CL2014002556A1 - Compuestos derivados de ácidos indaniloxidihidrobenzofuranilacéticos, agonistas del receptor gpr40; composiicon farmaceutica; y su uso en el tratamiento de enfermedades o afecciones como diabetes, resistencia a la insulina, obesidad, entre otras. - Google Patents
Compuestos derivados de ácidos indaniloxidihidrobenzofuranilacéticos, agonistas del receptor gpr40; composiicon farmaceutica; y su uso en el tratamiento de enfermedades o afecciones como diabetes, resistencia a la insulina, obesidad, entre otras.Info
- Publication number
- CL2014002556A1 CL2014002556A1 CL2014002556A CL2014002556A CL2014002556A1 CL 2014002556 A1 CL2014002556 A1 CL 2014002556A1 CL 2014002556 A CL2014002556 A CL 2014002556A CL 2014002556 A CL2014002556 A CL 2014002556A CL 2014002556 A1 CL2014002556 A1 CL 2014002556A1
- Authority
- CL
- Chile
- Prior art keywords
- indanyloxidihydrobenzofuranylacetic
- obesity
- diabetes
- diseases
- acids
- Prior art date
Links
- 206010022489 Insulin Resistance Diseases 0.000 title 1
- 208000008589 Obesity Diseases 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 235000020824 obesity Nutrition 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12161240 | 2012-03-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014002556A1 true CL2014002556A1 (es) | 2015-02-13 |
Family
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Family Applications (1)
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| CL2014002556A CL2014002556A1 (es) | 2012-03-26 | 2014-09-25 | Compuestos derivados de ácidos indaniloxidihidrobenzofuranilacéticos, agonistas del receptor gpr40; composiicon farmaceutica; y su uso en el tratamiento de enfermedades o afecciones como diabetes, resistencia a la insulina, obesidad, entre otras. |
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| Country | Link |
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| US (1) | US8642585B2 (OSRAM) |
| EP (2) | EP2831064B1 (OSRAM) |
| JP (2) | JP6040486B2 (OSRAM) |
| KR (1) | KR20140139088A (OSRAM) |
| CN (1) | CN104321319A (OSRAM) |
| AP (1) | AP2014007903A0 (OSRAM) |
| AR (1) | AR090493A1 (OSRAM) |
| AU (1) | AU2013241926A1 (OSRAM) |
| CA (1) | CA2868474A1 (OSRAM) |
| CL (1) | CL2014002556A1 (OSRAM) |
| CO (1) | CO7091175A2 (OSRAM) |
| EA (1) | EA201401053A1 (OSRAM) |
| EC (1) | ECSP14023238A (OSRAM) |
| HK (1) | HK1201260A1 (OSRAM) |
| MA (1) | MA20150065A1 (OSRAM) |
| MX (1) | MX2014011465A (OSRAM) |
| PE (1) | PE20142019A1 (OSRAM) |
| PH (1) | PH12014502141A1 (OSRAM) |
| SG (1) | SG11201405713UA (OSRAM) |
| TN (1) | TN2014000398A1 (OSRAM) |
| TW (1) | TW201400466A (OSRAM) |
| UY (1) | UY34704A (OSRAM) |
| WO (2) | WO2013144098A1 (OSRAM) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20120302566A1 (en) * | 2010-12-01 | 2012-11-29 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids |
| US8642585B2 (en) * | 2012-03-26 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids |
| WO2015024526A1 (en) * | 2013-08-23 | 2015-02-26 | Fujian Haixi Pharmaceuticals Co., Ltd | Carboxylic acid compounds in treatment of diabetes mellitus |
| AP2016009176A0 (en) | 2013-11-14 | 2016-04-30 | Cadila Healthcare Ltd | Novel heterocyclic compounds |
| US9957219B2 (en) | 2013-12-04 | 2018-05-01 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| US10059667B2 (en) | 2014-02-06 | 2018-08-28 | Merck Sharp & Dohme Corp. | Antidiabetic compounds |
| WO2016022446A1 (en) * | 2014-08-08 | 2016-02-11 | Merck Sharp & Dohme Corp. | [5,6]-fused bicyclic antidiabetic compounds |
| EP3347358B1 (en) * | 2015-09-09 | 2019-11-27 | Boehringer Ingelheim International GmbH | [{[2,3-dihydro-1h-inden-1-yl]amino}-2h,3h-furo[3,2-b]pyridin-3-yl]acetic acids, pharmaceutical compositions and uses thereof |
| EP3544958B1 (en) | 2016-11-28 | 2021-03-24 | Boehringer Ingelheim International GmbH | Indanylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
| US10919859B2 (en) | 2017-01-26 | 2021-02-16 | Boehringer Ingelheim International Gmbh | Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
| CN110248929B (zh) | 2017-01-26 | 2023-05-12 | 勃林格殷格翰国际有限公司 | 苄基氨基吡嗪基环丙烷甲酸、其药物组合物和用途 |
| US10913720B2 (en) | 2017-01-26 | 2021-02-09 | Boehringer Ingelheim International Gmbh | Benzyloxypyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
| US10603317B2 (en) | 2017-01-26 | 2020-03-31 | Boehringer Ingelheim International Gmbh | Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
| WO2018138026A1 (en) | 2017-01-26 | 2018-08-02 | Boehringer Ingelheim International Gmbh | Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
| CN110300755B (zh) * | 2017-02-08 | 2022-10-04 | 勃林格殷格翰国际有限公司 | 茚满基氨基氮杂二氢苯并呋喃乙酸、用于治疗糖尿病的药物组合物 |
| JPWO2018181847A1 (ja) * | 2017-03-31 | 2020-03-05 | 武田薬品工業株式会社 | 芳香環化合物 |
| EP3720835B1 (en) * | 2017-12-04 | 2022-07-13 | Basf Se | Method for preparing ethers of cycloaliphatic or araliphatic diols |
| WO2019149959A1 (en) * | 2018-02-05 | 2019-08-08 | Glaxosmithkline Intellectual Property Development Limited | Ghrelin o-acyltransferase inhibitors |
| CN111712494A (zh) | 2018-02-13 | 2020-09-25 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
| US12083118B2 (en) | 2018-03-29 | 2024-09-10 | Arbutus Biopharma Corporation | Substituted 1,1′-biphenyl compounds, analogues thereof, and methods using same |
| EP4600247A3 (en) | 2018-04-19 | 2025-11-19 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| KR20230159715A (ko) | 2018-07-13 | 2023-11-21 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| WO2020047035A1 (en) * | 2018-08-29 | 2020-03-05 | Chemocentryx, Inc. | Methods of treating cancer with small molecule pd-l1 inhibitors |
| TW202028183A (zh) * | 2018-10-10 | 2020-08-01 | 大陸商江蘇豪森藥業集團有限公司 | 含氮雜芳類衍生物調節劑、其製備方法和應用 |
| AU2019366355B2 (en) | 2018-10-24 | 2022-10-13 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| WO2021071837A1 (en) | 2019-10-07 | 2021-04-15 | Kallyope, Inc. | Gpr119 agonists |
| BR112022017039A2 (pt) | 2020-02-28 | 2022-11-16 | Kallyope Inc | Agonistas de gpr40 |
| JP2023526625A (ja) | 2020-05-19 | 2023-06-22 | キャリーオペ,インク. | Ampkアクチベーター |
| CN116390925A (zh) | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1735408A (zh) * | 2002-11-08 | 2006-02-15 | 武田药品工业株式会社 | 受体机能调节剂 |
| JP4594611B2 (ja) * | 2002-11-08 | 2010-12-08 | 武田薬品工業株式会社 | 受容体機能調節剤 |
| US7960369B2 (en) | 2002-11-08 | 2011-06-14 | Takeda Pharmaceutical Company Limited | Receptor function regulator |
| JP4805552B2 (ja) * | 2003-05-30 | 2011-11-02 | 武田薬品工業株式会社 | 縮合環化合物 |
| EP1630152A4 (en) | 2003-05-30 | 2009-09-23 | Takeda Pharmaceutical | CONDENSED CYCLIC COMPOUND |
| MX2008012529A (es) | 2006-03-30 | 2008-10-14 | Asahi Kasei Pharma Corp | Derivado biciclico substituido y uso del mismo. |
| JP4401428B2 (ja) | 2006-06-27 | 2010-01-20 | 武田薬品工業株式会社 | 縮合環化合物 |
| EP2289868B1 (en) | 2008-06-25 | 2014-08-13 | Daiichi Sankyo Company, Limited | Carboxylic acid compound |
| ES2450567T3 (es) | 2008-10-15 | 2014-03-25 | Amgen, Inc | Moduladores de GPR40 espirocíclicos |
| WO2010143733A1 (en) | 2009-06-09 | 2010-12-16 | Takeda Pharmaceutical Company Limited | Novel fused cyclic compound and use thereof |
| TW201643169A (zh) * | 2010-07-09 | 2016-12-16 | 艾伯維股份有限公司 | 作為s1p調節劑的螺-哌啶衍生物 |
| US20120302566A1 (en) | 2010-12-01 | 2012-11-29 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids |
| US8642585B2 (en) * | 2012-03-26 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids |
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2013
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- 2013-03-22 UY UY0001034704A patent/UY34704A/es unknown
- 2013-03-25 PE PE2014001462A patent/PE20142019A1/es not_active Application Discontinuation
- 2013-03-25 MA MA37429A patent/MA20150065A1/fr unknown
- 2013-03-25 KR KR20147030011A patent/KR20140139088A/ko not_active Withdrawn
- 2013-03-25 HK HK15101722.6A patent/HK1201260A1/xx unknown
- 2013-03-25 EP EP13712760.1A patent/EP2831064B1/en active Active
- 2013-03-25 JP JP2015502284A patent/JP6040486B2/ja active Active
- 2013-03-25 WO PCT/EP2013/056313 patent/WO2013144098A1/en not_active Ceased
- 2013-03-25 MX MX2014011465A patent/MX2014011465A/es unknown
- 2013-03-25 SG SG11201405713UA patent/SG11201405713UA/en unknown
- 2013-03-25 AR ARP130100969A patent/AR090493A1/es unknown
- 2013-03-25 AP AP2014007903A patent/AP2014007903A0/xx unknown
- 2013-03-25 TW TW102110560A patent/TW201400466A/zh unknown
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- 2013-03-25 EA EA201401053A patent/EA201401053A1/ru unknown
- 2013-03-25 CA CA2868474A patent/CA2868474A1/en not_active Abandoned
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2014
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- 2014-09-25 CL CL2014002556A patent/CL2014002556A1/es unknown
- 2014-09-25 PH PH12014502141A patent/PH12014502141A1/en unknown
- 2014-09-26 CO CO14213969A patent/CO7091175A2/es unknown
- 2014-10-17 EC ECIEPI201423238A patent/ECSP14023238A/es unknown
Also Published As
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| AU2013241926A1 (en) | 2014-09-18 |
| US20130252937A1 (en) | 2013-09-26 |
| WO2013144097A1 (en) | 2013-10-03 |
| WO2013144098A1 (en) | 2013-10-03 |
| PE20142019A1 (es) | 2014-12-18 |
| CN104321319A (zh) | 2015-01-28 |
| TN2014000398A1 (en) | 2015-12-21 |
| AR090493A1 (es) | 2014-11-19 |
| ECSP14023238A (es) | 2015-09-30 |
| US8642585B2 (en) | 2014-02-04 |
| PH12014502141A1 (en) | 2014-12-01 |
| UY34704A (es) | 2013-09-30 |
| AP2014007903A0 (en) | 2014-08-31 |
| JP2015511612A (ja) | 2015-04-20 |
| MA20150065A1 (fr) | 2015-02-27 |
| KR20140139088A (ko) | 2014-12-04 |
| JP6040486B2 (ja) | 2016-12-07 |
| EP2831053B1 (en) | 2016-06-22 |
| CO7091175A2 (es) | 2014-10-21 |
| JP6131492B2 (ja) | 2017-05-24 |
| EP2831064A1 (en) | 2015-02-04 |
| EP2831053A1 (en) | 2015-02-04 |
| JP2015511613A (ja) | 2015-04-20 |
| EA201401053A1 (ru) | 2015-04-30 |
| EP2831064B1 (en) | 2016-02-17 |
| HK1201260A1 (en) | 2015-08-28 |
| TW201400466A (zh) | 2014-01-01 |
| SG11201405713UA (en) | 2014-10-30 |
| MX2014011465A (es) | 2015-01-12 |
| CA2868474A1 (en) | 2013-10-03 |
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