composicion farmaceutica que los comprende; metodo para tratar o mejorar un cancer; y su uso para el tratamiento terapeutico y/o profilactico del cancer.

Info

Publication number
CL2015000886A1
CL2015000886A1 CL2015000886A CL2015000886A CL2015000886A1 CL 2015000886 A1 CL2015000886 A1 CL 2015000886A1 CL 2015000886 A CL2015000886 A CL 2015000886A CL 2015000886 A CL2015000886 A CL 2015000886A CL 2015000886 A1 CL2015000886 A1 CL 2015000886A1
Authority
CL
Chile
Prior art keywords
iap
inhibitors
cancer
protein binding
azaindolins
Prior art date
Application number
CL2015000886A
Other languages
English (en)
Inventor
Joan Heather Hogg
Robert Francis Kester
Weiling Liang
Weiya Yun
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2015000886A1 publication Critical patent/CL2015000886A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CL2015000886A 2012-10-11 2015-04-08 Compuestos derivados de azaindolinas sustituidas, inhibidores de la union de proteinas smac al inhibidor de proteinas de apoptosis (iap) y/o inhibidores de la union de proteina caspasa activada a los iap; composicion farmaceutica que los comprende; metodo para tratar o mejorar un cancer; y su uso para el tratamiento terapeutico y/o profilactico del cancer. CL2015000886A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261712305P 2012-10-11 2012-10-11

Publications (1)

Publication Number Publication Date
CL2015000886A1 true CL2015000886A1 (es) 2015-07-17

Family

ID=49304982

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015000886A CL2015000886A1 (es) 2012-10-11 2015-04-08 Compuestos derivados de azaindolinas sustituidas, inhibidores de la union de proteinas smac al inhibidor de proteinas de apoptosis (iap) y/o inhibidores de la union de proteina caspasa activada a los iap; composicion farmaceutica que los comprende; metodo para tratar o mejorar un cancer; y su uso para el tratamiento terapeutico y/o profilactico del cancer.

Country Status (19)

Country Link
US (1) US9309248B2 (es)
EP (1) EP2906559B1 (es)
JP (1) JP6333826B2 (es)
KR (1) KR20150067182A (es)
CN (1) CN104540825B (es)
AU (1) AU2013328870A1 (es)
CA (1) CA2880324A1 (es)
CL (1) CL2015000886A1 (es)
CR (1) CR20150148A (es)
EA (1) EA201590656A1 (es)
ES (1) ES2623304T3 (es)
HK (1) HK1206738A1 (es)
IL (1) IL237115A (es)
MA (1) MA38009B1 (es)
MX (1) MX2015004525A (es)
PE (1) PE20150965A1 (es)
PH (1) PH12015500399A1 (es)
SG (1) SG11201501314TA (es)
WO (1) WO2014056871A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016079527A1 (en) 2014-11-19 2016-05-26 Tetralogic Birinapant Uk Ltd Combination therapy
WO2016097773A1 (en) 2014-12-19 2016-06-23 Children's Cancer Institute Therapeutic iap antagonists for treating proliferative disorders
JP2019522633A (ja) 2016-05-20 2019-08-15 ジェネンテック， インコーポレイテッド Ｐｒｏｔａｃ抗体コンジュゲート及び使用方法
BR112020000010A2 (pt) * 2017-07-06 2020-07-21 Janssen Pharmaceutica Nv derivados substituídos de azaindolina como inibidores de nik
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2118985A1 (en) * 1993-04-02 1994-10-03 Dinesh V. Patel Heterocyclic inhibitors of farnesyl protein transferase
CA2447999C (en) * 2001-05-23 2011-04-26 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
WO2006017295A2 (en) * 2004-07-12 2006-02-16 Idun Pharmaceuticals, Inc. Tetrapeptide analogs
EP1907388A1 (en) 2005-07-15 2008-04-09 F. Hoffmann-Roche AG Novel heteroaryl fused cyclic amines
WO2009136290A1 (en) 2008-05-05 2009-11-12 Aegera Therapeutics, Inc. Functionalized pyrrolidines and use thereof as iap inhibitors
US8835393B2 (en) * 2008-08-02 2014-09-16 Genentech, Inc. Inhibitors of IAP
US8232273B2 (en) * 2008-12-19 2012-07-31 Genentech, Inc. Heterocyclic compounds and methods of use
JP5529282B2 (ja) * 2009-10-28 2014-06-25 ジョイアント ファーマスーティカルズ、インク． 二量体Ｓｍａｃ模倣薬
WO2011092293A2 (en) 2010-02-01 2011-08-04 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
CA2879870A1 (en) * 2012-10-11 2014-04-17 F. Hoffmann-La Roche Ag Azaindolines

Also Published As

Publication number Publication date
US9309248B2 (en) 2016-04-12
KR20150067182A (ko) 2015-06-17
CA2880324A1 (en) 2014-04-17
PH12015500399A1 (en) 2015-04-27
JP6333826B2 (ja) 2018-05-30
CN104540825A (zh) 2015-04-22
JP2015534570A (ja) 2015-12-03
MA38009B1 (fr) 2018-09-28
IL237115A (en) 2016-12-29
US20150266879A1 (en) 2015-09-24
HK1206738A1 (en) 2016-01-15
PE20150965A1 (es) 2015-06-20
EP2906559B1 (en) 2017-02-08
MX2015004525A (es) 2015-07-06
SG11201501314TA (en) 2015-03-30
ES2623304T3 (es) 2017-07-10
EA201590656A1 (ru) 2015-07-30
EP2906559A1 (en) 2015-08-19
MA38009A1 (fr) 2018-02-28
CN104540825B (zh) 2017-10-24
CR20150148A (es) 2015-04-30
AU2013328870A1 (en) 2015-02-26
WO2014056871A1 (en) 2014-04-17

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