CL2014001783A1 - Composicion farmaceutica liquida que comprende acido 1-{[4-[8-bromo-2-(2-isopropilcarbamoil-tiazol-4-il)-7-metoxi-quinolin-4-iloxi]-1-(r)-(2-ciclopentiloxicarbonilamino-3,3-(s)-dimetil-butiril)-pirrolidin-(s)-2-carbonil]-amino}-2-(s)-vinil-ciclopropan-(r)-carboxilico, inhibidor selectivo de la hcv ns3 serina proteasa; y metodo. - Google Patents

Composicion farmaceutica liquida que comprende acido 1-{[4-[8-bromo-2-(2-isopropilcarbamoil-tiazol-4-il)-7-metoxi-quinolin-4-iloxi]-1-(r)-(2-ciclopentiloxicarbonilamino-3,3-(s)-dimetil-butiril)-pirrolidin-(s)-2-carbonil]-amino}-2-(s)-vinil-ciclopropan-(r)-carboxilico, inhibidor selectivo de la hcv ns3 serina proteasa; y metodo.

Info

Publication number
CL2014001783A1
CL2014001783A1 CL2014001783A CL2014001783A CL2014001783A1 CL 2014001783 A1 CL2014001783 A1 CL 2014001783A1 CL 2014001783 A CL2014001783 A CL 2014001783A CL 2014001783 A CL2014001783 A CL 2014001783A CL 2014001783 A1 CL2014001783 A1 CL 2014001783A1
Authority
CL
Chile
Prior art keywords
cyclopentyloxycarbonylamino
cyclopropan
isopropylcarbamoyl
quinolin
hcv
Prior art date
Application number
CL2014001783A
Other languages
English (en)
Spanish (es)
Inventor
Mathias Braun
Carl Alan Busacca
Feng-Jing Chen
Edwin Louis Gump
Jenness B Majeska
Scott Pennino
Fenghe Qiu
Maria Fernanda Villagra
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47628447&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2014001783(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CL2014001783A1 publication Critical patent/CL2014001783A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CL2014001783A 2012-01-12 2014-07-03 Composicion farmaceutica liquida que comprende acido 1-{[4-[8-bromo-2-(2-isopropilcarbamoil-tiazol-4-il)-7-metoxi-quinolin-4-iloxi]-1-(r)-(2-ciclopentiloxicarbonilamino-3,3-(s)-dimetil-butiril)-pirrolidin-(s)-2-carbonil]-amino}-2-(s)-vinil-ciclopropan-(r)-carboxilico, inhibidor selectivo de la hcv ns3 serina proteasa; y metodo. CL2014001783A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261586087P 2012-01-12 2012-01-12

Publications (1)

Publication Number Publication Date
CL2014001783A1 true CL2014001783A1 (es) 2014-12-12

Family

ID=47628447

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014001783A CL2014001783A1 (es) 2012-01-12 2014-07-03 Composicion farmaceutica liquida que comprende acido 1-{[4-[8-bromo-2-(2-isopropilcarbamoil-tiazol-4-il)-7-metoxi-quinolin-4-iloxi]-1-(r)-(2-ciclopentiloxicarbonilamino-3,3-(s)-dimetil-butiril)-pirrolidin-(s)-2-carbonil]-amino}-2-(s)-vinil-ciclopropan-(r)-carboxilico, inhibidor selectivo de la hcv ns3 serina proteasa; y metodo.

Country Status (27)

Country Link
US (2) US20140037719A1 (h)
EP (1) EP2802313A1 (h)
JP (1) JP2015503616A (h)
KR (1) KR20140109433A (h)
CN (1) CN104244926A (h)
AP (1) AP2014007760A0 (h)
AR (1) AR089710A1 (h)
AU (1) AU2013208024A1 (h)
BR (1) BR112014017058A8 (h)
CA (1) CA2861041A1 (h)
CL (1) CL2014001783A1 (h)
CO (1) CO7000774A2 (h)
EA (1) EA201400808A1 (h)
EC (1) ECSP14013104A (h)
HK (1) HK1204982A1 (h)
IL (1) IL233550A0 (h)
IN (1) IN2014DN05759A (h)
MA (1) MA35865B1 (h)
MX (1) MX2014008205A (h)
NZ (1) NZ626353A (h)
PE (1) PE20141817A1 (h)
PH (1) PH12014501598A1 (h)
SG (1) SG11201404042VA (h)
TN (1) TN2014000295A1 (h)
TW (1) TW201340969A (h)
UY (1) UY34569A (h)
WO (1) WO2013106506A1 (h)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA119315C2 (uk) 2012-07-03 2019-06-10 Гіліад Фармассет Елелсі Інгібітори вірусу гепатиту с
EP2970335B1 (en) 2013-03-15 2019-05-08 Gilead Sciences, Inc. Macrocyclic and bicyclic inhibitors of hepatitis c virus

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5329976A (en) * 1991-12-09 1994-07-19 Habley Medical Technology Corporation Syringe-filling and medication mixing dispenser
US6323180B1 (en) 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
UY28240A1 (es) * 2003-03-27 2004-11-08 Boehringer Ingelheim Pharma Fases cristalinas de un potente inhibidor de la hcv
UY28323A1 (es) 2003-05-21 2004-12-31 Boehringer Ingelheim Int Compuestos inhibidores de la hepatitis c
EP1753775B1 (en) 2004-05-25 2012-12-26 Boehringer Ingelheim International GmbH Process for preparing acyclic hcv protease inhibitors
WO2006130552A2 (en) * 2005-06-02 2006-12-07 Schering Corporation Methods of treating hepatitis c virus
EA018603B1 (ru) 2008-09-16 2013-09-30 Бёрингер Ингельхайм Интернациональ Гмбх Кристаллические формы 2-тиазолил-4-хинолинилоксипроизводного, активного ингибитора hcv
SI2358355T1 (sl) * 2008-11-21 2014-02-28 Boehringer Ingelheim Gmbh Farmacevtski sestavek potentnega inhibitorja HCV za oralno dajanje
PL2451438T3 (pl) 2009-07-07 2014-07-31 Boehringer Ingelheim Int Kompozycja farmaceutyczna inhibitora proteazy wirusowego zapalenia wątroby typu C

Also Published As

Publication number Publication date
PH12014501598A1 (en) 2014-10-08
ECSP14013104A (es) 2015-11-30
AU2013208024A1 (en) 2014-07-10
IL233550A0 (en) 2014-08-31
EP2802313A1 (en) 2014-11-19
NZ626353A (en) 2016-02-26
KR20140109433A (ko) 2014-09-15
BR112014017058A2 (pt) 2017-06-13
US20150190458A1 (en) 2015-07-09
MA35865B1 (fr) 2014-12-01
US20140037719A1 (en) 2014-02-06
TW201340969A (zh) 2013-10-16
CO7000774A2 (es) 2014-07-21
MX2014008205A (es) 2014-08-08
CA2861041A1 (en) 2013-07-18
EA201400808A1 (ru) 2015-02-27
CN104244926A (zh) 2014-12-24
AP2014007760A0 (en) 2014-07-31
JP2015503616A (ja) 2015-02-02
HK1204982A1 (en) 2015-12-11
PE20141817A1 (es) 2014-12-17
TN2014000295A1 (en) 2015-12-21
UY34569A (es) 2013-07-31
SG11201404042VA (en) 2014-08-28
IN2014DN05759A (h) 2015-04-10
WO2013106506A1 (en) 2013-07-18
AR089710A1 (es) 2014-09-10
BR112014017058A8 (pt) 2017-07-04

Similar Documents

Publication Publication Date Title
CL2014003171A1 (es) Composicion liofilizada que comprende al menos una benzodiazepina de formula (i), al menos un excipiente higroscopico seleccionado de disacaridos y dextrano; metodo de preparacion de la composicion farmaceutica.
LTC2331547I2 (lt) Pirolopirimidino junginiai, kaip CDK inhibitoriai
SMT201600398B (it) Inibitori di proteina chinasi (varianti), uso di questi nel trattamento di malattie oncologiche e composizione farmaceutica basata su questi
DK3136030T3 (da) Fremgangsmåde til lyofilisering
CL2010001426A1 (es) Compuestos derivados de triciclos, inhibidores de la proteina quinasa; composicion farmaceutica que los comprende; utiles en el tratamiento de enfermedades oncologicas e inmunologicas.
DK2459715T3 (da) Fremgangsmåde til at oprense rekombinant adamts13 og andre proteiner og sammensætninger deraf
BRPI0923184A2 (pt) inibidores de hcv ns3 protease
EA200900091A1 (ru) Новые показания к применению прямых ингибиторов тромбина в лечении сердечно-сосудистых заболеваний
ATE543816T1 (de) Azacycloalkanderivate als inhibitoren von stearoyl-coenzym-a-delta-9-desaturase
WO2012069655A3 (en) Improved capping modules for designed ankyrin repeat proteins
EA200970247A1 (ru) Способ получения оптического активного n-защищенного 3-аминопирролидина или оптически активного n-защищенного 3-аминопиперидина и соответствующих кетонов путем оптического разделения рацемических смесей аминов с использованием бактериальной омега-трансаминазы
PE20131397A1 (es) Terapia de combinacion para tratar infeccion por hcv
DK1910288T3 (da) 3-aminocarbazolsammensætninger, farmaceutiske sammensætninger, der indeholder disse, samt fremgangsmåde til deres fremstilling
CL2013001591A1 (es) Compuestos derivados de triazolopiridina; inhibidores de pde10a; proceso de obtencion; composicion farmaceutica; y uso en el tratamiento o profilaxis de trastornos psicoticos, esquizofrenia, ansiedad, entre otras enfermedades.
WO2009008913A3 (en) P1-nonepimerizable ketoamide inhibitors of hcv ns3 protease
WO2013106689A8 (en) Hcv ns3 protease inhibitors
DK1986918T3 (da) Fremgangsmåde til blisterpakning
IT1397646B1 (it) Collagenasi ricombinanti di c. histolyticum e metodo per la loro produzione.
BR112013010836A2 (pt) inibidores específicos de ns3 protease de hcv
CL2014002138A1 (es) Formas solidas cristalinas de compuestos pirrolidin-benzodiazol-naftalen-diazol-pirrolidin sustituidos, inhibidores de la proteina no estructural 5a (ns5a) del virus de la hepatitis c (hcv); composicion farmaceutica y capsula de gel que las comprende.
BR112014016803A2 (pt) amidas macrocíclicas como inibidoras de protease
CL2014001783A1 (es) Composicion farmaceutica liquida que comprende acido 1-{[4-[8-bromo-2-(2-isopropilcarbamoil-tiazol-4-il)-7-metoxi-quinolin-4-iloxi]-1-(r)-(2-ciclopentiloxicarbonilamino-3,3-(s)-dimetil-butiril)-pirrolidin-(s)-2-carbonil]-amino}-2-(s)-vinil-ciclopropan-(r)-carboxilico, inhibidor selectivo de la hcv ns3 serina proteasa; y metodo.
EA201001823A1 (ru) Новые гетероциклические карбоксамиды для применения в качестве ингибиторов тромбина
EA201190256A1 (ru) Способ снижения уровня убиквитинилированных белков
UY30137A1 (es) Monohidrato de rimonabant, su procedimiento de preparación y composiciones farmacéuticas que lo contienen